中性粒细胞哮喘动物模型建立的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

李三 ^1,2,3 ,  朱黎明 ^1,2,3 , 戴爱国 ^1,3

1. ;
2. ;
3. ;

Corresponding author：

朱黎明, Email: zhuliming3298@sina.com

Keywords：

DOI：

10.7507/1671-6205.2016122

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Citation： 李三, 朱黎明, 戴爱国. 中性粒细胞哮喘动物模型建立的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(5): 529-533. doi: 10.7507/1671-6205.2016122 Copy

1.	Douwes J, Gibson P, Pekkanen J, et al.Non-eosinophilic asthma:importance and possible mechanisms.Thorax, 2002, 57:643-648.
2.	Bruijnzeel PL, Uddin M, Koenderman L.Targeting neutrophilic inflammation in severe neutrophilic asthma:can we target the disease-relevant neutrophil phenotype? J Leukoc Biol, 2015, 98:549-556.
3.	Takeshi N, Fusa H, Kouki M, et al.Important role of neutrophils in the late asthmatic response in mice.Life Sci, 2011, 88:1127-1135.
4.	Simpson JL, Guest M, Boggess MM, et al.Occupational exposures, smoking and airway in flammation in refractory asthma.BMC Pulm Med, 2014, 14:207.
5.	Simpson JL, Scott R, Boyle MJ, et al.Inflammatory subtypes in asthma:assessment and identification using induced sputum.Respirology, 2006, 11:54-61.
6.	Pabst R.Animal models for asthma:controversial aspects and unsolved problems.Pathobiology, 2002-2003, 70:252-254.
7.	Hayashi T, Adachi Y, Hasegawa K, et al.Less sensitivity for late airway inflammation in males than females in BA LB/c mice.Scand J Immunol, 2003, 57:562-567.
8.	陈清华.白化豚鼠与花色豚鼠在免疫学方面的比较研究.畜牧兽医科技信息, 2009, 8:41.
9.	Jonasson S, Hedenstierna G, Hjoberg J.Concomitant administration of nitric oxide and glucocorticoids improves protection against bronchoconstriction in a murine model of asthma.J Appl Physiol, 2010, 109:521-531.
10.	Wang PL, Thevenot P, Saravia J, et al.Radical-containing particles activate dendritic cells and enhance Th17 inflammation in a mouse model of asthma.Am J Respir Cell Mol Biol, 2011, 45:977-983.
11.	Hao M, Lin JT, Shu J, et al.Clarithromycin might attenuate the airway inflammation of smoke exposed asthmatic mice via affecting HDAC2.J Thorac Dis, 2015, 7:1189-1197.
12.	Patel KK, Vicencio AG, Du Z, et al.Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma.Pediatr Infect Dis J, 2010, 29:1093-1098.
13.	Lajoie S, Lewkowich IP, Suzuki Y, et al.Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.Nat Immunol, 2010, 11:928-935.
14.	Bogaert P, Naessens T, De Koker S, et al.Inflammatory signatures for eosinophilic vs.neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints.Am J Physiol Lung Cell Mol Physiol, 2011, 300:679-690.
