支气管循环生理及其在不同肺疾病中的病理变化_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

刘芸 , 林雪 ,  王业

四川大学华西医院呼吸与危重症医学科（四川成都 610041）;

Corresponding author：

王业, Email: doctordream0630@163.com

Keywords：

DOI：

10.7507/1671-6205.202409064

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Citation： 刘芸, 林雪, 王业. 支气管循环生理及其在不同肺疾病中的病理变化. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(2): 135-139. doi: 10.7507/1671-6205.202409064 Copy

1.	Mitzner W, Wagner E. On the purported discovery of the bronchial circulation by Leonardo da Vinci. J Aappl physiol (1985), 1992, 73(3): 1196-1201.
2.	Suresh K, Shimoda LA. Lung Circulation. Compr Physiol. 2016, 6(2): 897-943.
3.	Charan NB, Turk GM, Dhand R. Gross and subgross anatomy of bronchial circulation in sheep. J Appl Physiol Respir Environ Exerc Physiolo, 1984, 57(3): 658-664.
4.	Hartmann IJ, Remy-Jardin M, Menchini L, et al. Ectopic origin of bronchial arteries: assessment with multidetector helical CT angiography. Eur Radiol, 2007, 17(8): 1943-1953.
5.	Lee CM, Leung TK, Wang HJ, et al. Identification of a Coronary-to-Bronchial-Artery Communication With MDCT Shows the Diagnostic Potential of This New Technology Case Report and Review. J Thorac Imaging, 2007, 22(3): 274-276.
6.	Walker CM, Rosado-de-Christenson ML, Martinez-Jimenez S, et al. Bronchial arteries: anatomy, function, hypertrophy, and anomalies. Radiographics, 2015, 35(1): 32-49.
7.	Parsons GH, Bommer WJ, Siefkin AD, et al. Drainage routes of bronchial blood flow in anaesthetized sheep. Pulm Pharmacol Ther, 2007, 20(2): 109-111.
8.	Schraufnagel DE, Pearse DB, Mitzner WA, et al. Three-dimensional structure of the bronchial microcirculation in sheep. Anat Rec, 1995, 243(3): 357-366.
9.	Saidel GM, Kruse KL, Primiano FP Jr. Model Simulation of Heat and Water Transport Dynamics in an Airway. J Biomech Eng, 1983, 105(2): 188-193.
10.	Lakshminarayan S, Agostoni PG, Kirk W. Vagal cooling and positive end-expiratory pressure reduce systemic to pulmonary bronchial blood flow in dogs. Respiration, 1990, 57(2): 85-89.
11.	Abdi S, Traber LD, Herndon DN, et al. Bronchial blood flow reduction with positive end-expiratory pressure after acute lung injury. Crit Care Med, 1990, 18(10): 1152-1157.
12.	Wagner EM, Mitzner WA, Bleecker ER. Effects of airway pressure on bronchial blood flow. J Appl Physiol(1985), 1987, 62(2): 561-566.
13.	Behera D, Bernard S, Butler J, et al. Positive end expiratory pressure reduces bronchial blood flow after aspiration injury. Respiration, 1995, 62(1): 10-15.
14.	Sherrier RH, Chiles C, Newman GE. Chronic multiple pulmonary emboli. Regional response of the bronchial circulation. Invest Radiol, 1989, 24(6): 437-441.
15.	Humbert M, Guignabert C, Bonnet S, et al. Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives. Eur Respir J, 2019, 53(1): 1801887.
16.	Lung MA, Wang JC, Cheng KK. Bronchial circulation: an auto-perfusion method for assessing its vasomotor activity and the study of alpha- and beta-adrenoceptors in the bronchial artery. Life Sci, 1976, 19(4): 577-580.
17.	Martling CR, Matran R, Alving K, et al. Innervation of lower airways and neuropeptide effects on bronchial and vascular tone in the pig. Cell Tissue Res, 1990, 260(2): 223-233.
18.	Lim LH, Bochner BS, Wagner EM. Leukocyte recruitment in the airways: an intravital microscopic study of rat tracheal microcirculation. Am J Physiol Lung Cell Mol Physiol, 2002, 282(5): L959-967.
19.	Wagner EM, Foster WM. Importance of airway blood flow on particle clearance from the lung. J Appli Physiol (1985), 1996, 81(5): 1878-1883.
20.	Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary. Am J Respir Crit Care Med, 2017, 195(5): 557-82.
