Characteristics analysis of cervical lymph node metastasis in papillary thyroid carcinoma coexisting with Hashimoto thyreoiditis: a literatures review_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

DUAN Chengcheng , SHEN Keyu , XIAO Siqi , WU Xianji , YU Wenxi ,  ZHANG Guang

Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University; Jilin Provincial Key Laboratory of Surgical Translational Medicine; Jilin Provincial Engineering Laboratory of Thyroid Disease Prevention and Control, Changchun 130033, P. R. China;

Corresponding author：

ZHANG Guang, Email: zhangguang@jlu.edu.cn

Keywords：

Hashimoto thyroiditis; thyroid papillary carcinoma; cervical lymph node metastasis; risk factor; ultrasonic characteristics

DOI：

10.7507/1007-9424.202308070

Video：

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Objective To summarize the characteristics of cervical lymph node metastasis (LNM) in the papillary thyroid carcinoma (PTC) coexisting with Hashimoto thyroiditis (HT). Method The literatures related to cervical LNM of PTC coexisting with HT in recent years were collected and summarized. Results Compared with the PTC patients without HT, the more enlarged lymph nodes could be detected, and the cervival central LNM rate was lower, but there was still controversy about cervival lateral LNM in the patients with PTC coexisting with HT. The male, young, large tumor diameter, extraglandular invasion, multifocal cancer, BRAF gene mutation, and higher thyroid peroxidase antibody and thyroglobulin antibody levels, as well as the ultrasound features such as thyroid nodule aspect ratio >1, extremely low echo, calcification, and lymph node calcification, liquefaction, and disappearance of hilar lymph nodes could be used to evaluate the risk factors of cervical LNM for the patients with PTC coexisting with HT. Conclusions From the results of this review, it is suggests that the rate of central LNM is lower in patients with PTC coexisting with HT, but the status of LNM in the cervical lateral region remains to be explored. The relevant risk factors in combination with ultrasonic characteristics could help evaluate cervical lymph node status, could provide basis for early detection of metastatic lymph nodes and the formulation of individualized surgical plans, and improve the prognosis of patients.

Citation： DUAN Chengcheng, SHEN Keyu, XIAO Siqi, WU Xianji, YU Wenxi, ZHANG Guang. Characteristics analysis of cervical lymph node metastasis in papillary thyroid carcinoma coexisting with Hashimoto thyreoiditis: a literatures review. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2023, 30(12): 1507-1513. doi: 10.7507/1007-9424.202308070 Copy

