Recurrent Pulmonary Artery Aneurysm Caused by Behcet's Disease: A Case Report and Literature Review_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 LiuJie ¹ , ChenRongchang ¹ , ZhongNanshan ¹ , GuYingying ² , ZengQingsi ³ , LiuFanglan ⁴

1. National Clinical Reseach Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, China;
2. ;
3. ;
4. ;

Corresponding author：

LiuJie, Email: ljgird001@163.com

Keywords：

Behcet's disease; Pulmonary artery aneurysm

DOI：

10.7507/1671-6205.2014068

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Objective To improve the knowledge of clinical features,image and pathology of Behcet's disease with the pulmonary artery aneurysm. Methods One typical female patient aged 40 years with recurrent pulmonary artery aneurysm caused by Behcet's disease was analyzed including clinical data,image and pathological features.The Pubmed (1967.1 to 2013.10) and Wanfang database (1982.1 to 2013.10) were searched with "Behcet's disease","pulmonary artery aneurysm" as search terms. Results Recurrent hemoptysis was major clinical manifestation of pulmonary artery aneurysm caused by Behcet's disease.Features of image including hilar enlargement,pulmonary artery aneurysm and primary thrombus.During the first hospitalization,the patient was diagnosed as pulmonary artery aneurysm.Then pulmonary lobectomy was performed and pathology examination revealed artery aneurysm and primary thrombus.During the second hospitalization,she was diagnosed as pulmonary thromboembolism and it was considered as failure of treatment of anticoagulant therapy.During the third hospitalization,she was diagnosed as pulmonary artery aneurysm of Behcet's disease,and recurrent hemoptysis was fully ameliorated by the combination treatment of glucocorticoid and immunodepressant. Conclusion Pulmonary artery aneurysm is the typical feature of pulmonary vascular lesions of Behcet's disease,and recurrent hemoptysis is major clinical manifestation.CT angiography can identify location of pulmonary artery aneurysm.The key drugs of therapy are imunosuppressive drugs in combination with steroids.

Citation： LiuJie, ChenRongchang, ZhongNanshan, GuYingying, ZengQingsi, LiuFanglan. Recurrent Pulmonary Artery Aneurysm Caused by Behcet's Disease: A Case Report and Literature Review. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(3): 281-285. doi: 10.7507/1671-6205.2014068 Copy

1.	Gurgun C,Ercan E,Ceyhan C,et al.Cardiovascular involvement in Behcet's disease.Jpn Heart J,2002,43:389-398.
2.	Gunen H,Evereklioglu C,Kosar F,et al.Thoracic involvement in Behcet's disease and its correlation with multiple parameters.Lung,2000,178:161-170.
3.	Schneider F,Gouny P,Van Laere O,et al.Vascular complications after surgical repair of aneurysms in Behcet's disease.J Cardiovasc Surg(Torino),2002,43:501-505.
4.	Tunaci M,Ozkokmaz B,Tunaci A,et al.CT findings of pulmonary artery aneurysms during treatment for Behcet's disease.AJR,1999,172:729-733.
5.	Fresko I,Yurdakul S,Hamuryundan V,et al.The management of Behcet's disease.Ann Med Interne,1999,150:576-581.
6.	Mahendran C,Singh P,Mani NB,et al.Successful treatment of pulmonary artery aneurysms secondary to possible Behcet's disease.Respiration,2002,69:355-358.
7.	Erkan F,Gul A,Tasali E.Pulmonary manifestations of Behcet's disease.Thorax,2001,56:572-578.
8.	Park JH,Chung JW,Joh JH,et al.Aortic and arterial aneurysms in Behcet's disease:management with stent-grafts-initial expericnce.Radiology,2001,220:745-750.
9.	Hamuryudan V,Er T,Seyahi E,et al.Pulmonary artery aneurysms in Behcet's syndrome.Am J Med,2004,117:867-870.
10.	Kural-Seyahi E,Fresko I,Seyahi N,et al.The long-term mortality and morbidity of Behcet's syndrome:a 2-decade outcome survey of 387 patients followed at adedicated center.Medicine(Baltimore),2003,82:60-76.
11.	Takahama M, Yamamoto R,Nakajima R,et al.Successful surgical treatment of pulmonary artery aneurysm in Behçet's syndrome.Interact Cardiovasc Thorac Surg,2009,8:390-392.
12.	Uzun O,Erkan L,Akpolat I,et al.Pulmonary involvement in Behçet's disease.Respiration,2008,75:310-321.

1. Gurgun C,Ercan E,Ceyhan C,et al.Cardiovascular involvement in Behcet's disease.Jpn Heart J,2002,43:389-398.
2. Gunen H,Evereklioglu C,Kosar F,et al.Thoracic involvement in Behcet's disease and its correlation with multiple parameters.Lung,2000,178:161-170.
3. Schneider F,Gouny P,Van Laere O,et al.Vascular complications after surgical repair of aneurysms in Behcet's disease.J Cardiovasc Surg(Torino),2002,43:501-505.
4. Tunaci M,Ozkokmaz B,Tunaci A,et al.CT findings of pulmonary artery aneurysms during treatment for Behcet's disease.AJR,1999,172:729-733.
5. Fresko I,Yurdakul S,Hamuryundan V,et al.The management of Behcet's disease.Ann Med Interne,1999,150:576-581.
6. Mahendran C,Singh P,Mani NB,et al.Successful treatment of pulmonary artery aneurysms secondary to possible Behcet's disease.Respiration,2002,69:355-358.
7. Erkan F,Gul A,Tasali E.Pulmonary manifestations of Behcet's disease.Thorax,2001,56:572-578.
8. Park JH,Chung JW,Joh JH,et al.Aortic and arterial aneurysms in Behcet's disease:management with stent-grafts-initial expericnce.Radiology,2001,220:745-750.
9. Hamuryudan V,Er T,Seyahi E,et al.Pulmonary artery aneurysms in Behcet's syndrome.Am J Med,2004,117:867-870.
10. Kural-Seyahi E,Fresko I,Seyahi N,et al.The long-term mortality and morbidity of Behcet's syndrome:a 2-decade outcome survey of 387 patients followed at adedicated center.Medicine(Baltimore),2003,82:60-76.
11. Takahama M, Yamamoto R,Nakajima R,et al.Successful surgical treatment of pulmonary artery aneurysm in Behçet's syndrome.Interact Cardiovasc Thorac Surg,2009,8:390-392.
12. Uzun O,Erkan L,Akpolat I,et al.Pulmonary involvement in Behçet's disease.Respiration,2008,75:310-321.

Chinese Journal of Respiratory and Critical Care Medicine

Recurrent Pulmonary Artery Aneurysm Caused by Behcet's Disease: A Case Report and Literature Review

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