Efficacy and Safety of Acellular Dermal Matrix in Preventing Frey Syndrome: A Systematic Review_Chinese Journal of Evidence-Based Medicine

Authors：

ZENG Xiantao ¹ , GUO Yi ² , XIA Lingyun ¹ , HUANG Wei ¹ ,  LENG Weidong ¹ , LIU Dongyan ¹

1. Department of Oral and Maxillofacial Centre, Taihe Hospital, Hubei University of Medical, Shiyan 442000, China;2. Department of Epidemiology, School of Public Health, Wuhan University, Wuhan 430071, China;

Corresponding author：

LENG Weidong, Email: lwd35@163.com

Keywords：

Acellular dermal matrix; Prevention; Frey syndrome; Systematic review; Meta-analysis

DOI：

10.7507/1672-2531.20110014

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective　To evaluate the efficacy and safety of acellular dermal matrix (ADM) in preventing Frey syndrome.
Methods　Studies of acellular dermal matrix in preventing Frey syndrome were searched in The Cochrane Library (Issue 1, 2010), MEDLINE, EMbase, SIGLE, GreyNet, NTIS, CBMdisc, VIP, CNKI and WANFANG DATA from 1995 to 2010. All the studies were selected, extracted and evaluated by four reviewers independently, and meta-analyses were performed with RevMan 5.0.0 software.
Results　A total of 15 studies involving 472 participants were included in the review. The studies showed that implantation of the ADM was able to efficiently reduce the incidence of Frey syndrome, and the difference in both subjective and objective was significant between the two groups after the therapy (RR=0.11, 95%CI 0.06 to 0.18, P lt;0.01; RR=0.14, 95%CI 0.10 to 0.19, P lt;0.01). The rate of temporary facial nerve paralysis was lower than that of the control group but the difference was not significant (OR=0.78, 95%CI 0.37 to 1.66, P=0.53). The incidens of both seroma and mucocele were higher than that of the control group but the difference was not significant(OR=2.63, 95%CI 0.09 to 79.25, P=0.58) and they could be alleviated by placing drainage tube and partial pressure bandage. The incidence rate of salivary fistula was lower than that of the control group and the difference was significant (OR=0.24, 95%CI 0.08 to 0.69, P=0.009).
Conclusion　The result of this system review shows that, the ADM can effectively and safely reduce the incidence of Frey syndrome. To perform preoperative hypersensitivity check for iodine or iodophors, to conduct rapid frozen section for defining the character of tumor, to fix the ADM stably, to place vacuum-drainage and to make partial pressure bandage are suggested.

Citation： ZENG Xiantao,GUO Yi,XIA Lingyun,HUANG Wei,LENG Weidong,LIU Dongyan. Efficacy and Safety of Acellular Dermal Matrix in Preventing Frey Syndrome: A Systematic Review. Chinese Journal of Evidence-Based Medicine, 2011, 11(1): 76-83. doi: 10.7507/1672-2531.20110014 Copy

