生长分化因子-15 在肺栓塞中的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

刘露 ¹ , 胡天佑 ² ,  张一梅 ¹

2. ;
1. ;

Corresponding author：

张一梅, Email: zhangyimei1957@163.com

Keywords：

DOI：

10.7507/1671-6205.201605010

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Citation： 刘露, 胡天佑, 张一梅. 生长分化因子-15 在肺栓塞中的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(2): 206-208. doi: 10.7507/1671-6205.201605010 Copy

1.	中华医学会心血管病学分会肺血管病血组, 中国医师协会心血管内科医师分会. 急性肺血栓栓塞症诊断治疗中国专家共识. 中华内科杂志, 2010, 49(1): 74-81.
2.	Ago T, Sadoshima J. GDF-15, a cardioprotective TGF-beta superfamily protein. Circ Res, 2006, 98(3): 294-297.
3.	Schopfer DW, Ku IA, Regan M, et al. Growth differentiation factor 15 and cardiovascular events in patients with stable ischemic heart disease (The Heart and Soul Study). Am Heart J, 2014, 167(2): 186-192.
4.	Lin JF, Wu S, Hsu SY, et al. Growth-differentiation factor-15 and major cardiac events. Am J Med Sci, 2014, 347(4): 305-311.
5.	Olechnicki M, Kasprzak K, Goch A. Growth differentiation factor 15- - a new marker in heart diseases. Pol Merkur Lekarski, 2010, 28(168): 470-472.
6.	顾宇英, 赵萌涛, 宗明. 上海地区汉族健康人群血清GDF-15水平分析. 同济大学学报, 2010, 31(3): 96-99.
7.	Azhar M, Schultz Jel J, Grupp I, et al. Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev, 2003, 14(5): 391-407.
8.	Kempf T, Zarbock A, Widera C, et al. GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med, 2011, 17(5): 581-588.
9.	Bootcov MR, Bauskin AR, Valenzuela SM, et al. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci USA, 1997, 94(21): 11514-11519.
10.	Xu J, Kimball TR, Lorenz JN, et al. GDF-15/MIC-1 function as a protective antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res, 2006, 98(3): 342-350.
11.	Nickel N, Jonigk D, Kempf T, et al. GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells. Respir Res, 2011, 12(1): 62.
12.	Frank D, Kulm C, Brors B, et al. Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program. Hypertension, 2008, 51(2): 309-318.
13.	Clerk A, Kenp TJ, Zoumpoulidon G, et al. Cardiac myocyte gene expression profiling during H₂O₂-induced apoptosis. Physiol Genomics, 2007, 29(2): 118-127.
14.	Brown DA, Breit SN, Buring J, et al. Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study. Lancet, 2002, 359(9324): 2159-2163.
15.	Lankeit M, Kempf T, Dellas C, et al. Growth differentiation factor-15 for prognostic assessment of patients with acute pulmonary embolism. Am J Respir Crit Care Med, 2008, 177(9): 1018-1025.
16.	Rossaint J, Vestweber D, Zarbock A, et al. GDF-15 prevents platelet integrin activation and thrombus formation. J Thromb Haemost, 2013, 11(2): 335-44.
17.	阮丽波, 金会艳, 陈军. 家兔急性肺栓塞对生长分化因子-15的影响及意义. 中国现代医学杂志, 2015, 25(4): 12-16.
18.	Guidelines on diagnosis and management of acute pulmonary embolism. Task Force on Pulmonary Embolism, European Society of Cardiology. Eur Heart J, 2000, 21(16): 1301-1336.
19.	Watts JA, Gellar MA, Stuart L, et al. Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism. Histol Histopathol, 2011, 26(10): 1287-1294.
20.	Nickel N, Kempf T, Tapken H, et al. Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med, 2008, 178(5): 534-541.
21.	Lind L, Wallentin L, Kempf T, et al. Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the elderly: results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study. Eur Heart J, 2009, 30(19): 2346-2353.
22.	田伟萌, 王华, 梁天亚, 等. 住院心力衰竭患者GDF-15的改变及相关研究. 中国医刊, 2016, 51(2): 38-41.
23.	Duran L, Kayhan S, Guzel A, et al. The prognostic values of GDF-15 in comparison with NT-proBNP in patients with normotesive acute pulmonary embolism. Clin Lab, 2014, 60(8): 1365-1371.
24.	方建江, 李波, 何旭娟, 等. 血浆肌钙蛋白I、B型钠尿肽及D-二聚体检测在急性肺栓塞预后评估中的意义. 中国呼吸与危重监护杂志, 2012, 11(1): 61-64.
25.	吕亚辉, 李杰. 联合检测BNP、TNI、CRP及D-二聚体在肺栓塞患者中的诊断、病情判定及预后的指导意义. 中国医药导刊, 2014, 16(10): 1290-1292.

