Association between TLR5 rs5744174 gene polymorphism and <i>Streptococcus pneumoniae</i> pneumonia_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHONG Youqing ,  ZHOU Xiangdong , LI Qi , TAN Yingjiao

Department of Respiratory Medicine, First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, P. R. China;

Corresponding author：

ZHOU Xiangdong, Email: zxd999@263.net

Keywords：

Streptococcus pneumoniae pneumonia; Toll-like receptor 5; Gene polymorphism; Correlation

DOI：

10.7507/1671-6205.201908050

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Objective To investigate the correlation between TLR5 rs5744174 gene polymorphism and Streptococcus pneumoniae pneumonia.Methods One-hundred and six patients with Streptococcus pneumoniae pneumonia admitted to this hospital from January 2014 to October 2018 were selected as an observation group, and 85 healthy subjects were selected as a control group during the same period. The clinical and pathological data of the subjects were collected, polymorphism of TLR5 rs5744174 gene was analyzed by PCR and sequencing, and the relationships between cell classification count, C-reactive protein (CRP) level in bronchoalveolar lavage fluid (BALF) and TLR5 rs5744174 gene polymorphism in the patients with Streptococcus pneumoniae pneumonia were analyzed.Results There were significant differences in age, smoking, alcoholism, diabetes and the other general data between the observation group and the control group (P<0.05). The distribution of TLR5 rs5744174 genotype in the observation group and the control group was in accordance with Hardy-Weinberg equilibrium test level (χ²_{=16.89 for the observation group, χ²_{=10.76 for the control group, both P>0.05). There was no significant difference in the distribution frequency of TLR5 rs5744174 (C < T) genotype and allele between the two groups (P>0.05). There were significant differences in the proportion of diabetes mellitus among the three genotypes (CC, CT, TT) of the patients with Streptococcus pneumoniae pneumonia (P<0.05). The percentage of neutrophils and CRP levels in BALF were significantly different (P<0.05).}}Conclusion The polymorphism of TLR5 rs5744174 gene may not be related to the occurrence of Streptococcus pneumoniae pneumonia, but is related to the proportion of complicated diabetes mellitus, the percentage of neutrophils and the level of CRP in patients with Streptococcus pneumoniae pneumonia, which may affect the degree of inflammation.

Citation： ZHONG Youqing, ZHOU Xiangdong, LI Qi, TAN Yingjiao. Association between TLR5 rs5744174 gene polymorphism and Streptococcus pneumoniae pneumonia. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(4): 342-345. doi: 10.7507/1671-6205.201908050 Copy

1.	王露霞, 郑英俊, 郭振辉, 等. 呼吸机相关性肺炎患者血与痰标本中分离的鲍曼不动杆菌分子流行病学分析. 中国感染与化疗杂志, 2018, 18(1): 58-63.
2.	田永露, 田琴琴, 陈云秀, 等. 新生期肺炎链球菌肺炎对 VA 的影响及其与肺部免疫及气道反应性的关系研究. 免疫学杂志, 2017, 33(12): 1013-1020.
3.	张丽娜, 丛培玮, 李乡南. 中药复方对链球菌性肺炎小鼠炎症 p38MAPK 信号转导通路的影响. 中华中医药学刊, 2017, 35(4): 936-939.
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7.	田琴琴, 刘茹, 陈云秀, 等. 新生期肺炎链球菌肺炎对成年期肺组织免疫状态及气道高反应的影响. 免疫学杂志, 2015, 31(12): 1051-1055.
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9.	刘毅, 万玉立, 唐神结, 等. Toll 样受体家族基因多态性与结核易感性研究进展. 中华流行病学杂志, 2018, 39(8): 1130-1134.
10.	赵呈祥, 戴开宇, 杜雨露, 等. 猪 TLR5 基因表达水平与 F18 大肠杆菌侵染关系分析. 中国畜牧兽医, 2018, 45(5): 1163-1169.
11.	王伟, 黄静妍, 谭金晶, 等. Toll 样受体 5 基因遗传多态性与中风风痰瘀阻证显著关联的探讨. 辽宁中医杂志, 2016, 475(12): 2495-2497.
12.	龚爱媚, 薛超, 廖蕴华, 等. TLR5 rs2072493 A/G 基因多态性与广西人群抗中性粒细胞胞浆抗体相关性小血管炎的关系. 广东医学, 2016, 37(7): 999-1002.
13.	王华庆, 安志杰. 肺炎球菌性疾病免疫预防专家共识 (2017 版). 中国预防医学杂志, 2018, 19(3): 161-191.
14.	李海燕, 郑有光, 韩利红, 等. 难治性哮喘患者肺部感染病原菌分析及肺泡灌洗液与血清炎症因子水平. 中华医院感染学杂志, 2018, 28(3): 355-359.
15.	张美娟, 邱胜丰. 尿肺炎链球菌、白细胞计数和 C 反应蛋白联合检测在儿童下呼吸道感染中的诊断价值. 检验医学与临床, 2015, 12(17): 2486-2487.

