Citation: 李钊, 姚婉贞. 慢性阻塞性肺疾病与细菌感染及抗感染治疗. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(4): 414-418. doi: 10.7507/1671-6205.2014102 Copy
1. | Mannino DM,Buist AS.Global burden of COPD:risk factors,prevalence,and future trends.Lancet,2007,370:765-773. |
2. | NHLBI.Chronic obstructive pulmonary disease data fact sheet.03-5229.NIH Publication; 2003. |
3. | Global surveillance,prevention and control of chronic respiratory diseases.A comprehensive approach.WHO;2007,ISBN 9789241563468;2007 http://www.who.int/respiratory/publications/global_surveillance/en/index.html. |
4. | Zhong N,Wang C,Yao W,et al.Prevalence of chronic obstructive pulmonary disease in China:a large,population-based survey.Am J Respir Crit Care Med,2007,176:753-760. |
5. | Wilson R,Sethi S,Anzueto A,et al.Antibiotics for treatment and prevention of exacerbations of chronic obstructive pulmonary disease.J Infect,2013,67:495-515. |
6. | Sethi S,Evans N,Grant BJ,et al.New strains of bacteria and exacerbations of chronic obstructive pulmonary disease.N Engl J Med,2002,347:465-471. |
7. | Rothberg MB,Pekow PS,Lahti M,et al.Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease.JAMA,2010,303:2035-2042. |
8. | Kumar V,Abbas AK,Aster JC,et al.Pathological basis of disease,8th Edition.Philadelphia:Elsevier Saunders,2009,161:683-688. |
9. | Hoenderdos K,Condliffe A.The neutrophil in chronic obstructive pulmonary disease.Am J Respir Cell Mol Biol,2013,48:531-539. |
10. | Murphy TF,Sethi S.Bacterial infection in chronic obstructive pulmonary disease.Am Rev Respir Dis,1992,146:1067-1083. |
11. | Sethi S.Bacterial Infection and the Pathogenesis of COPD.Chest,2000,117:286-291. |
12. | Ganesan S,Sajjan US.Repair and Remodeling of airway epithelium after injury in chronic obstructive pulmonary disease.Curr Respir Care Rep,2013,2(3). |
13. | Zakharkina T,Heinzel E,Koczulla RA,et al.Analysis of the airway microbiota of healthy individuals and patients with chronic obstructive pulmonary disease by T-RFLP and clone sequencing.PLoS One,2013,8(7):e68302. |
14. | Matkovic Z,Miravitlles M.Chronic bronchial infection in COPD.Is there an infective phenotype? Respir Med,2013,107:10-22. |
15. | Bansal M,Khatri M,Taneja V.Potential role of periodontal infection in respiratory diseases-a review.J Med Life,2013,6:244-248. |
16. | Hurst JR,Wilkinson TM,Perera WR.Relationships among bacteria,upper airway,lower airway,and systemic inflammation in COPD.Chest,2005,127:1219-1226. |
17. | Wark PA,Tooze M,Powell H,et al.Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission.Respirology,2013,18:996-1002. |
18. | Murphy TF,Brauer AL,Eschberger K,et al.Pseudomonas aeruginosa in chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2008,177:853-860. |
19. | Sethi S,Sethi R,EschbergerK,et al. Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2007,176:356-361. |
20. | Murphy TF,Brauer AL,Sethi S,et al.Haemophilus haemolyticus:a human respiratory tract commensal to be distinguished from Haemophilus influenzae.J Infect Dis,2007,195:81-89. |
21. | Miravitlles M,Kruesmann F,Haverstock D,et al.Sputum colour and bacteria in chronic bronchitis exacerbations:a pooled analysis.Eur Respir J,2012,39:1354-1360. |
22. | Soler N,Agustí C,Angrill J,et al.Bronchoscopic validation of the signify-cance of sputum purulence in severe exacerbations of chronic obstructive pulmonary disease.Thorax,2007,62:29-35. |
