Clinical Evidence for Magnesium Sulfate Treatment of Severe Asthma_Chinese Journal of Evidence-Based Medicine

Authors：

FU Juanjuan , MAO Bin

Department of Integrated Traditional Chinese and Western Medicine, West China Medical School of Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Magnesium sulfate; Asthma; Evidence-based treatment

DOI：

10.7507/1672-2531.20080243

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To assess the systematic reviews of magnesium sulfate used to treat severe asthma.
Methods 　An electronic search was performed in The Cochrane Library (Issue 2, 2008), ACP Journal Club (1991 to June 2008), MEDLINE (1990 to June 2008), Chinese Journal Full-text Database (1979 to June 2008), Chinese Scientific and Technological Periodical Databases (VIP) (1980 to June 2008), and Chinese Bio-medicine Database (CBM) (1980 to June 2008) to collect systematic reviews of magnesium sulfate treatment for severe asthma. The retrieved systematic reviews were reassessed, and then we adopted the evidence for clinical practice.
Results 　Nine systematic reviews were included, and all of them included 14.1 ± 2.9 items of QUOROM (the quality of reporting of Meta-analyses) on average. In general, the included systematic reviews had comparatively high quality. Evidence illustrated that intravenous infusion of magnesium sulfate could improve pulmonary function and reduce hospital admission without any serious side effects. However, no evidence could verify that patients with asthma can benefit from aerosolized and oral magnesium sulfate. In a specific case with severe asthma, we used magnesium sulfate via intravenous infusion which helped the control of symptoms with no adverse reactions.
Conclusion 　 Magnesium sulfate via intravenous infusion can improve pulmonary function and reduce hospital admission rates. Due to its effectiveness, safety, and low cost, it deserves widespread application in patients with severe asthma.

Citation： FU Juanjuan,MAO Bin. Clinical Evidence for Magnesium Sulfate Treatment of Severe Asthma. Chinese Journal of Evidence-Based Medicine, 2008, 08(12): 1126-1129. doi: 10.7507/1672-2531.20080243 Copy

1.	CHINA, Global Strategy for Asthma Management and Prevention: Revised 2006. In: htpp//www.ginasthma.org.
2.	GINA, Global Strategy for Asthma Management and Prevention:.
3.	The Evidence-Based Medicine Working Group. Users’ Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice. Chicago: AMA Press. 2002.
4.	Phillips B, Ball C, Sackett D, et al. Levels of evidence and grades of recommendation. Available from:URL:http://www.cebm.net/.
5.	Rodrigo G, Rodrigo C, Burschtin O, et al. Efficacy of Magnesium Sulfate in Acute Adult Asthma: A Meta-Analysis of Randomized Trials. Am J Emerg Med, 2000, 18(2): 216-221.
6.	Rowe BH, Bretzlaff JA, Bourdon C, et al. Intravenous Magnesium Sulfate Treatment for Acute Asthma in the Emergency Department: A Systematic Review of the Literature. Ann Emerg Med, 2000, 36(3): 181-190.
7.	Rowe BH, Bretzlaff JA, Bourdon C, et al. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database of Systematic Reviews 2000, Issue 1. Art. No.: CD001490.
8.	Cheuk DKL, Chau TCH，Lee SL, et al. A meta-analysis on intravenous magnesium sulphate fortreating acute asthma. Arch Dis Child, 2005, 90: 74-77.
9.	Rowe BH, Camargo CA. The role of magnesium sulfate in the acute and chronic management of asthma. Cur Opin Pulm Med, 2008, 14: 70.
10.	Blitz M, Blitz S, Hughes R, et al. Aerosolized Magnesium Sulfate for Acute Asthma: A Systematic Review. Chest, 2005, 128: 337-344.
11.	Blitz M, Blitz S, Beasely R, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003898.
12.	鲁晓勇, 周建英. 以不同溶媒雾化吸入沙丁胺醇对哮喘急性发作治疗作用的Meta分析.浙江大学学报 (医学版), 2006, 35(3): 336-341.
13.	Villeneuve EJ, Zed PJ. Nebulized Magnesium Sulfate in the Management of Acute Exacerbations of Asthma. Ann Pharmacother, 2006, 40: 1118-1124.
14.	Moher D, Cook DJ, Eastwood S, et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Lancet, 1999, 354: 1896-1900.

1. CHINA, Global Strategy for Asthma Management and Prevention: Revised 2006. In: htpp//www.ginasthma.org.
2. GINA, Global Strategy for Asthma Management and Prevention:.
3. The Evidence-Based Medicine Working Group. Users’ Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice. Chicago: AMA Press. 2002.
4. Phillips B, Ball C, Sackett D, et al. Levels of evidence and grades of recommendation. Available from:URL:http://www.cebm.net/.
5. Rodrigo G, Rodrigo C, Burschtin O, et al. Efficacy of Magnesium Sulfate in Acute Adult Asthma: A Meta-Analysis of Randomized Trials. Am J Emerg Med, 2000, 18(2): 216-221.
6. Rowe BH, Bretzlaff JA, Bourdon C, et al. Intravenous Magnesium Sulfate Treatment for Acute Asthma in the Emergency Department: A Systematic Review of the Literature. Ann Emerg Med, 2000, 36(3): 181-190.
7. Rowe BH, Bretzlaff JA, Bourdon C, et al. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database of Systematic Reviews 2000, Issue 1. Art. No.: CD001490.
8. Cheuk DKL, Chau TCH，Lee SL, et al. A meta-analysis on intravenous magnesium sulphate fortreating acute asthma. Arch Dis Child, 2005, 90: 74-77.
9. Rowe BH, Camargo CA. The role of magnesium sulfate in the acute and chronic management of asthma. Cur Opin Pulm Med, 2008, 14: 70.
10. Blitz M, Blitz S, Hughes R, et al. Aerosolized Magnesium Sulfate for Acute Asthma: A Systematic Review. Chest, 2005, 128: 337-344.
11. Blitz M, Blitz S, Beasely R, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003898.
12. 鲁晓勇, 周建英. 以不同溶媒雾化吸入沙丁胺醇对哮喘急性发作治疗作用的Meta分析.浙江大学学报 (医学版), 2006, 35(3): 336-341.
13. Villeneuve EJ, Zed PJ. Nebulized Magnesium Sulfate in the Management of Acute Exacerbations of Asthma. Ann Pharmacother, 2006, 40: 1118-1124.
14. Moher D, Cook DJ, Eastwood S, et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Lancet, 1999, 354: 1896-1900.

Chinese Journal of Evidence-Based Medicine

Clinical Evidence for Magnesium Sulfate Treatment of Severe Asthma

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content