Polymorphism of Resistin Gene SNP-420C/G and Risks to Type 2 Diabetes among the Chinese Han Population: A Meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

ZHANG Siqing , GUO Jingqin , ZHONG Shumei

Department of Endocrinology and Metabolism, Ganzhou People’s Hospital, Ganzhou 341000, China;

Corresponding author：

Keywords：

Type 2 diabetes; Resistin gene; SNP-420; Polymorphism; Meta-analysis

DOI：

10.7507/1672-2531.20110047

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Objective 　To investigate the association of the polymorphism of resistin gene SNP-420C/G and type 2 diabetes (T2DM) among the Chinese Han population.
Methods 　Such databases as CNKI, WanFang database, VIP, SinoMed, and PubMed were electronically searched from January 2001 to July 2010 to collect case-control studies on polymorphism of resistin gene SNP-420C/G and T2DM among the Chinese Han population. The quality of the included studies was evaluated and the data was extracted. RevMan 4.2 software was used for meta-analyses.
Results 　A total of five case-control studies were identified, involving 709 cases in the T2DM group and 572 cases in the control group. The results of meta-analysis showed that the Chinese Han population with CC genotypes of SNP-420 had no higher risks to T2DM (OR=1.02, 95%CI 0.81 to 1.29), and the Chinese Han population with GG genotypes of SNP-420 still had no higher risks to T2DM (OR=1.34, 95%CI 0.95 to 1.90).
Conclusion 　Current evidence suggests that there is no association between the polymorphism of resistin gene SNP-420C/G and risk to T2DM among the Chinese Han population.

Citation： ZHANG Siqing,GUO Jingqin,ZHONG Shumei. Polymorphism of Resistin Gene SNP-420C/G and Risks to Type 2 Diabetes among the Chinese Han Population: A Meta-analysis. Chinese Journal of Evidence-Based Medicine, 2011, 11(3): 278-282. doi: 10.7507/1672-2531.20110047 Copy

1.	1 Yang W, Lu J, Weng J, et al . Prevalence of Diabetes among Men and Women in China. N Engl J Med , 2010, 362(12): 1090-1101.
2.	2 Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, et al . Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab , 2003,88(11): 5452-5455.
3.	3 Azuma K, Katsukawa F, Oguchi S, et al . Correlation between serum resistin level and adiposity in obese individuals. Obesity Research , 2003,11(8): 997-1001.
4.	4 McTernan PG, Fisher FM, Valsamakis G, et al . Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. J Clin Endocrinol Metab , 2003, 88(12): 6098–6106.
5.	5 Engert JC, Vohl MC, Williams SM, et al . 5' flanking variants of resistin are associated with obesity. Diabetes , 2002, 51(5): 1629-1634.
6.	6 Smith SR, Bai F, Charbonneau C, et al . A promoter genotype and oxidative stress potentially link resistin to human insulin resistance. Diabetes , 2003,52(7): 1611-1618.
7.	7 Osawa H, Yamada K, Onuma H, et al . The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. Am J Hum Genet , 2004,75(4): 678-686.
8.	8 Little J, Higgins JP, Ioannidis JP, et al . Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. Eur J Epidemiol , 2009, 24(1): 37-55.
9.	12 Chi S, Lan C, Zhang S, et al . Association of -394C>G and -420C>G polymorphisms in the RETN gene with T2DM and CHD and a new potential SNP might be exist in exon 3 of RETN gene in Chinese. Mol Cell Biochem , 2009, 330(1-2): 31-38.
10.	14 Steppan CM, Bailey ST, Bhat S, et al . The hormone resistin links obesity to diabetes. Nature , 2001, 409(6818): 307-312.
11.	赵杰. 2型糖尿病抵抗素基因单核苷酸多态性(SNPs)及胰岛素抵抗相关因素研究. 内蒙古医学杂志, 2007, 39(4): 416-419.
12.	张维, 毕娅欣. 抵抗素基因多态性与2型糖尿病及肥胖相关性研究. 实用全科医学, 2007, 5(6): 478-479.
13.	梁梅花, 张巾超, 陈峰, 等. 中国汉族人群 resistin 基因5′调控区与2型糖尿病的关系. 哈尔滨医科大学学报, 2003. 37(4): 321-323.
14.	梁梅花, 张巾超, 刘枫晨, 等. Resistin基因多态性与2型糖尿病相关性研究. 国际遗传学杂志, 2008, 31(1): 12-16.

1. 1 Yang W, Lu J, Weng J, et al . Prevalence of Diabetes among Men and Women in China. N Engl J Med , 2010, 362(12): 1090-1101.
2. 2 Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, et al . Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab , 2003,88(11): 5452-5455.
3. 3 Azuma K, Katsukawa F, Oguchi S, et al . Correlation between serum resistin level and adiposity in obese individuals. Obesity Research , 2003,11(8): 997-1001.
4. 4 McTernan PG, Fisher FM, Valsamakis G, et al . Resistin and type 2 diabetes: regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes. J Clin Endocrinol Metab , 2003, 88(12): 6098–6106.
5. 5 Engert JC, Vohl MC, Williams SM, et al . 5' flanking variants of resistin are associated with obesity. Diabetes , 2002, 51(5): 1629-1634.
6. 6 Smith SR, Bai F, Charbonneau C, et al . A promoter genotype and oxidative stress potentially link resistin to human insulin resistance. Diabetes , 2003,52(7): 1611-1618.
7. 7 Osawa H, Yamada K, Onuma H, et al . The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. Am J Hum Genet , 2004,75(4): 678-686.
8. 8 Little J, Higgins JP, Ioannidis JP, et al . Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement. Eur J Epidemiol , 2009, 24(1): 37-55.
9. 12 Chi S, Lan C, Zhang S, et al . Association of -394C>G and -420C>G polymorphisms in the RETN gene with T2DM and CHD and a new potential SNP might be exist in exon 3 of RETN gene in Chinese. Mol Cell Biochem , 2009, 330(1-2): 31-38.
10. 14 Steppan CM, Bailey ST, Bhat S, et al . The hormone resistin links obesity to diabetes. Nature , 2001, 409(6818): 307-312.
11. 赵杰. 2型糖尿病抵抗素基因单核苷酸多态性(SNPs)及胰岛素抵抗相关因素研究. 内蒙古医学杂志, 2007, 39(4): 416-419.
12. 张维, 毕娅欣. 抵抗素基因多态性与2型糖尿病及肥胖相关性研究. 实用全科医学, 2007, 5(6): 478-479.
13. 梁梅花, 张巾超, 陈峰, 等. 中国汉族人群 resistin 基因5′调控区与2型糖尿病的关系. 哈尔滨医科大学学报, 2003. 37(4): 321-323.
14. 梁梅花, 张巾超, 刘枫晨, 等. Resistin基因多态性与2型糖尿病相关性研究. 国际遗传学杂志, 2008, 31(1): 12-16.

Chinese Journal of Evidence-Based Medicine

Polymorphism of Resistin Gene SNP-420C/G and Risks to Type 2 Diabetes among the Chinese Han Population: A Meta-analysis

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