系统性糖皮质激素在呼吸危重症治疗中的获益与风险_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

肖永久 ,  汪建新

解放军总医院呼吸科（北京 100853）;

Corresponding author：

汪建新, Email: wangjx301@126.com

Keywords：

DOI：

10.7507/1671-6205.2016142

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Citation： 肖永久, 汪建新. 系统性糖皮质激素在呼吸危重症治疗中的获益与风险. Chinese Journal of Respiratory and Critical Care Medicine, 2016, 15(6): 619-624. doi: 10.7507/1671-6205.2016142 Copy

1.	Kiser TH, Allen RR, Valuck RJ, et al. Outcomes associated with corticosteroid dosage in critically ill patients with acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2014, 189:1052-1064.
2.	Haskell RJ, Wong BM, Hansen JE. A double-blind, randomized clinical trial of methylprednisolone in status asthmaticus. Arch Intern Med, 1983, 143:1324-1327.
3.	Rowe BH, Sevcik W, Villa-Roel C. Management of severe acute asthma in the emergency department. Curr Opin Crit Care, 2011, 17:335-341.
4.	Umberto MG, Bell W, Sinclair S, et al. Pathophysiology of acute respiratory distress syndrome. Glucocorticoid receptor-mediated regulation of inflammation and response to prolonged glucocorticoid treatment. Presse Med, 2011, 40:543-560.
5.	Lemiale V, Debrumetz A, Delannoy A, et al. Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia. Respir Res, 2013, 14:87.
6.	Ranzani OT, Ferrer M, Esperatti M, et al. Association between systemic corticosteroids and outcomes of intensive care unit-acquired pneumonia. Crit Care Med, 2012, 40:2552-2561.
7.	王玲, 孙鸿展, 崔雪华, 等.医院ICU获得性肺炎相关因素调查分析.齐鲁护理杂志, 2014, 20:67-68.
8.	孔庆玲, 马先宾, 汪秀芹, 等.ICU患者深部真菌感染的调查与控制.中华医院感染学杂志, 2014, 24:3717-3719.
9.	陈雪梅, 张欣, 庹田.ICU呼吸机相关性肺炎危险因素的Logistic回归性分析以及病原菌研究.临床合理用药杂志, 2014, 7(7A):8-10.
10.	WHO:the Top 10 Causes of Death. 2013. Available from:http://www.who.int/mediacentre/factsheets/fs310/en/index.html.
11.	Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign:International Guidelines for Management of Severe Sepsis and Septic Shock, 2012. Intensive Care Med, 2013, 39:165-228.
12.	陈丽萍, 陈军, 陈颖, 等.糖皮质激素治疗社区获得性肺炎疗效及安全性Meta分析.中华急诊医学杂志, 2014, 23:65-70.
13.	宋志芳, 郭晓红, 王树云, 等.糖皮质激素在重症社区获得性肺炎致急性呼吸窘迫综合征综合救治中的价值探讨.中国危重病急救医学, 2003, 15:669-674.
14.	Torres A, Sibila O, Ferrer M, et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response:a randomized clinical trial. JAMA, 2015, 313:677-686.
15.	田欣伦, 江梅, 孙雪峰, 等.糖皮质激素治疗成人社区获得性肺炎适应证的荟萃分析.中华结核和呼吸杂志, 2016, 39:280-285.
16.	Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids in the treatment of severe sepsis and septic shock in adults:a systematic review. JAMA, 2009, 301:2362-2375.
17.	Magne D, Angoulvant A, Botterel F, et al. Pneumocystosis:a network survey in the Paris area 2003-2008. Eur J Clin Microbiol Infect Dis, 2011, 30:673-675.
18.	Azoulay E, Mokart D, Rabbat A, et al. Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure:prospective multicenter data. Crit Care Med, 2008. 36:100-107.
19.	Bollée G, Sarfati C, Thiéry G, et al. Clinical picture of Pneumocystis jiroveci pneumonia in cancer patients. Chest, 2007, 132:1305-1310.
20.	Gagnon S, Boota AM, Fischl MA, et al. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome:a double-blind, placebo-controlled trial. N Engl J Med, 1990, 323:1444-1450.
