The changes and clinical significance of serum complement C1q tumor necrosis factor related protein 5 in patients with chronic obstructive pulmonary disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

XIE Xiaoyun ¹ ,  SONG Yanhong ² , YU Xuemei ² , RONG Shuhui ² , LIU Jingbin ² , LIU Lanxiang ³ , XU Lijie ³

1. Inner Mongolia Medical University, Baotou, Inner Mongolia 014032, P. R. China;
2. Department of Respiratory Medicine, The Fourth Affiliated Hospital of Inner Mongolia Medical University, Baotou, Inner Mongolia 014032, P. R. China;
3. Department of Medical Examination Center, The Fourth Affiliated Hospital of Inner Mongolia Medical University, Baotou, Inner Mongolia 014032, P. R. China;

Corresponding author：

SONG Yanhong, Email: songyanhong369@163.com

Keywords：

Chronic obstructive pulmonary disease; Complement C1q tumor necrosis factor related protein 5; High sensitivity C-reactive protein; Forced expiratory volume in one second

DOI：

10.7507/1671-6205.201703036

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ObjectiveTo explore the serum concentrations of complement C1q tumor necrosis factor related protein 5 (CTRP5) in patients with acute exacerbations and stable stage of chronic obstructive pulmonary disease (COPD), and analyze the correlation of CTRP5 with high sensitivity C-reactive protein (hs-CRP) and FEV₁/FVC and FEV₁%pred.MethodsThirty hospitalized patients with acute exacerbation of COPD and 30 outpatients with stable COPD according with diagnostic criteria and inclusive criteria were sampled successively. At the same time 30 healthy volunteers were selected as normal control. All subjects were measured the concentrations of CTRP5 and hs-CRP in serum and lung function test was performed.ResultsThe serum CTRP5 and hs-CRP concentrations of the acute exacerbation group was higher than those in the stable group and the control group. The serum CTRP5 and hs-CRP concentrations of the stable group was also higher than those of the control group. The FEV₁/FVC of the acute exacerbation group was lower than those of the stable group and the control group; and the FEV₁/FVC of the stable group was lower than that of the control group. The FEV₁%pred of three groups by analysis indicated the difference was statistically significant. Further pairwise comparisons demonstrated that the FEV₁%pred of two COPD groups were lower than that of the control group but the FEV₁%pred of the acute exacerbation group and stable group was not significantly different. The correlation analysis of the acute exacerbation group and the stable group demonstrated that the levels of serum CTRP5 and hs-CRP were postively correlated and the level of serum CTRP5 was negatively correlated with FEV₁/FVC and FEV₁%pred.ConclusionsThe level of CTRP5 in serum of COPD patients is increased. No matter in acute exacerbation or stable phase, the level of serum CTRP5 is positively correlated with hs-CRP and negatively correlated with FEV₁/FVC and FEV₁%pred, which suggests that CTRP5 is involved in the pathogenesis of COPD but the exact mechanism needs further study.

Citation： XIE Xiaoyun, SONG Yanhong, YU Xuemei, RONG Shuhui, LIU Jingbin, LIU Lanxiang, XU Lijie. The changes and clinical significance of serum complement C1q tumor necrosis factor related protein 5 in patients with chronic obstructive pulmonary disease. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(2): 113-118. doi: 10.7507/1671-6205.201703036 Copy

