Comparation of HRCT in connective tissue disease associated interstitial pneumonia_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 FANG Xuemei ^△ , ZHAO Dawei , ZHOU Guiming , FANG Fang , ZHAO Wenbo ,  FU Weilin

Department of Radiology, Characteristic Medical Center of Chinese People’s Armed Police Force (PAP), Tianjin 300162, P. R. China;

Corresponding author：

FANG Xuemei, Email: xm198401192@126.com; FU Weilin, Email: 617914816@qq.com

Keywords：

Connective tissue disease; Interstitial pneumonia; High resolution computed tomography

DOI：

10.7507/1671-6205.201812001

Video：

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Objective To identify characteristic high-resolution computed tomography (HRCT) findings for connective tissue disease (CTD) associated interstitial pneumonia (IP).Methods The HRCT findings of 76 patients with CTD-IP were evaluated, the abnormalities were compared among CTD-IP patients using χ² test, nonparametric test, and binary logistic regression analysis.Results In rheumatoid arthritis associated IP (RA-IP), traction bronchiectasis was identified as the significant indicator based on binary logistic regression analyses. Traction bronchiectasis and honeycombing was identified as the most frequent finding based on χ² test. In polymyositis/dermatomyositis associated IP (PM/DM-IP), consolidation was identified as the most frequent findings based on χ² test, which reflected the higher frequency of the pathological organising pneumonia patterns. In systemic lupus erythematosus associated IP, traction bronchiectasis was identified as the least frequent findings based on χ² test. In systemic sclerosis associated IP, esophageal dilatation was the most extensive based on Kruskale-Wallis test. In primary Sjogren’s syndrome associated IP, honeycombing was identified as the least frequent findings based on χ² test. RA-IP was identified as the most frequent among CTD-IP which characterized as the predominance of honeycombing; PM/DM-IP was identified as the most frequent among CTD which characterized as the predominance of consolidation.Conclusion Several characteristic HRCT findings are identified in CTD-IP patients which are helpful for estimating underlying CTD.

Citation： FANG Xuemei, ZHAO Dawei, ZHOU Guiming, FANG Fang, ZHAO Wenbo, FU Weilin. Comparation of HRCT in connective tissue disease associated interstitial pneumonia. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(6): 549-553. doi: 10.7507/1671-6205.201812001 Copy

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2.	Assayag D, Elicker BM, Urbania TH, et al. Rheumatoid arthritis-associated interstitial lung disease: radiologic identification of usual interstitial pneumonia pattern. Radiology, 2014, 270(2): 583-588.
3.	Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum, 2010, 62(9): 2569-2581.
4.	Asano Y, Jinnin M, Kawaguchi Y, et al. Diagnostic criteria, severity classification and guidelines of systemic sclerosis. J Dermatol, 2018, 45(6): 633-691.
5.	Lundberg IE, Tjarnlund A, Bottai M, et al. 2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups. Arthritis Rheumatol, 2017, 69(12): 2271-2282.
6.	Petri M, Orbai AM, Alarcon GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum, 2012, 64(8): 2677-2686.
7.	Shiboski CH, Shiboski SC, Seror R, et al. 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjogren's syndrome: A consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis, 2017, 76(1): 9-16.
8.	van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum, 2013, 65(11): 2737-2747.
9.	Park WH, Kim SS, Shim SC, et al. Visual assessment of chest computed tomography findings in anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis: Is it associated with airway abnormalities?. Lung, 2016, 194(1): 97-105.
10.	Lynch DA. Lung disease related to collagen vascular disease. J Thorac Imaging, 2009, 24(4): 299-309.
11.	Tanaka N, Kunihiro Y, Kubo M, et al. HRCT findings of collagen vascular disease-related interstitial pneumonia (CVD-IP): a comparative study among individual underlying diseases. Clin Radiol, 2018, 73(9): 833 e831-833 e810.
12.	Nishino M, Itoh H, Hatabu H. A practical approach to high-resolution CT of diffuse lung disease. Eur J Radiol, 2014, 83(1): 6-19.
13.	Balbir-Gurman A, Guralnik L, Yigla M, et al. Imaging aspects of interstitial lung disease in patients with rheumatoid arthritis: Literature review. Autoimmun Rev, 2018, 17(2): 87-93.
14.	Silva CI, Muller NL. Interstitial lung disease in the setting of collagen vascular disease. Semin Roentgenol, 2010, 45(1): 22-28.
15.	Kelly CA, Saravanan V, Nisar M, et al. Rheumatoid arthritis-related interstitial lung disease: associations, prognostic factors and physiological and radiological characteristics--a large multicentre UK study. Rheumatology (Oxford), 2014, 53(9): 1676-1682.
16.	Leonel D, Lucia C, A M, et al. Pulmonary function test: its correlation with pulmonary high-resolution computed tomography in patients with rheumatoid arthritis. Rheumatol Int, 2012, 32(7): 2111-2116.
17.	Chen J, Shi Y, Wang X, et al. Asymptomatic preclinical rheumatoid arthritis-associated interstitial lung disease. Clin Dev Immunol, 2013, 2013: 406927.
18.	Perez-Dorame R, Mejia M, Mateos-Toledo H, et al. Rheumatoid arthritis-associated interstitial lung disease: lung inflammation evaluated with high resolution computed tomography scan is correlated to rheumatoid arthritis disease activity. Reumatol Clin, 2015, 11(1): 12-16.