15.	Dejager L, Dendoncker K, Eggermont M, et al.Neutralizing TNF-α restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation.Mucosal Immunol, 2015, 8:1212-1225.
16.	李海银, 朱黎明, 戴爱国, 等.豚鼠中性粒细胞性哮喘模型的建立.中华哮喘杂志(电子版), 2012, 6:245-249.
17.	Starkhammar M, Kumlien Georen S, Swedin L, et al.Intranasal administration of poly(I:C) and LPS in BALB/c mice induces airway hyperresponsiveness and inflammation via different pathways.PLoS One, 2012, 7:32-110.
18.	Bergquist M, Jonasson S, Hjoberg J, et al.Comprehensive multiplexed protein quantiation delineates eosinophilic and neutrophilic experimental asthma.BMC Pulm Med, 2014, 14:110.
19.	敖小冬, 农光民, 刘静, 等.中性粒细胞性支气管哮喘小鼠模型建立的探索.中华哮喘杂志(电子版), 2012, 6:100-105.
20.	刘晓微, 蒋敏, 农光民, 等.中性粒细胞性支气管哮喘小鼠模型的建立及其气道高反应规律的研究.中华哮喘杂志(电子版), 2013, 7:1-5.
21.	赵燕, 冉雪梅, 黄毅, 等.构建以Th17应答为主致气道中性粒细胞增高的小鼠哮喘模型.第三军医大学学报, 2013, 35:1376-1378.
22.	Lanckacker EA, Tournoy KG, Hammad H, et al.Short cigarette smoke exposure facilitates sensitization and asthma development in mice.Eur Respir J, 2013, 41:1189-1199.
23.	刘巧维. HIF1α及Th17/Treg失衡对烟雾暴露哮喘大鼠气道炎症的影响及西罗莫司治疗作用的研究[学位论文].中国人民解放军医学院, 2013.
24.	Bai H, Yang J, Qiu H, et al.Intranasal inoculation of Chlamydia trachomatis mouse pneumonitis agent induces significant neutrophil infiltration which is not efficient in controlling the infection in mice.Immunology, 2005, 114:246-254.
25.	Horvat JC, Starkey MR, Kim RY, et al.Chlamydial respiratory infection during allergen Sensitization drives neutrophilic allergic airways disease.J Immunol, 2010, 184:4159-4169.
26.	Srivastava KD, Dunkin D, Liu C, et al.Herbal formula ASHMI suppresses neutrophil predominant airway inflammation in a ragweed sensitized murine asthma model.Ann Allergy Asthma Immunol, 2014, 112:339-347.
27.	宋甲富, 蔡绍曦.维生素D对中性粒细胞哮喘小鼠模型的炎症抑制作用及可能机制[学位论文].南方医科大学, 2013.
28.	Jiang CX, Fan XS, Gu PC, et al.The effect of Qi`ao Decoction on ovalbumin induced and lipopolysaccharide enhanced severe asthma mice and its mechanism.Chin J Nat Med, 2013, 11:638-644.
29.	Liu R, Bai J, Xu G, et al.Multi-allergen challenge stimulates steriod-resistant airway inflammationvia NF-kappaB-mediated IL-8 expression.Inflammation, 2013, 36:845-854.
30.	Hamelmann E, Schwarze J, Takeda K, et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography.Am J Respir Crit Care Med, 1997, 156:766-775.
31.	Berndt A, Leme AS, Williams LK, et al.Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice.Physiol Genomics, 2011, 43:1-11.
32.	Lundblad LK.Issues determining direct airways hyperresponsiveness in mice.Front Physiol, 2012, 3:408.

