Clinical Characteristics of Immunity Function in Patients with Nosocomial Infection in Intensive Care Unit_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

LongPan , ShenGuofeng ,  LiXiang , NiJindi , ShenYunle , XiaZhuye

Intensive Care Unit of Minhang Hospital, Fudan University, Shanghai, 201199, China;

Corresponding author：

LiXiang, Email: 18918169826@163.com

Keywords：

Nosocomial infection; Community acquired pneumonia; T lymphocytes; Immunity function

DOI：

10.7507/1671-6205.2016006

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the role of CD3⁺CD4⁺T cells in patients with nosocomial infection in ICU. Methods One-hundred and eleven patients who admitted in ICU and in respiratory department from March to December in 2014 were recruited in the study.There were 33 patients with community-acquired pneumonia (CAP group), 31 patients without nosocomial infection (NNI group), and 47 patients with hospital-acquired pneumonia (HAP group).The counts of T cells, B cells, CD3⁺CD4⁺ T cells, CD3⁺CD8⁺ T cells, and NK cells were compared among three groups. Results The comparison among the groups had no statistical significance in sex and age(P > 0.05).The three groups had statistical significance in APACHEⅡscore, CD3⁺CD4⁺T cells, T cells and B cells, but had no statistical significance in CD3⁺CD8⁺T cells, CD3⁺CD4⁺/CD3⁺CD8⁺ T cells, NK cells, white blood cells, neutrophils, procalcitonin or C reactive protein.CD3⁺CD4⁺T cells of HAP group were less than other two groups.The area under the ROC curve (AUC) was 0.660, with a threshold of 29.96%, a sensitivity of 93.8%, and a specificity of 40.4%. Conclusion CD3⁺CD4⁺ T cell is an independent predictor for nosocomial infection.

Citation： LongPan, ShenGuofeng, LiXiang, NiJindi, ShenYunle, XiaZhuye. Clinical Characteristics of Immunity Function in Patients with Nosocomial Infection in Intensive Care Unit. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(1): 22-25. doi: 10.7507/1671-6205.2016006 Copy

1.	王蔚, 周愚, 赵灵, 等.侵袭性肺曲霉菌感染诊治进展.中国呼吸与危重监护杂志, 2011, 10:500-504.
2.	Geginat J, Paroni M, Maglie S, et al. Plasticity of human CD4 T cell subsets. Front Immunol, 2014, 16:630-640.
3.	Geffers C, Gastmeier P. Nosocomial infections and multidrug-resistant organisms in Germany:epidemiological data from KISS (the Hospital Infection Surveillance System). Dtsch Arztebl Int, 2011, 108:87-93.
4.	Kleppa E, Klinge KF, Galaphaththi-Arachchige HN, et al. Schistosoma haematobium infection and CD4⁺ T-Cell levels:a cross-sectional study of young South African women. PLoS One, 2015, 10:1-10.
5.	吴丽娟, 刘丁, 陈伟, 等.外周血T淋巴细胞免疫功能与医院感染的关系.重庆医学, 2006, 35:2124-2125.
6.	Monneret G, Lepape A, Venet F. Reversing ICU-acquired immunosuppression:an innovative biomarker-guided therapeutic strategy for decreasing sepsis mortality and nosocomial infection rate. Pathol Biol (Paris), 2011, 59:329-333.
7.	张丽娜, 吴铁军, 刘志军.脓毒症患者血中CD4⁺CD25⁺调节性T细胞水平检测的临床意义.中国呼吸与危重监护杂志, 2010, 9:416-418.
8.	Yin Y, Qin J, Dai Y, et al. The CD4+/CD8+ ratio in pulmonary tuberculosis:systematic and meta-analysis article. Iran J Public Health, 2015, 44:185-193.
9.	程明霞, 蒋坤, 蔡静, 等.脑卒中患者免疫功能与医院感染的调查分析.中华医院感染学杂志, 2014, 8:1926-1927.
10.	李纯, 林颖颖, 高畅, 等. CD4⁺T细胞在CD8⁺T细胞介导的排斥反应中的作用.中华医学杂志, 2014, 34:2690-2694.

1. 王蔚, 周愚, 赵灵, 等.侵袭性肺曲霉菌感染诊治进展.中国呼吸与危重监护杂志, 2011, 10:500-504.
2. Geginat J, Paroni M, Maglie S, et al. Plasticity of human CD4 T cell subsets. Front Immunol, 2014, 16:630-640.
3. Geffers C, Gastmeier P. Nosocomial infections and multidrug-resistant organisms in Germany:epidemiological data from KISS (the Hospital Infection Surveillance System). Dtsch Arztebl Int, 2011, 108:87-93.
4. Kleppa E, Klinge KF, Galaphaththi-Arachchige HN, et al. Schistosoma haematobium infection and CD4⁺ T-Cell levels:a cross-sectional study of young South African women. PLoS One, 2015, 10:1-10.
5. 吴丽娟, 刘丁, 陈伟, 等.外周血T淋巴细胞免疫功能与医院感染的关系.重庆医学, 2006, 35:2124-2125.
6. Monneret G, Lepape A, Venet F. Reversing ICU-acquired immunosuppression:an innovative biomarker-guided therapeutic strategy for decreasing sepsis mortality and nosocomial infection rate. Pathol Biol (Paris), 2011, 59:329-333.
7. 张丽娜, 吴铁军, 刘志军.脓毒症患者血中CD4⁺CD25⁺调节性T细胞水平检测的临床意义.中国呼吸与危重监护杂志, 2010, 9:416-418.
8. Yin Y, Qin J, Dai Y, et al. The CD4+/CD8+ ratio in pulmonary tuberculosis:systematic and meta-analysis article. Iran J Public Health, 2015, 44:185-193.
9. 程明霞, 蒋坤, 蔡静, 等.脑卒中患者免疫功能与医院感染的调查分析.中华医院感染学杂志, 2014, 8:1926-1927.
10. 李纯, 林颖颖, 高畅, 等. CD4⁺T细胞在CD8⁺T细胞介导的排斥反应中的作用.中华医学杂志, 2014, 34:2690-2694.

Chinese Journal of Respiratory and Critical Care Medicine

Clinical Characteristics of Immunity Function in Patients with Nosocomial Infection in Intensive Care Unit

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