Effect of continuous positive airway pressure therapy on serum IL-23 and CRP levels in patients with obstructive sleep apnea hypopnea syndrome_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHOU Xiaolei , ZHANG Juan , ZHAO Zhiguo , KUANG Hongping , TANG Bingxiang ,  ZHANG Manlin

Department of Respiratory and Critical Care Medicine, Henan Chest Hospital, Zhengzhou, Henan 450000, P. R. China;

Corresponding author：

ZHANG Manlin, Email: f6222050@126.com

Keywords：

Obstructive sleep apnea hypopnea syndrome; Interleukin-23; C-reactive protein; Continuous positive airway pressure

DOI：

10.7507/1671-6205.201812006

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the pathogenesis and treatment of obstructive sleep apnea hypopnea syndrome (OSAHS) by detecting the changes of serum interleukin-23 (IL-23) and C-reactive protein (CRP) levels of the OSAHS patients before and after treatment with continuous positive airway pressure (CPAP).Methods Fifty-eight patients with moderate to severe OSAHS diagnosed by polysomnography were recruited as an experimental group, 57 out-patient healthy subjects with matched age, sex and body mass index of the experimental group were enrolled as a control group. The serum concentrations of IL-23 and CRP in the experimental group were detected and compared before and after CPAP application for 3 months. The serum concentrations of IL-23 and CRP in the control group were also measured.Results The serum levels of IL-23 and CRP in the OSAHS patients were significantly higher than those in the normal control subjects (P<0.05). The serum levels of IL-23 and CRP in the OSAHS patients after CPAP treatment were significantly lower than those before CPAP treatment (P<0.05). The serum concentrations of IL-23 and CRP were positively correlated with apnea hypopnea index (r=0.756, r=0.345, P<0.05, respectively), and negatively correlated with mean oxygen saturation (r=–0.715, r=–0.334, P<0.05, respectively).Conclusions The serum levels of IL-23 and CRP are positively correlated with the severity of OSAHS. After CPAP treatment, the levels of IL-23 and CRP decrease, which indicates that CPAP treatment may reduce the inflammatory reaction and correct anoxia of OSAHS patients.

Citation： ZHOU Xiaolei, ZHANG Juan, ZHAO Zhiguo, KUANG Hongping, TANG Bingxiang, ZHANG Manlin. Effect of continuous positive airway pressure therapy on serum IL-23 and CRP levels in patients with obstructive sleep apnea hypopnea syndrome. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(1): 36-40. doi: 10.7507/1671-6205.201812006 Copy

