• Department of Hepatobiliary Pancreatic Surgery, The First People’s Hospital of Kunming / The Affiliated Calmette Hospital of Kunming Medical University, Kunming 650100, P. R. China;
GAO Hongqiang, Email: 13708466595@163.com
Export PDF Favorites Scan Get Citation

Objective To summarize the progress in research on the role of hydrogen sulfide (H2S) in liver diseases. Method The relevant literature at home and abroad in recent years was searched and reviewed. Results The H2S played an important role in the occurrence and development of the liver diseases through anti-oxidative stress, anti-inflammation, regulation of autophagy, endoplasmic reticulum stress, angiogenesis, cell death, and other mechanisms. However, the relevant mechanisms are still controversial. Future studies needed to deeply explore the specific role of H2S in the different liver diseases, and how to accurately control its level in vivo and achieve targeted drug administration. Conclusions The concentration of H2S in vivo can be regulated by supplementing exogenous H2S, adjusting intestinal microbiota or inhibiting key enzymes of H2S synthesis, which provides a new strategy for the treatment of liver diseases. However, the relevant mechanisms are still controversial, and future research needs to delve into the specific role of H2S in different liver diseases, as well as how to precisely control its levels in vivo and achieve targeted drug delivery.

Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved