Clinical significance of interleukin-8, Clara cell protein 16 and intercellular adhesion molecule-1 in exhaled breath condensate in acute respiratory distress syndrome_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

ZHOU Yaqing , PU Zunguo ,  LIU Aiming , DING Hongsheng

Department of Critical Care Medicine, Hai'an Hospital, Nantong University, Nantong, Jiangsu 226600, P. R. China;

Corresponding author：

LIU Aiming, Email: 372683340@qq.com

Keywords：

Acute respiratory distress syndrome; Exhaled breath condensate; Interleukin-8; Clara cell protein 16; Intercellular adhesion molecule-1

DOI：

10.7507/1671-6205.202011074

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Objective To explore clinical significance of interleukin-8 (IL-8), clarada protein 16 (CC16), and intercellular adhesion molecule-1 (ICAM-1) in exhaled breath condensate (EBC) and serum samples collected from patients with acute respiratory distress syndrome (ARDS). Methods A total of 45 ARDS patients were assigned into a mild ARDS group (n=20), a moderate ARDS group (n=15) and a severe ARDS group (n=10) based on the Berlin definition. During the same study period, 45 healthy subjects were recruited as control. Serum and EBC levels of IL-8, CC16 and ICAM-1 were detected on the first and fifth day of admission. Results Compared with the control group, serum and EBC IL-8, CC16 and ICAM-1 were significantly higher in the ARDS groups (P<0.05). Serum and EBC IL-8 levels increased with the severity of ARDS, whereas no significant difference was detected between the three groups (P>0.05). Compared with the mild group and the moderate group, serum and EBC CC16 levels were significantly higher in the severe ARDS group. At the first day after admission, serum ICAM-1 was higher in the severe and moderate ARDS groups than that in the mild ARDS group (P<0.05). Meanwhile, EBC ICAM-1 was significantly different between the three groups (P<0.05). At the fifth day after admission, different EBC ICAM-1 was identified between the severe ARDS group and the other two groups (P<0.05). Regardless of ARDS severity, there were no significant differences in serum and EBC IL-8 and CC16 levels at the first and fifth days after admission (P>0.05). However, serum and EBC ICAM-1 at the first and fifth days showed significant difference (except in the mild ARDS group) (P<0.05). The levels of ICAM-1 in serum and EBC of death group were significantly higher than those of survival group (P<0.05). Conclusion Serum and EBC IL-8, CC16 and ICAM-1 are of significance in diagnosis and prognosis evaluation of ARDS.

Citation： ZHOU Yaqing, PU Zunguo, LIU Aiming, DING Hongsheng. Clinical significance of interleukin-8, Clara cell protein 16 and intercellular adhesion molecule-1 in exhaled breath condensate in acute respiratory distress syndrome. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(12): 857-861. doi: 10.7507/1671-6205.202011074 Copy

1.	Cnfalonieri M, Salton F, Fabiano F. Acute respiratory distress syndrome. Eur Respir Rev, 2017, 26(144): 160116.
2.	Han S, Mallampalli RK. The acute respiratory distress syndrome: from mechanism to translation. J Immunol, 2015, 194(3): 855-860.
3.	郭晓芳, 梁培, 陈鸣, 等. 腹膜炎患者术后急性呼吸窘迫综合征的临床特点及危险因素分析. 东南国防医药, 2020, 22(6): 603-607.
4.	Liu L, Yang Y, Gao Z, et al. Practice of diagnosis and management of acute respiratory distress syndrome in mainland China: a cross-sectional study. J Thorac Dis, 2018, 10(9): 5394-5404.
5.	罗靖莹, 郭阳, 黄玮玮, 等. 间充质干细胞传递线粒体对肺微血管内皮细胞的修复作用. 医学研究生学报, 2019, 32(9): 931-936.
6.	Capelozzi VL, Allen TC, Beasley MB, et al. Molecular and immune biomarkers in acute respiratory distress syndrome: a perspective from Members of the Pulmonary Pathology Society. Arch Pathol Lab Med, 2017, 141(12): 1719-1727.
7.	Blondonnet R, Constantin JM, Sapin V, et al. A pathophysiologic approach to biomarkers in acute respiratory distress syndrome. Dis Markers, 2016, 2016: 3501373.
8.	Konstantindi EM, Lappas AS, Tzortzi AS, et al. Exhaled breath condensate: technical and diagnostic aspects. Sci World J, 2015, 2015: 435160.
9.	Aksenov AA, Zamuruyev KO, Pasamontes A, et al. Analytical methodologies for broad metabolite coverage of exhaled breath condensate. J Chromatogr B Analyt Technol Biomed Life Sci, 2017, 1061-1062: 17-25.
10.	Lee AL, Button BM, Denehy L, et al. Exhaled breath condensate pepsin: potential noninvasive test for gastroesophageal reflux in COPD and bronchiectasis. Respir Care, 2015, 60(2): 244-250.
11.	Corhay JL, Moermans C, Henket M, et al. Increased of exhaled breath condensate neutrophil chemotaxis in acute exacerbation of COPD. Respir Res, 2014, 15: 115.
12.	Ferguson ND, Fan E, Camporota L, et al. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med, 2012, 38(10): 1573-1582.
13.	Ware LB, Koyama T, Zhao Z, et al. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care (London, England), 2013, 17(5): R253.
14.	Makabe H, Kojika M, Takahashi G, et al. Interleukin-18 levels reflect the long-term prognosis of acute lung injury and acute respiratory distress syndrome. J Anesth, 2012, 26(5): 658-663.
15.	傅萱, 林锦乐, 张文武, 等. ARDS生物标志物的研究进展. 中华危重病急救医学, 2017, 29(7): 656-661.
16.	Agrawal A, Matthay MA, Kangelaris KN, et al. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med, 2013, 187(7): 736-742.
17.	Xu W, Song Y. Biomarkers for patients with trauma associated acute respiratory distress syndrome. Mil Med Res, 2017, 4: 25.
18.	Garcia-Laorden MI, Lorente JA, Flores C, et al. Biomarkers for the acute respiratory distress syndrome: how to make the diagnosis more precise. Ann Transl Med, 2017, 5(14): 283.

