Concurrence of Obstructive Sleep Apnea Hypopnea Syndrome with Asthma_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

DuJing , LiLinwei , ZuPing , DengYan , HeTailing , YuanYuru ,  LiangBinmiao

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China;

Corresponding author：

LiangBinmiao, Email: liangbinmiao@163.com

Keywords：

Asthma; Obstructive sleep apnea hypopnea syndrome; Risk factors

DOI：

10.7507/1671-6205.2015092

Video：

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Objective To evaluate the prevalence of obstructive sleep apnea hypopnea syndrome (OSAHS) in patients with asthma, and explore the association of OSAHS with asthma. Methods Patients who were diagnosed as asthma between March 2014 and February 2015 were recruited in the study. They were categorized into an OSAHS group and a non-OSAHS group according to the Berlin questionnaire. The data of clinical characteristics and pulmonary function test were collected. Logistic regression analysis was performed to evaluate the factors associated with the incidence of OSAHS in asthma. Results A total of 64 patients with asthma were enrolled and 36 patients were complicated with OSAHS. The body mass index (BMI), allergic rhinitis history, inspiratory capacity, maximal mid-expiratory flow and provoking dose which make FEV₁ reduce 20% were significantly different between two groups (all P < 0.05). Multivariate logistic regression analysis revealed that the increased BMI was an independent risk factor of OSAHS in patients with asthma. Conclusion The occurrence of OSAHS with asthma is very high, and BMI may be an important associated risk factor.

Citation： DuJing, LiLinwei, ZuPing, DengYan, HeTailing, YuanYuru, LiangBinmiao. Concurrence of Obstructive Sleep Apnea Hypopnea Syndrome with Asthma. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(4): 372-375. doi: 10.7507/1671-6205.2015092 Copy

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19.	Campana LM, Malhotra A, Suki B, et al.The effect of lung stretch during sleep on airway mechanics in overweight and obese asthma.Respir Physiol Neurobiol, 2013, 185:304-312.
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21.	Teodorescu M, Consens FB, Bria WF, et al.Correlates of daytime sleepiness in patients with asthma.Sleep Med, 2006, 7:607-613.
22.	Lopez-Jimenez F, Sert Kuniyoshi FH, Gami A, et al.Obstructive sleep apnea:implications for cardiac and vascular disease.Chest, 2008, 133:793-804.
23.	陶松雪, 潘家华.儿童肥胖与哮喘.安徽医学, 2009, 30:1365-1367.
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1. Popkin BM, Gordon-Larsen P.The nutrition transition:worldwide obesity dynamics and their determinants.Int J Obes Relat Metab Disord, 2004, 28:S2-S9.
2. Alkhalil M, Schulman E, Getsy J.Obstructive sleep apnea syndrome and asthma:what are the links? J Clin Sleep Med, 2009, 5:71-78.
3. Alkhalil M, Schulman ES, Getsy J.Obstructive sleep apnea syndrome and asthma:the role of continuous positive airway pressure treatment.Ann Allergy Asthma Immunol, 2008, 101:350-357.
4. Subramanian S, Hesselbacher SE, Aguilar R, et al.The NAMES assessment:a novel combined-modality screening tool for obstructive sleep apnea.Sleep Breath, 2011, 15:819-826.
5. 中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案).中华哮喘杂志(电子版), 2008, 2:3-13.
6. 朱耀国, 任叶慧, 孙黎黎.肥胖的诊断与治疗进展.中国医刊, 2003, 7:32-34.
7. 中华医学会呼吸病学分会.肺功能检查指南(第三部分)--组织胺和乙酰甲胆碱支气管激发试验.中华结核和呼吸杂志, 2014, 37:566-571.
8. Netzer NC, Stoohs RA, Netzer CM, et al.Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome.Ann Intern Med, 1999, 131:485-491.
9. Tishler PV, Larkin EK, Schluchter MD, et al.Incidence of sleep disordered breathing in an urban adult population:the relative importance of risk factors in the development of sleep-disordered breathing.JAMA, 2003, 289:2230-2237.
10. Young T, Peppard PE, Gottlieb DJ.Epidemiology of obstructive sleep apnea:a population health perspective.Am J Respir Crit Care Med, 2002, 165:1217-1239.
11. Global Initiative for Asthma(GINA) 2014:Global strategy for asthma management and prevention.http://www.ginasthma.org.
12. 吕向裴, 张成, 马靖, 等.柏林问卷在慢性阻塞性睡眠呼吸暂停低通气综合征筛查中的应用价值.中华结核和呼吸杂志, 2011, 34:515-519.
13. 徐治波, 冯玉麟.变应性鼻炎、支气管哮喘--同一气道, 同一种病.实用医院临床杂志, 2006, 3:10-11.
14. Bousquet J, Van Cauwenberge P, Khaltaev N.Allergic rhinitis and its impact on asthma.J Allergy Clin Immunol, 2001, 108:S147-S334.
15. Braido F, Baiardini I, Lagasio C, et al.Allergic rhinitis in asthma.Panminerva Med, 2011, 53:97-107.
16. 谷庆隆, 张庆丰.鼻塞对阻塞性睡眠呼吸暂停综合症发展影响的研究.临床耳喉科杂志, 2003, 17:213-214.
17. Cotes JE, Chinn DJ, Reed JW.Body mass, fat percentage, and fat free mass as reference variables for lung function:effects on terms for age and sex.Thorax, 2001, 56:839-844.
18. Watson RA, Pride NB.Postural changes in lung volumes and respiratory resistance in subjects with obesity.J Appl Physiol, 2005, 98:512-517.
19. Campana LM, Malhotra A, Suki B, et al.The effect of lung stretch during sleep on airway mechanics in overweight and obese asthma.Respir Physiol Neurobiol, 2013, 185:304-312.
20. 李淼, 尚云晓.气道平滑肌细胞在哮喘气道重塑中的作用.国际儿科杂志, 2010, 37:571-574.
21. Teodorescu M, Consens FB, Bria WF, et al.Correlates of daytime sleepiness in patients with asthma.Sleep Med, 2006, 7:607-613.
22. Lopez-Jimenez F, Sert Kuniyoshi FH, Gami A, et al.Obstructive sleep apnea:implications for cardiac and vascular disease.Chest, 2008, 133:793-804.
23. 陶松雪, 潘家华.儿童肥胖与哮喘.安徽医学, 2009, 30:1365-1367.
24. Hamid YH, Rose CS, Urhammer SA, et al.Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes.Diabetologia, 2005, 48:251-260.

Chinese Journal of Respiratory and Critical Care Medicine

Concurrence of Obstructive Sleep Apnea Hypopnea Syndrome with Asthma

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