1.	Donati M, Gandolfo L, Privitera A, et al. Superficial parotidectomy as first choice for parotid tumours. Chir Ital, 2007, 59(1): 91-97.
2.	Marchese-Ragona R, De Filippis C, Marioni G, et al. Treatment of complications of parotid gland surgery. Acta Otorhinolaryngol Ital, 2005, 25(3): 174-178.
3.	Koch M, Zenk J, Iro H. Long-term results of morbidity after parotid gland surgery in benign disease. Laryngoscope, 2010, 120(4): 724-730.
4.	Frey L. Le syndrome du nerf auriculotemporal. Rev Neuro, 1923, 2: 92-104.
5.	Harrison K, Donaldson I. Frey’s syndrome. J R Soc Med, 1979, 72: 503-508.
6.	de Bree R, van der Waal I, Leemans CR. Management of frey syndrome. Head & Neck, 2007, 29(8): 773-778 .
7.	Rustemeyer J, Eufinger H, Bremerich A. The incidence of Frey’s syndrome. J Cranio-Maxillofac Surg, 2008, 36(1): 34-37.
8.	Malatskey S, Rabinovich I, Fradis M, et al. Frey syndrome-delayed clinical onset: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2002, 94(3): 338-340.
9.	Wenzel GI, Draf W. Unusually long latency before the appearance of Frey’s syndrome after parotidectomy. HNO, 2004, 52(6): 554-556.
10.	Baek CH, Chung MK, Jeong HS, et al. Questionnaire evaluation of sequelae over 5 years after parotidectomy for benign diseases. J of Plast Reconstr and Aesthet Surg, 2009, 62: 633-638.
11.	Clayman MA, Clayman SM, Seagle MB. A review of the surgical and medical treatment of Frey syndrome. Ann Plast Surg, 2006, 57(5): 581-584.
12.	Martos Díaz P, Bances del Castillo R, Mancha de la Plata M, et al. Clinical results in the management of Frey’s Syndrome with injections of Botulinum Toxin. Med Oral Patol Oral Cir Bucal, 2008, 13(4): E248-252.
13.	Curry JM, Fisher KW, Heffelfinger RN, et al. Superficial Musculoaponeurotic System Elevation and Fat Graft Reconstruction After Superficial Parotidectomy. Laryngoscope, 2008, 118(2): 210-215.
14.	Rubinstein RY, Rosen A, Leeman D. Frey syndrome: treatment with temporoparietal fascia flap interposition. Arch Otolaryngol Head Neck Surg, 1999, 125(7): 808-811.
15.	Oa A, Ps K. Prevention of Frey’s syndrome and volume deficit after parotidectomy using the superficial temporal artery fascial flap. Br J Plast Surg, 1999, 52(4): 256-260.
16.	Terzis JK, Olivares FS. Uses of the superficial temporal fascial flap in facial paralysis. Plast Reconstr Surg, 2008, 122(6): 176e-185e.
17.	Filho WQ, Dedivitis RA, Rapoport A, et al. Sternocleidomastoid Muscle Flap Preventing Frey Syndrome following Parotidectomy. World J Surg, 2004, 28, 361-364.
18.	Guntinas-Lichius O, Gabriel B, Klussmann JP. Risk of facial palsy and severe Frey’s syndrome after conservative parotidectomy for benign disease: analysis of 610 operations. Acta Otolaryngol, 2006, 126(10): 1104-1109.
