Objective 　To investigate the efficacy and safety of nebulized budesonide for acute exacerbation of chronic obstructive pulmonary disease, and to formulate an evidence-based treatment protocol for a patient with acute exacerbation of chronic obstructive pulmonary disease.
Methods 　We searched The Cochrane Library (Issue 4, 2009), MEDLINE (1990 to February 2010), ACP Journal Club (1991 to February 2010) and Chinese Journal Full-text Database (1979 to February 2010), and critically appraised the available evidence.
Results 　Four randomized controlled trials were included, and all were of relatively high quality. Evidence showed that nebulized budesonide could alleviate symptoms, improve pulmonary function without any serious side effects. Given the current evidence, we used nebulized budesonide which helped the control of symptoms with no adverse effects.
Conclusion 　Nebulised budesonide may be an effective and safe alternative to systemic corticosteroids in the treatment of acute exacerbation of chronic obstructive pulmonary disease.

Citation： JIANG Hongli,MAO Bing. Evidence-Based Treatment of a Patient with Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Nebulized Budesonide. Chinese Journal of Evidence-Based Medicine, 2010, 10(6): 756-758. doi: 10.7507/1672-2531.20100488 Copy