慢性阻塞性肺疾病急性加重住院患者的临床预后指标_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

王凤燕 , 赵海金 ,  蔡绍曦

南方医科大学南方医院呼吸与危重症医学科慢性气道疾病实验室(广东广州 510515);

Corresponding author：

蔡绍曦, Email: caishaox@fimmu.com

Keywords：

DOI：

10.7507/1671-6205.2014103

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Citation： 王凤燕, 赵海金, 蔡绍曦. 慢性阻塞性肺疾病急性加重住院患者的临床预后指标. Chinese Journal of Respiratory and Critical Care Medicine, 2014, 13(4): 419-423. doi: 10.7507/1671-6205.2014103 Copy

1.	Rowe BH,Bhutani M,Stickland MK,et al.Assessment and management of chronic obstructive pulmonary disease in the emergency department and beyond.Expert Rev Respir Med,2011,5:549-559.
2.	Steer J,Gibson GJ,Bourke SC.Predicting outcomes following hospitalization for acute exacerbations of COPD.QJM,2010,103:817-829.
3.	Perera PN,Armstrong EP,Sherrill DL,et al.Acute exacerbations of COPD in the United States:inpatient burden and predictors of costs and mortality.COPD,2012,9:131-141.
4.	Chen YH,Yao WZ,Cai BQ,et al.Economic analysis in admitted patients with acute exacerbation of chronic obstructive pulmonary disease.Chin Med J(Engl),2008,121:587-591.
5.	Roche N,Rabbat A,Zureik M,et al.Chronic obstructive pulmonary disease exacerbations in emergency departments:predictors of outcome.Curr Opin Pulm Med,2010,16:112-117.
6.	Stone RA,Lowe D,Potter JM,et al.Managing patients with COPD exacerbation:does age matter? Age Ageing,2012,41:461-468.
7.	Skyba P,Kluchova Z,Joppa P,et al.Nutritional status in relation to respiratory impairment and systemic inflammation in patients with acute exacerbations of COPD.Med Sci Monit,2009,15:R528-R533.
8.	杨华,周志才,奚峰.营养状况对慢性阻塞性肺疾病急性加重期严重程度及预后的评估.实用老年医学,2013,27:328-330.
9.	Zapatero A,Barba R,Ruiz J,et al.Malnutrition and obesity:influence in mortality and readmissions in chronic obstructive pulmonary disease patients.J Hum Nutr Diet,2013,26 Suppl 1:16-22.
10.	Kohansal R,Martinez-Camblor P,Agusti A,et al.The natural history of chronic airflow obstruction revisited:an analysis of the Framingham offspring cohort.Am J Respir Crit Care Med,2009,180:3-10.
11.	Alfageme I,Reyes N,Merino M,et al.The effect of airflow limitation on the cause of death in patients with COPD.Chron Respir Dis,2010,7:135-145.
12.	Fruchter O,Yigla M.Predictors of long-term survival in elderly patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease.Respirology,2008,13:851-855.
13.	Martinez-Rivera C,Portillo K,Munoz-Ferrer A,et al.Anemia is a mortality predictor in hospitalized patients for COPD exacerbation.COPD,2012,9:243-250.
14.	Haja MH,Murphy S,Clague H,et al.Anemia and performance status as prognostic markers in acute hypercapnic respiratory failure due to chronic obstructive pulmonary disease.Int J Chron Obstruct Pulmon Dis,2013,8:151-157.
