核因子E2相关因子2在慢性阻塞性肺疾病中的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

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付文丽 ¹ ,  LIU Weiying ² , ZHANG Sha ¹ , WANG Juan ¹ , LI Leping ¹

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2. ;

Corresponding author：

LIU Weiying, Email: lwy70828@126.com

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DOI：

10.7507/1671-6205.202204077

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Citation： LIU Weiying, ZHANG Sha, WANG Juan, LI Leping. 核因子E2相关因子2在慢性阻塞性肺疾病中的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(8): 598-601. doi: 10.7507/1671-6205.202204077 Copy

1.	Wang C, Xu JY, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet, 2018, 391(10131): 1706-1717.
2.	Mizumura K, Maruoka S, Shimizu T, et al. Role of Nrf2 in the pathogenesis of respiratory diseases. Respir Investig, 2020, 58(1): 28-35.
3.	Son ES, Park JW, Kim YJ, et al. Effects of antioxidants on oxidative stress and inflammatory responses of human bronchial epithelial cells exposed to particulate matter and cigarette smoke extract. Toxicol In Vitro, 2020, 67: 104883.
4.	Liu QM, Gao Y, Ci XX. Role of Nrf2 and its activators in respiratory diseases. Oxid Med Cell Longev, 2019, 2019: 7090534.
5.	Audousset C, McGovern T, Martin JG. Role of Nrf2 in disease: novel molecular mechanisms and therapeutic approaches - pulmonary disease/asthma. Front Physiol, 2021, 12: 727806.
6.	Otsuki A, Yamamoto M. Cis-element architecture of Nrf2-sMaf heterodimer binding sites and its relation to diseases. Arch Pharm Res, 2020, 43(3): 275-285.
7.	Jiao ZX, Chang JC, Li J, et al. Sulforaphane increases Nrf2 expression and protects alveolar epithelial cells against injury caused by cigarette smoke extract. Mol Med Rep, 2017, 16(2): 1241-1247.
8.	Prange R, Thiedmann M, Bhandari A, et al. A drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention. Aging (Albany NY), 2018, 10(8): 2122-2135.
9.	Sidhaye VK, Holbrook JT, Burke A, et al. Compartmentalization of anti-oxidant and anti-inflammatory gene expression in current and former smokers with COPD. Respir Res, 2019, 20(1): 190.
10.	Li DR, Sun D, Zhu YH. Expression of nuclear factor erythroid-2-related factor 2, broad complex-tramtrack-bric a brac and Cap'n'collar homology 1 and γ-glutamic acid cysteine synthase in peripheral blood of patients with chronic obstructive pulmonary disease and its clinical significance. Exp Ther Med, 2021, 21(5): 516.
11.	Posso SV, Quesnot N, Moraes JA, et al. AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway. Int Immunopharmacol, 2018, 56: 330-338.
12.	Xiang Y, Fu L, Xiang HX, et al. Correlations among pulmonary DJ-1, VDR and Nrf-2 in patients with chronic obstructive pulmonary disease: a case-control study. Int J Med Sci, 2021, 18(11): 2449-2456.
13.	Fratta Pasini AM, Stranieri C, Ferrari M, et al. Oxidative stress and Nrf2 expression in peripheral blood mononuclear cells derived from COPD patients: an observational longitudinal study. Respir Res, 2020, 21(1): 37.
14.	Jia GH, Yu SW, Sun WL, et al. Hydrogen sulfide attenuates particulate matter-induced emphysema and airway inflammation through Nrf2-dependent manner. Front Pharmacol, 2020, 11: 29.
15.	Zhou YY, Xu XY, Wu J, et al. Allyl isothiocyanate treatment alleviates chronic obstructive pulmonary disease through the Nrf2-Notch1 signaling and upregulation of MRP1. Life Sci, 2020, 243: 117291.
16.	Korytina GF, Akhmadishina LZ, Aznabaeva YG, et al. Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary disease. Gene, 2019, 692: 102-112.
17.	Sugitani A, Asai K, Watanabe T, et al. A polymorphism rs6726395 in Nrf2 contributes to the development of emphysema-associated age in smokers without COPD. Lung, 2019, 197(5): 559-564.
