鞘脂生物合成调节因子 3与支气管哮喘的相关性及其研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

展楠楠 , 王益德 ,  王玲

新疆医科大学附属中医医院呼吸与危重症医学科三病区（新疆乌鲁木齐 830000）;

Corresponding author：

王玲, Email: 1801904170@qq.com

Keywords：

DOI：

10.7507/1671-6205.202208030

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Citation： 展楠楠, 王益德, 王玲. 鞘脂生物合成调节因子 3与支气管哮喘的相关性及其研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2023, 22(12): 904-908. doi: 10.7507/1671-6205.202208030 Copy

1.	Chiarella SE, Barnes PJ. Endogenous inhibitory mechanisms in asthma. J Allergy Clin Immunol Glob, 2023, 2(4): 100135.
2.	da Silva Santos MAC, Amorim MMF, Caetano LB, et al. Clinical, functional, and inflammatory characteristics of asthma among adults aged over 60 years old: a case-control study. J Asthma, 2023, 60(9): 1653-1660.
3.	Betancor D, Olaguibel JM, Rodrigo-Muñoz JM, et al. Lung function abnormalities and their correlation with clinical characteristics and inflammatory markers in adult asthma. J Investig Allergol Clin Immunol, 2023, 33(4): 294-296.
4.	杜敏, 魏维, 周光红, 等. Th2倾向型典型哮喘与咳嗽变异性哮喘外周血单个核细胞基因表达谱的差异性研究. 中国呼吸与危重监护杂志, 2023, 22(6): 395-402.
5.	Bernstein JA, Llanos JP, Hunter G, et al. Efficacy of biologics in patients with allergic severe asthma, overall and by blood eosinophil count: a literature review. Adv Ther, 2023, 40(11): 4721-4740.
6.	Caughey GH. Update on mast cell proteases as drug targets. Immunol Allergy Clin North Am, 2023, 43(4): 777-787.
7.	Moffatt MF, Kabesch M, Liang LM, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature, 2007, 448(7152): 470-473.
8.	Khoramipour M, Jalali A, Abbasi B, et al. Evaluation of the association between clinical parameters and ADAM33 and ORMDL3 asthma gene single-nucleotide polymorphisms with the severity of COVID-19. Int Immunopharmacol, 2023, 123: 110707.
9.	Nowakowska J, Olechnowicz A, Langwiński W, et al. Increased expression of ORMDL3 in allergic asthma: a case control and in vitro study. J Asthma, 2023, 60(3): 458-467.
10.	Haas-Neil S, Dvorkin-Gheva A, Forsythe P. Severe, but not moderate asthmatics share blood transcriptomic changes with post-traumatic stress disorder and depression. PLoS One, 2022, 17(10): e0275864.
11.	Ding Z, Yu F, Sun Y, et al. ORMDL3 promotes angiogenesis in chronic asthma through the ERK1/2/VEGF/MMP-9 pathway. Front Pediatr, 2022, 9: 708555.
12.	Thio CL, Chang YJ. The modulation of pulmonary group 2 innate lymphoid cell function in asthma: from inflammatory mediators to environmental and metabolic factors. Exp Mol Med, 2023, 55(9): 1872-1884.
13.	Meloun A, León B. Sensing of protease activity as a triggering mechanism of Th2 cell immunity and allergic disease. Front Allergy, 2023, 4: 1265049.
14.	van-der Ploeg EK, Krabbendam L, Vroman H, et al. Type-2 CD8⁺ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations. Nat Commun, 2023, 14(1): 5137.
15.	姚庆美, 陈玥, 黎友伦, 等. 重症哮喘气道上皮细胞损伤机制及潜在生物治疗靶点. 中国呼吸与危重监护杂志, 2022, 21(12): 899-903.
16.	冯净净, 邵川, 李俊卿, 等. 抑制p38丝裂素活化蛋白激酶途径调控Th17和Treg失衡减轻脂多糖诱导的小鼠急性肺损伤. 中国呼吸与危重监护杂志, 2023, 23(1): 44-51.
17.	Liu J, Su BT, Tao PZ, et al. Interplay of IL-33 and IL-35 modulates Th2/Th17 responses in cigarette smoke exposure HDM-Induced asthma[J/OL]. Inflammation, 2023: 10.1007/s10753-023-01902-6. https://link.springer.com/article/10.1007/s10753-023-01902-6.
18.	Jin R, Yuan WX, Xu HG, et al. Characterization of a novel isoform of the human ORMDL3 gene. Cell Tissue Res, 2011, 346(2): 203-208.
19.	Brown RDR, Spiegel S. ORMDL in metabolic health and disease. Pharmacol Ther, 2023, 245: 108401.
20.	Laubhahn K, Böck A, Zeber K, et al. 17q12-21 risk-variants influence cord blood immune regulation and multitrigger-wheeze. Pediatr Allergy Immunol, 2022, 33(2): e13721.
21.	Schedel M, Michel S, Gaertner VD, et al. Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in Th2 cytokine levels. J Allergy Clin Immunol, 2015, 136(4): 893-903, e14.
