Predictive value of inspiratory capacity and total lung capacity on acute exacerbation of chronic obstructive pulmonary disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

CHEN Min , WANG Xiaoxia ,  CHEN Feng

Department of Pulmonary and Critical Care Medicine, the No. 3 People’s Hospital of Chengdu, Chengdu, Sichuan 610031, P. R. China;

Corresponding author：

CHEN Feng, Email: cfch204@sina.com

Keywords：

Chronic obstructive pulmonary disease; Inspiratory capacity; Total lung capacity

DOI：

10.7507/1671-6205.202108077

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To study the predictive value of inspiratory capacity (IC) and total lung capacity (TLC) on acute exacerbation of patients with chronic obstructive pulmonary disease (COPD). Methods The in-patients due to acute exacerbation of COPD (AECOPD) from February 2017 to March 2019 were recruited in the study. Research data were collected during the recovery period and one year follow-up , and the patients were divided into two groups according to whether there was another acute exacerbation. Results A total of 372 patients were included in the study. In the patients with acute exacerbation, the age and TLC as a percentage of the expected value (TLC%pred) were higher, while IC as a percentage of the expected value (IC%pred) and the ratio of IC and TLC (IC/TLC) were lower. Univariate analysis revealed that IC/TLC≤25% was a significant predictor of acute exacerbation (P<0.001) after the AECOPD patients were discharged. Multivariable analysis revealed age (OR=1.25, 95%CI 1.17 to 1.44, P<0.001) and IC/TLC≤25% (OR=1.68, 95%CI 1.36 to 2.07, P<0.001) were independent risk factors of AECOPD.Conclusions Decreased IC/TLC significantly correlates with poor prognosis of COPD. IC/TLC≤25% is an independent risk factor for acute exacerbation.

Citation： CHEN Min, WANG Xiaoxia, CHEN Feng. Predictive value of inspiratory capacity and total lung capacity on acute exacerbation of chronic obstructive pulmonary disease. Chinese Journal of Respiratory and Critical Care Medicine, 2021, 20(10): 690-693. doi: 10.7507/1671-6205.202108077 Copy

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8.	Casanova C, Cote C, Marin JM, et al. Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD. Chest, 2008, 134(4): 746-752.
9.	Boutou AK, Shrikrishna D, Tanner RJ, et al. Lung function indices for predicting mortality in COPD. Eur Respir J, 2013, 42(3): 616-625.
10.	Chan HP, Mukhopadhyay A, Chong PL, et al. Role of BMI, airflow obstruction, St George's Respiratory Questionnaire and age index in prognostication of Asian COPD. Respirology, 2017, 22(1): 114-119.
11.	Nishimura K, Izumi T, Tsukino M, et al. Dyspnea is a better predictor of 5-year survival than airway obstructive in patients with COPD. Chest, 2002, 121(5): 1434-1440.
12.	Lourens MS, van den Berg B, Aerts JG, et al. Expiratory time constants in mechanically ventilated patients with and without COPD. Intensive Care Med, 2000, 26(11): 1612-1618.
13.	曾斌, 张鸣生. 慢性阻塞性肺疾病动态过度充气与康复治疗. 中国康复医学杂志, 2016, 31(10): 1171-1174.
14.	Laveneziana P, Webb KA, Wadell K, et al. Does expiratory muscle activity influence dynamic hyperinflation and exertional dyspnea in COPD?. Respir Physiol Neurobiol, 2014, 199: 24-33.
15.	Callens E, Graba S, Gillet-Juvin K, et al. Measurement of dynamic hyperinflation after a 6-minute walk test in patients with COPD. Chest, 2009, 136(6): 1466-1472.
16.	Parshall MB, Schwartzstein RM, Adams L, et al. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med, 2012, 185(4): 435-452.

1. Wang C, Xu JY, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health study): a national cross-sectional study. Lancet, 2018, 391(10131): 1706-1717.
2. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (2018 report)(EB/OL). Available at:http://goldcopd.org.
3. de Torres JP, Casanova C, Marín JM, et al. Prognostic evaluation of COPD patients: GOLD 2011 versus BODE and the COPD comorbidity index COTE. Thorax, 2014, 69(9): 799-804.
4. Neder JA, Alharbi A, Berton DC, et al. Exercise ventilatory inefficiency adds to lung function in predicting mortality in COPD. COPD, 2016, 13(4): 416-424.
5. Calverley PM, Koulouris NG. Flow limitation and dynamic hyperinflation: key concepts in modern respiratory physiology. Eur Respir J, 2005, 25(1): 186-199.
6. O’Donnell DE, Revill SM, Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2001, 164(5): 770-777.
7. O’Donnell DE, Laveneziana P. The clinical importance of dynamic lung hyperinflation in COPD. COPD, 2006, 3(4): 219-232.
8. Casanova C, Cote C, Marin JM, et al. Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD. Chest, 2008, 134(4): 746-752.
9. Boutou AK, Shrikrishna D, Tanner RJ, et al. Lung function indices for predicting mortality in COPD. Eur Respir J, 2013, 42(3): 616-625.
10. Chan HP, Mukhopadhyay A, Chong PL, et al. Role of BMI, airflow obstruction, St George's Respiratory Questionnaire and age index in prognostication of Asian COPD. Respirology, 2017, 22(1): 114-119.
11. Nishimura K, Izumi T, Tsukino M, et al. Dyspnea is a better predictor of 5-year survival than airway obstructive in patients with COPD. Chest, 2002, 121(5): 1434-1440.
12. Lourens MS, van den Berg B, Aerts JG, et al. Expiratory time constants in mechanically ventilated patients with and without COPD. Intensive Care Med, 2000, 26(11): 1612-1618.
13. 曾斌, 张鸣生. 慢性阻塞性肺疾病动态过度充气与康复治疗. 中国康复医学杂志, 2016, 31(10): 1171-1174.
14. Laveneziana P, Webb KA, Wadell K, et al. Does expiratory muscle activity influence dynamic hyperinflation and exertional dyspnea in COPD?. Respir Physiol Neurobiol, 2014, 199: 24-33.
15. Callens E, Graba S, Gillet-Juvin K, et al. Measurement of dynamic hyperinflation after a 6-minute walk test in patients with COPD. Chest, 2009, 136(6): 1466-1472.
16. Parshall MB, Schwartzstein RM, Adams L, et al. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med, 2012, 185(4): 435-452.

Chinese Journal of Respiratory and Critical Care Medicine

Predictive value of inspiratory capacity and total lung capacity on acute exacerbation of chronic obstructive pulmonary disease

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