A retrospective study to evaluate the efficacy and safety of CT-guided percutaneous and cone beam CT-guided transbronchial ablation for multiple primary lung cancer_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

HUANG Zhihong , CHEN Junxiang , XIE Fangfang , ZHENG Xiaoxuan ,  SUN Jiayuan

Department of Respiratory Endoscopy, Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, P. R. China;

Corresponding author：

SUN Jiayuan, Email: xkyyjysun@163.com

Keywords：

Multiple primary lung cancer; percutaneous; transbronchial; ablation therapy; cone beam computed tomography

DOI：

10.7507/1671-6205.202210090

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous and cone beam CT-guided transbronchial ablation in the treatment of early multiple primary lung cancer (MPLC). Methods Retrospective analysis was performed on patients who met inclusion criteria in Shanghai Chest Hospital between May 2020 to June 2022. According to ablation pathway, lesions were divided into two groups: percutaneous ablation group and transbronchial ablation group. Results A total of 13 MPLC patients with 26 lesions were included (14 percutaneous ablation and 12 transbronchial ablation). There were no statistically significant differences in solid component, lesion location, lung field and lesion size between the two groups. The distance from the parietal pleura in the transbronchial ablation group was longer than that in percutaneous ablation group (P=0.03). The median follow-up period time were 13 months and 12 months for group percutaneous ablation and transbronchial ablation. No significant differences were found in 3-month complete ablation rate (100.0% vs. 83.3%), 1-year local control rate (100.0% vs. 91.7%) and severe complication rate (7.1% vs. 16.7%). The minor complication rate in percutaneous ablation group was higher than that in transbronchial ablation group (50.0% vs 0.0%, P=0.02). Conclusions Percutaneous ablation and transbronchial ablation have high efficacy and safety, and the latter involves lower minor complication rate. They complement each other, which provide the individualized treatments for early MPLC patients who are not suitable for or refuse surgery.

Citation： HUANG Zhihong, CHEN Junxiang, XIE Fangfang, ZHENG Xiaoxuan, SUN Jiayuan. A retrospective study to evaluate the efficacy and safety of CT-guided percutaneous and cone beam CT-guided transbronchial ablation for multiple primary lung cancer. Chinese Journal of Respiratory and Critical Care Medicine, 2022, 21(10): 704-709. doi: 10.7507/1671-6205.202210090 Copy

