The Logistic regression analysis of risk factors for emphysema based CT quantitative assessment_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

FANG Yuan , GUAN Yu , XIA Yi ,  FAN Li , LIU Shiyuan , XIAO Xiangsheng

Department of Radiology, Changzheng Hospital of the Second Military Medical University, Shanghai 200003, P. R. China;

Corresponding author：

FAN Li, Email: fanli0930@163.com

Keywords：

Computed tomography; Emphysema; Quantitation; Logistic regression analysis

DOI：

10.7507/1671-6205.201612039

Video：

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Objective To explore the positive rate of emphysema in groups under Low-dose CT screening, then take the regression analysis on related risk factors for emphysema. Methods A total of 1 175 volunteers involved in low-dose CT screening and completing the questionnaire were collected and taken the CT quantitative assessment for emphysema, then the positive rate of emphysema was calculated. Questionnaire data were collected and non-conditional Logistic regression was used to analyze the factors in the questionnaire. Results Ninety-seven cases of emphysema had been detected in 1 175 volunteers, and the positive rate was 8.26%. The positive rate for the males and the females was 9.90% (71/717) and 5.68% (26/458), respectively. Three risk factors (smoking, second-hand smoking, history of chronic bronchitis) were screened out by Logistic regression. Conclusions According to the results of the regression analysis, smoking, second-hand smoking and history of chronic bronchitis are main risk factors for emphysema. Some effective measures could be made against emphysema in high risk population. In that way the morbidity and perniciousness of emphysema could be reduced.

Citation： FANG Yuan, GUAN Yu, XIA Yi, FAN Li, LIU Shiyuan, XIAO Xiangsheng. The Logistic regression analysis of risk factors for emphysema based CT quantitative assessment. Chinese Journal of Respiratory and Critical Care Medicine, 2017, 16(6): 595-598. doi: 10.7507/1671-6205.201612039 Copy

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2.	Yahaba M, Kawata N, Iesato K, et al. The effects of emphysema on airway disease: Correlations between multi-detector CT and pulmonary function tests in smokers. Eur J Radiol, 2014, 83(6): 1022-1028.
3.	Wang R, Sui X, Schoepf UJ, et al. Ultralow-radiation-dose chest CT: accuracy for lung densitometry and emphysema detection. Am J Roentgenol, 2015, 204(4): 743-749.
4.	Madani A, Zanen J, De MV, et al. Pulmonary emphysema: objective quantification at multi-detector row CT--comparison with macroscopic and microscopic morphometry. Radiology, 2006, 238(3): 1036-1043.
5.	Gu S, Leader J, Zheng B, et al. Direct assessment of lung function in COPD using CT densitometric measures. Physiol Meas, 2014, 35(5): 833-845.
6.	Gierada DS, Pilgram TK, Whiting BR, et al. Comparison of standard- and low-radiation-dose CT for quantification of emphysema. Am J Roentgenol, 2007, 188(1): 42-47.
7.	Madani A, De Maertelaer V, Zanen J, et al. Pulmonary emphysema: radiation dose and section thickness at multi-detector CT quantification comparison with macroscopic and microscopic morphometry. Radiology, 2007, 243(1): 250-257.
8.	Grydeland TB, Dirksen A, Coxson HO. Quantitative computed tomography: emphysema and airway wall thickness by sex, age and smoking. Eur Respir J, 2009, 34(4): 858-865.
9.	Shaker SB, Dirksen A, Lo P, et al. Factors influencing the decline in lung density in a Danish lung cancer screening cohort. Eur Respir J, 2012, 40(5): 1142-1148.
10.	Young W, Karp S, Bialick P, et al. Health, secondhand smoke exposure, and smoking behavior impacts of no-smoking policies in public housing, Colorado, 2014-2015. Prev Chronic Dis, 2016, 13: E148. Available at: https://www.cdc.gov/pcd/issues/2016/16_0008.htm.
11.	赵晶, 潘纪戍. COPD 表现型的 CT 定量诊断. 国际医学放射学杂志, 2011, 34(3): 250-256.
12.	Koyama S, Sato E, Haniuda M, et al. Decreased level of vascular endothelial growth factor in bronchoalveolar lavage fluid of normal smokers and patients with pulmonary fibrosis. Am J Respir Crit Care Med, 2002, 166(3): 382-385.
13.	Kasahara Y, Tuder RM, Cool CD, et al. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med, 2001, 163(3 Pt 1): 737-744.

1. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南 (2013 年修订版)(一). 中华结核和呼吸杂志, 2013, 36(4): 484-491.
2. Yahaba M, Kawata N, Iesato K, et al. The effects of emphysema on airway disease: Correlations between multi-detector CT and pulmonary function tests in smokers. Eur J Radiol, 2014, 83(6): 1022-1028.
3. Wang R, Sui X, Schoepf UJ, et al. Ultralow-radiation-dose chest CT: accuracy for lung densitometry and emphysema detection. Am J Roentgenol, 2015, 204(4): 743-749.
4. Madani A, Zanen J, De MV, et al. Pulmonary emphysema: objective quantification at multi-detector row CT--comparison with macroscopic and microscopic morphometry. Radiology, 2006, 238(3): 1036-1043.
5. Gu S, Leader J, Zheng B, et al. Direct assessment of lung function in COPD using CT densitometric measures. Physiol Meas, 2014, 35(5): 833-845.
6. Gierada DS, Pilgram TK, Whiting BR, et al. Comparison of standard- and low-radiation-dose CT for quantification of emphysema. Am J Roentgenol, 2007, 188(1): 42-47.
7. Madani A, De Maertelaer V, Zanen J, et al. Pulmonary emphysema: radiation dose and section thickness at multi-detector CT quantification comparison with macroscopic and microscopic morphometry. Radiology, 2007, 243(1): 250-257.
8. Grydeland TB, Dirksen A, Coxson HO. Quantitative computed tomography: emphysema and airway wall thickness by sex, age and smoking. Eur Respir J, 2009, 34(4): 858-865.
9. Shaker SB, Dirksen A, Lo P, et al. Factors influencing the decline in lung density in a Danish lung cancer screening cohort. Eur Respir J, 2012, 40(5): 1142-1148.
10. Young W, Karp S, Bialick P, et al. Health, secondhand smoke exposure, and smoking behavior impacts of no-smoking policies in public housing, Colorado, 2014-2015. Prev Chronic Dis, 2016, 13: E148. Available at: https://www.cdc.gov/pcd/issues/2016/16_0008.htm.
11. 赵晶, 潘纪戍. COPD 表现型的 CT 定量诊断. 国际医学放射学杂志, 2011, 34(3): 250-256.
12. Koyama S, Sato E, Haniuda M, et al. Decreased level of vascular endothelial growth factor in bronchoalveolar lavage fluid of normal smokers and patients with pulmonary fibrosis. Am J Respir Crit Care Med, 2002, 166(3): 382-385.
13. Kasahara Y, Tuder RM, Cool CD, et al. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med, 2001, 163(3 Pt 1): 737-744.

Chinese Journal of Respiratory and Critical Care Medicine

The Logistic regression analysis of risk factors for emphysema based CT quantitative assessment

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