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1. Bliddal S, Nielsen CH, Feldt-Rasmussen U. Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity. F1000Res, 2017, 6: 1776.
2. Dailey ME, Lindsay S, Skahen R. Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland. AMA Arch Surg, 1955, 70(2): 291-297.
3. Chen J, Li XL, Zhao CK, et al. Conventional ultrasound, immunohistochemical factors and BRAF^V600E mutation in predicting central cervical lymph node metastasis of papillary thyroid carcinoma. Ultrasound Med Biol, 2018, 44(11): 2296-2306.
4. Pagano L, Mele C, Sama MT, et al. Thyroid cancer phenotypes in relation to inflammation and autoimmunity. Front Biosci (Landmark Ed), 2018, 23(12): 2267-2282.
5. Uhliarova B, Hajtman A. Hashimoto’s thyroiditis—an independent risk factor for papillary carcinoma. Braz J Otorhinolaryngol, 2018, 84(6): 729-735.
6. Konturek A, Barczyński M, Wierzchowski W, et al. Coexistence of papillary thyroid cancer with Hashimoto thyroiditis. Langenbecks Arch Surg, 2013, 398(3): 389-394.
7. Xu JY, Ding K, Mu L, et al. Hashimoto’s thyroiditis: a “Double-Edged Sword” in thyroid carcinoma. Front Endocrinol (Lausanne), 2022, 13: 801925.
8. 吴佳奇, 王虹, 杜琳瑶, 等. 桥本甲状腺炎合并甲状腺乳头状癌超声特征与颈部淋巴结转移的相关性研究. 哈尔滨医科大学学报, 2018, 52(4): 387-390.
9. Abbasgholizadeh P, Naseri A, Nasiri E, et al. Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis. Thyroid Res, 2021, 14(1): 26.
10. 谭碧星. 桥本氏甲状腺炎背景下甲状腺乳头状癌的超声特征、BRAF^V600E突变及侵袭性情况的研究. 张家口: 河北北方学院, 2022.
11. Molnár C, Molnár S, Bedekovics J, et al. Thyroid carcinoma coexisting with Hashimoto’s thyreoiditis: clinicopathological and molecular characteristics clue up pathogenesis. Pathol Oncol Res, 2019, 25(3): 1191-1197.
12. Wen X, Wang B, Jin Q, et al. Thyroid antibody status is associated with central lymph node metastases in papillary thyroid carcinoma patients with Hashimoto’s thyroiditis. Ann Surg Oncol, 2019, 26(6): 1751-1758.
13. Liang J, Zeng W, Fang F, et al. Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1 392 patients. Acta Otorhinolaryngol Ital, 2017, 37(5): 393-400.
14. Lai V, Yen TW, Rose BT, et al. The effect of thyroiditis on the yield of central compartment lymph nodes in patients with papillary thyroid cancer. Ann Surg Oncol, 2015, 22(13): 4181-4186.
15. Sulaieva O, Selezniov O, Shapochka D, et al. Hashimoto’s thyroiditis attenuates progression of papillary thyroid carcinoma: deciphering immunological links. Heliyon, 2020, 6(1): e03077.
16. Kebebew E, Treseler PA, Ituarte PH, et al. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg, 2001, 25(5): 632-637.
17. Zhu F, Shen YB, Li FQ, et al. The effects of Hashimoto thyroiditis on lymph node metastases in unifocal and multifocal papillary thyroid carcinoma: a retrospective Chinese cohort study. Medicine (Baltimore), 2016, 95(6): e2674.
18. Dobrinja C, Makovac P, Pastoricchio M, et al. Coexistence of chronic lymphocytic thyroiditis and papillary thyroid carcinoma. Impact on presentation, management, and outcome. Int J Surg, 2016, 28 Suppl 1: S70-S74. doi: 10.1016/j.ijsu.2015.12.059.
19. Song E, Jeon MJ, Park S, et al. Influence of coexistent Hashimoto’s thyroiditis on the extent of cervical lymph node dissection and prognosis in papillary thyroid carcinoma. Clin Endocrinol (Oxf), 2018, 88(1): 123-128.
20. Wang L, Chen J, Yuan X, et al. Lymph node metastasis of papillary thyroid carcinoma in the context of Hashimoto’s thyroiditis. BMC Endocr Disord, 2022, 22(1): 12.
21. Liu Y, Lv H, Zhang S, et al. The impact of coexistent Hashimoto’s thyroiditis on central compartment lymph node metastasis in papillary thyroid carcinoma. Front Endocrinol (Lausanne), 2021, 12: 772071.
22. Paulson LM, Shindo ML, Schuff KG. Role of chronic lymphocytic thyroiditis in central node metastasis of papillary thyroid carcinoma. Otolaryngol Head Neck Surg, 2012, 147(3): 444-449.
23. 郑荆洲, 童传明, 吴高松. 微小甲状腺癌合并桥本氏甲状腺炎的临床病理及颈淋巴结转移特征. 中国普通外科杂志, 2014, 23(11): 1557-1560.