22.	Lluis A, Schedel M, Liu J, et al. Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion. J Allergy Clin Immunol, 2011, 127(6): 1587-1594, e6.
23.	Adam E, Hansen KK, Astudillo Fernandez O, et al. The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism. J Biol Chem, 2007, 281(11): 6910-6923.
24.	Lee JH, Son SH, Kim NJ, et al. NJK14047 suppression of the p38 MAPK ameliorates OVA-induced allergic asthma during sensitization and challenge periods. Biomol Ther (Seoul), 2023, 31(2): 183-192.
25.	Ma XC, Long F, Yun Y, et al. ORMDL3 and its implication in inflammatory disorders. Int J Rheum Dis, 2018, 21(6): 1154-1162.
26.	Zhao YF, Luo YM, Xiong W, et al. Genetic variation in ORMDL3 gene may contribute to the risk of asthma: a meta-analysis. Hum Immunol, 2014, 75(9): 960-967.
27.	Kitazawa H, Masuko H, Kanazawa J, et al. ORMDL3/GSDMB genotype is associated with distinct phenotypes of adult asthma. Allergol Int, 2021, 70(4): 495-497.
28.	Yu X, Yu C, Ren Z, et al. Genetic variants of 17q21 are associated with childhood-onset asthma and related phenotypes in a northeastern Han Chinese population: a case-control study. Tissue Antigens, 2014, 83(5): 330-336.
29.	Kitazawa H, Masuko H, Kanazawa J, et al. ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization. Allergol Int, 2021, 70(1): 55-60.
30.	王玲, 魏研荣, 王丽霞, 等. 乌鲁木齐地区维吾尔族ORMDL3基因单核苷酸多态位点与哮喘易感性的研究. 分子诊断与治疗杂志, 2019, 11(1): 11-16.
31.	Chen R, Michaeloudes C, Liang YM, et al. ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells. J Allergy Clin Immunol, 2022, 149(4): 1445-1457, e5.
32.	Levin MC, Andersson L, Borén J. Cardiomyocytes, sphingolipids and cardio myotoxicity. Curr Opin Lipidol, 2023, 34(4): 180-188.
33.	Breslow DK, Collins SR, Bodenmiller B, et al. ORM family proteins mediate sphingolipid homeostasis. Nature, 2010, 463(7284): 1048-1053.
34.	Demkova L, Bugajev V, Utekal P, et al. Simultaneous reduction of all ORMDL proteins decreases the threshold of mast cell activation. Sci Rep, 2023, 13(1): 9615.
35.	Li SS, Xie T, Liu P, et al. Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex. Nat Struct Mol Biol, 2021, 28(3): 249-257.
36.	Xie T, Liu P, Wu XY, et al. Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nat Commun, 2023, 14(1): 3475.
37.	Clarke BA, Majumder S, Zhu HL, et al. The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice. Elife, 2019, 8: e51067.
38.	James BN, Weigel C, Green CD, et al. Neutrophilia in severe asthma is reduced in ORMDL3 overexpressing mice. FASEB J, 2023, 37(3): e22799.
39.	Moheimani F, Hsu AC, Reid AT, et al. The genetic and epigenetic landscapes of the epithelium in asthma. Respir Res, 2016, 17(1): 119.
40.	Cantero-Recasens G, Fandos C, Rubio-Moscardo F, et al. The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet, 2010, 19(1): 111-121.
41.	Li J, Ullah MA, Jin HP, et al. ORMDL3 functions as a negative regulator of antigen-mediated mast cell activation via an ATF6-UPR-Autophagy-Dependent pathway. Front Immunol, 2021, 12: 604974.
42.	Wang H, Liu Y, Shi J, et al. ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/2-MMP-9 pathway. Biochem Biophys Res Commun, 2019, 516(3): 739-746.
43.	Peng WP, Xu Y, Zhou YH, et al. Sanzi Yangqin decoction alleviates allergic asthma by modulating Th1/Th2 balance: coupling network pharmacology with biochemical pharmacology. Evid Based Complement Alternat Med, 2022, 2022: 9037154.
44.	张胜碧, 刘燕玲, 李岚. 地龙提取液对卵清蛋白诱导哮喘小鼠气道重塑及肺组织MMP2、MMP9、TIMP-1表达的影响. 中国新药与临床杂志, 2021, 40(7): 523-530.
45.	Duan XJ, Zhang X, Li LR, et al. MiR-200a and miR-200b restrain inflammation by targeting ORMDL3 to regulate the ERK/MMP-9 pathway in asthma. Exp Lung Res, 2020, 46(9): 321-331.
46.	Solberg OD, Ostrin EJ, Love MI, et al. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med, 2012, 186(10): 965-974.

