Discussing on the Research of Heterogeneity in Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

1. Library of Hebei Medical University, Shijiazhuang 050017, China;2. Hebei Institute of Medical Information, Shijiazhuang 050021, China;3. Department of Epidemiology and Health Statistics, School of Public Health, Hebei Medical University, Shijiazhuang 050017, China;4. Mental Health Center, The First Hospital, Hebei Medical University, Shijiazhuang 050031, China;5. Department of Neurology, The First Hospital, Hebei Medical University, Shijiazhuang 050031, China;

Corresponding author：

Keywords：

Meta 分析; 异质性; 分类; 检验方法; 措施

DOI：

10.7507/1672-2531.20090196

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This paper is to discuss the research of heterogeneity in Meta-analysis, including the definition of the heterogeneity in Meta-analysis and classification it into clinical heterogeneity, methodological heterogeneity and statistical heterogeneity, the strategies for diminishing clinical heterogeneity and methodological heterogeneity, the five testing methods in statistical heterogeneity (Q statistic, I2 statistic, H statistic, Galbraith plot and L’Abbe plot) and the examples and applying conditions of the five testing methods, classification of meta-analysis into exploratory meta-analysis and analytic meta-analysis according if the meta-analysis has heterogeneity, and the strategies and the flowchart when existing the heterogeneity in meta-analysis.

Citation： WANG Dan,ZHAI Junxia,MOU Zhenyun,ZONG Hongxia,ZHAO Xiaodong,WANG Xueyi,Gu Ping. Discussing on the Research of Heterogeneity in Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2009, 09(10): 1115-1118. doi: 10.7507/1672-2531.20090196 Copy

1.	Glass GV. Primary, secondary, and Meta-analysis of research. Educ Res, 1976, 5: 3-8. .
2.	王家良, 主编. 循证医学. 第2版. 北京: 人民卫生出版社, 2006, 81, 84-85, 87-88, 89-90. .
3.	2009.09.10.http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=search&term=meta-analysis. .
4.	George DS. Meta-analysis: Unsolved and future developments.BMJ, 1998, 316: 221-225. .
5.	Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 Updated September 2006. The Cochrane Collaboration, 2006, 136. .
6.	2009.09.10. http://www.cochrane.org/resources/glossary.htm. .
7.	吴泰相, 刘关键, 李静. 影响系统评价质量的主要因素浅析. 中国循证医学杂志, 2005, 5: 51-58. .
8.	Furberg CT, Morgan TM. Lessons from overviews of cardiovascular trials. Stat Med, 1987, 6: 295-303. .
9.	王丹, 牟振云, 翟俊霞, 等. 西酞普兰与阿米替林治疗老年抑郁症随机对照试验的Meta分析. 现代预防医学, 2009, 36(13): 2404-2407. .
10.	Rosenberg C, Lauritzen L, Brix J, et al. Citalopram versus amitriptyline in elderly depressed patients with or without mild cognitive dysfunction: a danish multicentre trial in general practice. Psychopharmacol Bull, 2007, 40(1): 63-73. .
11.	董继承, 刘彩兴, 张正爱, 等. 西酞普兰治疗老年脑卒中后抑郁临床对照研究. 精神医学杂志, 2007, 20(4): 235-236. .
12.	陈亚男. 西酞普兰治疗阿尔茨海默病伴发抑郁症状的疗效对照观察. 四川精神卫生, 2007, 20(1): 48. .
13.	孟巍. 西酞普兰与阿米替林治疗中老年抑郁症疗效观察. 中国误诊学杂志, 2006, 6(14): 2691. .
14.	Higgins JPT, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ, 2003, 327: 557-560. .
15.	何寒青, 陈坤. Meta分析中的异质性检验方法. 中国卫生统计, 2006, 23(6): 486-487, 490. .
16.	Martin Bland. Meta-analysis: dealing with heterogeneity. York: University of York, 2006, 6. .
17.	L’Abbe KA, Detsky AS, O’Rourke K. Meta-analysis in clinical research. Annals of Internal Medicine, 1987, 107: 224-233. .
18.	王丹, 牟振云, 翟俊霞, 等. Stata软件在Meta分析中异质性检验的应用. 中华流行病学杂志, 2008, 29(7): 726-729. .
19.	Anello C, Fleiss JL.Exploratory or analytic meta-analysis:Should we distinguish between them? J Clin Epidemiol, 1995, 48: 109-116. .
20.	Fleiss JL. The statistical basis of meta-analysis. Stat Methods Med Res, 1993, 2: 121-145. .
21.	王建华. 流行病学. 第6版. 北京: 人民卫生出版社, 2004, 179. .
22.	Colditz GA, Burdick E, Moseller F. Heterogeneity in meta-analysis of data from epidemiologic studies:Commentary. Am J Epidemiol, 1995, 142: 371-382.