24. Donangelo I, Walts AE, Bresee C, et al. Lymphocytic thyroiditis is associated with increased number of benign cervical nodes and fewer central neck compartment metastatic lymph nodes in patients with differentiated thyroid cancer. Endocr Pract, 2016, 22(10): 1192-1198.
25. 车勇军, 连蕾, 侯钰, 等. 桥本氏甲状腺炎合并甲状腺乳头状癌患者的临床病理特征及其与BRAF基因突变的相关性研究. 中国耳鼻咽喉头颈外科, 2023, 30(2): 69-73.
26. 王欢, 柴芳, 林本瑞, 等. 合并桥本甲状腺炎的甲状腺乳头状癌中央区淋巴结转移的危险因素. 中国老年学杂志, 2021, 41(7): 1396-1399.
27. 刘文, 程若川. 甲状腺乳头状癌中央区淋巴结转移的预测因素. 中国普外基础与临床杂志, 2018, 25(1): 99-103.
28. 邱丽浈, 邱友燕, 陈晓珠, 等. 甲状腺乳头状癌合并桥本甲状腺炎临床病理特征及颈部淋巴结转移影响因素分析. 广州医科大学学报, 2022, 50(3): 70-75.
29. Sun Y, Lv H, Zhang S, et al. Gender-specific risk of central compartment lymph node metastasis in papillary thyroid carcinoma. Int J Endocrinol, 2018, 2018: 6710326.
30. Eldien MMS, Abdou AG, Rageh T, et al. Immunohistochemical expression of ER-α and PR in papillary thyroid carcinoma. Ecancermedicalscience, 2017, 11: 748.
31. 张广, 张纯海, 付言涛, 等. 甲状腺炎合并甲状腺癌颈淋巴结转移情况及相关因素探讨. 中国普外基础与临床杂志, 2011, 18(6): 625-628.
32. Zhou L, Chen G, Sheng L, et al. Influence factors for lymph node metastasis in papillary thyroid carcinoma: Hashimoto’s thyroiditis has a weak effect on central or lateral lymph node metastasis. Cancer Manag Res, 2021, 13: 3953-3961.
33. 赵凯军, 葛冠男, 郑美娜, 等. 桥本甲状腺炎合并其他甲状腺疾病的年龄分布研究. 中国地方病防治杂志, 2016, 31(11): 1216-1218.
34. 丁金旺, 潘钢, 项洋锋, 等. 甲状腺乳头状癌合并桥本甲状腺炎患侧中央区淋巴结转移的临床危险因素分析. 浙江医学, 2021, 43(15): 1643-1646,1651.
35. Zeng B, Min Y, Feng Y, et al. Hashimoto’s thyroiditis is associated with central lymph node metastasis in classical papillary thyroid cancer: analysis from a high-volume single-center experience. Front Endocrinol (Lausanne), 2022, 13: 868606.
36. Amin MB, Greene FL, Edge SB. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin, 2017, 67(2): 93-99.
37. Chen S, Niu C, Peng Q, et al. Sonographic characteristics of papillary thyroid carcinoma with coexistent Hashimoto’s thyroiditis in the preoperative prediction of central lymph node metastasis. Front Endocrinol (Lausanne), 2021, 12: 556851. doi: 10.3389/fendo.2021.556851.
38. Konturek A, Barczyński M, Nowak W, et al. Risk of lymph node metastases in multifocal papillary thyroid cancer associated with Hashimoto’s thyroiditis. Langenbecks Arch Surg, 2014, 399(2): 229-236.
39. Dong S, Xie XJ, Xia Q, et al. Indicators of multifocality in papillary thyroid carcinoma concurrent with Hashimoto’s thyroiditis. Am J Cancer Res, 2019, 9(8): 1786-1795.
40. Dong S, Xia Q, Wu YJ. High TPOAb levels (>1 300 IU/mL) indicate multifocal PTC in Hashimoto’s thyroiditis patients and support total thyroidectomy. Otolaryngol Head Neck Surg, 2015, 153(1): 20-26.
41. Min Y, Huang Y, Wei M, et al. Preoperatively predicting the central lymph node metastasis for papillary thyroid cancer patients with Hashimoto’s thyroiditis. Front Endocrinol (Lausanne), 2021, 12: 713475.
42. Shen CT, Zhang XY, Qiu ZL, et al. Thyroid autoimmune antibodies in patients with papillary thyroid carcinoma: a double-edged sword? Endocrine, 2017, 58(1): 176-183.
43. Paparodis R, Imam S, Todorova-Koteva K, et al. Hashimoto’s thyroiditis pathology and risk for thyroid cancer. Thyroid, 2014, 24(7): 1107-1114.
44. Vasileiadis I, Boutzios G, Charitoudis G, et al. Thyroglobulin antibodies could be a potential predictive marker for papillary thyroid carcinoma. Ann Surg Oncol, 2014, 21(8): 2725-2732.
45. Lubin D, Baraban E, Lisby A, et al. Papillary thyroid carcinoma emerging from Hashimoto thyroiditis demonstrates increased PD-L1 expression, which persists with metastasis. Endocr Pathol, 2018, 29(4): 317-323.
46. 罗雪, 赵代伟, 陈松, 等. 程序性细胞死亡配体1在甲状腺乳头状癌合并桥本甲状腺炎中的表达及其临床意义. 中国普外基础与临床杂志, 2021, 28(9): 1155-1158.
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Characteristics analysis of cervical lymph node metastasis in papillary thyroid carcinoma coexisting with Hashimoto thyreoiditis: a literatures review

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