Diagnostic Value of CT-Guided Percutaneous Lung Biopsy in Pulmonary Diseases_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

XiSuya ^1,2 ,  XuYu ¹ , GaoZhancheng ¹

1. Department of Respiratory and Critical Care Medicine，Peking University People’s Hospital，Beijing，100044，China;
2. ;

Corresponding author：

XuYu, Email: lizard_xy@163.com

Keywords：

CT-guided percutaneous lung biopsy; Histopathology; Tissue culture

DOI：

10.7507/1671-6205.2016113

Video：

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Objective To evaluate the diagnostic value of computer tomography (CT)-guided percutaneous lung biopsy and tissue culture in pulmonary diseases. Methods After the preoperative evaluation, 48 patients underwent CT-guided percutaneous lung biopsy were analyzed, and 16 patients accepted tissue culture. The clinical significance of combined diagnostic rate of histopathology and tissue culture was investigated. Results All patients were punctured successfully. The pathological diagnosis confirmed 26 (54.2%) cases with malignant lesions and 16 (33.3%) cases with benign lesions. Six cases could not be pathological diagnosed. The pathological diagnostic rate was 87.5%. Sixteen patients accepted tissue culture. Among them 3 cases with benign lesions were cultured. The positive rate of tissue culture was 18.8%, and improved to 30.0% in the patients with benign lesion. The combined diagnostic rate of histopathology and tissue culture was 89.6%. In addition, the accuracy rate of pathological diagnosis in the group of lung nodules was 95.0%, higher than the others. The accuracy rate of pathological diagnosis in lung nodules of 2cm~3cm in diameter was 100.0%, and the positive rate of tissue culture in lung lump of 3cm~5cm in diameter was 25.0%. The incidence of pneumothorax and hemorrhage was 14.6%. Conclusions CT-guided percutaneous lung biopsy is a safe and effective diagnostic method. For pulmonary infectious diseases, combination of CT-guided percutaneous lung biopsy and tissue culture can improve the early diagnostic rate.

Citation： Xi Suya, Xu Yu, Gao Zhancheng. Diagnostic Value of CT-Guided Percutaneous Lung Biopsy in Pulmonary Diseases. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(5): 490-494. doi: 10.7507/1671-6205.2016113 Copy

1.	方林, 华绪柏. CT引导下经皮肺穿刺活检对肺占位疾病应用分析.中国实用内科杂志, 2013, 33(S1):130-132.
2.	姜晓红, 罗明兴, 李晓玲, 等. 40例CT引导下经皮肺穿刺活检临床病理分析.中国呼吸与危重监护杂志, 2007, 6:301-302.
3.	张春芳, 印洪林, 陆珍凤, 等.642例CT引导下经皮肺穿刺活检病理诊断分析.临床与试验病理学杂志, 2011, 27:376-379.
4.	Yang W, Sun W, Li Q, et al. Diagnostic accuracy of CT-guided transthoracic needle biopsy for solitary pulmonary nodules. PLoS One, 2015, 10:e0131373.
5.	Cardoso LV, Souza Júnior AS. Clinical application of CT and CT-guided percutaneous transthoracic needle biopsy in patients with indeterminate pulmonary nodules.J Bras Pneumol, 2014, 40:380-388.
6.	马玙.肺结核与肺癌.中国实用内科杂志, 2015, 35:675-678.
7.	孟家晓, 李品林, 王建华, 等.经皮肺穿刺活检+组织培养在菌阴肺结核诊断中的价值.影像诊断与介入放射学, 2013, 22:177-180.
8.	燕军, 李吉臣, 张西岭, 等. CT引导下肺组织穿刺活检病理检查联合组织培养诊断特殊类型肺炎的价值.中华实用诊断与治疗杂志, 2015, 29:660-661.
9.	赵罡, 史晓宝, 卢再鸣, 等. CT引导下肺内直径小于等于30mm以下结节穿刺活检:探讨穿刺活检准确率的影响因素及其安全性.中国临床医学影像杂志, 2015, 26:391-394.
10.	Yamagami T, Iida S, Kato T, et al. Combining fine-needle aspiration and core biopsy under CT fluoroscopy guidance:a better way to treat patients with lung nodules? Am J Roentgenol, 2003, 180:811-815.
11.	张磊, 庄平, 张晋, 等. CT引导下经皮肺活检术诊断正确率及并发症的影响因素.临床肿瘤学杂志, 2011, 16:342-345.
12.	Hung WH, Chang CC, Ho SY, et al. Systemic air embolism causing acute stroke and myocardial infarction after percutaneous transthoracic lung biopsy-a case report. J Cardiothorac Surg, 2015, 10:121-123.
13.	倪颖梦, 时国朝, 万欢英, 等. CT引导下经皮肺穿刺的安全性及其影响因素.中国呼吸与危重监护杂志, 2011, 10:162-167.
14.	Khan MF, Straub R, Moghaddam SR, et al. Variables affecting the risk of pneumothorax and intrapulmonal hemorrhage in CT-guided transthoracic biopsy. Eur Radiol, 2008, 18:1356-1363.