15.	Rasmussen L,Christensen S,Lenler-Petersen P,et al.Anemia and 90-day mortality in COPD patients requiring invasive mechanical ventilation.Clin Epidemiol,2011,3:1-5.
16.	黄东明,周晓峰.C反应蛋白、中性粒细胞比例在慢性阻塞性肺疾病急性加重期的意义.中国基层医药,2011,18:1747-1749.
17.	李婧,赵海金,王凤燕,等.影响慢性阻塞性肺疾病急性加重患者住院病死率的危险因素.中华医学杂志,2013,93:1374-1377.
18.	Holland M,Alkhalil M,Chandromouli S,et al.Eosinopenia as a marker of mortality and length of stay in patients admitted with exacerbations of chronic obstructive pulmonary disease.Respirology,2010,15:165-167.
19.	漆波,张鹤,李国智,等.慢性阻塞性肺疾病急性加重患者住院死亡影响因素研究.中国呼吸与危重监护杂志,2013,12:24-28.
20.	Sanjaume M,Almagro P,Rodriguez-Carballeira M,et al.Post-hospital mortality in patients re-admitted due to COPD.Utility of BODE index.Rev Clin Esp,2009,209:364-370.
21.	Matkovic Z,Huerta A,Soler N,et al.Predictors of adverse outcome in patients hospitalised for exacerbation of chronic obstructive pulmonary disease.Respiration,2012,84:17-26.
22.	Ferrer M,Sellares J,Valencia M,et al.Non-invasive ventilation after extubation in hypercapnic patients with chronic respiratory disorders:randomised controlled trial.Lancet,2009,374:1082-1088.
23.	Heidari B.The importance of C-reactive protein and other inflammatory markers in patients with chronic obstructive pulmonary disease.Caspian J Intern Med,2012,3:428-435.
24.	Antonescu-Turcu AL,Tomic R.C-reactive protein and copeptin:prognostic predictors in chronic obstructive pulmonary disease exacerbations.Curr Opin Pulm Med,2009,15:120-125.
25.	Ruiz-Gonzalez A,Lacasta D,Ibarz M,et al.C-reactive protein and other predictors of poor outcome in patients hospitalized with exacerbations of chronic obstructive pulmonary disease.Respirology,2008,13:1028-1033.
26.	Tofan F,Rahimi-Rad MH,Rasmi Y,et al.High sensitive C-reactive protein for prediction of adverse outcome in acute exacerbation of chronic obstructive pulmonary disease.Pneumologia,2012,61:160-162.
27.	Martins CS,Rodrigues MJ,Miranda VP,et al.Prognostic value of cardiac troponin I in patients with COPD acute exacerbation.Neth J Med,2009,67:341-349.
28.	Hoiseth AD,Neukamm A,Karlsson BD,et al.Elevated high-sensitivity cardiac troponin T is associated with increased mortality after acute exacerbation of chronic obstructive pulmonary disease.Thorax,2011,66:775-781.
29.	Hoiseth AD,Omland T,Hagve TA,et al.NT-proBNP independently predicts long term mortality after acute exacerbation of COPD--a prospective cohort study.Respir Res,2012,13:97.
30.	Medina AM,Marteles MS,Saiz EB,et al.Prognostic utility of NT-proBNP in acute exacerbations of chronic pulmonary diseases.Eur J Intern Med,2011,22:167-171.
31.	Ai-Ping C,Lee KH,Lim TK.In hospital and 5 year mortality of patients treated in the ICU for acute exacerbation of COPD.A retrospective study.Chest,2005,128:518-524.
