Prevalence and risk factors of asthma in Chengdu among adolescents aged over 14 years and adults_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

HU Qian , WU Songze ,  LIU Chuntao

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LIU Chuntao, Email: taosen666@tom.com

Keywords：

Asthma; Prevalence; Risk factors; Epidemiology

DOI：

10.7507/1671-6205.201911107

Video：

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Objective In order to improve the prevention and treatment of bronchial asthma, the prevalence and risk factors of asthma in Chengdu among residents over 14 years old were investigated.Methods A cross-sectional survey was conducted in Chengdu. The inhabitants (age > 14 years) recruited in this household questionnaire survey were through multi-stage cluster random sampling. Univariate and multivariate logistic regression were used to analyze the risk factors of asthma.Results A total of 3 477 subjects were finally recruited in this study. Of them, 131 were asthmatic patients; and the prevalence rate was 3.8%. There were significant differences observed in the prevalence of asthma among people of different ages, residences, occupations and educational levels (χ²=191.084, P<0.05; χ²=9.114, P<0.05; χ²=114.268, P<0.05; χ²=62.123, P<0.05). Univariate regression analysis showed that the risk factors of asthma included five factors (measles, chickenpox, pneumonia, tracheobronchitis and intestinal parasitic diseases) related to childhood illness, and two factors (asthma and chronic bronchitis) related to the first-degree relatives (P<0.05). In addition, active smoking history was a risk factor for asthma in men (P<0.05). Multivariate logistic regression indicated that measles, pneumonia, tracheobronchitis, intestinal parasitic diseases in childhood and first-degree relatives suffering from asthma were independent risk factors for asthma.Conclusions This study describes the epidemiological characteristics of asthma in Chengdu among adolescents (age>14 years) and adults. The history of measles, pneumonia, tracheobronchitis, and intestinal parasitic diseases in childhood, and first-degree relatives suffering from asthma are the independent risk factors for asthma. In addition, active smoking history is a risk factor for asthma in men.

Citation： HU Qian, WU Songze, LIU Chuntao. Prevalence and risk factors of asthma in Chengdu among adolescents aged over 14 years and adults. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(2): 183-189. doi: 10.7507/1671-6205.201911107 Copy

1.	Huang K, Yang T, Xu J, et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet, 2019, 394(10196): 407-418.
2.	支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案). 支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案). 中华哮喘杂志(电子版), 2008, 2(1): 3-13.
3.	Lin J, Wang W, Chen P, et al. Prevalence and risk factors of asthma in mainland China: the CARE study. Respir Med, 2018, 137: 48-54.
4.	To T, Stanojevic S, Moores G, et al. Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health, 2012, 12: 204.
5.	Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med, 2006, 355(21): 2226-2235.
6.	Chen Y, Stewart P, Johansen H, et al. Sex difference in hospitalization due to asthma in relation to age. J Clin Epidemiol, 2003, 56(2): 180-187.
7.	Almqvist C, Worm M, Leynaert B, et al. Impact of gender on asthma in childhood and adolescence: a GA²LEN review. Allergy, 2008, 63(1): 47-57.
8.	Shah R, Newcomb DC. Sex bias in asthma prevalence and pathogenesis. Front Immunol, 2018, 9: 2997.
9.	Keet CA, McCormack MC, Pollack CE, et al. Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic. J Allergy Clin Immunol, 2015, 135(3): 655-62.
10.	Oraka E, Iqbal S, Flanders WD, et al. Racial and ethnic disparities in current asthma and emergency department visits: findings from the National Health Interview Survey, 2001-2010. J Asthma, 2013, 50(5): 488-496.
11.	Kumar P, Ram U. Patterns, factors associated and morbidity burden of asthma in India. PLoS One, 2017, 12(10): e0185938.
12.	Wang DX, Xiao W, Ma DD, et al. Cross-sectional epidemiological survey of asthma in Jinan, China. Respirology, 2013, 18(2): 313-322.
13.	Burgess JA, Abramson MJ, Gurrin LC, et al. Childhood infections and the risk of asthma: A longitudinal study over 37 years. Chest, 2012, 142(3): 647-654.
14.	Kimura H, Konno S, Isada A, et al. Contrasting associations of body mass index and measles with asthma and rhinitis in young adults. Allergy Asthma Proc, 2015, 36(4): 293-299.
15.	Roost HP, Gassner M, Grize L, et al. Influence of MMR-vaccinations and diseases on atopic sensitization and allergic symptoms in Swiss schoolchildren. Pediatr Allergy Immunol, 2004, 15(5): 401-407.
16.	Kramer MS, Matush L, Vanilovich I, et al. Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trial. BMJ, 2007, 335(7624): 815.
17.	Klopp A, Vehling L, Becker AB, et al. Modes of infant feeding and the risk of childhood asthma: a prospective birth Cohort Study. J Pediatr, 2017, 190: 192-199.
18.	Lodge CJ, Tan DJ, Lau MX, et al. Breastfeeding and asthma and allergies: A systematic review and meta-analysis. Acta Paediatr, 2015, 104(467): 38-53.
19.	Kim SY, Sim S, Choi HG, et al. Active and passive smoking impacts on asthma with quantitative and temporal relations: A Korean Community Health Survey. Sci Rep, 2018, 8(1): 8614.
20.	Coogan PF, Castro-Webb N, Yu j, et al. Active and passive smoking and the incidence of asthma in the Black Women's Health Study. Am J Respir Crit Care Med, 2015, 191(2): 168-176.
21.	Chalmers GW, Macleod KJ, Little SA, et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax, 2002, 57(3): 226-230.