1.	Chen WQ, Zheng RS, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2.	Tie HT, Luo J, Shi R, et al. Characteristics and prognosis of synchronous multiple primary lung cancer after surgical treatment: A systematic review and meta-analysis of current evidence. Cancer Med, 2021, 10(2): 507-520.
3.	郏琴, 孙依萍, 蔡蓉, 等. 肺内同时性多原发癌的临床诊断与治疗. 中国呼吸与危重监护杂志, 2012, 11(6): 550-553.
4.	Amin SA, Alam M, Baine MJ, et al. The impact of stereotactic body radiation therapy on the overall survival of patients diagnosed with early-stage non-small cell lung cancer. Radiother Oncol, 2021, 155: 254-260.
5.	Moding EJ, Liang R, Lartey FM, et al. Predictors of respiratory decline following stereotactic ablative radiotherapy to multiple lung tumors. Clin Lung Cancer, 2019, 20(6): 461-468. e462.
6.	Zemlyak A, Moore WH, Bilfinger TV. Comparison of survival after sublobar resections and ablative therapies for stage Ⅰ non-small cell lung cancer. J Am Coll Surg, 2010, 211(1): 68-72.
7.	Wang YZ, Liu B, Cao PK, et al. Comparison between computed tomography-guided percutaneous microwave ablation and thoracoscopic lobectomy for stage Ⅰ non-small cell lung cancer. Thorac Cancer, 2018, 9(11): 1376-1382.
8.	Kheir F, Thakore SR, Uribe Becerra JP, t al. Cone-Beam Computed Tomography-Guided Electromagnetic Navigation for Peripheral Lung Nodules. Respiration, 2021, 100(1): 44-51.
9.	Chen JX, Xie FF, Zheng XX, et al. Mobile 3-dimensional (3D) C-arm system-assisted transbronchial biopsy and ablation for ground-glass opacity pulmonary nodules: a case report. Transl Lung Cancer Res, 2021, 10(7): 3312-3319.
10.	Detterbeck FC, Franklin WA, Nicholson AG, et al. The IASLC Lung Cancer Staging Project: Background Data and Proposed Criteria to Distinguish Separate Primary Lung Cancers from Metastatic Foci in Patients with Two Lung Tumors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer. J Thorac Oncol, 2016, 11(5): 651-665.
11.	中国临床肿瘤学会肿瘤消融治疗专家委员会, 中国医师协会肿瘤消融治疗技术专家组, 中国抗癌协会肿瘤消融治疗专业委员会, 等.影像引导下热消融治疗原发性和转移性肺部肿瘤临床实践指南(2021年版). 中华内科杂志, 2021, 60(12): 1088-1105.
12.	Sacks D, McClenny TE, Cardella JF, et al. Society of Interventional Radiology Clinical Practice Guidelines. J Vasc Interv Radiol, 2003, 14(9 Pt 2): S199-S202.
13.	温敬利, 王馨雨, 顾书君, 等. 多原发肺癌临床诊治进展. 中华结核和呼吸杂志, 2022, 45(8): 826-834.
14.	Liu B, Ye X. Management of pulmonary multifocal ground-glass nodules: How many options do we have?. J Cancer Res Ther, 2020, 16(2): 199-202.
15.	孔晨, 白冲. 经支气管镜治疗周围型肺癌. 中华结核和呼吸杂志, 2020, 43(6): 534-539.
16.	傅毅立, 张文谦, 陈硕, 等. CT引导经皮与电磁导航引导经支气管微波消融治疗肺磨玻璃结节近期疗效对比. 中华医学杂志, 2021, 101(33): 2576-2581.
17.	Xie FF, Chen JX, Jiang YF, et al. Microwave ablation via a flexible catheter for the treatment of nonsurgical peripheral lung cancer: a pilot study. Thorac Cancer, 2022, 13(7): 1014-1020.
18.	Qu RR, Tu DH, Hu SJ, et al. Electromagnetic navigation bronchoscopy-guided microwave ablation combined with uniportal video-assisted thoracoscopic surgery for multiple ground glass opacities. Ann Thorac Surg, 2022, 113(4): 1307-1315.
19.	Bao FC, Yu FH, Wang R, et al. Electromagnetic bronchoscopy guided microwave ablation for early stage lung cancer presenting as ground glass nodule. Transl Lung Cancer Res, 2021, 10(9): 3759-3770.
20.	Cazzato RL, Battistuzzi JB, Catena V, et al. Cone-beam computed tomography (CBCT) versus CT in lung ablation procedure: which is faster?. Cardiovasc Intervent Radiol, 2015, 38(5): 1231-1236.
21.	Huang GH, Yang X, Li WH, et al. A feasibility and safety study of computed tomography-guided percutaneous microwave ablation: a novel therapy for multiple synchronous ground-glass opacities of the lung. Int J Hyperthermia, 2020, 37(1): 414-422.
22.	Chan JWY, Lau RWH, Ngai JCL, et al. Transbronchial microwave ablation of lung nodules with electromagnetic navigation bronchoscopy guidance - a novel technique and initial experience with 30 cases. Transl Lung Cancer Res, 2021, 10(4): 1608-1622.
23.	Ye X, Fan WJ, Wang ZM, et al. Clinical Practice Guidelines on Image-Guided Thermal Ablation of Primary and Metastatic Lung Tumors (2022 Edition). J Cancer Res Ther, 2022, 18(5): 1213-1230.
24.	Han YJ, Kim HJ, Kong KA, et al. Diagnosis of small pulmonary lesions by transbronchial lung biopsy with radial endobronchial ultrasound and virtual bronchoscopic navigation versus CT-guided transthoracic needle biopsy: a systematic review and meta-analysis. PLoS One, 2018, 13(1): e0191590.

