Evidence-based Treatment for a Patient of Ⅱ B Stage Non-Small Cell Lung Cancer_Chinese Journal of Evidence-Based Medicine

Authors：

ZENG Wen ¹ , WANG Xiaogang ² ,  YUE Jirong ³

1. Department of Gold Card, West China Hospital, Sichuan University, Chengdu 610041, China; 2. Chengdu Wuhou Qu Tiaosanta Community Hospital, Sichuan Province, Chengdu 610041, China;3. Department of Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

YUE Jirong, Email: yuejirong11@hotmail.com

Keywords：

Non-small cell lung cancer; Operation; Evidence-based treatment

DOI：

10.7507/1672-2531.20090242

Video：

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Objective 　To report evidence-based treatment for 2 case of Ⅱ B stage non-small cell lung cancer.
Methods 　We searched systematic reviews and randomized controlled trials in The Cochrane Library (Issue 2, 2009), MEDLINE (PubMed, January 1970 to June 2009) and ACP Journal Club (1996 to June 2009), and evaluated the evidence.
Results 　The best clinical evidence for Ⅰ and Ⅱ stage non-small cell lung cancer patients showed that in the patients with resectable nonsmall cell lung cancer, postoperative adjuvant radiotherapy and chemotherapy could not improve survival compared with surgery alone. We did not find evidence which indicated that preoperative chemotherapy improved survival in people with resectable non-small cell lung cancer.
Conclusion 　In accordance with the wishes of the patient and family, they do not accept the radiotherapy and chemotherapy, but choose palliative and supportive therapy.

Citation： ZENG Wen,WANG Xiaogang,YUE Jirong. Evidence-based Treatment for a Patient of Ⅱ B Stage Non-Small Cell Lung Cancer. Chinese Journal of Evidence-Based Medicine, 2009, 09(12): 1336-1338. doi: 10.7507/1672-2531.20090242 Copy

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1. Depierre A, Milleron B, Moro-Sibilot D, et al. Preoperative chemotherapy followed by surgery compared with primary surgery in resectable Stage I (except T1N0), II and IIIA non-small cell lung cancer. J Clin Oncol, 2002, 20(1): 247-253.
2. Auperin A, Le Pechoux C, Pignon JP, et al. Concomitant radiochemotherapy based on platin compounds in patients with locally advanced non-small cell lung cancer (NSCLC): a Meta-analysis of individual data from 1764 patients. Ann Oncol, 2006, 17(3): 473-483.
3. PORT Meta-analysis Trialists Group. Postoperative radiotherapy for non-small cell lung cancer. Cochrane Database Syst Rev, 2005, (2): CD002142.
4. Chris J. Williams, Postoperative radiotherapy decreases survival in early-stage non-small-cell lung cancer. Evidence-Based Medicine, 1999, 4: 84.
5. Grilli R, Oxman AD, Julian JA. Chemotherapy for advanced nonsmall- cell lung cancer: how much benefit is enough? J Clin Oncol, 1993, 11: 1866-1872.
6. Wake B, Taylor R, Sandercock J. Hyperfractionated/accelerated radiotherapy regimens for the treatment of non-small cell lung cancer. A systematic review of clinical and cost-effectiveness. West Midlands Health Technology Assessment Collaboration (WMHTAC), 2002, (DPHE Report No. 35): 65.
7. Pignon JP, Arriagada R, Ihde DC, et al. A Meta-analysis of thoracic radiotherapy for small-cell lung cancer. N Engl J Med, 1992, 327(23): 1618-1624.
8. Burdett SS, Stewart LA, Rydzewska L. Chemotherapy and surgery versus surgery alone in non-small cell lung cancer, Source Cochrane Database of Systematic Reviews. 3, 2008.
9. Berghmans T, Paesmans M, Meert AP, et al. Survival improvement in resectable non-small cell lung cancer with (neo)adjuvant chemotherapy: results of a meta-analysis of the literature. Lung Cancer, 2005, 49: 13-23.

Chinese Journal of Evidence-Based Medicine

Evidence-based Treatment for a Patient of Ⅱ B Stage Non-Small Cell Lung Cancer

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