AMPK在支气管哮喘中的作用及其研究进展_Chinese Journal of Respiratory and Critical Care Medicine

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雷佳慧 ¹ , 祝贺 ¹ , 肖亚丽 ¹ , 李怡 ¹ ,  赵丽敏 ²

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2. ;

Corresponding author：

赵丽敏, Email: zhaolimin2002@126.com

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DOI：

10.7507/1671-6205.202205041

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Citation： 雷佳慧, 祝贺, 肖亚丽, 李怡, 赵丽敏. AMPK在支气管哮喘中的作用及其研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(12): 893-898. doi: 10.7507/1671-6205.202205041 Copy

1.	Liu SK, Ma LB, Yuan Y, et al. Alanylglutamine relieved asthma symptoms by regulating gut microbiota and the derived metabolites in mice. Oxid Med Cell Longev, 2020, 2020: 7101407.
2.	Aslam M, Ladilov Y. Emerging role of cAMP/AMPK signaling. Cells, 2022, 11(2): 308.
3.	Rodríguez C, Muñoz M, Contreras C, et al. AMPK, metabolism, and vascular function. FEBS J, 2021, 288(12): 3746-3771.
4.	Yan Y, Mukherjee S, Harikumar KG, et al. Structure of an AMPK complex in an inactive, ATP-bound state. Science, 2021, 373(6553): 413-419.
5.	Lin SC, Hardie DG. AMPK: sensing glucose as well as cellular energy status. Cell Metab, 2018, 27(2): 299-313.
6.	Hedman AC, Li ZG, Gorisse L, et al. IQGAP1 binds AMPK and is required for maximum AMPK activation. J Biol Chem, 2021, 296: 100075.
7.	Neumann D. Is TAK1 a direct upstream kinase of AMPK?. Int J Mol Sci, 2018, 19(8): 2412.
8.	Wang JJ, Li JL, Song DY, et al. AMPK: implications in osteoarthritis and therapeutic targets. Am J Transl Res, 2020, 12(12): 7670-7681.
9.	Lee H, Zandkarimi F, Zhang YL, et al. Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol, 2020, 22(2): 225-234.
10.	Hsu CC, Peng D, Cai Z, et al. AMPK signaling and its targeting in cancer progression and treatment. Semin Cancer Biol, 2022, 85: 52-68.
11.	Hollstein PE, Eichner LJ, Brun SN, et al. The AMPK-related kinases SIK1 and SIK3 mediate key tumor-suppressive effects of LKB1 in NSCLC. Cancer Discov, 2019, 9(11): 1606-1627.
12.	Shukal DK, Malaviya PB, Sharma T. Role of the AMPK signalling pathway in the aetiopathogenesis of ocular diseases. Hum Exp Toxicol, 2022, 4: 9603271211063165.
13.	González A, Hall MN, Lin SC, et al. AMPK and TOR: the Yin and Yang of cellular nutrient sensing and growth control. Cell Metab, 2020, 31(3): 472-492.
14.	Yang YX, Jia YF, Ning Y, et al. TAK1-AMPK pathway in macrophages regulates hypothyroid atherosclerosis. Cardiovasc Drugs Ther, 2021, 35(3): 599-612.
15.	Jia JY, Bissa B, Brecht L, et al. AMPK, a regulator of metabolism and autophagy, is activated by lysosomal damage via a novel galectin- directed ubiquitin signal transduction system. Mol Cell, 2020, 77(5): 951-969. e9.
16.	Hunkeler M, Hagmann A, Stuttfeld E, et al. Structural basis for regulation of human acetyl-CoA carboxylase. Nature, 2018, 558(7710): 470-474.
17.	Kim M, Park K, Choi I. The metabolic suppressor 3-iodothyronamine enhances lipolysis in 3T3-L1 adipocytes via activation of the adenosine monophosphate-activated protein kinase/forkhead box O1 signaling pathway. J Physiol Pharmacol, 2020, 71(3): 409-416.
18.	Liu YJ, Song A, Yang X, et al. Farnesoid X receptor agonist decreases lipid accumulation by promoting hepatic fatty acid oxidation in db/db mice. Int J Mol Med, 2018, 42(3): 1723-1731.
19.	Liu LW, Liu C, Fang L. AMPK-SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane. Mol Med Rep, 2021, 23(1): 56.
20.	Ammar RA, Mohamed AF, Kamal MM, et al. Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome. Inflammopharmacology, 2022, 30(3): 919-934.
21.	Zhang N, Li P, Lin H, et al. IL-10 ameliorates PM2.5-induced lung injury by activating the AMPK/SIRT1/PGC-1α pathway. Environ Toxicol Pharmacol, 2021, 86: 103659.
22.	Gao HJ, Wu H. Maslinic acid activates renal AMPK/SIRT1 signaling pathway and protects against diabetic nephropathy in mice. BMC Endocr Disord, 2022, 22(1): 25.
