Relationship between Gln223Arg polymorphism of leptin receptor gene and obstructive sleep apnea hypopnea syndrome in Han population in Southwest China_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

CHEN Yunfen ¹ ,  ZHANG Xiangyan ² , LIU Weijia ² , ZHANG Cheng ² , WANG Zhongxin ²

1. The Sixth People's Hospital of Guiyang, Guiyang, Guizhou 550011, P. R. China;
2. Department of Respiratory and Critical Care Medicine, Guizhou People's Hospital, Guiyang, Guizhou 550002, P. R. China;

Corresponding author：

ZHANG Xiangyan, Email: zxy35762@126.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Leptin repetor; Gene Gln223Arg polymorphism

DOI：

10.7507/1671-6205.201608059

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Objective To investigate the relatingship between leptin receptor gene Gln223Arg polymorphism and obstructive sleep apnea hyponea syndrome (OSAHS) in Han population in Southwest China. Methods Two hundred and fifteen cases of subjects (including 116 cases in OSAHS group and 99 cases in control group) were selected in Han population in Southwest China. Polymerase chain reaction (PCR) was used to analyse Gln223Arg leptin receptor gene polymorphism. The levels of serum LEP and TI were determined by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Simultaneous determination of body mass index (BMI) and neck circumference (NC) and waist circumference (WC) were conducted. Results In the OSAHS group, the leptin receptor gene polymorphism Gln223Arg GG, AA and GA genotype frequency was 0.854, 0.017 and 0.129, respectively. G allele and A allele frequency frequency was 0.918 and 0.082, respectively. In the control group, leptin receptor gene polymorphisms Gln223Arg GG, AA and GA genotype frequency was 0.840, 0.020 and 0.14,respectively. G allele and A allele frequency was 0.90 and 0.10, respectively. Genotype frequencies of the two groups were not statistically significant (χ²=0.784, P>0.05). There were differences in BMI, WC and NC between the OSAHS patients with GG and the OSAHS patients with (GA+AA) genotype (P<0.05), but no difference was found in LEP and TI levels (allP>0.05). In control, mild, moderate and severe OSAHS group, the levels of serum LEP and TI were increased gradually, and the difference was statistically significant (allP<0.05). Conclusions Gln223Arg leptin receptor genotype polymorphisms may be involved in obesity, but they have no relationship with the incidence of OSAHS in Han population in Southwest China. In OSAHS patients, Gln223Arg polymorphism has no relationship with LEP or TI. Patients with OSAHS have hyperleptinemia and hyperinsulinemia.

Citation： CHEN Yunfen, ZHANG Xiangyan, LIU Weijia, ZHANG Cheng, WANG Zhongxin. Relationship between Gln223Arg polymorphism of leptin receptor gene and obstructive sleep apnea hypopnea syndrome in Han population in Southwest China. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(5): 474-477. doi: 10.7507/1671-6205.201608059 Copy