1. 方林, 华绪柏. CT引导下经皮肺穿刺活检对肺占位疾病应用分析.中国实用内科杂志, 2013, 33(S1):130-132.
2. 姜晓红, 罗明兴, 李晓玲, 等. 40例CT引导下经皮肺穿刺活检临床病理分析.中国呼吸与危重监护杂志, 2007, 6:301-302.
3. 张春芳, 印洪林, 陆珍凤, 等.642例CT引导下经皮肺穿刺活检病理诊断分析.临床与试验病理学杂志, 2011, 27:376-379.
4. Yang W, Sun W, Li Q, et al. Diagnostic accuracy of CT-guided transthoracic needle biopsy for solitary pulmonary nodules. PLoS One, 2015, 10:e0131373.
5. Cardoso LV, Souza Júnior AS. Clinical application of CT and CT-guided percutaneous transthoracic needle biopsy in patients with indeterminate pulmonary nodules.J Bras Pneumol, 2014, 40:380-388.
6. 马玙.肺结核与肺癌.中国实用内科杂志, 2015, 35:675-678.
7. 孟家晓, 李品林, 王建华, 等.经皮肺穿刺活检+组织培养在菌阴肺结核诊断中的价值.影像诊断与介入放射学, 2013, 22:177-180.
8. 燕军, 李吉臣, 张西岭, 等. CT引导下肺组织穿刺活检病理检查联合组织培养诊断特殊类型肺炎的价值.中华实用诊断与治疗杂志, 2015, 29:660-661.
9. 赵罡, 史晓宝, 卢再鸣, 等. CT引导下肺内直径小于等于30mm以下结节穿刺活检:探讨穿刺活检准确率的影响因素及其安全性.中国临床医学影像杂志, 2015, 26:391-394.
10. Yamagami T, Iida S, Kato T, et al. Combining fine-needle aspiration and core biopsy under CT fluoroscopy guidance:a better way to treat patients with lung nodules? Am J Roentgenol, 2003, 180:811-815.
11. 张磊, 庄平, 张晋, 等. CT引导下经皮肺活检术诊断正确率及并发症的影响因素.临床肿瘤学杂志, 2011, 16:342-345.
12. Hung WH, Chang CC, Ho SY, et al. Systemic air embolism causing acute stroke and myocardial infarction after percutaneous transthoracic lung biopsy-a case report. J Cardiothorac Surg, 2015, 10:121-123.
13. 倪颖梦, 时国朝, 万欢英, 等. CT引导下经皮肺穿刺的安全性及其影响因素.中国呼吸与危重监护杂志, 2011, 10:162-167.
14. Khan MF, Straub R, Moghaddam SR, et al. Variables affecting the risk of pneumothorax and intrapulmonal hemorrhage in CT-guided transthoracic biopsy. Eur Radiol, 2008, 18:1356-1363.

Chinese Journal of Respiratory and Critical Care Medicine

Diagnostic Value of CT-Guided Percutaneous Lung Biopsy in Pulmonary Diseases

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