1. Chen WQ, Zheng RS, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
2. Tie HT, Luo J, Shi R, et al. Characteristics and prognosis of synchronous multiple primary lung cancer after surgical treatment: A systematic review and meta-analysis of current evidence. Cancer Med, 2021, 10(2): 507-520.
3. 郏琴, 孙依萍, 蔡蓉, 等. 肺内同时性多原发癌的临床诊断与治疗. 中国呼吸与危重监护杂志, 2012, 11(6): 550-553.
4. Amin SA, Alam M, Baine MJ, et al. The impact of stereotactic body radiation therapy on the overall survival of patients diagnosed with early-stage non-small cell lung cancer. Radiother Oncol, 2021, 155: 254-260.
5. Moding EJ, Liang R, Lartey FM, et al. Predictors of respiratory decline following stereotactic ablative radiotherapy to multiple lung tumors. Clin Lung Cancer, 2019, 20(6): 461-468. e462.
6. Zemlyak A, Moore WH, Bilfinger TV. Comparison of survival after sublobar resections and ablative therapies for stage Ⅰ non-small cell lung cancer. J Am Coll Surg, 2010, 211(1): 68-72.
7. Wang YZ, Liu B, Cao PK, et al. Comparison between computed tomography-guided percutaneous microwave ablation and thoracoscopic lobectomy for stage Ⅰ non-small cell lung cancer. Thorac Cancer, 2018, 9(11): 1376-1382.
8. Kheir F, Thakore SR, Uribe Becerra JP, t al. Cone-Beam Computed Tomography-Guided Electromagnetic Navigation for Peripheral Lung Nodules. Respiration, 2021, 100(1): 44-51.
9. Chen JX, Xie FF, Zheng XX, et al. Mobile 3-dimensional (3D) C-arm system-assisted transbronchial biopsy and ablation for ground-glass opacity pulmonary nodules: a case report. Transl Lung Cancer Res, 2021, 10(7): 3312-3319.
10. Detterbeck FC, Franklin WA, Nicholson AG, et al. The IASLC Lung Cancer Staging Project: Background Data and Proposed Criteria to Distinguish Separate Primary Lung Cancers from Metastatic Foci in Patients with Two Lung Tumors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer. J Thorac Oncol, 2016, 11(5): 651-665.
11. 中国临床肿瘤学会肿瘤消融治疗专家委员会, 中国医师协会肿瘤消融治疗技术专家组, 中国抗癌协会肿瘤消融治疗专业委员会, 等.影像引导下热消融治疗原发性和转移性肺部肿瘤临床实践指南(2021年版). 中华内科杂志, 2021, 60(12): 1088-1105.
12. Sacks D, McClenny TE, Cardella JF, et al. Society of Interventional Radiology Clinical Practice Guidelines. J Vasc Interv Radiol, 2003, 14(9 Pt 2): S199-S202.
13. 温敬利, 王馨雨, 顾书君, 等. 多原发肺癌临床诊治进展. 中华结核和呼吸杂志, 2022, 45(8): 826-834.
14. Liu B, Ye X. Management of pulmonary multifocal ground-glass nodules: How many options do we have?. J Cancer Res Ther, 2020, 16(2): 199-202.
15. 孔晨, 白冲. 经支气管镜治疗周围型肺癌. 中华结核和呼吸杂志, 2020, 43(6): 534-539.
16. 傅毅立, 张文谦, 陈硕, 等. CT引导经皮与电磁导航引导经支气管微波消融治疗肺磨玻璃结节近期疗效对比. 中华医学杂志, 2021, 101(33): 2576-2581.
17. Xie FF, Chen JX, Jiang YF, et al. Microwave ablation via a flexible catheter for the treatment of nonsurgical peripheral lung cancer: a pilot study. Thorac Cancer, 2022, 13(7): 1014-1020.
18. Qu RR, Tu DH, Hu SJ, et al. Electromagnetic navigation bronchoscopy-guided microwave ablation combined with uniportal video-assisted thoracoscopic surgery for multiple ground glass opacities. Ann Thorac Surg, 2022, 113(4): 1307-1315.
19. Bao FC, Yu FH, Wang R, et al. Electromagnetic bronchoscopy guided microwave ablation for early stage lung cancer presenting as ground glass nodule. Transl Lung Cancer Res, 2021, 10(9): 3759-3770.
20. Cazzato RL, Battistuzzi JB, Catena V, et al. Cone-beam computed tomography (CBCT) versus CT in lung ablation procedure: which is faster?. Cardiovasc Intervent Radiol, 2015, 38(5): 1231-1236.
21. Huang GH, Yang X, Li WH, et al. A feasibility and safety study of computed tomography-guided percutaneous microwave ablation: a novel therapy for multiple synchronous ground-glass opacities of the lung. Int J Hyperthermia, 2020, 37(1): 414-422.
22. Chan JWY, Lau RWH, Ngai JCL, et al. Transbronchial microwave ablation of lung nodules with electromagnetic navigation bronchoscopy guidance - a novel technique and initial experience with 30 cases. Transl Lung Cancer Res, 2021, 10(4): 1608-1622.
23. Ye X, Fan WJ, Wang ZM, et al. Clinical Practice Guidelines on Image-Guided Thermal Ablation of Primary and Metastatic Lung Tumors (2022 Edition). J Cancer Res Ther, 2022, 18(5): 1213-1230.
24. Han YJ, Kim HJ, Kong KA, et al. Diagnosis of small pulmonary lesions by transbronchial lung biopsy with radial endobronchial ultrasound and virtual bronchoscopic navigation versus CT-guided transthoracic needle biopsy: a systematic review and meta-analysis. PLoS One, 2018, 13(1): e0191590.

Chinese Journal of Respiratory and Critical Care Medicine

A retrospective study to evaluate the efficacy and safety of CT-guided percutaneous and cone beam CT-guided transbronchial ablation for multiple primary lung cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content