1. 王露霞, 郑英俊, 郭振辉, 等. 呼吸机相关性肺炎患者血与痰标本中分离的鲍曼不动杆菌分子流行病学分析. 中国感染与化疗杂志, 2018, 18(1): 58-63.
2. 田永露, 田琴琴, 陈云秀, 等. 新生期肺炎链球菌肺炎对 VA 的影响及其与肺部免疫及气道反应性的关系研究. 免疫学杂志, 2017, 33(12): 1013-1020.
3. 张丽娜, 丛培玮, 李乡南. 中药复方对链球菌性肺炎小鼠炎症 p38MAPK 信号转导通路的影响. 中华中医药学刊, 2017, 35(4): 936-939.
4. Cao L, Zhang T, Zhu J, et al. Polymorphism of TLR5 rs5744174 is associated with disease progression in Chinese patients with chronic HBV infection. APMIS, 2017, 125(8): 708-716.
5. 刘青, 施毅. 肺炎链球菌肺炎诊治进展. 东南国防医药, 2013, 15(5): 499-502.
6. 尹亚非, 史梦, 陆玲, 等. 肺炎链球菌临床分布情况及药敏分析. 重庆医学, 2017, 46(7): 55-57.
7. 田琴琴, 刘茹, 陈云秀, 等. 新生期肺炎链球菌肺炎对成年期肺组织免疫状态及气道高反应的影响. 免疫学杂志, 2015, 31(12): 1051-1055.
8. Jauneikaite E, Mary JCJ, William NVC, et al. Genetic diversity of Streptococcus pneumoniae causing meningitis and sepsis in Singapore during the first year of PCV7 implementation. Emerg Microbes Infect, 2014, 3(6): e39.
9. 刘毅, 万玉立, 唐神结, 等. Toll 样受体家族基因多态性与结核易感性研究进展. 中华流行病学杂志, 2018, 39(8): 1130-1134.
10. 赵呈祥, 戴开宇, 杜雨露, 等. 猪 TLR5 基因表达水平与 F18 大肠杆菌侵染关系分析. 中国畜牧兽医, 2018, 45(5): 1163-1169.
11. 王伟, 黄静妍, 谭金晶, 等. Toll 样受体 5 基因遗传多态性与中风风痰瘀阻证显著关联的探讨. 辽宁中医杂志, 2016, 475(12): 2495-2497.
12. 龚爱媚, 薛超, 廖蕴华, 等. TLR5 rs2072493 A/G 基因多态性与广西人群抗中性粒细胞胞浆抗体相关性小血管炎的关系. 广东医学, 2016, 37(7): 999-1002.
13. 王华庆, 安志杰. 肺炎球菌性疾病免疫预防专家共识 (2017 版). 中国预防医学杂志, 2018, 19(3): 161-191.
14. 李海燕, 郑有光, 韩利红, 等. 难治性哮喘患者肺部感染病原菌分析及肺泡灌洗液与血清炎症因子水平. 中华医院感染学杂志, 2018, 28(3): 355-359.
15. 张美娟, 邱胜丰. 尿肺炎链球菌、白细胞计数和 C 反应蛋白联合检测在儿童下呼吸道感染中的诊断价值. 检验医学与临床, 2015, 12(17): 2486-2487.

Chinese Journal of Respiratory and Critical Care Medicine

Association between TLR5 rs5744174 gene polymorphism and Streptococcus pneumoniae pneumonia

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