重症加强治疗病房有创机械通气患者早期肺康复研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

卢娇 , 梁国鹏 , 王波 ,  金晓东

四川大学华西医院重症医学科（四川成都 610041）;

Corresponding author：

金晓东, Email: zh_jxd@163.com

Keywords：

DOI：

10.7507/1671-6205.202105068

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Citation： 卢娇, 梁国鹏, 王波, 金晓东. 重症加强治疗病房有创机械通气患者早期肺康复研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(11): 831-836. doi: 10.7507/1671-6205.202105068 Copy

1.	中华医学会重症医学分会. 机械通气临床应用指南(2006). 中华危重病急救医学, 2007, 19(2): 65-72.
2.	Pham T, Brochard LJ, Slutsky AS. Mechanical ventilation: state of the art. Mayo Clin Proc, 2017, 92(9): 1382-1400.
3.	Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med, 2000, 342(18): 1301-1308.
4.	Serpa Neto A, Cardoso SO, Manetta JA, et al. Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis. JAMA, 2012, 308(16): 1651-1659.
5.	Van Vught LA, Klowenberg PM, Spitoni C, et al. Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis. JAMA, 2016, 315(14): 1469-1479.
6.	Dres M, Dubé BP, Mayaux J, et al. Coexistence and impact of limb muscle and diaphragm weakness at time of liberation from mechanical ventilation in medical intensive care unit patients. Am J Respir Crit Care Med, 2017, 195(1): 57-66.
7.	Goligher EC, Fan E, Herridge MS, et al. Evolution of diaphragm thickness during mechanical ventilation: impact of inspiratory effort. Am J Respir Crit Care Med, 2015, 192(9): 1080-1088.
8.	Petty TL. Pulmonary rehabilitation. Am Rev Respir Dis, 1980, 122(5 Pt 2): 159-161.
9.	Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med, 2013, 188(8): e13-e64.
10.	余佳丹, 喻鹏铭, 魏清川, 等. 重症康复研究进展. 华西医学, 2018, 33(10): 1207-1212.
11.	Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med, 2013, 369(22): 2126-2136.
12.	Vasques F, Duscio E, Cipulli F, et al. Determinants and prevention of ventilator-induced lung injury. Crit Care Clin, 2018, 34(3): 343-356.
13.	Beitler JR, Malhotra A, Thompson BT. Ventilator-induced lung injury. Clin Chest Med, 2016, 37(4): 633-646.
14.	Curley GF, Laffey JG, Zhang H, et al. Biotrauma and ventilator-induced lung injury: clinical implications. Chest, 2016, 150(5): 1109-1117.
15.	Metersky ML, Kalil AC. Management of Ventilator-Associated Pneumonia: Guidelines. Clin Chest Med, 2018, 39(4): 797-808.
16.	Jaillette E, Girault C, Brunin G, et al. Impact of tapered-cuff tracheal tube on microaspiration of gastric contents in intubated critically ill patients: a multicenter cluster-randomized cross-over controlled trial. Intensive Care Med, 2017, 43(11): 1562-1571.
17.	Blot SI, Rello J, Koulenti D. The value of polyurethane-cuffed endotracheal tubes to reduce microaspiration and intubation-related pneumonia: a systematic review of laboratory and clinical studies. Crit Care, 2016, 20(1): 203.
18.	Gil-Perotin S, Ramirez P, Marti V, et al. Implications of endotracheal tube biofilm in ventilator-associated pneumonia response: a state of concept. Crit Care, 2012, 16(3): R93.
19.	De Souza PR, De Andrade D, Cabral DB, et al. Endotracheal tube biofilm and ventilator-associated pneumonia with mechanical ventilation. Microsc Res Tech, 2014, 77(4): 305-312.
20.	Kollef MH. Prevention of hospital associated pneumonia and ventilator-associated pneumonia. Crit Care Med, 2004, 32(6): 1396-1404.
21.	Quenot JP, Ladoire S, Devoucoux F, et al. Effect of a nurse-implemented sedation protocol on the incidence of ventilator-associated pneumonia. Crit Care Med, 2007, 35(9): 2031-2036.
22.	Rouzé A, Martin-Loeches I, Nseir S. Airway devices in ventilator-associated pneumonia pathogenesis and prevention. Clin Chest Med, 2018, 39(4): 775-783.
23.	Fan E, Cheek F, Chlan L, et al. An official American Thoracic Society Clinical Practice Guideline: the Diagnosis of Intensive Care Unit-Acquired Weakness in Adults. Am J Respir Crit Care Med, 2014, 190(12): 1437-1446.
24.	Kress J, Hall JB. ICU-acquired weakness and recovery from critical illness. N Engl J Med, 2014, 370(17): 1626-1635.
25.	王海旭, 张晓娟, 段晓光, 等. ICU获得性肌无力的诊断与治疗. 中华急诊医学杂志, 2017, 26(10): 1187-1190.
26.	Vanhorebeek I, Latronico N, Van den Berghe G. ICU-acquired weakness. Intensive Care Med, 2020, 46(4): 637-653.
27.	Peñuelas O, Keough E, López-Rodríguez L, et al. Ventilator-induced diaphragm dysfunction: translational mechanisms lead to therapeutical alternatives in the critically ill. Intensive Care Med Exp, 2019, 7(Suppl 1): 48.
28.	何远超, 刘玲. 呼吸机相关膈肌功能障碍的主要发病机制. 中华医学杂志, 2019, 46(12): 3671-3674.
29.	Morton AB, Smuder AJ, Wiggs MP, et al. Increased SOD2 in the diaphragm contributes to exercise-induced protection against ventilator-induced diaphragm dysfunction. Redox Biol, 2019, 20: 402-413.
30.	McClung JM, Kavazis AN, DeRuisseau KC, et al. Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy. Am J Respir Crit Care Med, 2007, 175(2): 150-159.
31.	Jaber S, Jung B, Matecki S, et al. Clinical review: ventilator-induced diaphragmatic dysfunction-human studies confirm animal model findings!. Crit Care, 2011, 15(2): 206.
32.	Powers SK, Wiggs MP, Sollanek KJ, et al. Ventilator-induced diaphragm dysfunction: cause and effect. Am J Physiol Regul Integr Comp Physiol, 2013, 305(5): R464-R477.
33.	Liu YY, Li LF. Ventilator-induced diaphragm dysfunction in critical illness. Exp Biol Med (Maywood), 2018, 243(17-18): 1329-1337.
34.	Hodgson CL, Stiller K, Needham DM, et al. Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults. Crit Care, 2014, 18(6): 658.
35.	Sibilla A, Nydahl P, Greco N, et al. Mobilization of mechanically ventilated patients in Switzerland. J Intensive Care Med, 2020, 35(1): 55-62.
36.	刘钢, 胡少华, 段宗浩, 等. 多学科协作模式下早期分级呼吸重症康复训练应用于机械通气患者效果研究. 中国呼吸与危重监护杂志, 2021, 20(4): 254-260.
37.	吴淼, 倪朝民, 吴鸣, 等. 机械通气患者早期肺康复治疗的临床观察. 中国康复医学杂志, 2018, 33(7): 806-811.
38.	陆俊江, 廖建坤, 梁国兴, 等. 早期肺康复治疗在ICU机械通气患者中的应用效果研究. 中国现代药物应用, 2020, 14(8): 230-231.
39.	李大亮, 黄雪敏, 岑树坤, 等. 早期康复治疗对老年重症肺炎机械通气患者并发症及预后的影响. 中国呼吸与危重监护杂志, 2018, 17(1): 46-50.
40.	Corcoran JR, Herbsman JM, Bushnik T, et al. Early Rehabilitation in the medical and surgical intensive care units for patients with and without mechanical ventilation: an interprofessional performance improvement project. PMR, 2017, 9(2): 113-119.
41.	Schweickert WD, Pohlman MC, Pohlman AS, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet, 2009, 373(9678): 1874-1882.
42.	Morris P, Goad A, Thompson C, et al. Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med, 2008, 36(8): 2238-2243.