1. Glass GV. Primary, secondary, and Meta-analysis of research. Educ Res, 1976, 5: 3-8. .
2. 王家良, 主编. 循证医学. 第2版. 北京: 人民卫生出版社, 2006, 81, 84-85, 87-88, 89-90. .
3. 2009.09.10.http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=search&term=meta-analysis. .
4. George DS. Meta-analysis: Unsolved and future developments.BMJ, 1998, 316: 221-225. .
5. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 Updated September 2006. The Cochrane Collaboration, 2006, 136. .
6. 2009.09.10. http://www.cochrane.org/resources/glossary.htm. .
7. 吴泰相, 刘关键, 李静. 影响系统评价质量的主要因素浅析. 中国循证医学杂志, 2005, 5: 51-58. .
8. Furberg CT, Morgan TM. Lessons from overviews of cardiovascular trials. Stat Med, 1987, 6: 295-303. .
9. 王丹, 牟振云, 翟俊霞, 等. 西酞普兰与阿米替林治疗老年抑郁症随机对照试验的Meta分析. 现代预防医学, 2009, 36(13): 2404-2407. .
10. Rosenberg C, Lauritzen L, Brix J, et al. Citalopram versus amitriptyline in elderly depressed patients with or without mild cognitive dysfunction: a danish multicentre trial in general practice. Psychopharmacol Bull, 2007, 40(1): 63-73. .
11. 董继承, 刘彩兴, 张正爱, 等. 西酞普兰治疗老年脑卒中后抑郁临床对照研究. 精神医学杂志, 2007, 20(4): 235-236. .
12. 陈亚男. 西酞普兰治疗阿尔茨海默病伴发抑郁症状的疗效对照观察. 四川精神卫生, 2007, 20(1): 48. .
13. 孟巍. 西酞普兰与阿米替林治疗中老年抑郁症疗效观察. 中国误诊学杂志, 2006, 6(14): 2691. .
14. Higgins JPT, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ, 2003, 327: 557-560. .
15. 何寒青, 陈坤. Meta分析中的异质性检验方法. 中国卫生统计, 2006, 23(6): 486-487, 490. .
16. Martin Bland. Meta-analysis: dealing with heterogeneity. York: University of York, 2006, 6. .
17. L’Abbe KA, Detsky AS, O’Rourke K. Meta-analysis in clinical research. Annals of Internal Medicine, 1987, 107: 224-233. .
18. 王丹, 牟振云, 翟俊霞, 等. Stata软件在Meta分析中异质性检验的应用. 中华流行病学杂志, 2008, 29(7): 726-729. .
19. Anello C, Fleiss JL.Exploratory or analytic meta-analysis:Should we distinguish between them? J Clin Epidemiol, 1995, 48: 109-116. .
20. Fleiss JL. The statistical basis of meta-analysis. Stat Methods Med Res, 1993, 2: 121-145. .
21. 王建华. 流行病学. 第6版. 北京: 人民卫生出版社, 2004, 179. .
22. Colditz GA, Burdick E, Moseller F. Heterogeneity in meta-analysis of data from epidemiologic studies:Commentary. Am J Epidemiol, 1995, 142: 371-382.

Chinese Journal of Evidence-Based Medicine

Discussing on the Research of Heterogeneity in Meta-analysis

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