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2.	Li D, Wu Y, Tian P, et al. Adipokine CTRP-5 as a Potential Novel Inflammatory Biomarker in Chronic Obstructive Pulmonary Disease. Medicine (Baltimore), 2015, 94(3): e1503.
3.	Assad NA, Sood A. Leptin, adiponectin and pulmonary diseases. Biochimie, 2012, 94, (10): 2180-2189.
4.	宋艳红, 荣淑慧, 李维才, 等. 脂联素在慢性阻塞性肺疾病不同分期的表达.中国呼吸与危重监护杂志, 2014, 13(3): 237-240.
5.	Eker S, Ayaz L, Tamer L, et al. Leptin, visfatin, insulin resistance, and body composition change in chronic obstructive pulmonary disease. Scand J Clin Lab Invest., 2010, 70 (1): 40-44.
6.	雷虹, 张洁, 王瑾瑜, 等.补体 C1q/肿瘤坏死因子相关蛋白家族研究进展.生理科学进展, 2015, 46(1): 43-48.
7.	Schmid A, Kopp A, Aslanidis C, et al. Regulation and Function of C1Q/TNF-related Protein-5(CTRP-5) in the Context of Adipocyte Biology.Exp Clin Endocrinol Diabetes, 2013, 121(5): 310-317.
8.	毛燕青, 李苏, 王翎, 等.血清超敏 C 反应蛋白和前白蛋白在老年 COPD 患者中的变化.中国老年学杂志, 2010, 30(19): 2713-2725.
9.	Higashimoto Y, Iwata T, Okada M, et al. Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease. Respir Med, 2009, 103(8): 1231-1238.
10.	Karadag F, Kirdar S, Karul AB, et al. The value of C-reactive protein as a marker of systemic inflammation in stable chronic obstructive pulmonary disease. Eur J Intern Med, 2008, 19(2): 104-108.
11.	Park S-Y, Choi JH, Ryu HS, et al. C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase. J Biol Chem, 2009, 284(41): 27780-27789.
12.	Sin DD, Man SF, Systemic inflammation and mortality in chronic obstructive pulmonary disease. Can J PhysiolPharmacol, 2007, 85(1): 141-147.
13.	Remels AH, Gosker HR, Schrauwen P, et al.TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?. FASEB J, 2010, 24(12): 5052-5062.
14.	Yang W-M, Lee W. CTRP-5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. BiochemBiophysRes Commun, 2014, 452(3): 715-721.
15.	Zhang P, Cao M, Liu Y, et al. PDGF-induced airway smooth muscle proliferation is associated with Human antigen R activation and could be weakened by AMPK activation. Mol Biol Rep, 2012, 39(5): 5819-5829.

1. 中华医学会呼吸病学分会慢性阻塞性肺病学组, 慢性阻塞性肺疾病诊治指南 (2013 修订).中华结核和呼吸杂志, 2013, 36(4): 255-264.
2. Li D, Wu Y, Tian P, et al. Adipokine CTRP-5 as a Potential Novel Inflammatory Biomarker in Chronic Obstructive Pulmonary Disease. Medicine (Baltimore), 2015, 94(3): e1503.
3. Assad NA, Sood A. Leptin, adiponectin and pulmonary diseases. Biochimie, 2012, 94, (10): 2180-2189.
4. 宋艳红, 荣淑慧, 李维才, 等. 脂联素在慢性阻塞性肺疾病不同分期的表达.中国呼吸与危重监护杂志, 2014, 13(3): 237-240.
5. Eker S, Ayaz L, Tamer L, et al. Leptin, visfatin, insulin resistance, and body composition change in chronic obstructive pulmonary disease. Scand J Clin Lab Invest., 2010, 70 (1): 40-44.
6. 雷虹, 张洁, 王瑾瑜, 等.补体 C1q/肿瘤坏死因子相关蛋白家族研究进展.生理科学进展, 2015, 46(1): 43-48.
7. Schmid A, Kopp A, Aslanidis C, et al. Regulation and Function of C1Q/TNF-related Protein-5(CTRP-5) in the Context of Adipocyte Biology.Exp Clin Endocrinol Diabetes, 2013, 121(5): 310-317.
8. 毛燕青, 李苏, 王翎, 等.血清超敏 C 反应蛋白和前白蛋白在老年 COPD 患者中的变化.中国老年学杂志, 2010, 30(19): 2713-2725.
9. Higashimoto Y, Iwata T, Okada M, et al. Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease. Respir Med, 2009, 103(8): 1231-1238.
10. Karadag F, Kirdar S, Karul AB, et al. The value of C-reactive protein as a marker of systemic inflammation in stable chronic obstructive pulmonary disease. Eur J Intern Med, 2008, 19(2): 104-108.
11. Park S-Y, Choi JH, Ryu HS, et al. C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase. J Biol Chem, 2009, 284(41): 27780-27789.
12. Sin DD, Man SF, Systemic inflammation and mortality in chronic obstructive pulmonary disease. Can J PhysiolPharmacol, 2007, 85(1): 141-147.
13. Remels AH, Gosker HR, Schrauwen P, et al.TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?. FASEB J, 2010, 24(12): 5052-5062.
14. Yang W-M, Lee W. CTRP-5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. BiochemBiophysRes Commun, 2014, 452(3): 715-721.
15. Zhang P, Cao M, Liu Y, et al. PDGF-induced airway smooth muscle proliferation is associated with Human antigen R activation and could be weakened by AMPK activation. Mol Biol Rep, 2012, 39(5): 5819-5829.

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The changes and clinical significance of serum complement C1q tumor necrosis factor related protein 5 in patients with chronic obstructive pulmonary disease

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