1. Douwes J, Gibson P, Pekkanen J, et al.Non-eosinophilic asthma:importance and possible mechanisms.Thorax, 2002, 57:643-648.
2. Bruijnzeel PL, Uddin M, Koenderman L.Targeting neutrophilic inflammation in severe neutrophilic asthma:can we target the disease-relevant neutrophil phenotype? J Leukoc Biol, 2015, 98:549-556.
3. Takeshi N, Fusa H, Kouki M, et al.Important role of neutrophils in the late asthmatic response in mice.Life Sci, 2011, 88:1127-1135.
4. Simpson JL, Guest M, Boggess MM, et al.Occupational exposures, smoking and airway in flammation in refractory asthma.BMC Pulm Med, 2014, 14:207.
5. Simpson JL, Scott R, Boyle MJ, et al.Inflammatory subtypes in asthma:assessment and identification using induced sputum.Respirology, 2006, 11:54-61.
6. Pabst R.Animal models for asthma:controversial aspects and unsolved problems.Pathobiology, 2002-2003, 70:252-254.
7. Hayashi T, Adachi Y, Hasegawa K, et al.Less sensitivity for late airway inflammation in males than females in BA LB/c mice.Scand J Immunol, 2003, 57:562-567.
8. 陈清华.白化豚鼠与花色豚鼠在免疫学方面的比较研究.畜牧兽医科技信息, 2009, 8:41.
9. Jonasson S, Hedenstierna G, Hjoberg J.Concomitant administration of nitric oxide and glucocorticoids improves protection against bronchoconstriction in a murine model of asthma.J Appl Physiol, 2010, 109:521-531.
10. Wang PL, Thevenot P, Saravia J, et al.Radical-containing particles activate dendritic cells and enhance Th17 inflammation in a mouse model of asthma.Am J Respir Cell Mol Biol, 2011, 45:977-983.
11. Hao M, Lin JT, Shu J, et al.Clarithromycin might attenuate the airway inflammation of smoke exposed asthmatic mice via affecting HDAC2.J Thorac Dis, 2015, 7:1189-1197.
12. Patel KK, Vicencio AG, Du Z, et al.Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma.Pediatr Infect Dis J, 2010, 29:1093-1098.
13. Lajoie S, Lewkowich IP, Suzuki Y, et al.Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.Nat Immunol, 2010, 11:928-935.
14. Bogaert P, Naessens T, De Koker S, et al.Inflammatory signatures for eosinophilic vs.neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints.Am J Physiol Lung Cell Mol Physiol, 2011, 300:679-690.
15. Dejager L, Dendoncker K, Eggermont M, et al.Neutralizing TNF-α restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation.Mucosal Immunol, 2015, 8:1212-1225.
16. 李海银, 朱黎明, 戴爱国, 等.豚鼠中性粒细胞性哮喘模型的建立.中华哮喘杂志(电子版), 2012, 6:245-249.
17. Starkhammar M, Kumlien Georen S, Swedin L, et al.Intranasal administration of poly(I:C) and LPS in BALB/c mice induces airway hyperresponsiveness and inflammation via different pathways.PLoS One, 2012, 7:32-110.
18. Bergquist M, Jonasson S, Hjoberg J, et al.Comprehensive multiplexed protein quantiation delineates eosinophilic and neutrophilic experimental asthma.BMC Pulm Med, 2014, 14:110.
19. 敖小冬, 农光民, 刘静, 等.中性粒细胞性支气管哮喘小鼠模型建立的探索.中华哮喘杂志(电子版), 2012, 6:100-105.
20. 刘晓微, 蒋敏, 农光民, 等.中性粒细胞性支气管哮喘小鼠模型的建立及其气道高反应规律的研究.中华哮喘杂志(电子版), 2013, 7:1-5.
21. 赵燕, 冉雪梅, 黄毅, 等.构建以Th17应答为主致气道中性粒细胞增高的小鼠哮喘模型.第三军医大学学报, 2013, 35:1376-1378.
22. Lanckacker EA, Tournoy KG, Hammad H, et al.Short cigarette smoke exposure facilitates sensitization and asthma development in mice.Eur Respir J, 2013, 41:1189-1199.
23. 刘巧维. HIF1α及Th17/Treg失衡对烟雾暴露哮喘大鼠气道炎症的影响及西罗莫司治疗作用的研究[学位论文].中国人民解放军医学院, 2013.
24. Bai H, Yang J, Qiu H, et al.Intranasal inoculation of Chlamydia trachomatis mouse pneumonitis agent induces significant neutrophil infiltration which is not efficient in controlling the infection in mice.Immunology, 2005, 114:246-254.
25. Horvat JC, Starkey MR, Kim RY, et al.Chlamydial respiratory infection during allergen Sensitization drives neutrophilic allergic airways disease.J Immunol, 2010, 184:4159-4169.
26. Srivastava KD, Dunkin D, Liu C, et al.Herbal formula ASHMI suppresses neutrophil predominant airway inflammation in a ragweed sensitized murine asthma model.Ann Allergy Asthma Immunol, 2014, 112:339-347.
27. 宋甲富, 蔡绍曦.维生素D对中性粒细胞哮喘小鼠模型的炎症抑制作用及可能机制[学位论文].南方医科大学, 2013.
28. Jiang CX, Fan XS, Gu PC, et al.The effect of Qi`ao Decoction on ovalbumin induced and lipopolysaccharide enhanced severe asthma mice and its mechanism.Chin J Nat Med, 2013, 11:638-644.
29. Liu R, Bai J, Xu G, et al.Multi-allergen challenge stimulates steriod-resistant airway inflammationvia NF-kappaB-mediated IL-8 expression.Inflammation, 2013, 36:845-854.
30. Hamelmann E, Schwarze J, Takeda K, et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography.Am J Respir Crit Care Med, 1997, 156:766-775.
31. Berndt A, Leme AS, Williams LK, et al.Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice.Physiol Genomics, 2011, 43:1-11.
32. Lundblad LK.Issues determining direct airways hyperresponsiveness in mice.Front Physiol, 2012, 3:408.

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