19.	曲延刚, 孙乐刚, 王玉良, 等. 腮腺手术置入涤纶薄片预防Frey综合症. 实用口腔医学杂志, 2002, 18(2): 175-176.
20.	李德志, 吴跃煌, 王晓雷, 等. 腮腺肿瘤术后Frey综合征预防的初步研究.中华外科杂志, 2006, 44(15): 1033-1035.
21.	郭锡久, 阮兴朝, 冉红兵, 等. 膨体聚四氟乙烯植入整复腮腺术后凹陷畸形. 中国美容医学, 2005, 14(6): 697-698.
22.	Clayman MA, Clayman LZ. Use of AlloDerm as a barrier to treat chronic Frey’s syndrome. Otolaryngol Head Neck Surg, 2001, 124(6): 687.
23.	Papadogeorgakis N, Petsinis V, Christopoulos P, et al. Use of a porcine dermal collagen graft (Permacol) in parotid surgery. Br J Oral Maxillofac Surg, 2009, 47(5):378-381.
24.	邱蔚六, 主编. 口腔颌面外科学. 第6版. 北京: 人民卫生出版社, 2008: 371-372.
25.	Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2009. Available from www.cochrane-handbook.org.
26.	田刚, 江中明, 朱强. 口腔组织补片预防味觉出汗综合症的临床观察. 中国现代实用医学杂志, 2006, 5(8): 70-71.
27.	俞凯, 杨钧, 李满敬, 等. 脱细胞异体真皮基质预防味觉出汗综合症的临床观察. 中华口腔医学杂志, 2007, 42(9): 570-571.
28.	孙海鹏, 冯力, 翁汝涟, 等. 脱细胞异体真皮基质预防腮腺切除术后味觉出汗综合症和面部凹陷的临床研究. 广东牙病防治, 2008, 16(4): 161-163.
29.	张瑞鑫. 脱细胞真皮基质（ADM）在预防Frey’s综合症中的应用. 山东: 山东大学口腔临床医学, 2008.
30.	廖湘凌, 吴斌, 张艳, 等. 脱细胞真皮基质用于预防腮腺切除术后Frey综合症. 河北医科大学学报, 2008, 29(2): 223-235.
31.	董作青, 张凡, 魏奉才, 等. 应用脱细胞真皮基质预防腮腺切除术后Frey综合症. 山东大学学报（医学版）, 2008, 46(8): 801-803.
32.	劳军平, 陈巨峰, 欧阳可雄, 等. 组织瓣修复和异体脱细胞真皮基质植入预防腮腺切术后Frey综合症. 中山大学学报（医学科学版）, 2008, 39(3S): 158-1560.
33.	曾宪涛, 解龙川, 冷卫东, 等. 异种脱细胞真皮基质在预防Frey’s综合症中的应用. 临床口腔医学杂志, 2009, 25(6): 364-366.
34.	陈勇, 徐明耀.预防腮腺切除术后味觉出汗综合症的临床研究. 口腔医学研究, 2009, 25(1): 64-66.
35.	曾昭旋. 腮腺咬肌筋膜和脱细胞异体真皮基质在预防腮腺手术后Frey’s综合症中的应用. 临床口腔医学杂志, 2009, 26(1): 41-42.
36.	王时光, 张红杰, 王志兴. 脱细胞异体真皮基质预防味觉出汗综合症中的临床研究. 口腔颌面外科杂志, 2010, 20(1): 37-39.
37.	Ye WM, Zhu HG, Zheng JW, et al. Use of allogenic acellular dermal matrix in prevention of Frey’s syndrome after parotidectomy. Br J Oral Maxillofac Surg, 2008, 46(8): 649-652.
38.	Govindaraj S, Cohen M, Genden EM, et al. The Use of Acellular Dermis in the Prevention of Frey’s Syndrome. Laryngoscope, 2001, 111: 1993-1998.
39.	Sinha UK, Saadat D, Doherty CM, et al. Use of AlloDerm implant to prevent frey syndrome after parotidectomy. Arch Facial Plast Surg, 2003, 5(1): 109-112.
40.	CHEN WL, YANG ZH, HUANG ZQ, et al. SMAS fold flap and allograft dermal matrix repair parotid bed following parodectomy to prevent facial deformity and Frey’s syndrome. China J of Oral and Maxilloficial Sur, 2007, 5(4): 265-269.
41.	Harper JR. Tissue regeneration using a human acellular tissue matrix: A histological perspective. LifeCell Clinical Monograph Series, 2005.
42.	姜笃银, 付小兵, 盛志勇, 等. 无细胞异种真皮基质降解因素的研究. 中华实验外科杂志, 2003, 20(4): 360-361.
43.	姜笃银, 陈璧. 无细胞异种真皮基质研究进展. 中华烧伤杂志, 2003, 19: 66-68.