43.	Sommers J, Engelbert RH, Dettling-Ihnenfeldt D, et al. Physiotherapy in the intensive care unit: an evidence-based, expert driven, practical statement and rehabilitation recommendations. Clin Rehabil, 2015, 29(11): 1051-1063.
44.	Gundogdu I, Ozturk EA, Umay E, et al. Implementation of a respiratory rehabilitation protocol: weaning from the ventilator and tracheostomy in difficult-to-wean patients with spinal cord. Disabil Rehabil, 2017, 39(12): 1162-1170.
45.	Jang MH, Shin MJ, Shin YB. Pulmonary and physical rehabilitation in critically ill patients. Acute Crit Care, 2019, 34(1): 1-13.
46.	汪璐璐, 徐凤玲, 刘钢, 等. 机械通气患者早期肺康复分级方案的构建与应用研究. 中华护理杂志, 2020, 55(8): 1125-1132.
47.	闫鹏, 解立新. 危重症患者肺康复研究进展. 中国实用内科杂志, 2018, 38(5): 405-409.
48.	Kho ME, Molloy AJ, Clarke F, et al. CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients. BMJ Open, 2016, 6(4): e011659.
49.	Burtin C, Clerckx B, Robbeets C, et al. Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med, 2009, 37(9): 2499-2505.
50.	Camargo Pires-Neto R, Fogaça Kawaguchi YM, Sayuri Hirota A, et al. Very early passive cycling exercise in mechanically ventilated critically ill patients: physiological and safety aspects-a case series. PLoS One, 2013, 8(9): e74182.
51.	Nickels MR, Aitken LM, Barnett AG, et al. Acceptability, safety, and feasibility of in-bed cycling with critically ill patients. Aust Crit Care, 2020, 33(3): 236-243.
52.	Kho ME, Molloy AJ, Clarke FJ, et al. Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients. BMJ Open Respir Res, 2019, 6(1): e000383.
53.	Edwards J, McWilliams D, Thomas M, et al. Electrical muscle stimulation in the intensive care unit: an integrative review. J Intensive Care Soc, 2014, 15(2): 142-149.
54.	Chen YH, Hsiao HF, Li LF, et al. Effects of electrical muscle stimulation in subjects undergoing prolonged mechanical ventilation. Respir Care, 2019, 64(3): 262-271.
55.	张桂宁, 杨丽, 郭明娟, 等. 神经肌肉电刺激对ICU机械通气病人影响的Meta分析. 护理研究, 2019, 33(2): 187-194.
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1. 中华医学会重症医学分会. 机械通气临床应用指南(2006). 中华危重病急救医学, 2007, 19(2): 65-72.
2. Pham T, Brochard LJ, Slutsky AS. Mechanical ventilation: state of the art. Mayo Clin Proc, 2017, 92(9): 1382-1400.
3. Acute Respiratory Distress Syndrome Network, Brower RG, Matthay MA, Morris A, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med, 2000, 342(18): 1301-1308.
4. Serpa Neto A, Cardoso SO, Manetta JA, et al. Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis. JAMA, 2012, 308(16): 1651-1659.
5. Van Vught LA, Klowenberg PM, Spitoni C, et al. Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis. JAMA, 2016, 315(14): 1469-1479.
6. Dres M, Dubé BP, Mayaux J, et al. Coexistence and impact of limb muscle and diaphragm weakness at time of liberation from mechanical ventilation in medical intensive care unit patients. Am J Respir Crit Care Med, 2017, 195(1): 57-66.
7. Goligher EC, Fan E, Herridge MS, et al. Evolution of diaphragm thickness during mechanical ventilation: impact of inspiratory effort. Am J Respir Crit Care Med, 2015, 192(9): 1080-1088.
8. Petty TL. Pulmonary rehabilitation. Am Rev Respir Dis, 1980, 122(5 Pt 2): 159-161.
9. Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med, 2013, 188(8): e13-e64.
