前列环素I2在哮喘中的研究进展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

杨舒然 ¹ , 王素娟 ² , 左安力 ¹ , 郭子涵 ³ , 刘欣怡 ⁴ , 姬晓青 ¹ , 张振蕾 ¹ ,  鲁德玕 ¹

1. ;
2. ;
3. ;
4. ;

Corresponding author：

鲁德玕, Email: deganlu@126.com

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DOI：

10.7507/1671-6205.202410076

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Citation： 杨舒然, 王素娟, 左安力, 郭子涵, 刘欣怡, 姬晓青, 张振蕾, 鲁德玕. 前列环素I2在哮喘中的研究进展. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(6): 451-454. doi: 10.7507/1671-6205.202410076 Copy

1.	Kanj AN, Skalski JH. Gut Mycobiome and Asthma. J Fungi (Basel). 2024, 10(3): 192.
2.	Yuan L, Sun C. The protective effects of Arctiin in asthma by attenuating airway inflammation and inhibiting p38/NF-κB signaling. Aging (Albany NY). 2024, 16(6): 5038-5049.
3.	Sood V, Rogers L, Khurana S. Managing Corticosteroid-Related Comorbidities in Severe Asthma. Chest. 2021, 160(5): 1614-1623.
4.	Wang T, Han Y, Li H, et al. Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways. Environ Int. 2021, 147: 106314.
5.	Dietrich E, Jomard A, Osto E. Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation. Front Cardiovasc Med. 2022, 9: 989428.
6.	Patel K, Peebles RS Jr. Prostacyclin Regulation of Allergic Inflammation. Biomedicines. 2022, 10(11): 2862.
7.	Liu J, Jiang X, Li L, et al. Iloprost inhibits acute allergic nasal inflammation by GATA3 -ILC2 pathway in mice. Respir Physiol Neurobiol. 2020, 276: 103364.
8.	Wilt S, Kodani S, Le TNH, et al. Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies. Bioorg Chem. 2020, 103: 104165.
9.	Nørregaard R, Kwon TH, Frøkiær J. Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney. Kidney Res Clin Pract. 2015, 34(4): 194-200.
10.	Broos JY, van der Burgt RTM, Konings J, et al. Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression? J Neuroinflammation. 2024, 21(1): 21.
11.	Nakayama T. Prostacyclin analogues: prevention of cardiovascular diseases. Cardiovasc Hematol Agents Med Chem. 2006, 4(4): 351-359.
12.	Shen BQ, Sankaranarayanan I, Price TJ, et al. Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons. Sci Rep. 2023, 13(1): 4670.
13.	Zhou W, Hashimoto K, Goleniewska K, et al. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol. 2007, 178(2): 702-710.
14.	Li H, Bradbury JA, Dackor RT, et al. Cyclooxygenase-2 regulates Th17 cell differentiation during allergic lung inflammation. Am J Respir Crit Care Med. 2011, 184(1): 37-49.
15.	El-Haroun H, Clarke DL, Deacon K, et al. IL-1beta, BK, and TGF-beta1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA. Am J Physiol Lung Cell Mol Physiol. 2008, 294(3): L553-562.
16.	Tan W, Zhang B, Liu X, et al. Interleukin-33-Dependent Accumulation of Regulatory T Cells Mediates Pulmonary Epithelial Regeneration During Acute Respiratory Distress Syndrome. Front Immunol. 2021, 12: 653803.
17.	Leiter A, Veluswamy RR, Wisnivesky JP. The global burden of lung cancer: current status and future trends. Nat Rev Clin Oncol. 2023, 20(9): 624-639.
18.	Mi LL, Guo WW. Crosstalk between ILC2s and Th2 CD4(+) T Cells in Lung Disease. J Immunol Res. 2022, 2022: 8871037.
19.	Zhou W, Toki S, Zhang J, et al. Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses. Am J Respir Crit Care Med. 2016, 193(1): 31-42.