1. Donati M, Gandolfo L, Privitera A, et al. Superficial parotidectomy as first choice for parotid tumours. Chir Ital, 2007, 59(1): 91-97.
2. Marchese-Ragona R, De Filippis C, Marioni G, et al. Treatment of complications of parotid gland surgery. Acta Otorhinolaryngol Ital, 2005, 25(3): 174-178.
3. Koch M, Zenk J, Iro H. Long-term results of morbidity after parotid gland surgery in benign disease. Laryngoscope, 2010, 120(4): 724-730.
4. Frey L. Le syndrome du nerf auriculotemporal. Rev Neuro, 1923, 2: 92-104.
5. Harrison K, Donaldson I. Frey’s syndrome. J R Soc Med, 1979, 72: 503-508.
6. de Bree R, van der Waal I, Leemans CR. Management of frey syndrome. Head & Neck, 2007, 29(8): 773-778 .
7. Rustemeyer J, Eufinger H, Bremerich A. The incidence of Frey’s syndrome. J Cranio-Maxillofac Surg, 2008, 36(1): 34-37.
8. Malatskey S, Rabinovich I, Fradis M, et al. Frey syndrome-delayed clinical onset: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2002, 94(3): 338-340.
9. Wenzel GI, Draf W. Unusually long latency before the appearance of Frey’s syndrome after parotidectomy. HNO, 2004, 52(6): 554-556.
10. Baek CH, Chung MK, Jeong HS, et al. Questionnaire evaluation of sequelae over 5 years after parotidectomy for benign diseases. J of Plast Reconstr and Aesthet Surg, 2009, 62: 633-638.
11. Clayman MA, Clayman SM, Seagle MB. A review of the surgical and medical treatment of Frey syndrome. Ann Plast Surg, 2006, 57(5): 581-584.
12. Martos Díaz P, Bances del Castillo R, Mancha de la Plata M, et al. Clinical results in the management of Frey’s Syndrome with injections of Botulinum Toxin. Med Oral Patol Oral Cir Bucal, 2008, 13(4): E248-252.
13. Curry JM, Fisher KW, Heffelfinger RN, et al. Superficial Musculoaponeurotic System Elevation and Fat Graft Reconstruction After Superficial Parotidectomy. Laryngoscope, 2008, 118(2): 210-215.
14. Rubinstein RY, Rosen A, Leeman D. Frey syndrome: treatment with temporoparietal fascia flap interposition. Arch Otolaryngol Head Neck Surg, 1999, 125(7): 808-811.
15. Oa A, Ps K. Prevention of Frey’s syndrome and volume deficit after parotidectomy using the superficial temporal artery fascial flap. Br J Plast Surg, 1999, 52(4): 256-260.
16. Terzis JK, Olivares FS. Uses of the superficial temporal fascial flap in facial paralysis. Plast Reconstr Surg, 2008, 122(6): 176e-185e.
17. Filho WQ, Dedivitis RA, Rapoport A, et al. Sternocleidomastoid Muscle Flap Preventing Frey Syndrome following Parotidectomy. World J Surg, 2004, 28, 361-364.
18. Guntinas-Lichius O, Gabriel B, Klussmann JP. Risk of facial palsy and severe Frey’s syndrome after conservative parotidectomy for benign disease: analysis of 610 operations. Acta Otolaryngol, 2006, 126(10): 1104-1109.