21.	Bozzette SA, Sattler FR, Chiu J, et al. A controlled trial of early adjunctive treatment with corticosteroids for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. California Collaborative Treatment Group. N Engl J Med, 1990, 323:1451-1457.
22.	Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med, 2008, 359:2355-2365.
23.	Walters JA, Tan DJ, White CJ, et al. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev, 2014:Cd001288.
24.	Kiser TH, Vandivier RW. Severe acute exacerbations of chronic obstructive pulmonary disease:does the dosage of corticosteroids and type of antibiotic matter? Curr Opin Pulm Med, 2015, 21:142-148.
25.	Sun WP, Yuan GX, Hu YJ, et al. Effect of low-dose glucocorticoid on corticosteroid insufficient patients with acute exacerbation of chronic obstructive pulmonary disease. World J Emerg Med, 2015, 6:34-39.
26.	GINA. Global Strategy for Asthma Management and Prevention 2015. Available from:http://www.ginasthma.org/documents/4.
27.	Louie S, Morrissey BM, Kenyon NJ, et al. The critically ill asthmatic--from ICU to discharge. Clin Rev Allergy Immunol, 2012, 43(1-2):30-44.
28.	Schivo M, Phan C, Louie S, et al. Critical asthma syndrome in the ICU. Clin Rev Allergy Immunol, 2015, 48:31-44.
29.	Krishnan JA, Davis SQ, Naureckas ET, et al. An umbrella review:corticosteroid therapy for adults with acute asthma. Am J Med, 2009, 122:977-991.
30.	Rowe BH, Edmonds ML, Spooner CH, et al. Corticosteroid therapy for acute asthma. Respir Med, 2004, 98:275-284.
31.	Schatz M, Dombrowski MP, Wise R, et al. Asthma morbidity during pregnancy can be predicted by severity classification. J Allergy Clin Immunol, 2003, 112:283-288.
32.	Global strategy for asthma management and prevention.Global Initiative for Asthma (GINA). 2012. Available from:http://www.ginasthma.org[accessed 2014-01-17].
33.	British Thoracic Society & Scottish Intercollegiate Guidelines Network. British Guideline on the Management of Asthma. 2012, Available from:http://www.sign.ac.uk/pdf/sign101.pdf[accessed 2014-01-17].
34.	McCallister JW, Benninger CG, Frey HA, et al. Pregnancy related treatment disparities of acute asthma exacerbations in the emergency department. Respir Med, 2011, 105:1434-1440.
35.	Cossette B, Beauchesne MF, Forget A, et al. Systemic corticosteroids for the treatment of asthma exacerbations during and outside of pregnancy in an acute-care setting. Respir Med, 2014, 108:1260-1267.
36.	Meduri GU, Golden E, Freire AX, et al. Methylprednisolone infusion in early severe ARDS results of a randomized controlled trial. 2007. Chest, 2009, 136(5 Suppl):e30.
37.	Tang BM, Craig JC, Eslick GD, et al. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome:a systematic review and meta-analysis. Crit Care Med, 2009, 37:1594-1603.
38.	Meduri GU, Bridges L, Shih MC, et al. Prolonged glucocorticoid treatment is associated with improved ARDS outcomes:analysis of individual patients' data from four randomized trials and trial-level meta-analysis of the updated literature. Intensive Care Med, 2016, 42:829-840.
39.	刘玲, 李佳, 黄英姿, 等.应激剂量糖皮质激素对合并危重病相关皮质醇不足的急性呼吸窘迫综合征患者的影响.中华内科杂志, 2012, 51:599-603.