1. Huang K, Yang T, Xu J, et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet, 2019, 394(10196): 407-418.
2. 支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案). 支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案). 中华哮喘杂志(电子版), 2008, 2(1): 3-13.
3. Lin J, Wang W, Chen P, et al. Prevalence and risk factors of asthma in mainland China: the CARE study. Respir Med, 2018, 137: 48-54.
4. To T, Stanojevic S, Moores G, et al. Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health, 2012, 12: 204.
5. Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med, 2006, 355(21): 2226-2235.
6. Chen Y, Stewart P, Johansen H, et al. Sex difference in hospitalization due to asthma in relation to age. J Clin Epidemiol, 2003, 56(2): 180-187.
7. Almqvist C, Worm M, Leynaert B, et al. Impact of gender on asthma in childhood and adolescence: a GA²LEN review. Allergy, 2008, 63(1): 47-57.
8. Shah R, Newcomb DC. Sex bias in asthma prevalence and pathogenesis. Front Immunol, 2018, 9: 2997.
9. Keet CA, McCormack MC, Pollack CE, et al. Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic. J Allergy Clin Immunol, 2015, 135(3): 655-62.
10. Oraka E, Iqbal S, Flanders WD, et al. Racial and ethnic disparities in current asthma and emergency department visits: findings from the National Health Interview Survey, 2001-2010. J Asthma, 2013, 50(5): 488-496.
11. Kumar P, Ram U. Patterns, factors associated and morbidity burden of asthma in India. PLoS One, 2017, 12(10): e0185938.
12. Wang DX, Xiao W, Ma DD, et al. Cross-sectional epidemiological survey of asthma in Jinan, China. Respirology, 2013, 18(2): 313-322.
13. Burgess JA, Abramson MJ, Gurrin LC, et al. Childhood infections and the risk of asthma: A longitudinal study over 37 years. Chest, 2012, 142(3): 647-654.
14. Kimura H, Konno S, Isada A, et al. Contrasting associations of body mass index and measles with asthma and rhinitis in young adults. Allergy Asthma Proc, 2015, 36(4): 293-299.
15. Roost HP, Gassner M, Grize L, et al. Influence of MMR-vaccinations and diseases on atopic sensitization and allergic symptoms in Swiss schoolchildren. Pediatr Allergy Immunol, 2004, 15(5): 401-407.
16. Kramer MS, Matush L, Vanilovich I, et al. Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trial. BMJ, 2007, 335(7624): 815.
17. Klopp A, Vehling L, Becker AB, et al. Modes of infant feeding and the risk of childhood asthma: a prospective birth Cohort Study. J Pediatr, 2017, 190: 192-199.
18. Lodge CJ, Tan DJ, Lau MX, et al. Breastfeeding and asthma and allergies: A systematic review and meta-analysis. Acta Paediatr, 2015, 104(467): 38-53.
19. Kim SY, Sim S, Choi HG, et al. Active and passive smoking impacts on asthma with quantitative and temporal relations: A Korean Community Health Survey. Sci Rep, 2018, 8(1): 8614.
20. Coogan PF, Castro-Webb N, Yu j, et al. Active and passive smoking and the incidence of asthma in the Black Women's Health Study. Am J Respir Crit Care Med, 2015, 191(2): 168-176.
21. Chalmers GW, Macleod KJ, Little SA, et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax, 2002, 57(3): 226-230.

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Prevalence and risk factors of asthma in Chengdu among adolescents aged over 14 years and adults

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