Thyroid Hormone Concentrations in Preschool Children in Kashin-Beck Disease Endemic Area_Chinese Journal of Evidence-Based Medicine

Authors：

WU Taixiang ¹ ,  LI Youping ¹ , ZENG Xiaoqian ² , YUAN Yong ² , YANG Xunzhe ² , ZHUO Qi ² , PEI Fuxing ³

1.Chinese Evidence-based Medicine Center, Chinese Clinical Trial Register, the Chinese Cochrane Centre, INCLEN, West China Hospital, Sichuan University, Chengdu 610041, China2.West China School of Medicine, Sichuan University, Chengdu 610041, China3.Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

LI Youping, Email: txwutx@hotmail.com

Keywords：

Kasin-Beck disease, Etiology, Thyroid hormones, Indicator

DOI：

10.7507/1672-2531.20080022

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Objective 　To determine the thyroid hormone concentrations in preschool children in the Kasin-Beck disease (KBD) endemic area so as to explore the etiology of KBD.
Methods 　Children of 1-6 years old in Naidang village,Jinchuan county, Sichuan Province, China were included. Physical examination was performed, personal history and medical history were collected, and blood samples were drawn for the determination of thyroid hormones.
Results 　Blood samples were successfully collected from 14 children. Of them, 57.14% showed decreased TT3 levels, and 85.71% demonstrated decreased FT3 levels. All children showed significantly lower TT3 and FT3 average levels than the reference average value (P lt;0.000 01). The TT4, FT4and TSH levels were within the normal range.
Conclusion 　Most children in the KBD endemic area showed lower T3 levels, which may act as a key factor for cartilage hypogenesis. It is suggested that a decreased TT3 level be one of the indicators for the assessment of KBD preventative effect, early monitoring and diagnosis of preclinical or subclinical stage of KBD.

Citation： WU Taixiang,LI Youping,ZENG Xiaoqian,YUAN Yong,YANG Xunzhe,ZHUO Qi,PEI Fuxing. Thyroid Hormone Concentrations in Preschool Children in Kashin-Beck Disease Endemic Area. Chinese Journal of Evidence-Based Medicine, 2008, 08(2): 86-89. doi: 10.7507/1672-2531.20080022 Copy

1.	吴泰相, 裴福兴, 李幼平, 等. 大骨节病病因的脱碘酶功能障碍新假说. 中国循证医学杂志, 2008, 8(1): 4-9.
2.	李富忠, 黄慧, 邓佳云, 等. 四川省儿童大骨节病新发病情况调查.预防医学情报杂志, 2007, 23(1): 28-30.
3.	Rodrigo Moreno-Reyes, Carl Suetens, Fran?oise Mathieu,et al. Kashin-Beck Osteoarthropathy ?in Rural Tibet in Relation to Selenium and Iodine Status. The New England Journal of Medicine, 1998, 339(16): 1112-1120.
4.	Mello MA, Tuan RS. Effect of TGF-betal and? triiodothyronine on cartilage maturation: in vitro analysis using long-term high-density micromass cultures of chick embryonic limb mesenchymal cells.J Orthop Res, 2006, 24(11): 2095-2105.
5.	Makihira S, Yan W, Murakami H, et al. Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage. Endocrinology, 2003, 144(6): 2480-2488.
6.	Miura M,Tanaka K,KomatsuY, et al .Thyroid hormones promote chondrocyte differentiate in mouse ATDC5 cells and stimulate endochondral ossification in fetal mouse tibias through iodothronine deiodinases in the growth plate. J Bone Miner Ras, 2002, 17(3): 443-454.
7.	Gelsleichter J , Musick JA. Effects of insul in-like growth factor-I,corticosterone,and 3,3’ ,5-tri-iodo-L-thyronine on glycosaminoglycan synthesis in vertebal cartilage of the clearnose skate, Raja eglanteria, J Exp Zool, 1999, 284(5): 549-556.
8.	Will iams GR, Robson H, Shalet SM. Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth. J Endocrinol, 1998, 157(3): 391-403.
9.	Larsen PR, Berry MJ. Nutritional and hormonal regulation of thyroid hormone deiodinases. Ann Rev Nutr, 1995, 15: 323-352.
10.	Berry MJ, BanuL, Larsen PR. Type I iodothyronine deiodinases is a selenocysteine containing enzyme. Nature, 1991, 349: 438-440.

1. 吴泰相, 裴福兴, 李幼平, 等. 大骨节病病因的脱碘酶功能障碍新假说. 中国循证医学杂志, 2008, 8(1): 4-9.
2. 李富忠, 黄慧, 邓佳云, 等. 四川省儿童大骨节病新发病情况调查.预防医学情报杂志, 2007, 23(1): 28-30.
3. Rodrigo Moreno-Reyes, Carl Suetens, Fran?oise Mathieu,et al. Kashin-Beck Osteoarthropathy ?in Rural Tibet in Relation to Selenium and Iodine Status. The New England Journal of Medicine, 1998, 339(16): 1112-1120.
4. Mello MA, Tuan RS. Effect of TGF-betal and? triiodothyronine on cartilage maturation: in vitro analysis using long-term high-density micromass cultures of chick embryonic limb mesenchymal cells.J Orthop Res, 2006, 24(11): 2095-2105.
5. Makihira S, Yan W, Murakami H, et al. Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage. Endocrinology, 2003, 144(6): 2480-2488.
6. Miura M,Tanaka K,KomatsuY, et al .Thyroid hormones promote chondrocyte differentiate in mouse ATDC5 cells and stimulate endochondral ossification in fetal mouse tibias through iodothronine deiodinases in the growth plate. J Bone Miner Ras, 2002, 17(3): 443-454.
7. Gelsleichter J , Musick JA. Effects of insul in-like growth factor-I,corticosterone,and 3,3’ ,5-tri-iodo-L-thyronine on glycosaminoglycan synthesis in vertebal cartilage of the clearnose skate, Raja eglanteria, J Exp Zool, 1999, 284(5): 549-556.
8. Will iams GR, Robson H, Shalet SM. Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth. J Endocrinol, 1998, 157(3): 391-403.
9. Larsen PR, Berry MJ. Nutritional and hormonal regulation of thyroid hormone deiodinases. Ann Rev Nutr, 1995, 15: 323-352.
10. Berry MJ, BanuL, Larsen PR. Type I iodothyronine deiodinases is a selenocysteine containing enzyme. Nature, 1991, 349: 438-440.

Chinese Journal of Evidence-Based Medicine

Thyroid Hormone Concentrations in Preschool Children in Kashin-Beck Disease Endemic Area

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