- 1. Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu 610041, China;2. Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;
LI Youping,
Email: yzmylab@hotmail.com
Objective To collect and analyze published experimental and clinical studies about the protective function of ischemic preconditioning (IPC) to organs, in order to learn the history of IPC, the progress of experimental as well as clinical studies, and explore the mechanism of IPC in organ transplantation.
Methods The electronic search of MEDLINE (1966 to Aug. 2009), EMbase (1974 to Aug. 2009) and The Cochrane Library (Issue 2, 2009) were performed to include and exclude the retrieved articles by two reviewers independently. The included studies were further treated for analysis and discriptive review.
Results A total of 1 398 papers were included, of which about 75 percent were experimental studies, and only about 25 percent were clinical studies. About 73 percent studies focused on the heart and liver. Althrough the studies about the effects induced by IPC on the heart, brain, spinal cord and liver increased obviously in recent years, the clinical studies concerned the heart and liver operation and transplantation still far lagged behind experimental studies, especially very few clinical studies on the effect induced by IPC on kidney, lung, gastrointestinal tract and pancreas.
Conclusion IPC intervention can effectively protect the heart and lung from the I/RI during the surgical and transplatational operations, and the hepat-surgical and living liver transplantational operations. IPC can effectively protect the brain and spinal cord from I/RI, but no protective function to cadaveric liver transplantation. However, the IPC effects on the kidney and gastrointestinal tract are not confirmed and neither is the mechanism of the effect induced by IPC.
Citation： ZHEN Zipeng,HUANG Yuchuan,LI Youping. A Literature Review for the Protective Function of Ischemic Preconditioning to Organs. Chinese Journal of Evidence-Based Medicine, 2010, 10(2): 203-214. doi: 10.7507/1672-2531.20100386 Copy
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- 1. Verrier E. The microvascular cell and ischemia-reperfusion injury. J Cardiovasc Pharmacol, 1996, 27( Suppl1): S26-30.
- 2. Goode HF, Webster NR, Howdle PD, et al. Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplanta tion. Hepatology, 1994, 19(2): 354-359.
- 3. Langle F, Roth E, Steininger R, et al. Arginase release following liver reperfusion. Evidence of hemodynamic action of arginase infusions. Transplantation, 1995, 59(11): 1542-1549.
- 4. Gerlach J, Jorres A, Schon M, et al. Systemic liberation of interleukin-.
- 5. trial. J Thromb Thrombolysis, 1998, 6(2): 89-92.
- 6. Clavien PA, Camargo CA, Gorczynski R, et al. Acute reactant cytokines and neutrophil adhesion after warm ischemia in cirrhotic and noncirrhotic human livers. Hepatology, 1996, 23(6): 1456-1463.
- 7. Lentsch AB, Yoshidome H, Cheadle WG, et al. Chemokine involvement in hepatic ischemia/reperfusion injury in mice: Roles for macrophage inflammatory protein-2 and KC. Hepatology, 1998, 27(2): 507-512.
- 8. Colletti LM, Kunkel SL, Walz A, et al. Chemokine expression during hepatic ischemia/ reperfusion-induced lung injury in the rat. The role of epithelial neutrophil activating protein. J Clin Invest, 1995, 95(1): 134-142.
- 9. in the perioperative phase of liver transplantation. Transpl Int, 1997, 10(5): 401-404.
- 10. Boros P, Tarcsafalvi A, Wang L, et al. Intrahepatic expression and release of vascular endothelial growth factor following orthotopic liver transplantation in the rat. Transplantation, 2001, 72(5): 805-811.
- 11. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation, 1986, 74(5): 1124-1136.
- 12. Cohen MV, Baines CP, Downey JM. Ischemic preconditioning: from adenosine receptor to KATP channel. Annu Rev Physiol, 2000, 62: 79-109.
- 13. Przyklenk K, Bauer B, Ovize M, et al. Regional ischemic ‘preconditioning’ protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation, 1993, 87(3): 893-899.
- 14. Lazaris AM, Maheras AN, Vasdekis SN, et al. Protective effect of remote ischemic preconditioning in renal ischemia/reperfusion injury, in a model of thoracoabdominal aorta approach. J Surg Res, 2009, 154(2): 267-273.
- 15. Hausenloy DJ, Mwamure PK, Venugopal V, et al. Effect of remote ischemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet, 2007, 370(9587): 575-579.
- 16. Deutsch E, Berger M, Kussmaul WG, et al. Adaptation to ischemia during percutaneous transluminal coronary angioplasty: clinical, hemodynamic, and metabolic features. Circulation, 1990, 82(6): 2044-2051.
- 17. Yellon DM, Alkhulaifi AM, Pugsley WB. Preconditioning the human myocardium. Lancet, 1993, 342(8866): 276-277.
- 18. Jenkins DP, Pugsley WB, Alkhulaifi AM, et al. Ischaemic preconditioning reduces troponin T release in patients undergoing coronary artery bypass surgery. Heart, 1997, 77(4): 314-318.
- 19. Ottani F, Galvani M, Ferrini D, et al. Prodromal angina limits infarct size: a role for ischemic preconditioning. Circulation, 1995, 91(2): 291-297.
- 20. Kloner RA, Shook T, Przyklenk K, et al. Previous angina alters inhospital outcome in TIMI 4: a clinical correlate to preconditioning? Circulation, 1995, 91(1): 37-45.
- 21. Kloner RA, Shook T, Antman EM, et al. Prospective temporal analysis of the onset of preinfarction angina versus outcome: an ancillary study in TIMI-9B. Circulation, 1998, 97(11): 1042-1045.
- 22. Cleveland JC, Meldrum DR, Rowland RT, et al. Preconditioning and hypothermic cardioplegia protect human heart equally against ischemia. Ann Thorac Surg, 1997, 63: 147-152.
- 23. Engelman DT, Chen C, Watanabe M, et al. Improved 4-and 6-hour myocardial preservation by hypoxic preconditioning. Circulation, 1995, 92(Suppl II): 11417-11422.
- 24. Konstantinov IE, Li J, Cheung MM, et al. Remote ischemic preconditioning of the recipient reduces myocardial ischemia-reperfusion injury of the denervated donor heart via a Katp channel-dependent mechanism. Transplantation, 2005, 79(12): 1691-1695.
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