1. 中华医学会心血管病学分会肺血管病血组, 中国医师协会心血管内科医师分会. 急性肺血栓栓塞症诊断治疗中国专家共识. 中华内科杂志, 2010, 49(1): 74-81.
2. Ago T, Sadoshima J. GDF-15, a cardioprotective TGF-beta superfamily protein. Circ Res, 2006, 98(3): 294-297.
3. Schopfer DW, Ku IA, Regan M, et al. Growth differentiation factor 15 and cardiovascular events in patients with stable ischemic heart disease (The Heart and Soul Study). Am Heart J, 2014, 167(2): 186-192.
4. Lin JF, Wu S, Hsu SY, et al. Growth-differentiation factor-15 and major cardiac events. Am J Med Sci, 2014, 347(4): 305-311.
5. Olechnicki M, Kasprzak K, Goch A. Growth differentiation factor 15- - a new marker in heart diseases. Pol Merkur Lekarski, 2010, 28(168): 470-472.
6. 顾宇英, 赵萌涛, 宗明. 上海地区汉族健康人群血清GDF-15水平分析. 同济大学学报, 2010, 31(3): 96-99.
7. Azhar M, Schultz Jel J, Grupp I, et al. Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev, 2003, 14(5): 391-407.
8. Kempf T, Zarbock A, Widera C, et al. GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med, 2011, 17(5): 581-588.
9. Bootcov MR, Bauskin AR, Valenzuela SM, et al. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci USA, 1997, 94(21): 11514-11519.
10. Xu J, Kimball TR, Lorenz JN, et al. GDF-15/MIC-1 function as a protective antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res, 2006, 98(3): 342-350.
11. Nickel N, Jonigk D, Kempf T, et al. GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells. Respir Res, 2011, 12(1): 62.
12. Frank D, Kulm C, Brors B, et al. Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program. Hypertension, 2008, 51(2): 309-318.
13. Clerk A, Kenp TJ, Zoumpoulidon G, et al. Cardiac myocyte gene expression profiling during H₂O₂-induced apoptosis. Physiol Genomics, 2007, 29(2): 118-127.
14. Brown DA, Breit SN, Buring J, et al. Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study. Lancet, 2002, 359(9324): 2159-2163.
15. Lankeit M, Kempf T, Dellas C, et al. Growth differentiation factor-15 for prognostic assessment of patients with acute pulmonary embolism. Am J Respir Crit Care Med, 2008, 177(9): 1018-1025.
16. Rossaint J, Vestweber D, Zarbock A, et al. GDF-15 prevents platelet integrin activation and thrombus formation. J Thromb Haemost, 2013, 11(2): 335-44.
17. 阮丽波, 金会艳, 陈军. 家兔急性肺栓塞对生长分化因子-15的影响及意义. 中国现代医学杂志, 2015, 25(4): 12-16.
18. Guidelines on diagnosis and management of acute pulmonary embolism. Task Force on Pulmonary Embolism, European Society of Cardiology. Eur Heart J, 2000, 21(16): 1301-1336.
19. Watts JA, Gellar MA, Stuart L, et al. Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism. Histol Histopathol, 2011, 26(10): 1287-1294.
20. Nickel N, Kempf T, Tapken H, et al. Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med, 2008, 178(5): 534-541.
21. Lind L, Wallentin L, Kempf T, et al. Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the elderly: results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study. Eur Heart J, 2009, 30(19): 2346-2353.
22. 田伟萌, 王华, 梁天亚, 等. 住院心力衰竭患者GDF-15的改变及相关研究. 中国医刊, 2016, 51(2): 38-41.
23. Duran L, Kayhan S, Guzel A, et al. The prognostic values of GDF-15 in comparison with NT-proBNP in patients with normotesive acute pulmonary embolism. Clin Lab, 2014, 60(8): 1365-1371.
24. 方建江, 李波, 何旭娟, 等. 血浆肌钙蛋白I、B型钠尿肽及D-二聚体检测在急性肺栓塞预后评估中的意义. 中国呼吸与危重监护杂志, 2012, 11(1): 61-64.
25. 吕亚辉, 李杰. 联合检测BNP、TNI、CRP及D-二聚体在肺栓塞患者中的诊断、病情判定及预后的指导意义. 中国医药导刊, 2014, 16(10): 1290-1292.

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