10. 余佳丹, 喻鹏铭, 魏清川, 等. 重症康复研究进展. 华西医学, 2018, 33(10): 1207-1212.
11. Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med, 2013, 369(22): 2126-2136.
12. Vasques F, Duscio E, Cipulli F, et al. Determinants and prevention of ventilator-induced lung injury. Crit Care Clin, 2018, 34(3): 343-356.
13. Beitler JR, Malhotra A, Thompson BT. Ventilator-induced lung injury. Clin Chest Med, 2016, 37(4): 633-646.
14. Curley GF, Laffey JG, Zhang H, et al. Biotrauma and ventilator-induced lung injury: clinical implications. Chest, 2016, 150(5): 1109-1117.
15. Metersky ML, Kalil AC. Management of Ventilator-Associated Pneumonia: Guidelines. Clin Chest Med, 2018, 39(4): 797-808.
16. Jaillette E, Girault C, Brunin G, et al. Impact of tapered-cuff tracheal tube on microaspiration of gastric contents in intubated critically ill patients: a multicenter cluster-randomized cross-over controlled trial. Intensive Care Med, 2017, 43(11): 1562-1571.
17. Blot SI, Rello J, Koulenti D. The value of polyurethane-cuffed endotracheal tubes to reduce microaspiration and intubation-related pneumonia: a systematic review of laboratory and clinical studies. Crit Care, 2016, 20(1): 203.
18. Gil-Perotin S, Ramirez P, Marti V, et al. Implications of endotracheal tube biofilm in ventilator-associated pneumonia response: a state of concept. Crit Care, 2012, 16(3): R93.
19. De Souza PR, De Andrade D, Cabral DB, et al. Endotracheal tube biofilm and ventilator-associated pneumonia with mechanical ventilation. Microsc Res Tech, 2014, 77(4): 305-312.
20. Kollef MH. Prevention of hospital associated pneumonia and ventilator-associated pneumonia. Crit Care Med, 2004, 32(6): 1396-1404.
21. Quenot JP, Ladoire S, Devoucoux F, et al. Effect of a nurse-implemented sedation protocol on the incidence of ventilator-associated pneumonia. Crit Care Med, 2007, 35(9): 2031-2036.
22. Rouzé A, Martin-Loeches I, Nseir S. Airway devices in ventilator-associated pneumonia pathogenesis and prevention. Clin Chest Med, 2018, 39(4): 775-783.
23. Fan E, Cheek F, Chlan L, et al. An official American Thoracic Society Clinical Practice Guideline: the Diagnosis of Intensive Care Unit-Acquired Weakness in Adults. Am J Respir Crit Care Med, 2014, 190(12): 1437-1446.
24. Kress J, Hall JB. ICU-acquired weakness and recovery from critical illness. N Engl J Med, 2014, 370(17): 1626-1635.
25. 王海旭, 张晓娟, 段晓光, 等. ICU获得性肌无力的诊断与治疗. 中华急诊医学杂志, 2017, 26(10): 1187-1190.
26. Vanhorebeek I, Latronico N, Van den Berghe G. ICU-acquired weakness. Intensive Care Med, 2020, 46(4): 637-653.
27. Peñuelas O, Keough E, López-Rodríguez L, et al. Ventilator-induced diaphragm dysfunction: translational mechanisms lead to therapeutical alternatives in the critically ill. Intensive Care Med Exp, 2019, 7(Suppl 1): 48.
28. 何远超, 刘玲. 呼吸机相关膈肌功能障碍的主要发病机制. 中华医学杂志, 2019, 46(12): 3671-3674.
29. Morton AB, Smuder AJ, Wiggs MP, et al. Increased SOD2 in the diaphragm contributes to exercise-induced protection against ventilator-induced diaphragm dysfunction. Redox Biol, 2019, 20: 402-413.
30. McClung JM, Kavazis AN, DeRuisseau KC, et al. Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy. Am J Respir Crit Care Med, 2007, 175(2): 150-159.
