Diagnostic value and correlation analysis of peripheral blood neutrophil-to-lymphocyte ratio and red blood cell distribution width in patients with acute exacerbation of chronic obstructive pulmonary disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 LIU Yuanming , WEN Lu , XIAO Sanling , WANG Rui , LI Lingxue

Department of Respiratory and Critical Care Medicine, People’s Hospital of Pengzhou, Pengzhou, Sichuan 611930, P. R. China;

Corresponding author：

LIU Yuanming, Email: 158071252@qq.com

Keywords：

Chronic obstructive pulmonary disease; Neutrophil-to-lymphocyte ratio; Red blood cell distribution width; White blood cell count

DOI：

10.7507/1671-6205.202101025

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To explore the correlation and diagnostic value of neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) in peripheral blood of patients with exacerbation of chronic obstructive pulmonary disease (COPD). Methods One hundred patients with acute exacerbation of COPD who were hospitalized in the hospital between January 2019 and October 2020 were selected as exacerbation group, and another 100 patients with stable COPD who received treatment during the same time period were enrolled as stable group. The general data of patients were collected, and blood samples were collected to detect hemoglobin (Hb), platelet count (PLT), white blood cell count (WBC), neutrophil count, lymphocyte count and RDW, and the NLR was calculated. The correlation between the detection indicators was analyzed and receiver operating characteristic (ROC) curve was drawn to analyze the detection significance of related indicators. Results There were no statistical differences in the levels of Hb and PLT between the exacerbation group and the stable group (P>0.05). The levels of WBC, NLR, RDW and high-sensitivity C-reactive protein (hs-CRP) in the exacerbation group were significantly higher than those in the stable group (all P<0.05). NLR in the patients with acute exacerbation of COPD was positively correlated with serological indicators of WBC and hs-CRP (all P<0.05). ROC curve showed that the sensitivity and specificity of NLR in the diagnosis of acute exacerbation of COPD were 92.0% and 68.0% respectively, those of RDW were 91.0% and 58.0% respectively, those of hs-CRP were 77.0% and 71.0% respectively, and those of NLR+RDW were 90.0% and 73.0% respectively. NLR had the highest diagnostic specificity, RDW had the highest diagnostic sensitivity, and NLR+RDW had the best diagnostic efficiency. Conclusions Serological indicators of WBC, hs-CRP, NLR and RDW in patients with acute exacerbation of COPD will be abnormally increased, and NLR has a positive correlation with WBC and hs-CRP. NLR and RDW have high specificity and high sensitivity respectively in the diagnosis of patients with exacerbation of COPD, and their detection can strengthen the diagnosis and mastery of disease in patients.

Citation： LIU Yuanming, WEN Lu, XIAO Sanling, WANG Rui, LI Lingxue. Diagnostic value and correlation analysis of peripheral blood neutrophil-to-lymphocyte ratio and red blood cell distribution width in patients with acute exacerbation of chronic obstructive pulmonary disease. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(12): 842-845. doi: 10.7507/1671-6205.202101025 Copy

1.	李四香, 赵爽, 李为民. 中性粒细胞与淋巴细胞比值在慢性阻塞性肺疾病中的应用研究进展. 中国呼吸与危重监护杂志, 2020, 19(3): 304-308.
2.	孙峰, 燕存子, 夏宇, 等. 不伴红细胞增多的慢性阻塞性肺疾病患者并发肺栓塞的影响因素研究. 中国全科医学, 2020, 23(24): 3018-3022.
3.	杨仲岳, 陈晓梅, 石亚妹, 等. 中性粒细胞/淋巴细胞、血小板/淋巴细胞比值在类风湿关节炎中的研究进展. 中华医学杂志, 2020, 100(47): 3818-3820.
4.	汪二刚, 赵成岭, 邵传利, 等. 慢性阻塞性肺疾病炎症和过敏性指标的分析和应用. 中国临床研究, 2019, 32(11): 57-60.
5.	Mirza S, Clay RD, Koslow MA, et al. COPD Guidelines: A Review of the 2018 GOLD Report. Mayo Clin Proc, 2018, 93(10): 1488-1502.
6.	高洁, 罗玫, 马唯. 妊娠期高血压疾病患者孕早期外周血中性粒细胞、单核细胞与淋巴细胞比值的观察. 中华全科医师杂志, 2019, 18(9): 851-855.
7.	路明, 姚婉贞. 2019年版慢性阻塞性肺疾病全球创议主要更新内容解读(非药物治疗篇). 中华结核和呼吸杂志, 2019, 42(3): 238-240,192.
8.	王明航, 毕丽婵, 殷露艳, 等. 慢性阻塞性肺疾病急性加重早期识别工具的应用. 中国老年学杂志, 2021, 41(10): 2216-2219.
9.	Yoshitomi R, Nakayama M, Sakoh T, et al. High neutrophil/lymphocyte ratio is associated with poor renal outcomes in Japanese patients with chronic kidney disease. Renal Failure, 2019, 41(1): 238-243.
10.	钱俊峰, 金元虹, 王洪源. 咽喉反流、炎症因子与慢性阻塞性肺疾病急性加重的相关性研究. 中国现代医学杂志, 2019, 29(8): 99-102.
11.	Sakurai K, Chubachi S, Irie H, et al. Clinical utility of blood neutrophil-lymphocyte ratio in Japanese COPD patients. BMC Pulmon Med, 2018, 18(1): 65-66.
12.	周凌, 蒋丕萍. 外周血中性粒细胞与淋巴细胞比值在急性呼吸窘迫综合征中的临床价值. 中国免疫学杂志, 2019, 35(2): 223-226,229.
13.	黄玮玮, 曾帆, 卢森, 等. 红细胞分布宽度对体外膜肺氧合患者预后的评估价值. 中华急诊医学杂志, 2021, 30(6): 723-729.
14.	孟婕, 王晓阳, 李肖肖, 等. 红细胞分布宽度与持续不卧床腹膜透析患者死亡的相关性. 中华肾脏病杂志, 2018, 34(2): 87-93.
15.	Ghazizadeh H, Mirinezhad MR, Seyedi SMR, et al. Prognostic factors associating with pro-oxidant-antioxidant balance; neutrophils to lymphocytes ratio, vitamin D, heat shock protein 27, and red cell distribution width. Arch Med Res, 2020, 51(3): 261-267.
16.	朱春明, 张鹤, 郑锐. 中性粒细胞/淋巴细胞比值、红细胞分布宽度与慢性阻塞性肺疾病急性加重的相关分析. 中国医科大学学报, 2018, 47(4): 312-315.