32.	Gunen H,Hacievliyagil SS,Kosar F,et al.Factors affecting survival of hospitalised patients with COPD.Eur Respir J,2005,26:234-241.
33.	Asiimwe AC,Brims FJ,Andrews NP,et al.Routine laboratory tests can predict in-hospital mortality in acute exacerbations of COPD.Lung,2011,189:225-232.
34.	Baker EH,Janaway CH,Philips BJ,et al.Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease.Thorax,2006,61:284-289.
35.	Chakrabarti B,Angus RM,Agarwal S,et al.Hyperglycaemia as a predictor of outcome during non-invasive ventilation in decompensated COPD.Thorax,2009,64:857-862.
36.	Roche N,Zureik M,Soussan D,et al.Predictors of outcomes in COPD exacerbation cases presenting to the emergency department.Eur Respir J,2008,32:953-961.
37.	Charlson ME,Pompei P,Ales KL,et al.A new method of classifying prognostic comorbidity in longitudinal studies:development and validation.J Chronic Dis,1987,40:373-383.
38.	Groenewegen KH,Schols AM,Wouters EF.Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD.Chest,2003,124:459-467.
39.	Parappil A,Depczynski B,Collett P,et al.Effect of comorbid diabetes on length of stay and risk of death in patients admitted with acute exacerbations of COPD.Respirology,2010,15:918-922.
40.	Papaioannou AI,Bartziokas K,Tsikrika S,et al.The impact of depressive symptoms on recovery and outcome of hospitalised COPD exacerbations.Eur Respir J,2013,41:815-823.
41.	Abrams TE,Vaughan-Sarrazin M,Van der Weg MW.Acute exacerbations of chronic obstructive pulmonary disease and the effect of existing psychiatric comorbidity on subsequent mortality.Psychosomatics,2011,52:441-449.
42.	Singanayagam A,Schembri S,Chalmers JD.Predictors of mortality in hospitalized adults with acute exacerbation of chronic obstructive pulmonary disease.Ann Am Thorac Soc,2013,10:81-89.
43.	刘双林,李琦,吴学玲,等.COPD急性加重时影响病死率危险因素的回顾性病例对照研究.第三军医大学学报,2009,31:1394-1396.
44.	Ranieri P,Bianchetti A,Margiotta A,et al.Predictors of 6-month mortality in elderly patients with mild chronic obstructive pulmonary disease discharged from a medical ward after acute nonacidotic exacerbation.J Am Geriatr Soc,2008,56:909-913.
45.	Aburto M,Esteban C,Moraza FJ,et al.COPD exacerbation:mortality prognosis factors in a respiratory care unit.Arch Bronconeumol,2011,47:79-84.
46.	张牧城,汪正光,程金霞,等.慢性阻塞性肺疾病和支气管哮喘生理评分对慢性阻塞性肺疾病急性加重期伴呼吸衰竭患者病情评估的价值研究.中国危重病急救医学,2010,22:275-278.
47.	Golish JA.The BODE index predicted death in chronic obstructive pulmonary disease.ACP J Club,2004,141:53.
48.	Ko FW,Tam W,Tung AH,et al.A longitudinal study of serial BODE indices in predicting mortality and readmissions for COPD.Respir Med,2011,105:266-273.
49.	Edwards L,Perrin K,Wijesinghe M,et al.The value of the CRB65 score to predict mortality in exacerbations of COPD requiring hospital admission.Respirology,2011,16:625-629.