23.	Gao Y, Fan XY, Gu WJ, et al. Hyperoside relieves particulate matter-induced lung injury by inhibiting AMPK/mTOR-mediated autophagy deregulation. Pharmacol Res, 2021, 167: 105561.
24.	Hwang HY, Shim JS, Kim D, et al. Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy, 2021, 17(10): 2783-2799.
25.	Jie C, Xuan W, Feng HD, et al. AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway. Eur J Med Res, 2021, 26(1): 28.
26.	Xu X, Gao WW, Li L, et al. Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway. J Neuroinflammation, 2021, 18(1): 119.
27.	Li X, Liu J, Lu QG, et al. AMPK: a therapeutic target of heart failure-not only metabolism regulation. Biosci Rep, 2019, 39(1): BSR20181767.
28.	Fang GX, Zhang PL, Liu JF, et al. Inhibition of GSK-3β activity suppresses HCC malignant phenotype by inhibiting glycolysis via activating AMPK/mTOR signaling. Cancer Lett, 2019, 463: 11-26.
29.	Finlay DK. N-myristoylation of AMPK controls T cell inflammatory function. Nat Immunol, 2019, 20(3): 252-254.
30.	Clark AJ, Parikh SM. Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1α. Kidney Int, 2021, 99(4): 828-840.
31.	Liu D, Ma ZQ, Di SY, et al. AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Radic Biol Med, 2018, 129: 59-72.
32.	Rahman MS, Kim YS. Mangiferin induces the expression of a thermogenic signature via AMPK signaling during brown-adipocyte differentiation. Food Chem Toxicol, 2020, 141: 111415.
33.	Zhu XP, Bian H, Wang L, et al. Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway. Free Radic Biol Med, 2019, 141: 192-204.
34.	Meng ZY, Liu Q, Sun FJ, et al. Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling. Lipids Health Dis, 2019, 18(1): 191.
35.	Ma WX, Jin QY, Guo HQ, et al. Metformin ameliorates inflammation and airway remodeling of experimental allergic asthma in mice by restoring AMPKα activity. Front Pharmacol, 2022, 13: 780148.
36.	Zhu YJ, Wang CY, Luo JJ, et al. The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway. Food Funct, 2021, 12(7): 3120-3131.
37.	Luan X, Cui C, Jiang J, et al. Salidroside mitigates airway inflammation in asthmatic mice via the AMPK/Akt/GSK3β signaling pathway. Int Arch Allergy Immunol, 2022, 183(3): 326-336.
38.	Xu C, Song YL, Wang ZG, et al. Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO-1 pathways. Immun Inflamm Dis, 2021, 9(4): 1406-1417.
39.	Caslin HL, Taruselli MT, Haque T, et al. Inhibiting glycolysis and ATP production attenuates IL-33-mediated mast cell function and peritonitis. Front Immunol, 2018, 9: 3026.
40.	You YN, Xing QQ, Zhao X, et al. Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission. Biomed Pharmacother, 2021, 138: 111403.
41.	Tsai ML, Tsai YG, Lin YC, et al. IL-25 induced ROS-mediated M2 macrophage polarization via AMPK-associated mitophagy. Int J Mol Sci, 2021, 23(1): 3.
42.	Chen XY, Luo YH, Wang MQ, et al. Wuhu decoction regulates dendritic cell autophagy in the treatment of respiratory syncytial virus (RSV)-induced mouse asthma by AMPK/ULK1 signaling pathway. Med Sci Monit, 2019, 25: 5389-5400.
43.	Pan YL, Liu L, Zhang QQ, et al. Activation of AMPK suppresses S1P-induced airway smooth muscle cells proliferation and its potential mechanisms. Mol Immunol, 2020, 128: 106-115.
44.	Wei YY, Xuan XC, Zhang XY, et al. Niclosamide ethanolamine induces trachea relaxation and inhibits proliferation and migration of trachea smooth muscle cells. Eur J Pharmacol, 2019, 853: 229-235.
45.	Liu L, Pan YL, Song Y, et al. Activation of AMPK α2 inhibits airway smooth muscle cells proliferation. Eur J Pharmacol, 2016, 791: 235-243.
46.	Jiang T, Zhao D, Zheng ZY, et al. Sigma-1 receptor alleviates airway inflammation and airway remodeling through AMPK/CXCR4 signal pathway. Inflammation, 2022, 45(3): 1298-1312.
47.	Sachdeva K, Do DC, Zhang Y, et al. Environmental exposures and asthma development: autophagy, mitophagy, and cellular senescence. Front Immunol, 2019, 10: 2787.