1. Kiser TH, Allen RR, Valuck RJ, et al. Outcomes associated with corticosteroid dosage in critically ill patients with acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2014, 189:1052-1064.
2. Haskell RJ, Wong BM, Hansen JE. A double-blind, randomized clinical trial of methylprednisolone in status asthmaticus. Arch Intern Med, 1983, 143:1324-1327.
3. Rowe BH, Sevcik W, Villa-Roel C. Management of severe acute asthma in the emergency department. Curr Opin Crit Care, 2011, 17:335-341.
4. Umberto MG, Bell W, Sinclair S, et al. Pathophysiology of acute respiratory distress syndrome. Glucocorticoid receptor-mediated regulation of inflammation and response to prolonged glucocorticoid treatment. Presse Med, 2011, 40:543-560.
5. Lemiale V, Debrumetz A, Delannoy A, et al. Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia. Respir Res, 2013, 14:87.
6. Ranzani OT, Ferrer M, Esperatti M, et al. Association between systemic corticosteroids and outcomes of intensive care unit-acquired pneumonia. Crit Care Med, 2012, 40:2552-2561.
7. 王玲, 孙鸿展, 崔雪华, 等.医院ICU获得性肺炎相关因素调查分析.齐鲁护理杂志, 2014, 20:67-68.
8. 孔庆玲, 马先宾, 汪秀芹, 等.ICU患者深部真菌感染的调查与控制.中华医院感染学杂志, 2014, 24:3717-3719.
9. 陈雪梅, 张欣, 庹田.ICU呼吸机相关性肺炎危险因素的Logistic回归性分析以及病原菌研究.临床合理用药杂志, 2014, 7(7A):8-10.
10. WHO:the Top 10 Causes of Death. 2013. Available from:http://www.who.int/mediacentre/factsheets/fs310/en/index.html.
11. Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign:International Guidelines for Management of Severe Sepsis and Septic Shock, 2012. Intensive Care Med, 2013, 39:165-228.
12. 陈丽萍, 陈军, 陈颖, 等.糖皮质激素治疗社区获得性肺炎疗效及安全性Meta分析.中华急诊医学杂志, 2014, 23:65-70.
13. 宋志芳, 郭晓红, 王树云, 等.糖皮质激素在重症社区获得性肺炎致急性呼吸窘迫综合征综合救治中的价值探讨.中国危重病急救医学, 2003, 15:669-674.
14. Torres A, Sibila O, Ferrer M, et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response:a randomized clinical trial. JAMA, 2015, 313:677-686.
15. 田欣伦, 江梅, 孙雪峰, 等.糖皮质激素治疗成人社区获得性肺炎适应证的荟萃分析.中华结核和呼吸杂志, 2016, 39:280-285.
16. Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids in the treatment of severe sepsis and septic shock in adults:a systematic review. JAMA, 2009, 301:2362-2375.
17. Magne D, Angoulvant A, Botterel F, et al. Pneumocystosis:a network survey in the Paris area 2003-2008. Eur J Clin Microbiol Infect Dis, 2011, 30:673-675.
18. Azoulay E, Mokart D, Rabbat A, et al. Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure:prospective multicenter data. Crit Care Med, 2008. 36:100-107.
19. Bollée G, Sarfati C, Thiéry G, et al. Clinical picture of Pneumocystis jiroveci pneumonia in cancer patients. Chest, 2007, 132:1305-1310.
20. Gagnon S, Boota AM, Fischl MA, et al. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome:a double-blind, placebo-controlled trial. N Engl J Med, 1990, 323:1444-1450.
21. Bozzette SA, Sattler FR, Chiu J, et al. A controlled trial of early adjunctive treatment with corticosteroids for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. California Collaborative Treatment Group. N Engl J Med, 1990, 323:1451-1457.
22. Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med, 2008, 359:2355-2365.
23. Walters JA, Tan DJ, White CJ, et al. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev, 2014:Cd001288.
24. Kiser TH, Vandivier RW. Severe acute exacerbations of chronic obstructive pulmonary disease:does the dosage of corticosteroids and type of antibiotic matter? Curr Opin Pulm Med, 2015, 21:142-148.
25. Sun WP, Yuan GX, Hu YJ, et al. Effect of low-dose glucocorticoid on corticosteroid insufficient patients with acute exacerbation of chronic obstructive pulmonary disease. World J Emerg Med, 2015, 6:34-39.
26. GINA. Global Strategy for Asthma Management and Prevention 2015. Available from:http://www.ginasthma.org/documents/4.
27. Louie S, Morrissey BM, Kenyon NJ, et al. The critically ill asthmatic--from ICU to discharge. Clin Rev Allergy Immunol, 2012, 43(1-2):30-44.
28. Schivo M, Phan C, Louie S, et al. Critical asthma syndrome in the ICU. Clin Rev Allergy Immunol, 2015, 48:31-44.
29. Krishnan JA, Davis SQ, Naureckas ET, et al. An umbrella review:corticosteroid therapy for adults with acute asthma. Am J Med, 2009, 122:977-991.
30. Rowe BH, Edmonds ML, Spooner CH, et al. Corticosteroid therapy for acute asthma. Respir Med, 2004, 98:275-284.
31. Schatz M, Dombrowski MP, Wise R, et al. Asthma morbidity during pregnancy can be predicted by severity classification. J Allergy Clin Immunol, 2003, 112:283-288.
32. Global strategy for asthma management and prevention.Global Initiative for Asthma (GINA). 2012. Available from:http://www.ginasthma.org[accessed 2014-01-17].
33. British Thoracic Society & Scottish Intercollegiate Guidelines Network. British Guideline on the Management of Asthma. 2012, Available from:http://www.sign.ac.uk/pdf/sign101.pdf[accessed 2014-01-17].
34. McCallister JW, Benninger CG, Frey HA, et al. Pregnancy related treatment disparities of acute asthma exacerbations in the emergency department. Respir Med, 2011, 105:1434-1440.
35. Cossette B, Beauchesne MF, Forget A, et al. Systemic corticosteroids for the treatment of asthma exacerbations during and outside of pregnancy in an acute-care setting. Respir Med, 2014, 108:1260-1267.
36. Meduri GU, Golden E, Freire AX, et al. Methylprednisolone infusion in early severe ARDS results of a randomized controlled trial. 2007. Chest, 2009, 136(5 Suppl):e30.
37. Tang BM, Craig JC, Eslick GD, et al. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome:a systematic review and meta-analysis. Crit Care Med, 2009, 37:1594-1603.
38. Meduri GU, Bridges L, Shih MC, et al. Prolonged glucocorticoid treatment is associated with improved ARDS outcomes:analysis of individual patients' data from four randomized trials and trial-level meta-analysis of the updated literature. Intensive Care Med, 2016, 42:829-840.
39. 刘玲, 李佳, 黄英姿, 等.应激剂量糖皮质激素对合并危重病相关皮质醇不足的急性呼吸窘迫综合征患者的影响.中华内科杂志, 2012, 51:599-603.

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系统性糖皮质激素在呼吸危重症治疗中的获益与风险

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