19. 曲延刚, 孙乐刚, 王玉良, 等. 腮腺手术置入涤纶薄片预防Frey综合症. 实用口腔医学杂志, 2002, 18(2): 175-176.
20. 李德志, 吴跃煌, 王晓雷, 等. 腮腺肿瘤术后Frey综合征预防的初步研究.中华外科杂志, 2006, 44(15): 1033-1035.
21. 郭锡久, 阮兴朝, 冉红兵, 等. 膨体聚四氟乙烯植入整复腮腺术后凹陷畸形. 中国美容医学, 2005, 14(6): 697-698.
22. Clayman MA, Clayman LZ. Use of AlloDerm as a barrier to treat chronic Frey’s syndrome. Otolaryngol Head Neck Surg, 2001, 124(6): 687.
23. Papadogeorgakis N, Petsinis V, Christopoulos P, et al. Use of a porcine dermal collagen graft (Permacol) in parotid surgery. Br J Oral Maxillofac Surg, 2009, 47(5):378-381.
24. 邱蔚六, 主编. 口腔颌面外科学. 第6版. 北京: 人民卫生出版社, 2008: 371-372.
25. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2009. Available from www.cochrane-handbook.org.
26. 田刚, 江中明, 朱强. 口腔组织补片预防味觉出汗综合症的临床观察. 中国现代实用医学杂志, 2006, 5(8): 70-71.
27. 俞凯, 杨钧, 李满敬, 等. 脱细胞异体真皮基质预防味觉出汗综合症的临床观察. 中华口腔医学杂志, 2007, 42(9): 570-571.
28. 孙海鹏, 冯力, 翁汝涟, 等. 脱细胞异体真皮基质预防腮腺切除术后味觉出汗综合症和面部凹陷的临床研究. 广东牙病防治, 2008, 16(4): 161-163.
29. 张瑞鑫. 脱细胞真皮基质（ADM）在预防Frey’s综合症中的应用. 山东: 山东大学口腔临床医学, 2008.
30. 廖湘凌, 吴斌, 张艳, 等. 脱细胞真皮基质用于预防腮腺切除术后Frey综合症. 河北医科大学学报, 2008, 29(2): 223-235.
31. 董作青, 张凡, 魏奉才, 等. 应用脱细胞真皮基质预防腮腺切除术后Frey综合症. 山东大学学报（医学版）, 2008, 46(8): 801-803.
32. 劳军平, 陈巨峰, 欧阳可雄, 等. 组织瓣修复和异体脱细胞真皮基质植入预防腮腺切术后Frey综合症. 中山大学学报（医学科学版）, 2008, 39(3S): 158-1560.
33. 曾宪涛, 解龙川, 冷卫东, 等. 异种脱细胞真皮基质在预防Frey’s综合症中的应用. 临床口腔医学杂志, 2009, 25(6): 364-366.
34. 陈勇, 徐明耀.预防腮腺切除术后味觉出汗综合症的临床研究. 口腔医学研究, 2009, 25(1): 64-66.
35. 曾昭旋. 腮腺咬肌筋膜和脱细胞异体真皮基质在预防腮腺手术后Frey’s综合症中的应用. 临床口腔医学杂志, 2009, 26(1): 41-42.
36. 王时光, 张红杰, 王志兴. 脱细胞异体真皮基质预防味觉出汗综合症中的临床研究. 口腔颌面外科杂志, 2010, 20(1): 37-39.
37. Ye WM, Zhu HG, Zheng JW, et al. Use of allogenic acellular dermal matrix in prevention of Frey’s syndrome after parotidectomy. Br J Oral Maxillofac Surg, 2008, 46(8): 649-652.
38. Govindaraj S, Cohen M, Genden EM, et al. The Use of Acellular Dermis in the Prevention of Frey’s Syndrome. Laryngoscope, 2001, 111: 1993-1998.
39. Sinha UK, Saadat D, Doherty CM, et al. Use of AlloDerm implant to prevent frey syndrome after parotidectomy. Arch Facial Plast Surg, 2003, 5(1): 109-112.
40. CHEN WL, YANG ZH, HUANG ZQ, et al. SMAS fold flap and allograft dermal matrix repair parotid bed following parodectomy to prevent facial deformity and Frey’s syndrome. China J of Oral and Maxilloficial Sur, 2007, 5(4): 265-269.
41. Harper JR. Tissue regeneration using a human acellular tissue matrix: A histological perspective. LifeCell Clinical Monograph Series, 2005.
42. 姜笃银, 付小兵, 盛志勇, 等. 无细胞异种真皮基质降解因素的研究. 中华实验外科杂志, 2003, 20(4): 360-361.
43. 姜笃银, 陈璧. 无细胞异种真皮基质研究进展. 中华烧伤杂志, 2003, 19: 66-68.

Chinese Journal of Evidence-Based Medicine

Efficacy and Safety of Acellular Dermal Matrix in Preventing Frey Syndrome: A Systematic Review

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content