1. 李四香, 赵爽, 李为民. 中性粒细胞与淋巴细胞比值在慢性阻塞性肺疾病中的应用研究进展. 中国呼吸与危重监护杂志, 2020, 19(3): 304-308.
2. 孙峰, 燕存子, 夏宇, 等. 不伴红细胞增多的慢性阻塞性肺疾病患者并发肺栓塞的影响因素研究. 中国全科医学, 2020, 23(24): 3018-3022.
3. 杨仲岳, 陈晓梅, 石亚妹, 等. 中性粒细胞/淋巴细胞、血小板/淋巴细胞比值在类风湿关节炎中的研究进展. 中华医学杂志, 2020, 100(47): 3818-3820.
4. 汪二刚, 赵成岭, 邵传利, 等. 慢性阻塞性肺疾病炎症和过敏性指标的分析和应用. 中国临床研究, 2019, 32(11): 57-60.
5. Mirza S, Clay RD, Koslow MA, et al. COPD Guidelines: A Review of the 2018 GOLD Report. Mayo Clin Proc, 2018, 93(10): 1488-1502.
6. 高洁, 罗玫, 马唯. 妊娠期高血压疾病患者孕早期外周血中性粒细胞、单核细胞与淋巴细胞比值的观察. 中华全科医师杂志, 2019, 18(9): 851-855.
7. 路明, 姚婉贞. 2019年版慢性阻塞性肺疾病全球创议主要更新内容解读(非药物治疗篇). 中华结核和呼吸杂志, 2019, 42(3): 238-240,192.
8. 王明航, 毕丽婵, 殷露艳, 等. 慢性阻塞性肺疾病急性加重早期识别工具的应用. 中国老年学杂志, 2021, 41(10): 2216-2219.
9. Yoshitomi R, Nakayama M, Sakoh T, et al. High neutrophil/lymphocyte ratio is associated with poor renal outcomes in Japanese patients with chronic kidney disease. Renal Failure, 2019, 41(1): 238-243.
10. 钱俊峰, 金元虹, 王洪源. 咽喉反流、炎症因子与慢性阻塞性肺疾病急性加重的相关性研究. 中国现代医学杂志, 2019, 29(8): 99-102.
11. Sakurai K, Chubachi S, Irie H, et al. Clinical utility of blood neutrophil-lymphocyte ratio in Japanese COPD patients. BMC Pulmon Med, 2018, 18(1): 65-66.
12. 周凌, 蒋丕萍. 外周血中性粒细胞与淋巴细胞比值在急性呼吸窘迫综合征中的临床价值. 中国免疫学杂志, 2019, 35(2): 223-226,229.
13. 黄玮玮, 曾帆, 卢森, 等. 红细胞分布宽度对体外膜肺氧合患者预后的评估价值. 中华急诊医学杂志, 2021, 30(6): 723-729.
14. 孟婕, 王晓阳, 李肖肖, 等. 红细胞分布宽度与持续不卧床腹膜透析患者死亡的相关性. 中华肾脏病杂志, 2018, 34(2): 87-93.
15. Ghazizadeh H, Mirinezhad MR, Seyedi SMR, et al. Prognostic factors associating with pro-oxidant-antioxidant balance; neutrophils to lymphocytes ratio, vitamin D, heat shock protein 27, and red cell distribution width. Arch Med Res, 2020, 51(3): 261-267.
16. 朱春明, 张鹤, 郑锐. 中性粒细胞/淋巴细胞比值、红细胞分布宽度与慢性阻塞性肺疾病急性加重的相关分析. 中国医科大学学报, 2018, 47(4): 312-315.

Chinese Journal of Respiratory and Critical Care Medicine

Diagnostic value and correlation analysis of peripheral blood neutrophil-to-lymphocyte ratio and red blood cell distribution width in patients with acute exacerbation of chronic obstructive pulmonary disease

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