1. Chiarella SE, Barnes PJ. Endogenous inhibitory mechanisms in asthma. J Allergy Clin Immunol Glob, 2023, 2(4): 100135.
2. da Silva Santos MAC, Amorim MMF, Caetano LB, et al. Clinical, functional, and inflammatory characteristics of asthma among adults aged over 60 years old: a case-control study. J Asthma, 2023, 60(9): 1653-1660.
3. Betancor D, Olaguibel JM, Rodrigo-Muñoz JM, et al. Lung function abnormalities and their correlation with clinical characteristics and inflammatory markers in adult asthma. J Investig Allergol Clin Immunol, 2023, 33(4): 294-296.
4. 杜敏, 魏维, 周光红, 等. Th2倾向型典型哮喘与咳嗽变异性哮喘外周血单个核细胞基因表达谱的差异性研究. 中国呼吸与危重监护杂志, 2023, 22(6): 395-402.
5. Bernstein JA, Llanos JP, Hunter G, et al. Efficacy of biologics in patients with allergic severe asthma, overall and by blood eosinophil count: a literature review. Adv Ther, 2023, 40(11): 4721-4740.
6. Caughey GH. Update on mast cell proteases as drug targets. Immunol Allergy Clin North Am, 2023, 43(4): 777-787.
7. Moffatt MF, Kabesch M, Liang LM, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature, 2007, 448(7152): 470-473.
8. Khoramipour M, Jalali A, Abbasi B, et al. Evaluation of the association between clinical parameters and ADAM33 and ORMDL3 asthma gene single-nucleotide polymorphisms with the severity of COVID-19. Int Immunopharmacol, 2023, 123: 110707.
9. Nowakowska J, Olechnowicz A, Langwiński W, et al. Increased expression of ORMDL3 in allergic asthma: a case control and in vitro study. J Asthma, 2023, 60(3): 458-467.
10. Haas-Neil S, Dvorkin-Gheva A, Forsythe P. Severe, but not moderate asthmatics share blood transcriptomic changes with post-traumatic stress disorder and depression. PLoS One, 2022, 17(10): e0275864.
11. Ding Z, Yu F, Sun Y, et al. ORMDL3 promotes angiogenesis in chronic asthma through the ERK1/2/VEGF/MMP-9 pathway. Front Pediatr, 2022, 9: 708555.
12. Thio CL, Chang YJ. The modulation of pulmonary group 2 innate lymphoid cell function in asthma: from inflammatory mediators to environmental and metabolic factors. Exp Mol Med, 2023, 55(9): 1872-1884.
13. Meloun A, León B. Sensing of protease activity as a triggering mechanism of Th2 cell immunity and allergic disease. Front Allergy, 2023, 4: 1265049.
14. van-der Ploeg EK, Krabbendam L, Vroman H, et al. Type-2 CD8⁺ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations. Nat Commun, 2023, 14(1): 5137.
15. 姚庆美, 陈玥, 黎友伦, 等. 重症哮喘气道上皮细胞损伤机制及潜在生物治疗靶点. 中国呼吸与危重监护杂志, 2022, 21(12): 899-903.
16. 冯净净, 邵川, 李俊卿, 等. 抑制p38丝裂素活化蛋白激酶途径调控Th17和Treg失衡减轻脂多糖诱导的小鼠急性肺损伤. 中国呼吸与危重监护杂志, 2023, 23(1): 44-51.
17. Liu J, Su BT, Tao PZ, et al. Interplay of IL-33 and IL-35 modulates Th2/Th17 responses in cigarette smoke exposure HDM-Induced asthma[J/OL]. Inflammation, 2023: 10.1007/s10753-023-01902-6. https://link.springer.com/article/10.1007/s10753-023-01902-6.
18. Jin R, Yuan WX, Xu HG, et al. Characterization of a novel isoform of the human ORMDL3 gene. Cell Tissue Res, 2011, 346(2): 203-208.
19. Brown RDR, Spiegel S. ORMDL in metabolic health and disease. Pharmacol Ther, 2023, 245: 108401.
20. Laubhahn K, Böck A, Zeber K, et al. 17q12-21 risk-variants influence cord blood immune regulation and multitrigger-wheeze. Pediatr Allergy Immunol, 2022, 33(2): e13721.
21. Schedel M, Michel S, Gaertner VD, et al. Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in Th2 cytokine levels. J Allergy Clin Immunol, 2015, 136(4): 893-903, e14.
22. Lluis A, Schedel M, Liu J, et al. Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion. J Allergy Clin Immunol, 2011, 127(6): 1587-1594, e6.
23. Adam E, Hansen KK, Astudillo Fernandez O, et al. The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism. J Biol Chem, 2007, 281(11): 6910-6923.