23. | Vollenweider DJ,Jarrett H,Steurer-Stey CA,et al.Antibiotics for exacer-bation of chronic obstructive pulmonary diseases.Cochrane Database Syst Rev,2012,12:CD010257. |
24. | Daniels JMA,Snijders D,de Graaff CS,et al.Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2010,181:150-157. |
25. | Llor C,Moragas A,Hem andez S,et al.Efficacy of antibiotic therapy for acute exacerbations of mild to moderate COPD.Am J Respir Crit Care Med,2012,186:716-723. |
26. | Groenewegen KH,Wouters EF.Bacterial infections in patients requiring admission for an acute exacerbation of COPD; a 1-year prospective study.Respir Med,2003,97:770-777. |
27. | Papi A,Bellettato CM,Braccioni F,et al.Infections and airway infla-mmation in chronic obstructive pulmonary disease severe exacerbations.Am J Respir Crit Care Med,2006,173:1114-1121. |
28. | Monsó E,Garcia-Aymerich J,Soler N,et al.Bacterial infection in exacer-bated COPD with changes in sputum characteristics.Epidemiol Infect,2003,131:799-804. |
29. | Leophonte P.Infections in chronic obstructive pulmonary disease.Ball Aead Natl Med,2004,188:47-64. |
30. | Lieberman D,Lieberman D.Pseudomonal infections in patients with COPD:epidemiology and management.Am J Respir Med,2003,2:459-468. |
31. | Lapteva IM,LaptevaEA,KorovkinVS.Lung function and bacterial pathogens in sputum of patients with acute exacerbation of COPD.Eur Respir J,2004,24:408. |
32. | Ye F,He LX,Cai BQ,et al.Spectrum and antimicrobial resistance of common pathogenic bacteria isolated from patients with acute exacerbation of chronic obstructive pulmonary disease in mainland of China.Chin Med J (Engl),2013,126:2207-2214. |
33. | Li XJ,Li Q,Si LY,Yuan QY.Bacteriological differences between COPD exacerbation and community-acquired pneumonia.Respir Care,2011,56:1818-1824. |
34. | Domenech A,Puig C,Martí S,et al.Infectious etiology of acute exacer-bations in severe COPD patients.J Infect,2013,67:516-523. |
35. | 姚婉贞,路明.慢性阻塞性肺疾病急性加重如何合理使用抗生素.中国实用内科杂志,2012,32:558-560. |
36. | National Institute of Health,National Heart Lung and Blood Institute.Global Initiative for Chronic Obstructive Pulmonary Disease.Global strategy for the Diagnosis,Management and Prevention of Chronic Obstructive Pulmonary Disease.Updated 2011; Available from URL:http://www.Goldcopd.Org. |
37. | Bandak SI,Bolzon LD,Turnak MR,et al.Cefaclor versus amoxicillin/clavulanate in acute bacterial exacerbations of chronic bronchitis:a randomised multicentre study.Int J Clin Pract,1999,53:578-583. |
38. | Chodosh S,DeAbate CA,Haverstock D,et al.The Bronchitis Study Group.Short course moxifloxacin therapy for treatment of acute bacterial exacerbations of chronic bronchitis.Respir Med,2000,94:18-27. |
39. | Weiss LR.Open-label,randomized comparison of clarithromycin,levofloxacin and cefuroxime axetil in the treatment of adults with acute bacterial exacerbations of chronic bronchitis.Clin Ther,2002,24:1414-1424. |
40. | Albert RK,Connett J,Bailey WC,et al.Azithromycin for prevention of exacerbations of COPD.N Engl J Med,2011,365:689-698. |
41. | Suzuki T,Yanai M,Yamaya M,et al.Erythromycin and common cold in COPD.Chest,2001,120:730-733. |
42. | Banerjee D,Honeybourne D,Khair OA.The effect of oral clarithromycin on bronchial airway inflammation in moderate-tosevere stable COPD:a randomized controlled trial.Treat Respir Med,2004,3:59-65. |
