HanQian , LuoQun , WuLulu , LiaoLiyue , ZhouYing , ChenRongchang
  • Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Disease, Guangzhou, Guangdong, 510120, China;
ChenRongchang, Email: chenrc@vip.163.com
Transbronchoscopic lung biopsy; Surgical lung biopsy; Idiopathic interstitial pneumonia; Diagnosis
10.7507/1671-6205.2015015
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

Objective To evaluate the effectiveness of different biopsy methods in the diagnosis of idiopathic interstitial pneumonia (IIP). Methods A retrospective analysis was performed in patients hospitalized and diagnosed as IIP between January 2010 to December 2013 in the Department of Respiratory Medicine, the First Affiliated Hospital of Guangzhou Medical University. The patients were divided based on initial diagnoses. The performance of invasive examinations including both transbronchoscopic lung biopsy (TBLB) and surgical lung biopsy (SLB) and final diagnoses were recorded. Results Three hundred and ninety-one patients were included in the study with mean age of 62.5±11.9 years. There were 299 patients receiving TBLB, 43 patients receiving SLB, and 49 patients receiving non-invasive examinations. Among 299 patients who underwent TBLB, parenchymal tissue was not obtained in 132 (44.1%) but successfully obtained in 167 (55.9%) patients, with 79 (47.3% out of 167) clinically helpful. TBLB-based specific diagnoses were as follows:30 cases of non-specific interstitial pneumonia (NSIP), 22 cases of cryptogenic organizing pneumonia (COP), 18 cases of idiopathic pulmonary fibrosis (IPF), 4 cases of acute interstitial pneumonia (AIP), 2 cases of respiratory bronchiolitis-interstitial lung disease (RB-ILD) and lymphocytic interstitial pneumonia (LIP) for each, 1 case of desquamative interstitial pneumonia (DIP), respectively. Among 43 patients who underwent SLB, parenchymal tissue was obtained in all cases with 40(93.0% out of 43) pathologically diagnostic, including 20 cases of NSIP, 12 cases of IPF, 3 cases of COP and LIP for each, and 2 cases of RB-ILD and DIP for each. Finally, among 181 patients who failed to obtain parenchymal tissue or did not undergo invasive examination, specific diagnoses could be established in 40 patients with all finally diagnosed as IPF. Conclusions The pathological diagnosis, either based on TBLB or SLB, is very important in the diagnostic procedure of IIP. The biopsy technique of hospital and patient conditions should be considered when making the decision of biopsy method.

Citation： HanQian, LuoQun, WuLulu, LiaoLiyue, ZhouYing, ChenRongchang. The Effectiveness of Different Biopsy Methods in Diagnosis of Idiopathic Interstitial Pneumonia. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(1): 64-67. doi: 10.7507/1671-6205.2015015 Copy

  • Previous Article

    Effects of Single Immunoglobin IL-1 Receptor Related Protein on Inflammation Induced by Cigarette Smoke Extract in A549 Cells

  • Next Article

    A Comparative Study of Semirigid Thoracoscopy and Rigid Thoracoscopy in Diagnosis of Unexplained Pleural Effusion