1. Rowe BH,Bhutani M,Stickland MK,et al.Assessment and management of chronic obstructive pulmonary disease in the emergency department and beyond.Expert Rev Respir Med,2011,5:549-559.
2. Steer J,Gibson GJ,Bourke SC.Predicting outcomes following hospitalization for acute exacerbations of COPD.QJM,2010,103:817-829.
3. Perera PN,Armstrong EP,Sherrill DL,et al.Acute exacerbations of COPD in the United States:inpatient burden and predictors of costs and mortality.COPD,2012,9:131-141.
4. Chen YH,Yao WZ,Cai BQ,et al.Economic analysis in admitted patients with acute exacerbation of chronic obstructive pulmonary disease.Chin Med J(Engl),2008,121:587-591.
5. Roche N,Rabbat A,Zureik M,et al.Chronic obstructive pulmonary disease exacerbations in emergency departments:predictors of outcome.Curr Opin Pulm Med,2010,16:112-117.
6. Stone RA,Lowe D,Potter JM,et al.Managing patients with COPD exacerbation:does age matter? Age Ageing,2012,41:461-468.
7. Skyba P,Kluchova Z,Joppa P,et al.Nutritional status in relation to respiratory impairment and systemic inflammation in patients with acute exacerbations of COPD.Med Sci Monit,2009,15:R528-R533.
8. 杨华,周志才,奚峰.营养状况对慢性阻塞性肺疾病急性加重期严重程度及预后的评估.实用老年医学,2013,27:328-330.
9. Zapatero A,Barba R,Ruiz J,et al.Malnutrition and obesity:influence in mortality and readmissions in chronic obstructive pulmonary disease patients.J Hum Nutr Diet,2013,26 Suppl 1:16-22.
10. Kohansal R,Martinez-Camblor P,Agusti A,et al.The natural history of chronic airflow obstruction revisited:an analysis of the Framingham offspring cohort.Am J Respir Crit Care Med,2009,180:3-10.
11. Alfageme I,Reyes N,Merino M,et al.The effect of airflow limitation on the cause of death in patients with COPD.Chron Respir Dis,2010,7:135-145.
12. Fruchter O,Yigla M.Predictors of long-term survival in elderly patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease.Respirology,2008,13:851-855.
13. Martinez-Rivera C,Portillo K,Munoz-Ferrer A,et al.Anemia is a mortality predictor in hospitalized patients for COPD exacerbation.COPD,2012,9:243-250.
14. Haja MH,Murphy S,Clague H,et al.Anemia and performance status as prognostic markers in acute hypercapnic respiratory failure due to chronic obstructive pulmonary disease.Int J Chron Obstruct Pulmon Dis,2013,8:151-157.
15. Rasmussen L,Christensen S,Lenler-Petersen P,et al.Anemia and 90-day mortality in COPD patients requiring invasive mechanical ventilation.Clin Epidemiol,2011,3:1-5.
16. 黄东明,周晓峰.C反应蛋白、中性粒细胞比例在慢性阻塞性肺疾病急性加重期的意义.中国基层医药,2011,18:1747-1749.
17. 李婧,赵海金,王凤燕,等.影响慢性阻塞性肺疾病急性加重患者住院病死率的危险因素.中华医学杂志,2013,93:1374-1377.
18. Holland M,Alkhalil M,Chandromouli S,et al.Eosinopenia as a marker of mortality and length of stay in patients admitted with exacerbations of chronic obstructive pulmonary disease.Respirology,2010,15:165-167.
19. 漆波,张鹤,李国智,等.慢性阻塞性肺疾病急性加重患者住院死亡影响因素研究.中国呼吸与危重监护杂志,2013,12:24-28.
20. Sanjaume M,Almagro P,Rodriguez-Carballeira M,et al.Post-hospital mortality in patients re-admitted due to COPD.Utility of BODE index.Rev Clin Esp,2009,209:364-370.
21. Matkovic Z,Huerta A,Soler N,et al.Predictors of adverse outcome in patients hospitalised for exacerbation of chronic obstructive pulmonary disease.Respiration,2012,84:17-26.
22. Ferrer M,Sellares J,Valencia M,et al.Non-invasive ventilation after extubation in hypercapnic patients with chronic respiratory disorders:randomised controlled trial.Lancet,2009,374:1082-1088.
23. Heidari B.The importance of C-reactive protein and other inflammatory markers in patients with chronic obstructive pulmonary disease.Caspian J Intern Med,2012,3:428-435.
24. Antonescu-Turcu AL,Tomic R.C-reactive protein and copeptin:prognostic predictors in chronic obstructive pulmonary disease exacerbations.Curr Opin Pulm Med,2009,15:120-125.
25. Ruiz-Gonzalez A,Lacasta D,Ibarz M,et al.C-reactive protein and other predictors of poor outcome in patients hospitalized with exacerbations of chronic obstructive pulmonary disease.Respirology,2008,13:1028-1033.
