The value of platelet volume indices in early period as prognostic indicators of sepsis_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WANG Wei ¹ , ZHOU Yu ² , CHEN Hua ¹ , ZHENG Wei ¹ ,  ZHAO Ling ¹

1. Department of Critical Care Medicine, Zhuhai Hospital of Jinan University, Zhuhai People’s Hospital, Zhuhai, Guangdong 519000, P. R. China;
2. Department of Anesthesiology, Zhuhai Hospital of Jinan University, Zhuhai People’s Hospital, Zhuhai, Guangdong 519000, P. R. China;

Corresponding author：

ZHAO Ling, Email: dr.zhaoling@126.com

Keywords：

Sepsis; Prognosis; Platelet volume indices; Mean platelet volume; Platelet distribution width

DOI：

10.7507/1671-6205.201806008

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the prognostic value of platelet volume indices ［mean platelet volume (MPV) and platelet distribution width (PDW)］ in early period for patients with sepsis .Methods This retrospective study was conducted in a general ICU at a University Hospital from January 2015 to January 2017. Patients with sepsis were divided into a survival group and a death group according to 28-day prognosis. The demographic and clinical data were recorded and analyzed, including platelet indices, Charlson comorbidity index, Glasgow Coma Scale (GCS) score and Acute Physiology and Chronic Health Evaluation Ⅱ (APACHEⅡ) score. Multivariable COX proportional hazard ratio model was used to evaluate the 28-day mortality risk, and receiver operating characteristic (ROC) curve were used to evaluate the value of platelet volume indices.Results A total of 209 patients were enrolled in this study. Mean arterial pressure, pH, platelet count, serum creatinine, bilirubin, troponin I, prothrombin time, GCS score and platelet volume indices showed significant differences between the survival group (n=137) and the death group (n=72) (all P<0.05). Multivariable COX regression analysis revealed that the PDW was independently associated with 28-day mortality in sepsis (HR=1.068, 95%CI 1.002-1.139, P=0.043). The area under the ROC curve of PDW was 0.762 (95%CI 0.694 - 0.831), with a sensitivity of 86% and a specificity of 63% at a cut-off value of 18.65%.Conclusion PDW can be used as a powerful prognostic indicator in patients with sepsis following 28-day.

Citation： WANG Wei, ZHOU Yu, CHEN Hua, ZHENG Wei, ZHAO Ling. The value of platelet volume indices in early period as prognostic indicators of sepsis. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(4): 357-361. doi: 10.7507/1671-6205.201806008 Copy

1.	Koenen RR. The prowess of platelets in immunity and inflammation. Thromb Haemost, 2016, 27, 116(4): 605-612.
2.	Graham SM, Liles WC. Platelets in sepsis: beyond hemostasis. Blood, 2016, 127(24): 2947-2949.
3.	Oztürk ZA, Dag MS, Kuyumcu ME, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases?. Eur Rev Med Pharmacol Sci, 2013, 17(3): 334-341.
4.	Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 2016, 23, 315(8): 801-810.
5.	Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012. Intensive Care Med, 2013, 39(2): 165-228.
6.	Cheng B, Xie G, Yao S, et al. Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China. Crit Care Med, 2007, 35(11): 2538-2546.
7.	Kaukonen KM, Bailey M, Suzuki S, et al. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA, 2014, 311(13): 1308-1316.
8.	Weng L, Zeng XY, Yin P, et al. Sepsis-related mortality in China: a descriptive analysis. Intensive Care Med, 2018, 44(7): 1071-1080.
9.	Martin CM, Priestap F, Fisher H, et al. A prospective, observational registry of patients with severe sepsis: the Canadian Sepsis Treatment and Response Registry. Crit Care Med, 2009, 37(1): 81-88.
10.	蒋涵, 贾超. 血小板白细胞聚集体水平在脓毒症并发急性呼吸窘迫综合征中的诊断价值. 中国呼吸与危重监护杂志, 2018, 17(1): 42-45.
11.	Cho SY, Jeon YL, Kim W, et al. Mean platelet volume and mean platelet volume/platelet count ratio in infective endocarditis. Platelets, 2014, 25(8): 559-561.
12.	Lancé MD, Sloep M, Henskens YM, et al. Mean platelet volume as a diagnostic marker for cardiovascular disease: drawbacks of preanalytical conditions and measuring techniques. Clin Appl Thromb Hemost, 2012, 18(6): 561-568.
13.	Ihara A, Kawamoto T, Matsumoto K, et al. Relationship between platelet indexes and coronary angiographic findings in patients with ischemic heart disease. Pathophysiol Haemost Thromb, 2006, 35(5): 376-379.
14.	Zhang Z, Xu X, Ni H, et al. Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care, 2014, 29(5): 885. e1-e6.
15.	Guclu E, Durmaz Y, Karabay O. Effect of severe sepsis on platelet count and their indices. Afr Health Sci, 2013, 13(2): 333-338.
16.	高艳霞, 李莉, 李毅, 等. 血小板参数在感染性休克患者中的变化. 中华危重病急救医学, 2014, 26(1): 28-32.
17.	Kim CH, Kim SJ, Lee MJ, et al. An increase in mean platelet volume from baseline is associated with mortality in patients with severe sepsis or septic shock. PLoS One, 2015, 5, 10(3): e0119437.
18.	Oh GH, Chung SP, Park YS, et al. Mean platelet volume to platelet count ratio as a promising predictor of early mortality in severe sepsis. Shock, 2017, 47(3): 323-330.
19.	Tajarernmuang P, Phrommintikul A, Limsukon A, et al. The role of mean platelet volume as a predictor of mortality in critically ill patients: a systematic review and meta-analysis. Crit Care Res Pract, 2016, 2016: 4370834.