21.	Davis BB, Shen YH, Tancredi DJ, et al. Leukocytes are recruited through the bronchial circulation to the lung in a spontaneously hypertensive rat model of COPD. PLoS One, 2012, 7(3): e33304.
22.	Paredi P, Barnes PJ. The airway vasculature: recent advances and clinical implications. Thorax, 2009, 64(5): 444-450.
23.	Louise M, Harkness VK, Hari S Sharma, et al. Pulmonary vascular changes in asthma and COPD. Pulm Pharmacol Ther, 2014, 29(2): 144-155.
24.	Reddel HK, Bacharier LB, Bateman ED, et al. Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes. Eur Respir J., 2021, 59(1): 2102730.
25.	Rossi RC, Anonni R, Ferreira DS, et al. Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma. Allergy, Asthma Clin Immunol, 2019, 15(1): 50.
26.	Wilson J. The bronchial microcirculation in asthma. Clin Exp Allergy, 2000, 30 Suppl(1): 51-3.
27.	Galambos C, Bates ML, Bush D, et al. Prominent Bronchopulmonary Vascular Anastomoses in Fatal Childhood Asthma. Ann Am Thorac Soc. 2018, 15(11): 1359-1362.
28.	Green FH, Butt JC, James AL, et al. Abnormalities of the bronchial arteries in asthma. Chest. 2006, 130(4): 1025-33.
29.	Kim KH, Hur J, Lee HY, et al. Cyclo-VEGI inhibits bronchial artery remodeling in a murine model of chronic asthma. Exp Lung Res, 2021, 47(10): 494-506.
30.	Visser SK, Bye P, Morgan L. Management of bronchiectasis in adults. Med J Aust, 2018, 209(4): 177-183.
31.	陈永富伍筱梅. 支气管扩张症的血管病变研究进展. 中国影像技术, 2005, 21(1): 147-9.
32.	LIEBOW AA, HALES MR, LINDSKOG GE. Enlargement of the bronchial arteries, and their anastomoses with the pulmonary arteries in bronchiectasis. Am J Pathol, 1949, 25(2): 211-231.
33.	Lu GD, Yan HT, Zhang JX, et al. Bronchial artery embolization for the management of frequent hemoptysis caused by bronchiectasis. BMC Pulm Med, 2022, 22(1): 394.
34.	Wiseman NE, Reed MH. Bronchopulmonary arterial malformation occurring in aspergillus lung infection complicating chronic granulomatous disease. J Pediatr Surg, 1981, 16(4): 457-460.
35.	Kathuria H, Hollingsworth HM, Vilvendhan R, et al. Management of life-threatening hemoptysis. J Intensive Care, 2020, 8(1): 23.
36.	Ando T, Kawashim M, Masuda K, et al. Exacerbation of chronic pulmonary aspergillosis was associated with a high rebleeding rate after bronchial artery embolization. Respir Investig, 2019, 57(3): 260-267.
37.	Sarioglu O, Capar AE, Yavuz MY, et al. Angiographic Findings and Outcomes of Bronchial Artery Embolization in Patients with Pulmonary Tuberculosis. Eur J med, 2020, 52(2): 126-31.
38.	Ghonge NP. Bronchial Artery Pseudoaneurysm from a Tuberculous Lymph Node. Radiology, 2021, 300(1): 37-37.
39.	Lin Q, Chen J, Yu T, et al. Risk factors for the recurrence in pulmonary tuberculosis patients with massive hemoptysis. Clin Respir J, 2023, 17(7): 663-671.
40.	Chau Y, Arnoffi P, Mondot L, et al. Bronchial Artery Angiographic Aspects of COVID-19. J Vasc Interv Radiol, 2022, 33(1): 89.
41.	Braithwaite SA, Kearns DJ, Douglas E, et al. Delayed Post COVID-19 Bronchial Artery Pseudoaneurysm Treated with Embolisation: Letter to the Editor. Cardiovasc Intervent Radiol, 2021, 44(10): 1663-1664.
42.	Ackermann M, Tafforeau P, Wagner WL, et al. The Bronchial Circulation in COVID-19 Pneumonia. Am J Respir Crit Care Med, 2022, 205(1): 121-25.
43.	Barral M, Sirol M, El Hajjam M, et al. Bronchial Artery Embolization Performed in COVID-19 Patients: Tolerance and Outcomes. Cardiovasc Intervent Radiol, 2020, 43(12): 1949-1951.
44.	Kaptein FHJ, Kroft LJM, Hammerschlag G, et al. Pulmonary infarction in acute pulmonary embolism. Thromb Res, 2021, 202: 162-69.
45.	Lang IM, Dorfmüller P, Vonk Noordegraaf AV. The Pathobiology of Chronic Thromboembolic Pulmonary Hypertension. Ann Am Thorac Soc, 2016, 13(Suppl 3): S215-S221.

