Relationship between Fatigue and Quality of Life in Patients with Obstructive Sleep Apnea_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LuoChun ^1,2 ,  LiangZongan ²

1. 四川大学华西医院呼吸与危重症医学科(四川成都 610041);
2. ;

Corresponding author：

LiangZongan, Email: liangzongan@yahoo.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Fatigue; Quality of life; Multidimensional fatigue inventory

DOI：

10.7507/1671-6205.2015017

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To assess the fatigue in patients with obstructive sleep apnea hypopnea syndrome (OSAHS), and analyze the factors caused fatigue and the relationship between quality of life (QOL) and fatigue. Methods One hundred and sixty-nine patients with OSAHS and 78 subjects without OSAHS diagnosed by polysomnography (PSG) between December 2010 and March 2011 in West China Hospital were recruited in the study. Fatigue was assessed by using multidimensional fatigue inventory (MFI), excessive daytime sleepiness by Epworth sleepiness scale(ESS), QOL by functional outcomes of sleep questionnaire (FOSQ). Results Fatigue in the patients with OSAHS was more severe than that of the controls (51.06±13.39 vs. 44.82±9.81, P < 0.001), but no difference was revealed in the patients with different degree of OSAHS. Fatigue was positively correlated with ESS score(r=0.210), total sleep time intervals(r=0.156), and the ratio of time of SpO₂ below 90% in total sleep time(r=0.153)(P < 0.05), and was negatively correlated with the average oxygen saturation(r=-0.171, P < 0.05) and all subscales of FOSQ(P < 0.01). Conclusions Fatigue in patients with OSAHS is more severe than that of controls. Fatigue can significantly reduce QOL, and the impact is greater than that of excessive daytime sleepiness.

Citation： LuoChun, LiangZongan. Relationship between Fatigue and Quality of Life in Patients with Obstructive Sleep Apnea. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(1): 72-75. doi: 10.7507/1671-6205.2015017 Copy

1.	Chervin RD.Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea.Chest, 2000, 118:372-379.
2.	Kales A, Caldwell AB, Cadieux RJ, et al.Severe obstructive sleep apnea-Ⅱ:Associated psychopathology and phychosocial consequences.J Chronic Dis, 1985, 38:427-434.
3.	Kales A, Cadieux RJ, Bixler EO, et al.Severe obstructive sleep apnea-Ⅰ:Onset, clinical course, and characteristics.J Chronic Dis, 1985, 38:419-425.
4.	中华医学会呼吸病学分会睡眠呼吸病学组.睡眠呼吸暂停低通气综合征诊治指南(草案).中华内科杂志, 2003, 42:594-597.
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8.	Robert NA, Kenneth L, Sharon L, et al.Daytime functioning in obstructive sleep apnea patients:exercise tolerance, subjective fatigue, and sleepiness.Appl Psychophysiol Biofeedback, 1998, 23:207-217.
9.	Bailes S, Libman E, Baltzan M, et al.Fatigue:the forgotten symptom of sleep apnea.J Psychosoma Res, 2011, 70:346-354.
10.	Bardwell WA, Moore P, Ancoli-Israel S, et al.Fatigue in obstructive sleep apnea:driven by depressive symptoms instead of apnea severity? Am J Psychiatry, 2003, 160:350-355.
11.	Amnow WS.Cardiovascular manifestations seen in obstructive sleep apnea.Compr Ther, 2007, 33:82-86.
12.	Peker Y, Carlson J, Hedner J.Increased incidence of coronary artery disease in sleep apnea:a long term follow-up.Eur Respir J, 2006, 28:596-602.
13.	Garrigne S, Pèpin JL, Defaye P, et al.High prevalence of sleep apnea syndrome in patients with long-term pacing:the European Multicenter Polysomnographic Study.Circulation, 2007, 115:1703-1709.
14.	Nieto FJ, Young TB, Lind BK, et al.Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study.Sleep Heart Health Study.JAMA, 2000, 283:1829-1836.
15.	Sharafkhaneh A, Sharafkhaneh H, Bredikus A, et al.Effect of atrial overdrive pacing on obstructive sleep apnea in patients with systolic heart failure.Sleep Med, 2007, 8:31-36.
16.	Bradley TD, Floras JS.Sleep apnea and heart failure:PartⅠ:obstructive sleep apnea.Circulation, 2003, 107:1671-1678.
17.	Hossain JL, Ahmad P, Reinish LW, et al.Subjective fatigue and subjective sleepiness:two independent consequences of sleep disorders? J Sleep Res, 2005, 14:245-253.
18.	阳书坤, 余勤, 张佳宾, 等.阻塞性睡眠呼吸暂停低通气综合征患者认知功能和生活质量的关系.中国心理卫生杂志, 2008, 22:133-136.
19.	魏兵, 聂秀红, 张连国, 等.OSAHS患者认知功能的变化与生活质量的关系.临床肺科杂志, 2009, 14:1610-1612.
20.	张晓雯, 蔡晓岚, 潘新良, 等.阻塞性睡眠呼吸暂停低通气综合征患者生活质量分析.山东大学学报(医学版), 2007, 45:97-100.
21.	刘松, 陈颖, 翟慧, 等.中重度阻塞性睡眠呼吸暂停低通气综合征患者生活质量评价及持续气道正压治疗作用.医学临床研究, 2011, 28:1841-1844.
22.	马丹, 刘辉国, 艾永循, 等.生活质量评价在阻塞性睡眠呼吸暂停综合征患者临床诊断中的作用.华中科技大学学报, 2007, 36:380-384.
23.	鲁丹.老年SAS患者生存质量及其影响因素分析.中国医药导刊, 2011, 13:226-228.
24.	Wattanachai C, Louise M, Ludi F, et al.Fatigue, tiredness, and lack of energy improve with treatment for OSA.J Clin Sleep Med, 2009, 5:222-227.