43. | Blasi F,Bonardi D,Aliberti S,et al.Long-term azithromycin use in patients with chronic obstructive pulmonary disease and tracheostomy.Pulmon Phamacol Ther,2010,23:200-207. |
44. | He ZY,Ou LM,Zhang JQ,et al.Effect of 6 months of erythromycin treatment on inflammatory cells in induced sputum and exacerbations in chronic obstructive pulmonary disease.Respiration,2010,80:445-452. |
45. | Pomares X,Montón C,Espasa M,et al.Long-term azithromycin therapy in patients with severe COPD and repeated exacerbations.Int J COPD,2011,6:449-456. |
46. | Seemungal TA,Wilkinson TM,Hurst JR,et al.Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations.Am J Respir Crit Care Med,2008,178:1139-1147. |
47. | Hodge S,Reynolds PN.Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocyte-derived macrophages in chronic obstructive pulmonary disease subjects.Respirology,2012,17:802-807. |
48. | Albert RK,Connett J,Bailey WC,et al.Azithromycin for prevention of exacerbations of COPD.N Engl J Med,2011,365:689-698. |
49. | Sethi S,Jones PW,Theron MS,et al.Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease:a randomized controlled trial.Respir Res,2010,11:10. |
50. | Ray WA,Murray KT,Hall K,et al.Azithromycin and the risk of cardio-vascular death.N Engl J Med,2012,366:1881-1890. |
51. | Miravitlles M,Soler-Cataluna JJ,Calle M,et al.Spanish COPD Guidelines (GesEPOC):pharmacological treatment of stable COPD.Arch Bronconeumol,2012,48:247-257. |
52. | Wilson R,Sethi S,Anzueto A,et al.Antibiotics for treatment and pre-vention of exacerbations of chronic obstructive pulmonary disease.J Infect,2013,67:497-515. |
53. | Ramsey B,Pepe MS,Quan JM,et al.Cystic Fibrosis Inhaled Tobramycin Study Group.Intermittent administration of inhaled tobramycin in patients with cystic fibrosis.N Engl J Med,1999,340:23-30. |
54. | Murphy TD,Anbar RD,Lester LA,et al.Treatment with tobramycin solution for inhalation reduces hospitalizations in young CF subjects with mild lung disease.Pediatr Pulmonol,2004,38:314-320. |
55. | Wilson R,Welte T,Polverino E,et al.Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis:a phase Ⅱ randomised study.Eur Resp J,2013,41:1107-1115. |
56. | Drobnic ME,Suñé P,Montoro JB,et al.Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa.Ann Pharmacother,2005,39:39-44. |
57. | Murray MP,Govan JR,Doherty CJ,et al.A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis.Am J Respir Crit Care Med,2011,183:491-499. |
58. | Wilson R,Welte T,Polverino E,et al.Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis:a phase Ⅱ randomised study.Eur Resp J,2013,41:1107-1115. |
59. | Dal Negro R,Micheletto C,Tognella S,et al.Tobramycin nebulizer solution in severe COPD patients colonized with Pseudomonas aeruginosa:effects on bronchial inflammation.Adv Ther,2008,25:1019-1030. |
60. | Couch LA.Treatment with tobramycin solution for inhalation in bronchie-ctasis patients with Pseudomonas aeruginosa.Chest,2001,120:114S-117S. |
61. | Bilton D,Henig N,Morrissey B,et al.Addition of inhaled tobramycin to ciprofloxacin for acute exacerbations of Pseudomonas aeruginosa infection in adult bronchiectasis.Chest,2006,130:1503-1510. |
62. | Hagerman JK,Hancock KE,Klepser ME.Aerosolised antibiotics:a critical appraisal of their use.Expert Opin Drug Deliv,2006,3:71-86. |
63. | 康怡,赖国祥,柳德灵.慢性阻塞性肺疾病与细菌感染.中国呼吸与危重监护杂志,2011,10:298-300. |
- 1. Mannino DM,Buist AS.Global burden of COPD:risk factors,prevalence,and future trends.Lancet,2007,370:765-773.