1. Mitzner W, Wagner E. On the purported discovery of the bronchial circulation by Leonardo da Vinci. J Aappl physiol (1985), 1992, 73(3): 1196-1201.
2. Suresh K, Shimoda LA. Lung Circulation. Compr Physiol. 2016, 6(2): 897-943.
3. Charan NB, Turk GM, Dhand R. Gross and subgross anatomy of bronchial circulation in sheep. J Appl Physiol Respir Environ Exerc Physiolo, 1984, 57(3): 658-664.
4. Hartmann IJ, Remy-Jardin M, Menchini L, et al. Ectopic origin of bronchial arteries: assessment with multidetector helical CT angiography. Eur Radiol, 2007, 17(8): 1943-1953.
5. Lee CM, Leung TK, Wang HJ, et al. Identification of a Coronary-to-Bronchial-Artery Communication With MDCT Shows the Diagnostic Potential of This New Technology Case Report and Review. J Thorac Imaging, 2007, 22(3): 274-276.
6. Walker CM, Rosado-de-Christenson ML, Martinez-Jimenez S, et al. Bronchial arteries: anatomy, function, hypertrophy, and anomalies. Radiographics, 2015, 35(1): 32-49.
7. Parsons GH, Bommer WJ, Siefkin AD, et al. Drainage routes of bronchial blood flow in anaesthetized sheep. Pulm Pharmacol Ther, 2007, 20(2): 109-111.
8. Schraufnagel DE, Pearse DB, Mitzner WA, et al. Three-dimensional structure of the bronchial microcirculation in sheep. Anat Rec, 1995, 243(3): 357-366.
9. Saidel GM, Kruse KL, Primiano FP Jr. Model Simulation of Heat and Water Transport Dynamics in an Airway. J Biomech Eng, 1983, 105(2): 188-193.
10. Lakshminarayan S, Agostoni PG, Kirk W. Vagal cooling and positive end-expiratory pressure reduce systemic to pulmonary bronchial blood flow in dogs. Respiration, 1990, 57(2): 85-89.
11. Abdi S, Traber LD, Herndon DN, et al. Bronchial blood flow reduction with positive end-expiratory pressure after acute lung injury. Crit Care Med, 1990, 18(10): 1152-1157.
12. Wagner EM, Mitzner WA, Bleecker ER. Effects of airway pressure on bronchial blood flow. J Appl Physiol(1985), 1987, 62(2): 561-566.
13. Behera D, Bernard S, Butler J, et al. Positive end expiratory pressure reduces bronchial blood flow after aspiration injury. Respiration, 1995, 62(1): 10-15.
14. Sherrier RH, Chiles C, Newman GE. Chronic multiple pulmonary emboli. Regional response of the bronchial circulation. Invest Radiol, 1989, 24(6): 437-441.
15. Humbert M, Guignabert C, Bonnet S, et al. Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives. Eur Respir J, 2019, 53(1): 1801887.
16. Lung MA, Wang JC, Cheng KK. Bronchial circulation: an auto-perfusion method for assessing its vasomotor activity and the study of alpha- and beta-adrenoceptors in the bronchial artery. Life Sci, 1976, 19(4): 577-580.
17. Martling CR, Matran R, Alving K, et al. Innervation of lower airways and neuropeptide effects on bronchial and vascular tone in the pig. Cell Tissue Res, 1990, 260(2): 223-233.
18. Lim LH, Bochner BS, Wagner EM. Leukocyte recruitment in the airways: an intravital microscopic study of rat tracheal microcirculation. Am J Physiol Lung Cell Mol Physiol, 2002, 282(5): L959-967.
19. Wagner EM, Foster WM. Importance of airway blood flow on particle clearance from the lung. J Appli Physiol (1985), 1996, 81(5): 1878-1883.
20. Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary. Am J Respir Crit Care Med, 2017, 195(5): 557-82.
21. Davis BB, Shen YH, Tancredi DJ, et al. Leukocytes are recruited through the bronchial circulation to the lung in a spontaneously hypertensive rat model of COPD. PLoS One, 2012, 7(3): e33304.
22. Paredi P, Barnes PJ. The airway vasculature: recent advances and clinical implications. Thorax, 2009, 64(5): 444-450.
