MDCT findings and clinicopathological analysis of pulmonary mucosa associated lymphoid tissue lymphoma_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 ZHANY Youyi ¹ , YANG Cheng ¹ , PU Hong ¹ , LI Juan ²

1. Department of Radiology, Sichuan Academy of Medical Sciences, Sichuan Province People’s Hospital, Chengdu, Sichuan 610072, P. R. China;
2. Department of Pathology, Sichuan Academy of Medical Sciences, Sichuan Province People’s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

ZHANY Youyi, Email: zhangyouyi108@163.com

Keywords：

Pulmonary neoplasms; Lymphoma; Pulmonary mucosa associated lymphoid tissue; Multidetector computed tomography; Pathology

DOI：

10.7507/1671-6205.201804004

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo study the clinical and pathological characteristics and imaging manifestations of pulmonary mucosa associated lymphoid tissue (MALT) lymphoma.MethodsThe clinical and multidetector computed tomography (MDCT) imaging data of 17 patients with pathological proven pulmonary MALT lymphoma were reviewed retrospectively.ResultsThe MDCT manifestations were divided into 4 types: ① pneumonia/consolidation, ② mass/nodule type, ③ bronchovascular lymphatic type, ④ mixed type. The imaging features included air bronchiectasis in 13 cases and bronchiectasis in 9 cases. Multiple small pulmonary nodules were found in 11 cases, ground glass opacity in 9 cases, 4 cases of pleural effusion, pulmonary hilar and mediastinal lymph node enlargement in 3 cases. Among these 17 cases, 4 had extra-pulmonary involvement and 2 without obvious symptoms. The main clinical symptoms including cough, expectoration, dyspnea, fever, chest pain, hemoptysis, night sweats. The pathological manifestation is the infiltration of a large number of B lymphocytes and nuclear heterocells.ConclusionsThe clinical manifestations of pulmonary MALT lymphoma are not specific, but the progress is slow, and may be associated with autoimmune diseases. The main MDCT findings of pulmonary MALT lymphoma include consolidation, nodules or masses with air bronchogram. Lymph node enlargement is rare. Clinical diagnosis should also be based on pathological results.

Citation： ZHANY Youyi, YANG Cheng, PU Hong, LI Juan. MDCT findings and clinicopathological analysis of pulmonary mucosa associated lymphoid tissue lymphoma. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(5): 488-491. doi: 10.7507/1671-6205.201804004 Copy

1.	Borie R, Wislez M, Antoine M, et al. Pulmonary mucosa-associated lymphoid tissue lymphoma revisited. Eur Respir J, 2016, 7(4): 1244-1260.
2.	Yamashita H, Ueda Y, Tomita K, et al. Mucosa-associated lymphoid tissue lymphoma of the trachea in a patient with breast cancer. Intern Med, 2015, 54(16): 2041-2044.
3.	Wislez M, Cadranel J, Antoine M, et al. Lymphoma of pul-monary mucosa-associated lymphoid tissue: CT scan findings and pathological correlations. Eur Respir J, 1999, 14(2): 423-429.
4.	Ekstrom SK, Vajdic CM, Falster M, et al. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood, 2008, 111(8): 4029-4038.
5.	Arai H, Tajiri M, Kaneko S, et al. Two surgical cases of thymic MALT lymphoma associated with multiple lung cysts: possible association with Sjögren's syndrome. Gen Thorac Cardiovasc Surg, 2017, 65(4): 229-234.
6.	Conconi A, Martinelli G, Thieblemont C, et al. Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type. Blood, 2003, 102: 2741-2745.
7.	Bae YA, Lee KS, Han J, et al. Marginal zone B-cell lym-phoma of bronchus-associated lymphoid tissue: imaging findings in 21 patients. Chest, 2008, 133(2): 433-440.
8.	Tian P, Wang Y, Wan C, et al. CT-guided needle biopsy in the diagnosis of lung adenocarcinoma accompanied by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: a rare combination. Int J Clin Exp Pathol, 2015, 8: 2074-2078.
9.	Stefanovic A, Morgensztern D, Fong T, et al. Pulmonary marginal zone lymphoma: a single centre experience and review of the SEER database. Leuk Lymphoma, 2008, 49: 1311-1320.
10.	Zhang WD, Guan YB, Li CX, et al. Pulmonary mucosa-associated lymphoid tissue lymphoma: computed tomography computed tomo-graphy imaging findings and follow-up. J Comput Assist Tomogr, 2011, 35: 608-613.

1. Borie R, Wislez M, Antoine M, et al. Pulmonary mucosa-associated lymphoid tissue lymphoma revisited. Eur Respir J, 2016, 7(4): 1244-1260.
2. Yamashita H, Ueda Y, Tomita K, et al. Mucosa-associated lymphoid tissue lymphoma of the trachea in a patient with breast cancer. Intern Med, 2015, 54(16): 2041-2044.
3. Wislez M, Cadranel J, Antoine M, et al. Lymphoma of pul-monary mucosa-associated lymphoid tissue: CT scan findings and pathological correlations. Eur Respir J, 1999, 14(2): 423-429.
4. Ekstrom SK, Vajdic CM, Falster M, et al. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood, 2008, 111(8): 4029-4038.
5. Arai H, Tajiri M, Kaneko S, et al. Two surgical cases of thymic MALT lymphoma associated with multiple lung cysts: possible association with Sjögren's syndrome. Gen Thorac Cardiovasc Surg, 2017, 65(4): 229-234.
6. Conconi A, Martinelli G, Thieblemont C, et al. Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type. Blood, 2003, 102: 2741-2745.
7. Bae YA, Lee KS, Han J, et al. Marginal zone B-cell lym-phoma of bronchus-associated lymphoid tissue: imaging findings in 21 patients. Chest, 2008, 133(2): 433-440.
8. Tian P, Wang Y, Wan C, et al. CT-guided needle biopsy in the diagnosis of lung adenocarcinoma accompanied by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: a rare combination. Int J Clin Exp Pathol, 2015, 8: 2074-2078.
9. Stefanovic A, Morgensztern D, Fong T, et al. Pulmonary marginal zone lymphoma: a single centre experience and review of the SEER database. Leuk Lymphoma, 2008, 49: 1311-1320.
10. Zhang WD, Guan YB, Li CX, et al. Pulmonary mucosa-associated lymphoid tissue lymphoma: computed tomography computed tomo-graphy imaging findings and follow-up. J Comput Assist Tomogr, 2011, 35: 608-613.

Previous Article
The role of rapid on-site evaluation in the diagnosis of lung space-occupying lesions
Next Article
Dynamic decrease of platelet count predicts poor outcome of acute respiratory distress syndrome

Chinese Journal of Respiratory and Critical Care Medicine

MDCT findings and clinicopathological analysis of pulmonary mucosa associated lymphoid tissue lymphoma

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content