1. Koenen RR. The prowess of platelets in immunity and inflammation. Thromb Haemost, 2016, 27, 116(4): 605-612.
2. Graham SM, Liles WC. Platelets in sepsis: beyond hemostasis. Blood, 2016, 127(24): 2947-2949.
3. Oztürk ZA, Dag MS, Kuyumcu ME, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases?. Eur Rev Med Pharmacol Sci, 2013, 17(3): 334-341.
4. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 2016, 23, 315(8): 801-810.
5. Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012. Intensive Care Med, 2013, 39(2): 165-228.
6. Cheng B, Xie G, Yao S, et al. Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China. Crit Care Med, 2007, 35(11): 2538-2546.
7. Kaukonen KM, Bailey M, Suzuki S, et al. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA, 2014, 311(13): 1308-1316.
8. Weng L, Zeng XY, Yin P, et al. Sepsis-related mortality in China: a descriptive analysis. Intensive Care Med, 2018, 44(7): 1071-1080.
9. Martin CM, Priestap F, Fisher H, et al. A prospective, observational registry of patients with severe sepsis: the Canadian Sepsis Treatment and Response Registry. Crit Care Med, 2009, 37(1): 81-88.
10. 蒋涵, 贾超. 血小板白细胞聚集体水平在脓毒症并发急性呼吸窘迫综合征中的诊断价值. 中国呼吸与危重监护杂志, 2018, 17(1): 42-45.
11. Cho SY, Jeon YL, Kim W, et al. Mean platelet volume and mean platelet volume/platelet count ratio in infective endocarditis. Platelets, 2014, 25(8): 559-561.
12. Lancé MD, Sloep M, Henskens YM, et al. Mean platelet volume as a diagnostic marker for cardiovascular disease: drawbacks of preanalytical conditions and measuring techniques. Clin Appl Thromb Hemost, 2012, 18(6): 561-568.
13. Ihara A, Kawamoto T, Matsumoto K, et al. Relationship between platelet indexes and coronary angiographic findings in patients with ischemic heart disease. Pathophysiol Haemost Thromb, 2006, 35(5): 376-379.
14. Zhang Z, Xu X, Ni H, et al. Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care, 2014, 29(5): 885. e1-e6.
15. Guclu E, Durmaz Y, Karabay O. Effect of severe sepsis on platelet count and their indices. Afr Health Sci, 2013, 13(2): 333-338.
16. 高艳霞, 李莉, 李毅, 等. 血小板参数在感染性休克患者中的变化. 中华危重病急救医学, 2014, 26(1): 28-32.
17. Kim CH, Kim SJ, Lee MJ, et al. An increase in mean platelet volume from baseline is associated with mortality in patients with severe sepsis or septic shock. PLoS One, 2015, 5, 10(3): e0119437.
18. Oh GH, Chung SP, Park YS, et al. Mean platelet volume to platelet count ratio as a promising predictor of early mortality in severe sepsis. Shock, 2017, 47(3): 323-330.
19. Tajarernmuang P, Phrommintikul A, Limsukon A, et al. The role of mean platelet volume as a predictor of mortality in critically ill patients: a systematic review and meta-analysis. Crit Care Res Pract, 2016, 2016: 4370834.

Chinese Journal of Respiratory and Critical Care Medicine

The value of platelet volume indices in early period as prognostic indicators of sepsis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content