- 2. NHLBI.Chronic obstructive pulmonary disease data fact sheet.03-5229.NIH Publication; 2003.
- 3. Global surveillance,prevention and control of chronic respiratory diseases.A comprehensive approach.WHO;2007,ISBN 9789241563468;2007 http://www.who.int/respiratory/publications/global_surveillance/en/index.html.
- 4. Zhong N,Wang C,Yao W,et al.Prevalence of chronic obstructive pulmonary disease in China:a large,population-based survey.Am J Respir Crit Care Med,2007,176:753-760.
- 5. Wilson R,Sethi S,Anzueto A,et al.Antibiotics for treatment and prevention of exacerbations of chronic obstructive pulmonary disease.J Infect,2013,67:495-515.
- 6. Sethi S,Evans N,Grant BJ,et al.New strains of bacteria and exacerbations of chronic obstructive pulmonary disease.N Engl J Med,2002,347:465-471.
- 7. Rothberg MB,Pekow PS,Lahti M,et al.Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease.JAMA,2010,303:2035-2042.
- 8. Kumar V,Abbas AK,Aster JC,et al.Pathological basis of disease,8th Edition.Philadelphia:Elsevier Saunders,2009,161:683-688.
- 9. Hoenderdos K,Condliffe A.The neutrophil in chronic obstructive pulmonary disease.Am J Respir Cell Mol Biol,2013,48:531-539.
- 10. Murphy TF,Sethi S.Bacterial infection in chronic obstructive pulmonary disease.Am Rev Respir Dis,1992,146:1067-1083.
- 11. Sethi S.Bacterial Infection and the Pathogenesis of COPD.Chest,2000,117:286-291.
- 12. Ganesan S,Sajjan US.Repair and Remodeling of airway epithelium after injury in chronic obstructive pulmonary disease.Curr Respir Care Rep,2013,2(3).
- 13. Zakharkina T,Heinzel E,Koczulla RA,et al.Analysis of the airway microbiota of healthy individuals and patients with chronic obstructive pulmonary disease by T-RFLP and clone sequencing.PLoS One,2013,8(7):e68302.
- 14. Matkovic Z,Miravitlles M.Chronic bronchial infection in COPD.Is there an infective phenotype? Respir Med,2013,107:10-22.
- 15. Bansal M,Khatri M,Taneja V.Potential role of periodontal infection in respiratory diseases-a review.J Med Life,2013,6:244-248.
- 16. Hurst JR,Wilkinson TM,Perera WR.Relationships among bacteria,upper airway,lower airway,and systemic inflammation in COPD.Chest,2005,127:1219-1226.
- 17. Wark PA,Tooze M,Powell H,et al.Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission.Respirology,2013,18:996-1002.
- 18. Murphy TF,Brauer AL,Eschberger K,et al.Pseudomonas aeruginosa in chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2008,177:853-860.
- 19. Sethi S,Sethi R,EschbergerK,et al. Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2007,176:356-361.
- 20. Murphy TF,Brauer AL,Sethi S,et al.Haemophilus haemolyticus:a human respiratory tract commensal to be distinguished from Haemophilus influenzae.J Infect Dis,2007,195:81-89.
- 21. Miravitlles M,Kruesmann F,Haverstock D,et al.Sputum colour and bacteria in chronic bronchitis exacerbations:a pooled analysis.Eur Respir J,2012,39:1354-1360.
- 22. Soler N,Agustí C,Angrill J,et al.Bronchoscopic validation of the signify-cance of sputum purulence in severe exacerbations of chronic obstructive pulmonary disease.Thorax,2007,62:29-35.
- 23. Vollenweider DJ,Jarrett H,Steurer-Stey CA,et al.Antibiotics for exacer-bation of chronic obstructive pulmonary diseases.Cochrane Database Syst Rev,2012,12:CD010257.