23. Louise M, Harkness VK, Hari S Sharma, et al. Pulmonary vascular changes in asthma and COPD. Pulm Pharmacol Ther, 2014, 29(2): 144-155.
24. Reddel HK, Bacharier LB, Bateman ED, et al. Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes. Eur Respir J., 2021, 59(1): 2102730.
25. Rossi RC, Anonni R, Ferreira DS, et al. Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma. Allergy, Asthma Clin Immunol, 2019, 15(1): 50.
26. Wilson J. The bronchial microcirculation in asthma. Clin Exp Allergy, 2000, 30 Suppl(1): 51-3.
27. Galambos C, Bates ML, Bush D, et al. Prominent Bronchopulmonary Vascular Anastomoses in Fatal Childhood Asthma. Ann Am Thorac Soc. 2018, 15(11): 1359-1362.
28. Green FH, Butt JC, James AL, et al. Abnormalities of the bronchial arteries in asthma. Chest. 2006, 130(4): 1025-33.
29. Kim KH, Hur J, Lee HY, et al. Cyclo-VEGI inhibits bronchial artery remodeling in a murine model of chronic asthma. Exp Lung Res, 2021, 47(10): 494-506.
30. Visser SK, Bye P, Morgan L. Management of bronchiectasis in adults. Med J Aust, 2018, 209(4): 177-183.
31. 陈永富伍筱梅. 支气管扩张症的血管病变研究进展. 中国影像技术, 2005, 21(1): 147-9.
32. LIEBOW AA, HALES MR, LINDSKOG GE. Enlargement of the bronchial arteries, and their anastomoses with the pulmonary arteries in bronchiectasis. Am J Pathol, 1949, 25(2): 211-231.
33. Lu GD, Yan HT, Zhang JX, et al. Bronchial artery embolization for the management of frequent hemoptysis caused by bronchiectasis. BMC Pulm Med, 2022, 22(1): 394.
34. Wiseman NE, Reed MH. Bronchopulmonary arterial malformation occurring in aspergillus lung infection complicating chronic granulomatous disease. J Pediatr Surg, 1981, 16(4): 457-460.
35. Kathuria H, Hollingsworth HM, Vilvendhan R, et al. Management of life-threatening hemoptysis. J Intensive Care, 2020, 8(1): 23.
36. Ando T, Kawashim M, Masuda K, et al. Exacerbation of chronic pulmonary aspergillosis was associated with a high rebleeding rate after bronchial artery embolization. Respir Investig, 2019, 57(3): 260-267.
37. Sarioglu O, Capar AE, Yavuz MY, et al. Angiographic Findings and Outcomes of Bronchial Artery Embolization in Patients with Pulmonary Tuberculosis. Eur J med, 2020, 52(2): 126-31.
38. Ghonge NP. Bronchial Artery Pseudoaneurysm from a Tuberculous Lymph Node. Radiology, 2021, 300(1): 37-37.
39. Lin Q, Chen J, Yu T, et al. Risk factors for the recurrence in pulmonary tuberculosis patients with massive hemoptysis. Clin Respir J, 2023, 17(7): 663-671.
40. Chau Y, Arnoffi P, Mondot L, et al. Bronchial Artery Angiographic Aspects of COVID-19. J Vasc Interv Radiol, 2022, 33(1): 89.
41. Braithwaite SA, Kearns DJ, Douglas E, et al. Delayed Post COVID-19 Bronchial Artery Pseudoaneurysm Treated with Embolisation: Letter to the Editor. Cardiovasc Intervent Radiol, 2021, 44(10): 1663-1664.
42. Ackermann M, Tafforeau P, Wagner WL, et al. The Bronchial Circulation in COVID-19 Pneumonia. Am J Respir Crit Care Med, 2022, 205(1): 121-25.
43. Barral M, Sirol M, El Hajjam M, et al. Bronchial Artery Embolization Performed in COVID-19 Patients: Tolerance and Outcomes. Cardiovasc Intervent Radiol, 2020, 43(12): 1949-1951.
44. Kaptein FHJ, Kroft LJM, Hammerschlag G, et al. Pulmonary infarction in acute pulmonary embolism. Thromb Res, 2021, 202: 162-69.
45. Lang IM, Dorfmüller P, Vonk Noordegraaf AV. The Pathobiology of Chronic Thromboembolic Pulmonary Hypertension. Ann Am Thorac Soc, 2016, 13(Suppl 3): S215-S221.

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支气管循环生理及其在不同肺疾病中的病理变化

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