1. Cnfalonieri M, Salton F, Fabiano F. Acute respiratory distress syndrome. Eur Respir Rev, 2017, 26(144): 160116.
2. Han S, Mallampalli RK. The acute respiratory distress syndrome: from mechanism to translation. J Immunol, 2015, 194(3): 855-860.
3. 郭晓芳, 梁培, 陈鸣, 等. 腹膜炎患者术后急性呼吸窘迫综合征的临床特点及危险因素分析. 东南国防医药, 2020, 22(6): 603-607.
4. Liu L, Yang Y, Gao Z, et al. Practice of diagnosis and management of acute respiratory distress syndrome in mainland China: a cross-sectional study. J Thorac Dis, 2018, 10(9): 5394-5404.
5. 罗靖莹, 郭阳, 黄玮玮, 等. 间充质干细胞传递线粒体对肺微血管内皮细胞的修复作用. 医学研究生学报, 2019, 32(9): 931-936.
6. Capelozzi VL, Allen TC, Beasley MB, et al. Molecular and immune biomarkers in acute respiratory distress syndrome: a perspective from Members of the Pulmonary Pathology Society. Arch Pathol Lab Med, 2017, 141(12): 1719-1727.
7. Blondonnet R, Constantin JM, Sapin V, et al. A pathophysiologic approach to biomarkers in acute respiratory distress syndrome. Dis Markers, 2016, 2016: 3501373.
8. Konstantindi EM, Lappas AS, Tzortzi AS, et al. Exhaled breath condensate: technical and diagnostic aspects. Sci World J, 2015, 2015: 435160.
9. Aksenov AA, Zamuruyev KO, Pasamontes A, et al. Analytical methodologies for broad metabolite coverage of exhaled breath condensate. J Chromatogr B Analyt Technol Biomed Life Sci, 2017, 1061-1062: 17-25.
10. Lee AL, Button BM, Denehy L, et al. Exhaled breath condensate pepsin: potential noninvasive test for gastroesophageal reflux in COPD and bronchiectasis. Respir Care, 2015, 60(2): 244-250.
11. Corhay JL, Moermans C, Henket M, et al. Increased of exhaled breath condensate neutrophil chemotaxis in acute exacerbation of COPD. Respir Res, 2014, 15: 115.
12. Ferguson ND, Fan E, Camporota L, et al. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med, 2012, 38(10): 1573-1582.
13. Ware LB, Koyama T, Zhao Z, et al. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care (London, England), 2013, 17(5): R253.
14. Makabe H, Kojika M, Takahashi G, et al. Interleukin-18 levels reflect the long-term prognosis of acute lung injury and acute respiratory distress syndrome. J Anesth, 2012, 26(5): 658-663.
15. 傅萱, 林锦乐, 张文武, 等. ARDS生物标志物的研究进展. 中华危重病急救医学, 2017, 29(7): 656-661.
16. Agrawal A, Matthay MA, Kangelaris KN, et al. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med, 2013, 187(7): 736-742.
17. Xu W, Song Y. Biomarkers for patients with trauma associated acute respiratory distress syndrome. Mil Med Res, 2017, 4: 25.
18. Garcia-Laorden MI, Lorente JA, Flores C, et al. Biomarkers for the acute respiratory distress syndrome: how to make the diagnosis more precise. Ann Transl Med, 2017, 5(14): 283.

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Clinical significance of interleukin-8, Clara cell protein 16 and intercellular adhesion molecule-1 in exhaled breath condensate in acute respiratory distress syndrome

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