26. Tofan F,Rahimi-Rad MH,Rasmi Y,et al.High sensitive C-reactive protein for prediction of adverse outcome in acute exacerbation of chronic obstructive pulmonary disease.Pneumologia,2012,61:160-162.
27. Martins CS,Rodrigues MJ,Miranda VP,et al.Prognostic value of cardiac troponin I in patients with COPD acute exacerbation.Neth J Med,2009,67:341-349.
28. Hoiseth AD,Neukamm A,Karlsson BD,et al.Elevated high-sensitivity cardiac troponin T is associated with increased mortality after acute exacerbation of chronic obstructive pulmonary disease.Thorax,2011,66:775-781.
29. Hoiseth AD,Omland T,Hagve TA,et al.NT-proBNP independently predicts long term mortality after acute exacerbation of COPD--a prospective cohort study.Respir Res,2012,13:97.
30. Medina AM,Marteles MS,Saiz EB,et al.Prognostic utility of NT-proBNP in acute exacerbations of chronic pulmonary diseases.Eur J Intern Med,2011,22:167-171.
31. Ai-Ping C,Lee KH,Lim TK.In hospital and 5 year mortality of patients treated in the ICU for acute exacerbation of COPD.A retrospective study.Chest,2005,128:518-524.
32. Gunen H,Hacievliyagil SS,Kosar F,et al.Factors affecting survival of hospitalised patients with COPD.Eur Respir J,2005,26:234-241.
33. Asiimwe AC,Brims FJ,Andrews NP,et al.Routine laboratory tests can predict in-hospital mortality in acute exacerbations of COPD.Lung,2011,189:225-232.
34. Baker EH,Janaway CH,Philips BJ,et al.Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease.Thorax,2006,61:284-289.
35. Chakrabarti B,Angus RM,Agarwal S,et al.Hyperglycaemia as a predictor of outcome during non-invasive ventilation in decompensated COPD.Thorax,2009,64:857-862.
36. Roche N,Zureik M,Soussan D,et al.Predictors of outcomes in COPD exacerbation cases presenting to the emergency department.Eur Respir J,2008,32:953-961.
37. Charlson ME,Pompei P,Ales KL,et al.A new method of classifying prognostic comorbidity in longitudinal studies:development and validation.J Chronic Dis,1987,40:373-383.
38. Groenewegen KH,Schols AM,Wouters EF.Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD.Chest,2003,124:459-467.
39. Parappil A,Depczynski B,Collett P,et al.Effect of comorbid diabetes on length of stay and risk of death in patients admitted with acute exacerbations of COPD.Respirology,2010,15:918-922.
40. Papaioannou AI,Bartziokas K,Tsikrika S,et al.The impact of depressive symptoms on recovery and outcome of hospitalised COPD exacerbations.Eur Respir J,2013,41:815-823.
41. Abrams TE,Vaughan-Sarrazin M,Van der Weg MW.Acute exacerbations of chronic obstructive pulmonary disease and the effect of existing psychiatric comorbidity on subsequent mortality.Psychosomatics,2011,52:441-449.
42. Singanayagam A,Schembri S,Chalmers JD.Predictors of mortality in hospitalized adults with acute exacerbation of chronic obstructive pulmonary disease.Ann Am Thorac Soc,2013,10:81-89.
43. 刘双林,李琦,吴学玲,等.COPD急性加重时影响病死率危险因素的回顾性病例对照研究.第三军医大学学报,2009,31:1394-1396.
44. Ranieri P,Bianchetti A,Margiotta A,et al.Predictors of 6-month mortality in elderly patients with mild chronic obstructive pulmonary disease discharged from a medical ward after acute nonacidotic exacerbation.J Am Geriatr Soc,2008,56:909-913.
45. Aburto M,Esteban C,Moraza FJ,et al.COPD exacerbation:mortality prognosis factors in a respiratory care unit.Arch Bronconeumol,2011,47:79-84.
46. 张牧城,汪正光,程金霞,等.慢性阻塞性肺疾病和支气管哮喘生理评分对慢性阻塞性肺疾病急性加重期伴呼吸衰竭患者病情评估的价值研究.中国危重病急救医学,2010,22:275-278.
47. Golish JA.The BODE index predicted death in chronic obstructive pulmonary disease.ACP J Club,2004,141:53.
48. Ko FW,Tam W,Tung AH,et al.A longitudinal study of serial BODE indices in predicting mortality and readmissions for COPD.Respir Med,2011,105:266-273.
49. Edwards L,Perrin K,Wijesinghe M,et al.The value of the CRB65 score to predict mortality in exacerbations of COPD requiring hospital admission.Respirology,2011,16:625-629.

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慢性阻塞性肺疾病急性加重住院患者的临床预后指标

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