Effect of Sanqi Tongshu Capsule on the Serum Level of IL-6 and VEGF Expression of Different Periods of Acute Cerebra Infarction_Chinese Journal of Evidence-Based Medicine

Authors：

LUO Yongjie ,  WANG Xiaoping

Department of Neurology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China;

Corresponding author：

WANG Xiaoping, Email: wangxiaopingzz@yahoo.com.cn

Keywords：

PTS; Acute cerebral infarction; Vascular endothelial growth factor; Interleukin-6

DOI：

10.7507/1672-2531.20100562

Video：

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Objective 　To research on the effect of protoparaxaxotrid saporlirs (PTS), active component in Sanqi Tongshu Capsule, on the expressions of the serum level of IL-6 and VEGF of patients with the acute cerebral infarction at different time points.
Method 　86 patients were randomly divided into two groups: PTS group and Nimodipine group, healthy person as control group. ELISA was applied to measure the serum level of IL-6 and VEGF in during different phases (3 d, 7 d, 14 d and 28 d after the onset of cerebral infarction).
Results 　The expressions of VEGF rose significantly in the all of ACI patients. The expressions of IL-6 rose significantly on third day, then began to decrease. The serum level of IL-6 declined significantly (P lt;0.05) and the serum level of VEGF rose in both of PTS group and Nimodipine group in contrast with control group (P lt;0.01).
Conclusion 　PTS can promote the expressions of VEGF after the cerebral infarction at different time points, and decrease the expressions of IL-6 in the early period of ACI, decreased，which may be one of the molecular mechanisms of this PTS in treating acute cerebral infarction.

Citation： LUO Yongjie,WANG Xiaoping. Effect of Sanqi Tongshu Capsule on the Serum Level of IL-6 and VEGF Expression of Different Periods of Acute Cerebra Infarction. Chinese Journal of Evidence-Based Medicine, 2010, 10(10): 1155-1158. doi: 10.7507/1672-2531.20100562 Copy

1.	中华神经科学会, 中华神经外科学会. 各类脑血管疾病诊断要点, 脑卒中患者临床神经功能缺损程度评分标准（1995）. 中华神经科杂志, 1996, 29(6): 379- 383.
2.	陈清棠. 脑卒中患者神经功能缺损程度评分标准（1995）附件3. 中华神经科杂志, 1996, 29(6): 382.
3.	Rosenstein JM, Mani N, Khaibulina A, et al. Neurotrophic effects of vascular endothelial growth factor on organo typic cortical explants and primary cortical neuron. Neurosci, 2003, 23(25): 11036-11044.
4.	Sun Y, Jin K, Xie L, et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest, 2003, 111(12): 1843-1851.
5.	Obrenovitch TP. Molecular ohysiology of preconditioning-Induced brain to lerance to ischemia. Physiol Rev, 2008, 88(1): 211-247.
6.	Selzner N, Selzner M, Odermatt B, et al. ICAM -1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. Gastroenterology, 2003, 124: 692-700.
7.	Ishihara K, Hirano T. Molecular basis of the cell specificity of cytokine action. Biochim Biophys Acta, 2002, 1592: 281-296.
8.	侯安会. 三七的临床运用和实验研究概要. 中医药信息, 1999, 6(1): 21-24.
9.	张英鸽, 刘天培. 人参皂甙对大鼠脑缺血再灌注损伤的保护作用. 中国药理学与毒理学杂志, 1994, 8(1): 12218.
10.	胡晓松, 周东, 周德明. PTS对脑缺血再灌注大鼠的保护作用. 中风与神经疾病杂志, 2004, 21(4): 354-356.
11.	刘宗超, 周关恩, 赵克建, 等. PTS对大鼠脑缺血/再灌注脑损伤保护作用的实验研究. 中风与神经疾病杂志, 2007, 24(1): 38-40.

1. 中华神经科学会, 中华神经外科学会. 各类脑血管疾病诊断要点, 脑卒中患者临床神经功能缺损程度评分标准（1995）. 中华神经科杂志, 1996, 29(6): 379- 383.
2. 陈清棠. 脑卒中患者神经功能缺损程度评分标准（1995）附件3. 中华神经科杂志, 1996, 29(6): 382.
3. Rosenstein JM, Mani N, Khaibulina A, et al. Neurotrophic effects of vascular endothelial growth factor on organo typic cortical explants and primary cortical neuron. Neurosci, 2003, 23(25): 11036-11044.
4. Sun Y, Jin K, Xie L, et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest, 2003, 111(12): 1843-1851.
5. Obrenovitch TP. Molecular ohysiology of preconditioning-Induced brain to lerance to ischemia. Physiol Rev, 2008, 88(1): 211-247.
6. Selzner N, Selzner M, Odermatt B, et al. ICAM -1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. Gastroenterology, 2003, 124: 692-700.
7. Ishihara K, Hirano T. Molecular basis of the cell specificity of cytokine action. Biochim Biophys Acta, 2002, 1592: 281-296.
8. 侯安会. 三七的临床运用和实验研究概要. 中医药信息, 1999, 6(1): 21-24.
9. 张英鸽, 刘天培. 人参皂甙对大鼠脑缺血再灌注损伤的保护作用. 中国药理学与毒理学杂志, 1994, 8(1): 12218.
10. 胡晓松, 周东, 周德明. PTS对脑缺血再灌注大鼠的保护作用. 中风与神经疾病杂志, 2004, 21(4): 354-356.
11. 刘宗超, 周关恩, 赵克建, 等. PTS对大鼠脑缺血/再灌注脑损伤保护作用的实验研究. 中风与神经疾病杂志, 2007, 24(1): 38-40.

Chinese Journal of Evidence-Based Medicine

Effect of Sanqi Tongshu Capsule on the Serum Level of IL-6 and VEGF Expression of Different Periods of Acute Cerebra Infarction

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