18.	Wang T, Dai F, Li GH, et al. Trans-4, 4'-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response. Free Radic Biol Med, 2020, 152: 525-539.
19.	Kubo H, Asai K, Kojima K, et al. Astaxanthin suppresses cigarette smoke-induced emphysema through Nrf2 activation in mice. Mar Drugs, 2019, 17(12): 673.
20.	Ban WH, Kang HH, Kim IK, et al. Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease. Korean J Intern Med, 2018, 33(4): 745-752.
21.	Cui WH, Zhang ZH, Zhang PP, et al. Nrf2 attenuates inflammatory response in COPD/emphysema: crosstalk with Wnt3a/β-catenin and AMPK pathways. J Cell Mol Med, 2018, 22(7): 3514-3525.
22.	Sohrabi F, Dianat M, Badavi M, et al. Gallic acid suppresses inflammation and oxidative stress through modulating Nrf2-HO-1-NF-κB signaling pathways in elastase-induced emphysema in rats. Environ Sci Pollut Res Int, 2021, 28(40): 56822-56834.
23.	陈炎波, 彭盼, 梁志科, 等. Nrf2激活剂抑制慢性阻塞性肺疾病小鼠NLRP3炎症小体的活化. 国际呼吸杂志, 2021, 41(24): 1873-1880.
24.	Xu YF, Li J, Lin ZW, et al. Isorhamnetin alleviates airway inflammation by regulating the Nrf2/Keap1 pathway in a mouse model of COPD. Front Pharmacol, 2022, 13: 860362.
25.	陈启宪, 刘朝晖, 梁志科. Nrf2-ARE途径调控慢性阻塞性肺疾病肺泡巨噬细胞功能的研究进展. 中国呼吸与危重监护杂志, 2018, 17(2): 210-213.
26.	Bewley MA, Budd RC, Ryan E, et al. Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists. Am J Respir Crit Care Med, 2018, 198(6): 739-750.
27.	Lee KH, Woo J, Kim J, et al. Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300. Respirology, 2021, 26(1): 102-111.
28.	Li J, Baker J, Higham A, et al. COPD lung studies of Nrf2 expression and the effects of Nrf2 activators. Inflammopharmacology, 2022, 30(4): 1431-1443.
29.	Hosaka Y, Araya J, Fujita Y, et al. Chaperone-mediated autophagy suppresses apoptosis via regulation of the unfolded protein response during chronic obstructive pulmonary disease pathogenesis. J Immunol, 2020, 205(5): 1256-1267.
30.	Tao SS, Zhang H, Xue L, et al. Vitamin D protects against particles-caused lung injury through induction of autophagy in an Nrf2-dependent manner. Environ Toxicol, 2019, 34(5): 594-609.
31.	Zhang H, Xue L, Li BY, et al. Therapeutic potential of bixin in PM2.5 particles-induced lung injury in an Nrf2-dependent manner. Free Radic Biol Med, 2018, 126: 166-176.
32.	Jain S, Durugkar S, Saha P, et al. Effects of intranasal azithromycin on features of cigarette smoke-induced lung inflammation. Eur J Pharmacol, 2022, 915: 174467.
33.	Liao WP, Lim AYH, Tan WSD, et al. Restoration of HDAC2 and Nrf2 by andrographolide overcomes corticosteroid resistance in chronic obstructive pulmonary disease. Br J Pharmacol, 2020, 177(16): 3662-3673.
34.	Tao FL, Zhou YY, Wang MW, et al. Metformin alleviates chronic obstructive pulmonary disease and cigarette smoke extract-induced glucocorticoid resistance by activating the nuclear factor E2-related factor 2/heme oxygenase-1 signaling pathway. Korean J Physiol Pharmacol, 2022, 26(2): 95-111.
35.	Chi YM, Di QG, Han GC, et al. Mir-29b mediates the regulation of Nrf2 on airway epithelial remodeling and Th1/Th2 differentiation in COPD rats. Saudi J Biol Sci, 2019, 26(8): 1915-1921.
36.	Xu LL, Wu J, Li NN, et al. AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis. Korean J Physiol Pharmacol, 2020, 24(6): 481-492.
37.	Wang L, Chen XY, Li X, et al. Developing a novel strategy for COPD therapy by targeting Nrf2 and metabolism reprogramming simultaneously. Free Radic Biol Med, 2021, 169: 436-445.
38.	Zhang ZX, Fu CL, Liu JX, et al. Hypermethylation of the Nrf2 promoter induces ferroptosis by inhibiting the Nrf2-GPX4 axis in COPD. Int J Chron Obstruct Pulmon Dis, 2021, 16: 3347-3362.
39.	Liu XM, Ma YM, Luo LJ, et al. Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway. Phytomedicine, 2022, 96: 153894.