- 24. Daniels JMA,Snijders D,de Graaff CS,et al.Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2010,181:150-157.
- 25. Llor C,Moragas A,Hem andez S,et al.Efficacy of antibiotic therapy for acute exacerbations of mild to moderate COPD.Am J Respir Crit Care Med,2012,186:716-723.
- 26. Groenewegen KH,Wouters EF.Bacterial infections in patients requiring admission for an acute exacerbation of COPD; a 1-year prospective study.Respir Med,2003,97:770-777.
- 27. Papi A,Bellettato CM,Braccioni F,et al.Infections and airway infla-mmation in chronic obstructive pulmonary disease severe exacerbations.Am J Respir Crit Care Med,2006,173:1114-1121.
- 28. Monsó E,Garcia-Aymerich J,Soler N,et al.Bacterial infection in exacer-bated COPD with changes in sputum characteristics.Epidemiol Infect,2003,131:799-804.
- 29. Leophonte P.Infections in chronic obstructive pulmonary disease.Ball Aead Natl Med,2004,188:47-64.
- 30. Lieberman D,Lieberman D.Pseudomonal infections in patients with COPD:epidemiology and management.Am J Respir Med,2003,2:459-468.
- 31. Lapteva IM,LaptevaEA,KorovkinVS.Lung function and bacterial pathogens in sputum of patients with acute exacerbation of COPD.Eur Respir J,2004,24:408.
- 32. Ye F,He LX,Cai BQ,et al.Spectrum and antimicrobial resistance of common pathogenic bacteria isolated from patients with acute exacerbation of chronic obstructive pulmonary disease in mainland of China.Chin Med J (Engl),2013,126:2207-2214.
- 33. Li XJ,Li Q,Si LY,Yuan QY.Bacteriological differences between COPD exacerbation and community-acquired pneumonia.Respir Care,2011,56:1818-1824.
- 34. Domenech A,Puig C,Martí S,et al.Infectious etiology of acute exacer-bations in severe COPD patients.J Infect,2013,67:516-523.
- 35. 姚婉贞,路明.慢性阻塞性肺疾病急性加重如何合理使用抗生素.中国实用内科杂志,2012,32:558-560.
- 36. National Institute of Health,National Heart Lung and Blood Institute.Global Initiative for Chronic Obstructive Pulmonary Disease.Global strategy for the Diagnosis,Management and Prevention of Chronic Obstructive Pulmonary Disease.Updated 2011; Available from URL:http://www.Goldcopd.Org.
- 37. Bandak SI,Bolzon LD,Turnak MR,et al.Cefaclor versus amoxicillin/clavulanate in acute bacterial exacerbations of chronic bronchitis:a randomised multicentre study.Int J Clin Pract,1999,53:578-583.
- 38. Chodosh S,DeAbate CA,Haverstock D,et al.The Bronchitis Study Group.Short course moxifloxacin therapy for treatment of acute bacterial exacerbations of chronic bronchitis.Respir Med,2000,94:18-27.
- 39. Weiss LR.Open-label,randomized comparison of clarithromycin,levofloxacin and cefuroxime axetil in the treatment of adults with acute bacterial exacerbations of chronic bronchitis.Clin Ther,2002,24:1414-1424.
- 40. Albert RK,Connett J,Bailey WC,et al.Azithromycin for prevention of exacerbations of COPD.N Engl J Med,2011,365:689-698.
- 41. Suzuki T,Yanai M,Yamaya M,et al.Erythromycin and common cold in COPD.Chest,2001,120:730-733.
- 42. Banerjee D,Honeybourne D,Khair OA.The effect of oral clarithromycin on bronchial airway inflammation in moderate-tosevere stable COPD:a randomized controlled trial.Treat Respir Med,2004,3:59-65.