20.	Zhou W, Zhang J, Toki S, et al. COX Inhibition Increases Alternaria-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice. J Immunol. 2020, 205(4): 1157-1166.
21.	Tang L, Zhang Y, Hu Y, et al. T Cell Exhaustion and CAR-T Immunotherapy in Hematological Malignancies. Biomed Res Int. 2021, 2021: 6616391.
22.	Norlander AE, Bloodworth MH, Toki S, et al. Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming. J Clin Invest. 2021, 131(7): e140690.
23.	Li W, Lin A, Qi L, et al. Immunotherapy: A promising novel endometriosis therapy. Front Immunol. 2023, 14: 1128301.
24.	Michael H, Li Y, Wang Y, et al. Trained immunity induced by in vivo peptide-based STAT6 inhibition prevents ragweed allergy in mice. Allergy Asthma Clin Immunol. 2021, 17(1): 42.
25.	Wong TH, Gau RJ, Chen YF, et al. Dendritic cells treated with a prostaglandin I(2) analog, iloprost, promote antigen-specific regulatory T cell differentiation in mice. Int Immunopharmacol. 2020, 79: 106106.
26.	Müller T, Dürk T, Blumenthal B, et al. Iloprost has potent anti-inflammatory properties on human monocyte-derived dendritic cells. Clin Exp Allergy. 2010, 40(8): 1214-1221.
27.	Idzko M, Hammad H, van Nimwegen M, et al. Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function. J Clin Invest. 2007, 117(2): 464-472.
28.	Kuo CH, Lin CH, Yang SN, et al. Effect of prostaglandin I2 analogs on cytokine expression in human myeloid dendritic cells via epigenetic regulation. Mol Med. 2012, 18(1): 433-444.
29.	Vélez-Del-Burgo A, Sánchez P, Suñen E, et al. Purified Native and Recombinant Major Alternaria alternata Allergen (Alt a 1) Induces Allergic Asthma in the Murine Model. J Fungi (Basel). 2021, 7(11): 896.
30.	Peinhaupt M, Sturm EM, Heinemann A. Prostaglandins and Their Receptors in Eosinophil Function and As Therapeutic Targets. Front Med (Lausanne). 2017, 4: 104.
31.	Zhou W, Goleniewska K, Zhang J, et al. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J Allergy Clin Immunol. 2014, 134(3): 698-705.
32.	Sturm EM, Schuligoi R, Konya V, et al. Inhibitory effect of prostaglandin I2 on bone marrow kinetics of eosinophils in the guinea pig. J Leukoc Biol. 2011, 90(2): 285-291.
33.	Konya V, Sturm EM, Schratl P, et al. Endothelium-derived prostaglandin I(2) controls the migration of eosinophils. J Allergy Clin Immunol. 2010, 125(5): 1105-1113.
34.	Hernandez-Lara MA, Yadav SK, Shah SD, et al. Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma. Int J Mol Sci. 2022, 23(19): 11868.
35.	Van Ly D, Burgess JK, Brock TG, et al. Prostaglandins but not leukotrienes alter extracellular matrix protein deposition and cytokine release in primary human airway smooth muscle cells and fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2012, 303(3): L239-250.
36.	Crosby LM, Waters CM. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol. 2010, 298(6): L715-731.
37.	Shioya S, Masuda T, Senoo T, et al. Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis. Exp Ther Med. 2018, 16(4): 3070-3076.
38.	Nagao K, Tanaka H, Komai M, et al. Role of prostaglandin I2 in airway remodeling induced by repeated allergen challenge in mice. Am J Respir Cell Mol Biol. 2003, 29(3 Pt 1): 314-320.