24. Lee JH, Son SH, Kim NJ, et al. NJK14047 suppression of the p38 MAPK ameliorates OVA-induced allergic asthma during sensitization and challenge periods. Biomol Ther (Seoul), 2023, 31(2): 183-192.
25. Ma XC, Long F, Yun Y, et al. ORMDL3 and its implication in inflammatory disorders. Int J Rheum Dis, 2018, 21(6): 1154-1162.
26. Zhao YF, Luo YM, Xiong W, et al. Genetic variation in ORMDL3 gene may contribute to the risk of asthma: a meta-analysis. Hum Immunol, 2014, 75(9): 960-967.
27. Kitazawa H, Masuko H, Kanazawa J, et al. ORMDL3/GSDMB genotype is associated with distinct phenotypes of adult asthma. Allergol Int, 2021, 70(4): 495-497.
28. Yu X, Yu C, Ren Z, et al. Genetic variants of 17q21 are associated with childhood-onset asthma and related phenotypes in a northeastern Han Chinese population: a case-control study. Tissue Antigens, 2014, 83(5): 330-336.
29. Kitazawa H, Masuko H, Kanazawa J, et al. ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization. Allergol Int, 2021, 70(1): 55-60.
30. 王玲, 魏研荣, 王丽霞, 等. 乌鲁木齐地区维吾尔族ORMDL3基因单核苷酸多态位点与哮喘易感性的研究. 分子诊断与治疗杂志, 2019, 11(1): 11-16.
31. Chen R, Michaeloudes C, Liang YM, et al. ORMDL3 regulates cigarette smoke-induced endoplasmic reticulum stress in airway smooth muscle cells. J Allergy Clin Immunol, 2022, 149(4): 1445-1457, e5.
32. Levin MC, Andersson L, Borén J. Cardiomyocytes, sphingolipids and cardio myotoxicity. Curr Opin Lipidol, 2023, 34(4): 180-188.
33. Breslow DK, Collins SR, Bodenmiller B, et al. ORM family proteins mediate sphingolipid homeostasis. Nature, 2010, 463(7284): 1048-1053.
34. Demkova L, Bugajev V, Utekal P, et al. Simultaneous reduction of all ORMDL proteins decreases the threshold of mast cell activation. Sci Rep, 2023, 13(1): 9615.
35. Li SS, Xie T, Liu P, et al. Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex. Nat Struct Mol Biol, 2021, 28(3): 249-257.
36. Xie T, Liu P, Wu XY, et al. Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nat Commun, 2023, 14(1): 3475.
37. Clarke BA, Majumder S, Zhu HL, et al. The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice. Elife, 2019, 8: e51067.
38. James BN, Weigel C, Green CD, et al. Neutrophilia in severe asthma is reduced in ORMDL3 overexpressing mice. FASEB J, 2023, 37(3): e22799.
39. Moheimani F, Hsu AC, Reid AT, et al. The genetic and epigenetic landscapes of the epithelium in asthma. Respir Res, 2016, 17(1): 119.
40. Cantero-Recasens G, Fandos C, Rubio-Moscardo F, et al. The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet, 2010, 19(1): 111-121.
41. Li J, Ullah MA, Jin HP, et al. ORMDL3 functions as a negative regulator of antigen-mediated mast cell activation via an ATF6-UPR-Autophagy-Dependent pathway. Front Immunol, 2021, 12: 604974.
42. Wang H, Liu Y, Shi J, et al. ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/2-MMP-9 pathway. Biochem Biophys Res Commun, 2019, 516(3): 739-746.
43. Peng WP, Xu Y, Zhou YH, et al. Sanzi Yangqin decoction alleviates allergic asthma by modulating Th1/Th2 balance: coupling network pharmacology with biochemical pharmacology. Evid Based Complement Alternat Med, 2022, 2022: 9037154.
44. 张胜碧, 刘燕玲, 李岚. 地龙提取液对卵清蛋白诱导哮喘小鼠气道重塑及肺组织MMP2、MMP9、TIMP-1表达的影响. 中国新药与临床杂志, 2021, 40(7): 523-530.
45. Duan XJ, Zhang X, Li LR, et al. MiR-200a and miR-200b restrain inflammation by targeting ORMDL3 to regulate the ERK/MMP-9 pathway in asthma. Exp Lung Res, 2020, 46(9): 321-331.
46. Solberg OD, Ostrin EJ, Love MI, et al. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med, 2012, 186(10): 965-974.

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鞘脂生物合成调节因子 3与支气管哮喘的相关性及其研究进展

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