1. Travis WD, Costabel U, Hansell DM, et al. An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med, 2013, 188(6): 733-748.
2. Assayag D, Elicker BM, Urbania TH, et al. Rheumatoid arthritis-associated interstitial lung disease: radiologic identification of usual interstitial pneumonia pattern. Radiology, 2014, 270(2): 583-588.
3. Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum, 2010, 62(9): 2569-2581.
4. Asano Y, Jinnin M, Kawaguchi Y, et al. Diagnostic criteria, severity classification and guidelines of systemic sclerosis. J Dermatol, 2018, 45(6): 633-691.
5. Lundberg IE, Tjarnlund A, Bottai M, et al. 2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups. Arthritis Rheumatol, 2017, 69(12): 2271-2282.
6. Petri M, Orbai AM, Alarcon GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum, 2012, 64(8): 2677-2686.
7. Shiboski CH, Shiboski SC, Seror R, et al. 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjogren's syndrome: A consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis, 2017, 76(1): 9-16.
8. van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum, 2013, 65(11): 2737-2747.
9. Park WH, Kim SS, Shim SC, et al. Visual assessment of chest computed tomography findings in anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis: Is it associated with airway abnormalities?. Lung, 2016, 194(1): 97-105.
10. Lynch DA. Lung disease related to collagen vascular disease. J Thorac Imaging, 2009, 24(4): 299-309.
11. Tanaka N, Kunihiro Y, Kubo M, et al. HRCT findings of collagen vascular disease-related interstitial pneumonia (CVD-IP): a comparative study among individual underlying diseases. Clin Radiol, 2018, 73(9): 833 e831-833 e810.
12. Nishino M, Itoh H, Hatabu H. A practical approach to high-resolution CT of diffuse lung disease. Eur J Radiol, 2014, 83(1): 6-19.
13. Balbir-Gurman A, Guralnik L, Yigla M, et al. Imaging aspects of interstitial lung disease in patients with rheumatoid arthritis: Literature review. Autoimmun Rev, 2018, 17(2): 87-93.
14. Silva CI, Muller NL. Interstitial lung disease in the setting of collagen vascular disease. Semin Roentgenol, 2010, 45(1): 22-28.
15. Kelly CA, Saravanan V, Nisar M, et al. Rheumatoid arthritis-related interstitial lung disease: associations, prognostic factors and physiological and radiological characteristics--a large multicentre UK study. Rheumatology (Oxford), 2014, 53(9): 1676-1682.
16. Leonel D, Lucia C, A M, et al. Pulmonary function test: its correlation with pulmonary high-resolution computed tomography in patients with rheumatoid arthritis. Rheumatol Int, 2012, 32(7): 2111-2116.
17. Chen J, Shi Y, Wang X, et al. Asymptomatic preclinical rheumatoid arthritis-associated interstitial lung disease. Clin Dev Immunol, 2013, 2013: 406927.
18. Perez-Dorame R, Mejia M, Mateos-Toledo H, et al. Rheumatoid arthritis-associated interstitial lung disease: lung inflammation evaluated with high resolution computed tomography scan is correlated to rheumatoid arthritis disease activity. Reumatol Clin, 2015, 11(1): 12-16.

Chinese Journal of Respiratory and Critical Care Medicine

Comparation of HRCT in connective tissue disease associated interstitial pneumonia

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