31. Jaber S, Jung B, Matecki S, et al. Clinical review: ventilator-induced diaphragmatic dysfunction-human studies confirm animal model findings!. Crit Care, 2011, 15(2): 206.
32. Powers SK, Wiggs MP, Sollanek KJ, et al. Ventilator-induced diaphragm dysfunction: cause and effect. Am J Physiol Regul Integr Comp Physiol, 2013, 305(5): R464-R477.
33. Liu YY, Li LF. Ventilator-induced diaphragm dysfunction in critical illness. Exp Biol Med (Maywood), 2018, 243(17-18): 1329-1337.
34. Hodgson CL, Stiller K, Needham DM, et al. Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults. Crit Care, 2014, 18(6): 658.
35. Sibilla A, Nydahl P, Greco N, et al. Mobilization of mechanically ventilated patients in Switzerland. J Intensive Care Med, 2020, 35(1): 55-62.
36. 刘钢, 胡少华, 段宗浩, 等. 多学科协作模式下早期分级呼吸重症康复训练应用于机械通气患者效果研究. 中国呼吸与危重监护杂志, 2021, 20(4): 254-260.
37. 吴淼, 倪朝民, 吴鸣, 等. 机械通气患者早期肺康复治疗的临床观察. 中国康复医学杂志, 2018, 33(7): 806-811.
38. 陆俊江, 廖建坤, 梁国兴, 等. 早期肺康复治疗在ICU机械通气患者中的应用效果研究. 中国现代药物应用, 2020, 14(8): 230-231.
39. 李大亮, 黄雪敏, 岑树坤, 等. 早期康复治疗对老年重症肺炎机械通气患者并发症及预后的影响. 中国呼吸与危重监护杂志, 2018, 17(1): 46-50.
40. Corcoran JR, Herbsman JM, Bushnik T, et al. Early Rehabilitation in the medical and surgical intensive care units for patients with and without mechanical ventilation: an interprofessional performance improvement project. PMR, 2017, 9(2): 113-119.
41. Schweickert WD, Pohlman MC, Pohlman AS, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet, 2009, 373(9678): 1874-1882.
42. Morris P, Goad A, Thompson C, et al. Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med, 2008, 36(8): 2238-2243.
43. Sommers J, Engelbert RH, Dettling-Ihnenfeldt D, et al. Physiotherapy in the intensive care unit: an evidence-based, expert driven, practical statement and rehabilitation recommendations. Clin Rehabil, 2015, 29(11): 1051-1063.
44. Gundogdu I, Ozturk EA, Umay E, et al. Implementation of a respiratory rehabilitation protocol: weaning from the ventilator and tracheostomy in difficult-to-wean patients with spinal cord. Disabil Rehabil, 2017, 39(12): 1162-1170.
45. Jang MH, Shin MJ, Shin YB. Pulmonary and physical rehabilitation in critically ill patients. Acute Crit Care, 2019, 34(1): 1-13.
46. 汪璐璐, 徐凤玲, 刘钢, 等. 机械通气患者早期肺康复分级方案的构建与应用研究. 中华护理杂志, 2020, 55(8): 1125-1132.
47. 闫鹏, 解立新. 危重症患者肺康复研究进展. 中国实用内科杂志, 2018, 38(5): 405-409.
48. Kho ME, Molloy AJ, Clarke F, et al. CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients. BMJ Open, 2016, 6(4): e011659.
49. Burtin C, Clerckx B, Robbeets C, et al. Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med, 2009, 37(9): 2499-2505.
50. Camargo Pires-Neto R, Fogaça Kawaguchi YM, Sayuri Hirota A, et al. Very early passive cycling exercise in mechanically ventilated critically ill patients: physiological and safety aspects-a case series. PLoS One, 2013, 8(9): e74182.
51. Nickels MR, Aitken LM, Barnett AG, et al. Acceptability, safety, and feasibility of in-bed cycling with critically ill patients. Aust Crit Care, 2020, 33(3): 236-243.
52. Kho ME, Molloy AJ, Clarke FJ, et al. Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients. BMJ Open Respir Res, 2019, 6(1): e000383.
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