1. Liu SK, Ma LB, Yuan Y, et al. Alanylglutamine relieved asthma symptoms by regulating gut microbiota and the derived metabolites in mice. Oxid Med Cell Longev, 2020, 2020: 7101407.
2. Aslam M, Ladilov Y. Emerging role of cAMP/AMPK signaling. Cells, 2022, 11(2): 308.
3. Rodríguez C, Muñoz M, Contreras C, et al. AMPK, metabolism, and vascular function. FEBS J, 2021, 288(12): 3746-3771.
4. Yan Y, Mukherjee S, Harikumar KG, et al. Structure of an AMPK complex in an inactive, ATP-bound state. Science, 2021, 373(6553): 413-419.
5. Lin SC, Hardie DG. AMPK: sensing glucose as well as cellular energy status. Cell Metab, 2018, 27(2): 299-313.
6. Hedman AC, Li ZG, Gorisse L, et al. IQGAP1 binds AMPK and is required for maximum AMPK activation. J Biol Chem, 2021, 296: 100075.
7. Neumann D. Is TAK1 a direct upstream kinase of AMPK?. Int J Mol Sci, 2018, 19(8): 2412.
8. Wang JJ, Li JL, Song DY, et al. AMPK: implications in osteoarthritis and therapeutic targets. Am J Transl Res, 2020, 12(12): 7670-7681.
9. Lee H, Zandkarimi F, Zhang YL, et al. Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol, 2020, 22(2): 225-234.
10. Hsu CC, Peng D, Cai Z, et al. AMPK signaling and its targeting in cancer progression and treatment. Semin Cancer Biol, 2022, 85: 52-68.
11. Hollstein PE, Eichner LJ, Brun SN, et al. The AMPK-related kinases SIK1 and SIK3 mediate key tumor-suppressive effects of LKB1 in NSCLC. Cancer Discov, 2019, 9(11): 1606-1627.
12. Shukal DK, Malaviya PB, Sharma T. Role of the AMPK signalling pathway in the aetiopathogenesis of ocular diseases. Hum Exp Toxicol, 2022, 4: 9603271211063165.
13. González A, Hall MN, Lin SC, et al. AMPK and TOR: the Yin and Yang of cellular nutrient sensing and growth control. Cell Metab, 2020, 31(3): 472-492.
14. Yang YX, Jia YF, Ning Y, et al. TAK1-AMPK pathway in macrophages regulates hypothyroid atherosclerosis. Cardiovasc Drugs Ther, 2021, 35(3): 599-612.
15. Jia JY, Bissa B, Brecht L, et al. AMPK, a regulator of metabolism and autophagy, is activated by lysosomal damage via a novel galectin- directed ubiquitin signal transduction system. Mol Cell, 2020, 77(5): 951-969. e9.
16. Hunkeler M, Hagmann A, Stuttfeld E, et al. Structural basis for regulation of human acetyl-CoA carboxylase. Nature, 2018, 558(7710): 470-474.
17. Kim M, Park K, Choi I. The metabolic suppressor 3-iodothyronamine enhances lipolysis in 3T3-L1 adipocytes via activation of the adenosine monophosphate-activated protein kinase/forkhead box O1 signaling pathway. J Physiol Pharmacol, 2020, 71(3): 409-416.
18. Liu YJ, Song A, Yang X, et al. Farnesoid X receptor agonist decreases lipid accumulation by promoting hepatic fatty acid oxidation in db/db mice. Int J Mol Med, 2018, 42(3): 1723-1731.
19. Liu LW, Liu C, Fang L. AMPK-SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane. Mol Med Rep, 2021, 23(1): 56.
20. Ammar RA, Mohamed AF, Kamal MM, et al. Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome. Inflammopharmacology, 2022, 30(3): 919-934.
21. Zhang N, Li P, Lin H, et al. IL-10 ameliorates PM2.5-induced lung injury by activating the AMPK/SIRT1/PGC-1α pathway. Environ Toxicol Pharmacol, 2021, 86: 103659.
22. Gao HJ, Wu H. Maslinic acid activates renal AMPK/SIRT1 signaling pathway and protects against diabetic nephropathy in mice. BMC Endocr Disord, 2022, 22(1): 25.
23. Gao Y, Fan XY, Gu WJ, et al. Hyperoside relieves particulate matter-induced lung injury by inhibiting AMPK/mTOR-mediated autophagy deregulation. Pharmacol Res, 2021, 167: 105561.
24. Hwang HY, Shim JS, Kim D, et al. Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy, 2021, 17(10): 2783-2799.