1. Chervin RD.Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea.Chest, 2000, 118:372-379.
2. Kales A, Caldwell AB, Cadieux RJ, et al.Severe obstructive sleep apnea-Ⅱ:Associated psychopathology and phychosocial consequences.J Chronic Dis, 1985, 38:427-434.
3. Kales A, Cadieux RJ, Bixler EO, et al.Severe obstructive sleep apnea-Ⅰ:Onset, clinical course, and characteristics.J Chronic Dis, 1985, 38:419-425.
4. 中华医学会呼吸病学分会睡眠呼吸病学组.睡眠呼吸暂停低通气综合征诊治指南(草案).中华内科杂志, 2003, 42:594-597.
5. Nater UM, Wagner D, Solomon L, et al.Coping styles in people with chronic fatigue syndrome identified from the general population of Wichita, KS.J Psychosom Res, 2006, 60:567-573.
6. Natelson BH, Weaver SA, Tseng CL, et al.Spinal fluid abnormalities in patients with chronic fatigue syndrome.Clin Diagn Lab Immunol, 2005, 12:52-55.
7. Reeves WC, Wagner D, Nisenbaum R, et al.Chronic fatigue syndrome-a clinically empirical approach to its definition and study.BMC Med, 2005, 3:19.
8. Robert NA, Kenneth L, Sharon L, et al.Daytime functioning in obstructive sleep apnea patients:exercise tolerance, subjective fatigue, and sleepiness.Appl Psychophysiol Biofeedback, 1998, 23:207-217.
9. Bailes S, Libman E, Baltzan M, et al.Fatigue:the forgotten symptom of sleep apnea.J Psychosoma Res, 2011, 70:346-354.
10. Bardwell WA, Moore P, Ancoli-Israel S, et al.Fatigue in obstructive sleep apnea:driven by depressive symptoms instead of apnea severity? Am J Psychiatry, 2003, 160:350-355.
11. Amnow WS.Cardiovascular manifestations seen in obstructive sleep apnea.Compr Ther, 2007, 33:82-86.
12. Peker Y, Carlson J, Hedner J.Increased incidence of coronary artery disease in sleep apnea:a long term follow-up.Eur Respir J, 2006, 28:596-602.
13. Garrigne S, Pèpin JL, Defaye P, et al.High prevalence of sleep apnea syndrome in patients with long-term pacing:the European Multicenter Polysomnographic Study.Circulation, 2007, 115:1703-1709.
14. Nieto FJ, Young TB, Lind BK, et al.Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study.Sleep Heart Health Study.JAMA, 2000, 283:1829-1836.
15. Sharafkhaneh A, Sharafkhaneh H, Bredikus A, et al.Effect of atrial overdrive pacing on obstructive sleep apnea in patients with systolic heart failure.Sleep Med, 2007, 8:31-36.
16. Bradley TD, Floras JS.Sleep apnea and heart failure:PartⅠ:obstructive sleep apnea.Circulation, 2003, 107:1671-1678.
17. Hossain JL, Ahmad P, Reinish LW, et al.Subjective fatigue and subjective sleepiness:two independent consequences of sleep disorders? J Sleep Res, 2005, 14:245-253.
18. 阳书坤, 余勤, 张佳宾, 等.阻塞性睡眠呼吸暂停低通气综合征患者认知功能和生活质量的关系.中国心理卫生杂志, 2008, 22:133-136.
19. 魏兵, 聂秀红, 张连国, 等.OSAHS患者认知功能的变化与生活质量的关系.临床肺科杂志, 2009, 14:1610-1612.
20. 张晓雯, 蔡晓岚, 潘新良, 等.阻塞性睡眠呼吸暂停低通气综合征患者生活质量分析.山东大学学报(医学版), 2007, 45:97-100.
21. 刘松, 陈颖, 翟慧, 等.中重度阻塞性睡眠呼吸暂停低通气综合征患者生活质量评价及持续气道正压治疗作用.医学临床研究, 2011, 28:1841-1844.
22. 马丹, 刘辉国, 艾永循, 等.生活质量评价在阻塞性睡眠呼吸暂停综合征患者临床诊断中的作用.华中科技大学学报, 2007, 36:380-384.
23. 鲁丹.老年SAS患者生存质量及其影响因素分析.中国医药导刊, 2011, 13:226-228.
24. Wattanachai C, Louise M, Ludi F, et al.Fatigue, tiredness, and lack of energy improve with treatment for OSA.J Clin Sleep Med, 2009, 5:222-227.

Chinese Journal of Respiratory and Critical Care Medicine

Relationship between Fatigue and Quality of Life in Patients with Obstructive Sleep Apnea

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