1. Wang C, Xu JY, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet, 2018, 391(10131): 1706-1717.
2. Mizumura K, Maruoka S, Shimizu T, et al. Role of Nrf2 in the pathogenesis of respiratory diseases. Respir Investig, 2020, 58(1): 28-35.
3. Son ES, Park JW, Kim YJ, et al. Effects of antioxidants on oxidative stress and inflammatory responses of human bronchial epithelial cells exposed to particulate matter and cigarette smoke extract. Toxicol In Vitro, 2020, 67: 104883.
4. Liu QM, Gao Y, Ci XX. Role of Nrf2 and its activators in respiratory diseases. Oxid Med Cell Longev, 2019, 2019: 7090534.
5. Audousset C, McGovern T, Martin JG. Role of Nrf2 in disease: novel molecular mechanisms and therapeutic approaches - pulmonary disease/asthma. Front Physiol, 2021, 12: 727806.
6. Otsuki A, Yamamoto M. Cis-element architecture of Nrf2-sMaf heterodimer binding sites and its relation to diseases. Arch Pharm Res, 2020, 43(3): 275-285.
7. Jiao ZX, Chang JC, Li J, et al. Sulforaphane increases Nrf2 expression and protects alveolar epithelial cells against injury caused by cigarette smoke extract. Mol Med Rep, 2017, 16(2): 1241-1247.
8. Prange R, Thiedmann M, Bhandari A, et al. A drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention. Aging (Albany NY), 2018, 10(8): 2122-2135.
9. Sidhaye VK, Holbrook JT, Burke A, et al. Compartmentalization of anti-oxidant and anti-inflammatory gene expression in current and former smokers with COPD. Respir Res, 2019, 20(1): 190.
10. Li DR, Sun D, Zhu YH. Expression of nuclear factor erythroid-2-related factor 2, broad complex-tramtrack-bric a brac and Cap'n'collar homology 1 and γ-glutamic acid cysteine synthase in peripheral blood of patients with chronic obstructive pulmonary disease and its clinical significance. Exp Ther Med, 2021, 21(5): 516.
11. Posso SV, Quesnot N, Moraes JA, et al. AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway. Int Immunopharmacol, 2018, 56: 330-338.
12. Xiang Y, Fu L, Xiang HX, et al. Correlations among pulmonary DJ-1, VDR and Nrf-2 in patients with chronic obstructive pulmonary disease: a case-control study. Int J Med Sci, 2021, 18(11): 2449-2456.
13. Fratta Pasini AM, Stranieri C, Ferrari M, et al. Oxidative stress and Nrf2 expression in peripheral blood mononuclear cells derived from COPD patients: an observational longitudinal study. Respir Res, 2020, 21(1): 37.
14. Jia GH, Yu SW, Sun WL, et al. Hydrogen sulfide attenuates particulate matter-induced emphysema and airway inflammation through Nrf2-dependent manner. Front Pharmacol, 2020, 11: 29.
15. Zhou YY, Xu XY, Wu J, et al. Allyl isothiocyanate treatment alleviates chronic obstructive pulmonary disease through the Nrf2-Notch1 signaling and upregulation of MRP1. Life Sci, 2020, 243: 117291.
16. Korytina GF, Akhmadishina LZ, Aznabaeva YG, et al. Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary disease. Gene, 2019, 692: 102-112.
17. Sugitani A, Asai K, Watanabe T, et al. A polymorphism rs6726395 in Nrf2 contributes to the development of emphysema-associated age in smokers without COPD. Lung, 2019, 197(5): 559-564.
18. Wang T, Dai F, Li GH, et al. Trans-4, 4'-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response. Free Radic Biol Med, 2020, 152: 525-539.
19. Kubo H, Asai K, Kojima K, et al. Astaxanthin suppresses cigarette smoke-induced emphysema through Nrf2 activation in mice. Mar Drugs, 2019, 17(12): 673.
20. Ban WH, Kang HH, Kim IK, et al. Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease. Korean J Intern Med, 2018, 33(4): 745-752.