25. Jie C, Xuan W, Feng HD, et al. AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway. Eur J Med Res, 2021, 26(1): 28.
26. Xu X, Gao WW, Li L, et al. Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia/macrophage polarization via FPR2/ALX-dependent AMPK-mTOR pathway. J Neuroinflammation, 2021, 18(1): 119.
27. Li X, Liu J, Lu QG, et al. AMPK: a therapeutic target of heart failure-not only metabolism regulation. Biosci Rep, 2019, 39(1): BSR20181767.
28. Fang GX, Zhang PL, Liu JF, et al. Inhibition of GSK-3β activity suppresses HCC malignant phenotype by inhibiting glycolysis via activating AMPK/mTOR signaling. Cancer Lett, 2019, 463: 11-26.
29. Finlay DK. N-myristoylation of AMPK controls T cell inflammatory function. Nat Immunol, 2019, 20(3): 252-254.
30. Clark AJ, Parikh SM. Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1α. Kidney Int, 2021, 99(4): 828-840.
31. Liu D, Ma ZQ, Di SY, et al. AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Radic Biol Med, 2018, 129: 59-72.
32. Rahman MS, Kim YS. Mangiferin induces the expression of a thermogenic signature via AMPK signaling during brown-adipocyte differentiation. Food Chem Toxicol, 2020, 141: 111415.
33. Zhu XP, Bian H, Wang L, et al. Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway. Free Radic Biol Med, 2019, 141: 192-204.
34. Meng ZY, Liu Q, Sun FJ, et al. Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling. Lipids Health Dis, 2019, 18(1): 191.
35. Ma WX, Jin QY, Guo HQ, et al. Metformin ameliorates inflammation and airway remodeling of experimental allergic asthma in mice by restoring AMPKα activity. Front Pharmacol, 2022, 13: 780148.
36. Zhu YJ, Wang CY, Luo JJ, et al. The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway. Food Funct, 2021, 12(7): 3120-3131.
37. Luan X, Cui C, Jiang J, et al. Salidroside mitigates airway inflammation in asthmatic mice via the AMPK/Akt/GSK3β signaling pathway. Int Arch Allergy Immunol, 2022, 183(3): 326-336.
38. Xu C, Song YL, Wang ZG, et al. Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO-1 pathways. Immun Inflamm Dis, 2021, 9(4): 1406-1417.
39. Caslin HL, Taruselli MT, Haque T, et al. Inhibiting glycolysis and ATP production attenuates IL-33-mediated mast cell function and peritonitis. Front Immunol, 2018, 9: 3026.
40. You YN, Xing QQ, Zhao X, et al. Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission. Biomed Pharmacother, 2021, 138: 111403.
41. Tsai ML, Tsai YG, Lin YC, et al. IL-25 induced ROS-mediated M2 macrophage polarization via AMPK-associated mitophagy. Int J Mol Sci, 2021, 23(1): 3.
42. Chen XY, Luo YH, Wang MQ, et al. Wuhu decoction regulates dendritic cell autophagy in the treatment of respiratory syncytial virus (RSV)-induced mouse asthma by AMPK/ULK1 signaling pathway. Med Sci Monit, 2019, 25: 5389-5400.
43. Pan YL, Liu L, Zhang QQ, et al. Activation of AMPK suppresses S1P-induced airway smooth muscle cells proliferation and its potential mechanisms. Mol Immunol, 2020, 128: 106-115.
44. Wei YY, Xuan XC, Zhang XY, et al. Niclosamide ethanolamine induces trachea relaxation and inhibits proliferation and migration of trachea smooth muscle cells. Eur J Pharmacol, 2019, 853: 229-235.
45. Liu L, Pan YL, Song Y, et al. Activation of AMPK α2 inhibits airway smooth muscle cells proliferation. Eur J Pharmacol, 2016, 791: 235-243.
46. Jiang T, Zhao D, Zheng ZY, et al. Sigma-1 receptor alleviates airway inflammation and airway remodeling through AMPK/CXCR4 signal pathway. Inflammation, 2022, 45(3): 1298-1312.
47. Sachdeva K, Do DC, Zhang Y, et al. Environmental exposures and asthma development: autophagy, mitophagy, and cellular senescence. Front Immunol, 2019, 10: 2787.

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