1.	Young T, Peppard PE, Gottlieb DJ.Epidemiology of obstructive sleep apnea. Respir Crit Care Med, 2002, 165(9): 1217-1239.
2.	李建瑞, 谈艺, 魏永祥, 等. 瘦素受体基因 Gln223Arg 多态性与阻塞性睡眠呼吸暂停低通气综合征的相关性.中国耳鼻咽喉头颈外科杂志, 2014, 21(9): 495-497.0.
3.	潘若望, 石南松. 瘦素受体基因 Gln223Arg 多态性与温州地区高血压合并肥胖的相关性研究.解放军医学杂志, 2008, 33(10): 1192-1194.0.
4.	中华医学会呼吸病学分会睡眠呼吸疾病学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(2011 年修订版). 中华结核和呼吸杂志, 2012, 35(1): 9-12.0.
5.	Mateuoka N, Ogawa Y, Hosoda K, et al. Human leptin receptor gene in obese Japanese subjects : evidence against either obesity causing mutaions or association of sequence variants with obesity.Diabetologin, 1997, 40: 1204-1210.
6.	黄蓉, 黄席珍, 黎明, 等. 瘦素受体基因 Gln223Arg 多态性与阻塞性睡眠呼吸暂停低通气综合征的关系. 中华结核和呼吸杂志, 2003, 26(9): 517-521.0.
7.	Thompson DB, Ravussin E, Bennet PH, et al. Structure and sequence vaviation at the human leptin receptor gene in lean and obese pima Indians.Hum Mol Genet, 1997, 6(5): 675-679.
8.	Yiannakouris N, Yannakoulia M, Melistas L, et al. The Gln223Arg polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability.J Clin Endocrinol Metab, 2001, 86(9): 4434-4439.
9.	Phillips BG, Kato M, Narkiewicz K, et al. Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea.Am Physiol Heart Circ Physiol, 2007, 279(1): 234-237.
10.	Ozturk L, Unal M, Tamer L, et al. The association of the severity of obstructive sleep apnea with plasma leptin levels.Arch Otolaryngol Hcad NeckSurg, 2003, 29(1): 538-540.
11.	Eun YG, Kim MG, Kwon KH, et al. Short-term effect of multilevel surgery on adipokines and proinflammatory cytokines in patients with obstructive sleepapnea.Acta Otolaryngol, 2010, 130(12): 1394-1398.

1. Young T, Peppard PE, Gottlieb DJ.Epidemiology of obstructive sleep apnea. Respir Crit Care Med, 2002, 165(9): 1217-1239.
2. 李建瑞, 谈艺, 魏永祥, 等. 瘦素受体基因 Gln223Arg 多态性与阻塞性睡眠呼吸暂停低通气综合征的相关性.中国耳鼻咽喉头颈外科杂志, 2014, 21(9): 495-497.0.
3. 潘若望, 石南松. 瘦素受体基因 Gln223Arg 多态性与温州地区高血压合并肥胖的相关性研究.解放军医学杂志, 2008, 33(10): 1192-1194.0.
4. 中华医学会呼吸病学分会睡眠呼吸疾病学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(2011 年修订版). 中华结核和呼吸杂志, 2012, 35(1): 9-12.0.
5. Mateuoka N, Ogawa Y, Hosoda K, et al. Human leptin receptor gene in obese Japanese subjects : evidence against either obesity causing mutaions or association of sequence variants with obesity.Diabetologin, 1997, 40: 1204-1210.
6. 黄蓉, 黄席珍, 黎明, 等. 瘦素受体基因 Gln223Arg 多态性与阻塞性睡眠呼吸暂停低通气综合征的关系. 中华结核和呼吸杂志, 2003, 26(9): 517-521.0.
7. Thompson DB, Ravussin E, Bennet PH, et al. Structure and sequence vaviation at the human leptin receptor gene in lean and obese pima Indians.Hum Mol Genet, 1997, 6(5): 675-679.
8. Yiannakouris N, Yannakoulia M, Melistas L, et al. The Gln223Arg polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability.J Clin Endocrinol Metab, 2001, 86(9): 4434-4439.
9. Phillips BG, Kato M, Narkiewicz K, et al. Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea.Am Physiol Heart Circ Physiol, 2007, 279(1): 234-237.
10. Ozturk L, Unal M, Tamer L, et al. The association of the severity of obstructive sleep apnea with plasma leptin levels.Arch Otolaryngol Hcad NeckSurg, 2003, 29(1): 538-540.
11. Eun YG, Kim MG, Kwon KH, et al. Short-term effect of multilevel surgery on adipokines and proinflammatory cytokines in patients with obstructive sleepapnea.Acta Otolaryngol, 2010, 130(12): 1394-1398.

Chinese Journal of Respiratory and Critical Care Medicine

Relationship between Gln223Arg polymorphism of leptin receptor gene and obstructive sleep apnea hypopnea syndrome in Han population in Southwest China

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