21. Cui WH, Zhang ZH, Zhang PP, et al. Nrf2 attenuates inflammatory response in COPD/emphysema: crosstalk with Wnt3a/β-catenin and AMPK pathways. J Cell Mol Med, 2018, 22(7): 3514-3525.
22. Sohrabi F, Dianat M, Badavi M, et al. Gallic acid suppresses inflammation and oxidative stress through modulating Nrf2-HO-1-NF-κB signaling pathways in elastase-induced emphysema in rats. Environ Sci Pollut Res Int, 2021, 28(40): 56822-56834.
23. 陈炎波, 彭盼, 梁志科, 等. Nrf2激活剂抑制慢性阻塞性肺疾病小鼠NLRP3炎症小体的活化. 国际呼吸杂志, 2021, 41(24): 1873-1880.
24. Xu YF, Li J, Lin ZW, et al. Isorhamnetin alleviates airway inflammation by regulating the Nrf2/Keap1 pathway in a mouse model of COPD. Front Pharmacol, 2022, 13: 860362.
25. 陈启宪, 刘朝晖, 梁志科. Nrf2-ARE途径调控慢性阻塞性肺疾病肺泡巨噬细胞功能的研究进展. 中国呼吸与危重监护杂志, 2018, 17(2): 210-213.
26. Bewley MA, Budd RC, Ryan E, et al. Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists. Am J Respir Crit Care Med, 2018, 198(6): 739-750.
27. Lee KH, Woo J, Kim J, et al. Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300. Respirology, 2021, 26(1): 102-111.
28. Li J, Baker J, Higham A, et al. COPD lung studies of Nrf2 expression and the effects of Nrf2 activators. Inflammopharmacology, 2022, 30(4): 1431-1443.
29. Hosaka Y, Araya J, Fujita Y, et al. Chaperone-mediated autophagy suppresses apoptosis via regulation of the unfolded protein response during chronic obstructive pulmonary disease pathogenesis. J Immunol, 2020, 205(5): 1256-1267.
30. Tao SS, Zhang H, Xue L, et al. Vitamin D protects against particles-caused lung injury through induction of autophagy in an Nrf2-dependent manner. Environ Toxicol, 2019, 34(5): 594-609.
31. Zhang H, Xue L, Li BY, et al. Therapeutic potential of bixin in PM2.5 particles-induced lung injury in an Nrf2-dependent manner. Free Radic Biol Med, 2018, 126: 166-176.
32. Jain S, Durugkar S, Saha P, et al. Effects of intranasal azithromycin on features of cigarette smoke-induced lung inflammation. Eur J Pharmacol, 2022, 915: 174467.
33. Liao WP, Lim AYH, Tan WSD, et al. Restoration of HDAC2 and Nrf2 by andrographolide overcomes corticosteroid resistance in chronic obstructive pulmonary disease. Br J Pharmacol, 2020, 177(16): 3662-3673.
34. Tao FL, Zhou YY, Wang MW, et al. Metformin alleviates chronic obstructive pulmonary disease and cigarette smoke extract-induced glucocorticoid resistance by activating the nuclear factor E2-related factor 2/heme oxygenase-1 signaling pathway. Korean J Physiol Pharmacol, 2022, 26(2): 95-111.
35. Chi YM, Di QG, Han GC, et al. Mir-29b mediates the regulation of Nrf2 on airway epithelial remodeling and Th1/Th2 differentiation in COPD rats. Saudi J Biol Sci, 2019, 26(8): 1915-1921.
36. Xu LL, Wu J, Li NN, et al. AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis. Korean J Physiol Pharmacol, 2020, 24(6): 481-492.
37. Wang L, Chen XY, Li X, et al. Developing a novel strategy for COPD therapy by targeting Nrf2 and metabolism reprogramming simultaneously. Free Radic Biol Med, 2021, 169: 436-445.
38. Zhang ZX, Fu CL, Liu JX, et al. Hypermethylation of the Nrf2 promoter induces ferroptosis by inhibiting the Nrf2-GPX4 axis in COPD. Int J Chron Obstruct Pulmon Dis, 2021, 16: 3347-3362.
39. Liu XM, Ma YM, Luo LJ, et al. Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway. Phytomedicine, 2022, 96: 153894.

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核因子E2相关因子2在慢性阻塞性肺疾病中的研究进展

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