LiLinwei , DuJing , DengYan , ZuPing , HeTailing , YuanYuru , LiangBinmiao
  • Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China;
LiangBinmiao, Email: liangbinmiao@163.com
Chronic obstructive pulmonary disease; Lung capacity; Diffusing capacity for carbon monoxide
10.7507/1671-6205.2015108
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Objective To assess the lung capacity and diffusing capacity in patients with chronic obstructive pulmonary disease (COPD) at different stages. Methods Patients who were diagnosed with COPD between January and March 2015 were recruited in the study. The data of clinical characteristics and spirometry test (the forced expiratory volume in the first second, FEV1) were collected. Total lung capacity (TLC) and residual volume (RV) were determined by body plethysmography and helium dilution method, and single breath diffusing capacity for carbon monoxide (DLCO) was also measured. Lung capacity and the deviations between two methods, and DLCO%pred were compared among the COPD patients at different stages. The correlation of spirometry with lung capacity and DLCO%pred were analyzed. Results A total of 170 patients with COPD were enrolled. With the severity of COPD, TLC%pred, RV%pred, RV/TLC and the deviations of the ones between two methods increased significantly, but DLCO%pred reduced significantly. FEV1%pred were negatively correlated with the deviations of lung capacity between two methods, and positively correlated with DLCO%pred. Conclusions Compared with helium dilution method, the body plethysmography is more accurate for evaluating the lung capacity of COPD. With the severity of airflow limitation, the diffusing capacity of COPD decreases gradually.

Citation： LiLinwei, DuJing, DengYan, ZuPing, HeTailing, YuanYuru, LiangBinmiao. Lung Capacity and Diffusing Capacity in Patients with Chronic Obstructive Pulmonary Disease at Different Stages. Chinese Journal of Respiratory and Critical Care Medicine, 2015, 14(5): 436-438. doi: 10.7507/1671-6205.2015108 Copy