1. Kanj AN, Skalski JH. Gut Mycobiome and Asthma. J Fungi (Basel). 2024, 10(3): 192.
2. Yuan L, Sun C. The protective effects of Arctiin in asthma by attenuating airway inflammation and inhibiting p38/NF-κB signaling. Aging (Albany NY). 2024, 16(6): 5038-5049.
3. Sood V, Rogers L, Khurana S. Managing Corticosteroid-Related Comorbidities in Severe Asthma. Chest. 2021, 160(5): 1614-1623.
4. Wang T, Han Y, Li H, et al. Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways. Environ Int. 2021, 147: 106314.
5. Dietrich E, Jomard A, Osto E. Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation. Front Cardiovasc Med. 2022, 9: 989428.
6. Patel K, Peebles RS Jr. Prostacyclin Regulation of Allergic Inflammation. Biomedicines. 2022, 10(11): 2862.
7. Liu J, Jiang X, Li L, et al. Iloprost inhibits acute allergic nasal inflammation by GATA3 -ILC2 pathway in mice. Respir Physiol Neurobiol. 2020, 276: 103364.
8. Wilt S, Kodani S, Le TNH, et al. Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies. Bioorg Chem. 2020, 103: 104165.
9. Nørregaard R, Kwon TH, Frøkiær J. Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney. Kidney Res Clin Pract. 2015, 34(4): 194-200.
10. Broos JY, van der Burgt RTM, Konings J, et al. Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression? J Neuroinflammation. 2024, 21(1): 21.
11. Nakayama T. Prostacyclin analogues: prevention of cardiovascular diseases. Cardiovasc Hematol Agents Med Chem. 2006, 4(4): 351-359.
12. Shen BQ, Sankaranarayanan I, Price TJ, et al. Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons. Sci Rep. 2023, 13(1): 4670.
13. Zhou W, Hashimoto K, Goleniewska K, et al. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol. 2007, 178(2): 702-710.
14. Li H, Bradbury JA, Dackor RT, et al. Cyclooxygenase-2 regulates Th17 cell differentiation during allergic lung inflammation. Am J Respir Crit Care Med. 2011, 184(1): 37-49.
15. El-Haroun H, Clarke DL, Deacon K, et al. IL-1beta, BK, and TGF-beta1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA. Am J Physiol Lung Cell Mol Physiol. 2008, 294(3): L553-562.
16. Tan W, Zhang B, Liu X, et al. Interleukin-33-Dependent Accumulation of Regulatory T Cells Mediates Pulmonary Epithelial Regeneration During Acute Respiratory Distress Syndrome. Front Immunol. 2021, 12: 653803.
17. Leiter A, Veluswamy RR, Wisnivesky JP. The global burden of lung cancer: current status and future trends. Nat Rev Clin Oncol. 2023, 20(9): 624-639.
18. Mi LL, Guo WW. Crosstalk between ILC2s and Th2 CD4(+) T Cells in Lung Disease. J Immunol Res. 2022, 2022: 8871037.
19. Zhou W, Toki S, Zhang J, et al. Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses. Am J Respir Crit Care Med. 2016, 193(1): 31-42.
20. Zhou W, Zhang J, Toki S, et al. COX Inhibition Increases Alternaria-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice. J Immunol. 2020, 205(4): 1157-1166.
21. Tang L, Zhang Y, Hu Y, et al. T Cell Exhaustion and CAR-T Immunotherapy in Hematological Malignancies. Biomed Res Int. 2021, 2021: 6616391.
22. Norlander AE, Bloodworth MH, Toki S, et al. Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming. J Clin Invest. 2021, 131(7): e140690.
23. Li W, Lin A, Qi L, et al. Immunotherapy: A promising novel endometriosis therapy. Front Immunol. 2023, 14: 1128301.
24. Michael H, Li Y, Wang Y, et al. Trained immunity induced by in vivo peptide-based STAT6 inhibition prevents ragweed allergy in mice. Allergy Asthma Clin Immunol. 2021, 17(1): 42.
25. Wong TH, Gau RJ, Chen YF, et al. Dendritic cells treated with a prostaglandin I(2) analog, iloprost, promote antigen-specific regulatory T cell differentiation in mice. Int Immunopharmacol. 2020, 79: 106106.
26. Müller T, Dürk T, Blumenthal B, et al. Iloprost has potent anti-inflammatory properties on human monocyte-derived dendritic cells. Clin Exp Allergy. 2010, 40(8): 1214-1221.
27. Idzko M, Hammad H, van Nimwegen M, et al. Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function. J Clin Invest. 2007, 117(2): 464-472.
28. Kuo CH, Lin CH, Yang SN, et al. Effect of prostaglandin I2 analogs on cytokine expression in human myeloid dendritic cells via epigenetic regulation. Mol Med. 2012, 18(1): 433-444.
29. Vélez-Del-Burgo A, Sánchez P, Suñen E, et al. Purified Native and Recombinant Major Alternaria alternata Allergen (Alt a 1) Induces Allergic Asthma in the Murine Model. J Fungi (Basel). 2021, 7(11): 896.
30. Peinhaupt M, Sturm EM, Heinemann A. Prostaglandins and Their Receptors in Eosinophil Function and As Therapeutic Targets. Front Med (Lausanne). 2017, 4: 104.
31. Zhou W, Goleniewska K, Zhang J, et al. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J Allergy Clin Immunol. 2014, 134(3): 698-705.
32. Sturm EM, Schuligoi R, Konya V, et al. Inhibitory effect of prostaglandin I2 on bone marrow kinetics of eosinophils in the guinea pig. J Leukoc Biol. 2011, 90(2): 285-291.
33. Konya V, Sturm EM, Schratl P, et al. Endothelium-derived prostaglandin I(2) controls the migration of eosinophils. J Allergy Clin Immunol. 2010, 125(5): 1105-1113.
34. Hernandez-Lara MA, Yadav SK, Shah SD, et al. Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma. Int J Mol Sci. 2022, 23(19): 11868.
35. Van Ly D, Burgess JK, Brock TG, et al. Prostaglandins but not leukotrienes alter extracellular matrix protein deposition and cytokine release in primary human airway smooth muscle cells and fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2012, 303(3): L239-250.
36. Crosby LM, Waters CM. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol. 2010, 298(6): L715-731.
37. Shioya S, Masuda T, Senoo T, et al. Plasminogen activator inhibitor-1 serves an important role in radiation-induced pulmonary fibrosis. Exp Ther Med. 2018, 16(4): 3070-3076.
38. Nagao K, Tanaka H, Komai M, et al. Role of prostaglandin I2 in airway remodeling induced by repeated allergen challenge in mice. Am J Respir Cell Mol Biol. 2003, 29(3 Pt 1): 314-320.

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