- 43. Blasi F,Bonardi D,Aliberti S,et al.Long-term azithromycin use in patients with chronic obstructive pulmonary disease and tracheostomy.Pulmon Phamacol Ther,2010,23:200-207.
- 44. He ZY,Ou LM,Zhang JQ,et al.Effect of 6 months of erythromycin treatment on inflammatory cells in induced sputum and exacerbations in chronic obstructive pulmonary disease.Respiration,2010,80:445-452.
- 45. Pomares X,Montón C,Espasa M,et al.Long-term azithromycin therapy in patients with severe COPD and repeated exacerbations.Int J COPD,2011,6:449-456.
- 46. Seemungal TA,Wilkinson TM,Hurst JR,et al.Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations.Am J Respir Crit Care Med,2008,178:1139-1147.
- 47. Hodge S,Reynolds PN.Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocyte-derived macrophages in chronic obstructive pulmonary disease subjects.Respirology,2012,17:802-807.
- 48. Albert RK,Connett J,Bailey WC,et al.Azithromycin for prevention of exacerbations of COPD.N Engl J Med,2011,365:689-698.
- 49. Sethi S,Jones PW,Theron MS,et al.Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease:a randomized controlled trial.Respir Res,2010,11:10.
- 50. Ray WA,Murray KT,Hall K,et al.Azithromycin and the risk of cardio-vascular death.N Engl J Med,2012,366:1881-1890.
- 51. Miravitlles M,Soler-Cataluna JJ,Calle M,et al.Spanish COPD Guidelines (GesEPOC):pharmacological treatment of stable COPD.Arch Bronconeumol,2012,48:247-257.
- 52. Wilson R,Sethi S,Anzueto A,et al.Antibiotics for treatment and pre-vention of exacerbations of chronic obstructive pulmonary disease.J Infect,2013,67:497-515.
- 53. Ramsey B,Pepe MS,Quan JM,et al.Cystic Fibrosis Inhaled Tobramycin Study Group.Intermittent administration of inhaled tobramycin in patients with cystic fibrosis.N Engl J Med,1999,340:23-30.
- 54. Murphy TD,Anbar RD,Lester LA,et al.Treatment with tobramycin solution for inhalation reduces hospitalizations in young CF subjects with mild lung disease.Pediatr Pulmonol,2004,38:314-320.
- 55. Wilson R,Welte T,Polverino E,et al.Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis:a phase Ⅱ randomised study.Eur Resp J,2013,41:1107-1115.
- 56. Drobnic ME,Suñé P,Montoro JB,et al.Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa.Ann Pharmacother,2005,39:39-44.
- 57. Murray MP,Govan JR,Doherty CJ,et al.A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis.Am J Respir Crit Care Med,2011,183:491-499.
- 58. Wilson R,Welte T,Polverino E,et al.Ciprofloxacin DPI in non-cystic fibrosis bronchiectasis:a phase Ⅱ randomised study.Eur Resp J,2013,41:1107-1115.
- 59. Dal Negro R,Micheletto C,Tognella S,et al.Tobramycin nebulizer solution in severe COPD patients colonized with Pseudomonas aeruginosa:effects on bronchial inflammation.Adv Ther,2008,25:1019-1030.
- 60. Couch LA.Treatment with tobramycin solution for inhalation in bronchie-ctasis patients with Pseudomonas aeruginosa.Chest,2001,120:114S-117S.
- 61. Bilton D,Henig N,Morrissey B,et al.Addition of inhaled tobramycin to ciprofloxacin for acute exacerbations of Pseudomonas aeruginosa infection in adult bronchiectasis.Chest,2006,130:1503-1510.
- 62. Hagerman JK,Hancock KE,Klepser ME.Aerosolised antibiotics:a critical appraisal of their use.Expert Opin Drug Deliv,2006,3:71-86.
- 63. 康怡,赖国祥,柳德灵.慢性阻塞性肺疾病与细菌感染.中国呼吸与危重监护杂志,2011,10:298-300.
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