1.	阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版)写作组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版). 中华全科医师杂志, 2015, 14(7): 509-515.
2.	李文鹏. 阻塞性睡眠呼吸暂停综合征与代谢综合征. 中国循环杂志, 2015, 30(5): 511-512.
3.	王蓓. 阻塞性睡眠呼吸暂停与心律失常. 临床内科杂志, 2017, 34(1): 13-15.
4.	郭凤霞, 储德节. 持续正压通气对 OSAHS 合并 2 型糖尿病患者睡眠、糖代谢及氧化应激的影响. 临床肺科杂志, 2017, 22(11): 1962-1965.
5.	黎娇, 况九龙. 阻塞性睡眠呼吸暂停低通气综合征氧化应激与心血管疾病相关性的研究进展. 实用医学杂志, 2014, 30(12): 2002-2004.
6.	Christou K, Markoulis N, Moulas AN, et al. Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients. Sleep Breath, 2003, 7(3): 105-110.
7.	陈实, 李承红, 孟庆华. OSAHS 患者胰岛素抵抗指数变化及其与血清炎症因子水平的相关性. 山东医药, 2017, 57(7): 66-68.
8.	Kang JH, Lin HC. Obstructive sleep apnea and the risk of autoimmune diseases: a longitudinal population-based study. Sleep Med, 2012, 13(6): 583-588.
9.	Tang C, Chen S, Qian H, et al. Interleukin-23: as a drug target for autoimmune inflammatory diseases. Immunology, 2011, 135(2): 112-124.
10.	Ngiow SF, Teng MW, Smyth MJ. A balance of interleukin-12 and -23 in cancer. Trends Immunol, 2013, 34(11): 548-555.
11.	Croxford AL, Mair F, Becher B. IL-23: one cytokine in control of autoimmunity. Eur J Immunol, 2012, 42(9): 2263-2273.
12.	Can M, Uygur F, Tanrıverdi H, et al. Effect of continuous positive airway pressure (CPAP) therapy on IL-23 in patients with obstructive sleep apnea. Immunol Res, 2016, 64(5-6): 1179-1184.
13.	Lin QC, Chen LD, Yu YH, et al. Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation. Eur Arch Otorhinolaryngol, 2014, 271(4): 825-831.
14.	Chami HA, Fontes JD, Vasan RS, et al. Vascular inflammation and sleep disordered breathing in a community-based cohort. Sleep, 2013, 36(5): 763-768.
15.	Guven SF, Turkkani MH, Ciftci B, et al. The relationship between high-sensitivity C-reactive protein levels and the severity of obstructive sleep apnea. Sleep Breath, 2012, 16(1): 217-221.
16.	Floss DM, Schröder J, Franke M, et al. Insights into IL-23 biology: from structure to function. Cytokine Growth Factor Rev, 2015, 26(5): 569-578.
17.	Ciprandi G, Cuppari C, Salpietro A, et al. Serum IL-23 strongly and inversely correlates with FEV1 in asthmatic children. Int Arch Allergy Immunol, 2012, 159(2): 183-186.
18.	Ciprandi G, Cuppari C, Salpietro A, et al. Serum IL-23 in asthmatic children. J Biol Regul Homeost Agents, 2012, 26(1 Suppl): S53-S61.
19.	刘燕, 顾永春, 汤颖, 等. Th17/Treg 平衡在阻塞性睡眠呼吸暂停低通气综合征中的作用及其机制. 中华医学杂志, 2016, 96(44): 3577-3581.
20.	Dong L, Xia JW, Gong Y, et al. Effect of lianhuaqingwen capsules on airway inflammation in patients with acute exacerbation of chronic obstructive pulmonary disease. Evid Based Complement Alternat Med, 2014, 2014: 637969.
21.	Ye J, Liu H, Zhang GH, et al. The Treg/Th17 imbalance in patients with obstructive sleep apnoea syndrome. Mediators Inflamm, 2012, 2012: 815308.
22.	Yokoe T, Minoguchi K, Matsuo H, et al. Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure. Circulation, 2003, 107(8): 1129-1134.
23.	Jin F, Liu J, Zhang X, et al. Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome. Mol Med Rep, 2017, 16(5): 6334-6339.
24.	Tie YX, Fu YY, Xu Z, et al. Relationship between C-reactive protein levels and obstructive sleep apnea syndrome. Genet Mol Res, 2015, 15(2): gmr7808.
25.	尹春丽. 成年男性 OSAHS 患者日间嗜睡相关因素分析[D]. 吉林大学, 2011.
26.	韩锋锋, 杨玲, 林建海. OSAHS 与单纯鼾症儿童睡眠效率及睡眠结构分析. 中国医师杂志, 2005, 7(5): 646-647.

1. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版)写作组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南(基层版). 中华全科医师杂志, 2015, 14(7): 509-515.
2. 李文鹏. 阻塞性睡眠呼吸暂停综合征与代谢综合征. 中国循环杂志, 2015, 30(5): 511-512.
3. 王蓓. 阻塞性睡眠呼吸暂停与心律失常. 临床内科杂志, 2017, 34(1): 13-15.
4. 郭凤霞, 储德节. 持续正压通气对 OSAHS 合并 2 型糖尿病患者睡眠、糖代谢及氧化应激的影响. 临床肺科杂志, 2017, 22(11): 1962-1965.
5. 黎娇, 况九龙. 阻塞性睡眠呼吸暂停低通气综合征氧化应激与心血管疾病相关性的研究进展. 实用医学杂志, 2014, 30(12): 2002-2004.
6. Christou K, Markoulis N, Moulas AN, et al. Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients. Sleep Breath, 2003, 7(3): 105-110.
7. 陈实, 李承红, 孟庆华. OSAHS 患者胰岛素抵抗指数变化及其与血清炎症因子水平的相关性. 山东医药, 2017, 57(7): 66-68.
8. Kang JH, Lin HC. Obstructive sleep apnea and the risk of autoimmune diseases: a longitudinal population-based study. Sleep Med, 2012, 13(6): 583-588.
9. Tang C, Chen S, Qian H, et al. Interleukin-23: as a drug target for autoimmune inflammatory diseases. Immunology, 2011, 135(2): 112-124.
10. Ngiow SF, Teng MW, Smyth MJ. A balance of interleukin-12 and -23 in cancer. Trends Immunol, 2013, 34(11): 548-555.
11. Croxford AL, Mair F, Becher B. IL-23: one cytokine in control of autoimmunity. Eur J Immunol, 2012, 42(9): 2263-2273.
12. Can M, Uygur F, Tanrıverdi H, et al. Effect of continuous positive airway pressure (CPAP) therapy on IL-23 in patients with obstructive sleep apnea. Immunol Res, 2016, 64(5-6): 1179-1184.
13. Lin QC, Chen LD, Yu YH, et al. Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation. Eur Arch Otorhinolaryngol, 2014, 271(4): 825-831.
14. Chami HA, Fontes JD, Vasan RS, et al. Vascular inflammation and sleep disordered breathing in a community-based cohort. Sleep, 2013, 36(5): 763-768.
15. Guven SF, Turkkani MH, Ciftci B, et al. The relationship between high-sensitivity C-reactive protein levels and the severity of obstructive sleep apnea. Sleep Breath, 2012, 16(1): 217-221.
16. Floss DM, Schröder J, Franke M, et al. Insights into IL-23 biology: from structure to function. Cytokine Growth Factor Rev, 2015, 26(5): 569-578.
17. Ciprandi G, Cuppari C, Salpietro A, et al. Serum IL-23 strongly and inversely correlates with FEV1 in asthmatic children. Int Arch Allergy Immunol, 2012, 159(2): 183-186.
18. Ciprandi G, Cuppari C, Salpietro A, et al. Serum IL-23 in asthmatic children. J Biol Regul Homeost Agents, 2012, 26(1 Suppl): S53-S61.
19. 刘燕, 顾永春, 汤颖, 等. Th17/Treg 平衡在阻塞性睡眠呼吸暂停低通气综合征中的作用及其机制. 中华医学杂志, 2016, 96(44): 3577-3581.
20. Dong L, Xia JW, Gong Y, et al. Effect of lianhuaqingwen capsules on airway inflammation in patients with acute exacerbation of chronic obstructive pulmonary disease. Evid Based Complement Alternat Med, 2014, 2014: 637969.
21. Ye J, Liu H, Zhang GH, et al. The Treg/Th17 imbalance in patients with obstructive sleep apnoea syndrome. Mediators Inflamm, 2012, 2012: 815308.
22. Yokoe T, Minoguchi K, Matsuo H, et al. Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure. Circulation, 2003, 107(8): 1129-1134.
23. Jin F, Liu J, Zhang X, et al. Effect of continuous positive airway pressure therapy on inflammatory cytokines and atherosclerosis in patients with obstructive sleep apnea syndrome. Mol Med Rep, 2017, 16(5): 6334-6339.
24. Tie YX, Fu YY, Xu Z, et al. Relationship between C-reactive protein levels and obstructive sleep apnea syndrome. Genet Mol Res, 2015, 15(2): gmr7808.
25. 尹春丽. 成年男性 OSAHS 患者日间嗜睡相关因素分析[D]. 吉林大学, 2011.
26. 韩锋锋, 杨玲, 林建海. OSAHS 与单纯鼾症儿童睡眠效率及睡眠结构分析. 中国医师杂志, 2005, 7(5): 646-647.

Chinese Journal of Respiratory and Critical Care Medicine

Effect of continuous positive airway pressure therapy on serum IL-23 and CRP levels in patients with obstructive sleep apnea hypopnea syndrome

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content