Smecta versus Xilei Powder for Oral Ulcer in Children: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

ZENG Xiantao ¹ , JIN Jing ² , XIANG Zhaoyan ³ , GUO Yi ⁴ , XIA Jing ¹ ,  LENG Weidong ¹

1. Department of Stomatology, Taihe Hospital, Hubei University of Medcine, Shiyan 442000, China; 2. Department of Stomatology, Xinqiao Hospital, Third Military Medcial University, Chongqing 400037, China; 3. Department of Paediatric, Taihe Hospital, Hubei University of Medcine, Shiyan 442000, China; 4. Department of Epidemiology, School of Public Health, Wuhan University, Wuhan 430071, China;

Corresponding author：

LENG Weidong, Email: lwd35@163.com

Keywords：

Smetca; Xilei Power; Children; Oral ulcer; Meta-analysis; Systematic review

DOI：

10.7507/1672-2531.20120053

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective　 To evaluate the clinical effectiveness of Smecta versus Xilei Powder in treatment of oral ulcer in children.
Methods　 CBM, CNKI, VIP and WanFang Data were searched for the randomized controlled trials (RCTs) of Smecta versus Xilei Powder in treatment of oral ulcer in children from the date of their establishment to June 31, 2010. The bibliographies of the included studies were searched, too. Two reviewers evaluated the quality of the included RCTs and extracted data critically and independently, and then the extracted data were analyzed by using RevMan 5.1 software.
Results　 Twenty-two RCTs involving 1 489 patients meeting the inclusion criteria. The results of meta-analyses showed that compared with Xilei Powder, Smecta could increase the total effective rate by 1.38 times (RR=1.38, 95%CI 1.31 to 1.45, P lt;0.000 01) and decrease the average course of treatment (MD= –1.54, 95%CI –1.77 to –1.31, P lt;0.000 01), with significant differences. Only 3 RCTs mentioned adverse events, but no adverse events were reported.
Conclusion　 The current evidence shows that Smecta is effective and safe in treatment of oral ulcer in children. Due to the limitations of the included RCTs, the quality of outcomes are moderate based on GRADE, which should be recommended by clinicians as “Weak Recommendation”. More large-sample and high-quality RCTs are needed to confirm the reliability of this study.

Citation： ZENG Xiantao,JIN Jing,XIANG Zhaoyan,GUO Yi,XIA Jing,LENG Weidong. Smecta versus Xilei Powder for Oral Ulcer in Children: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2012, 12(3): 326-333. doi: 10.7507/1672-2531.20120053 Copy

1.	Gherunpong S, Tsakos G, Sheiham A. The prevalence and severity of oral impacts on daily performances in thai primary school children. Health Qual Life Outcomes, 2004, 2: 57.
2.	Sepulveda E, Brethauer U, Rojas J, et al. Oral ulcers in children under chemotherapy: Clinical characteristics and their relation with herpes simplex virus type 1 and candida albicans. Med Oral Patol Oral Cir Bucal, 2005, 10 Suppl 1: E1-8.
3.	Shulman JD, Beach MM, Rivera-Hidalgo F. The prevalence of oral mucosal lesions in u.S. Adults: Data from the third national health and nutrition examination survey, 1988-1994. J Am Dent Assoc, 2004, 135(9): 1279-1286.
4.	Messadi DV, Younai F. Aphthous ulcers. Dermatol Ther, 2010, 23(3): 281-290.
5.	Farah CS, Lynch N, McCullough MJ. Oral fungal infections: An update for the general practitioner. Aust Dent J, 2010, 55 Suppl 1(48-54.
6.	Buczynski AK, Castro GF, Leao AT, et al. Impact of oral health on the quality of life of 3-6-years old hiv-infected children. Quality of life in hiv+ children. Eur J Paediatr Dent, 2011, 12(2): 81-86.
7.	Krisdapong S, Sheiham A, Tsakos G. Impacts of recurrent aphthous stomatitis on quality of life of 12- and 15-year-old thai children. Qual Life Res, 2011.
8.	Riordain RN, Meaney S, McCreary C. Impact of chronic oral mucosal disease on daily life: Preliminary observations from a qualitative study. Oral Dis, 2011, 17(3): 265-269.
9.	Faden H. Management of primary herpetic gingivostomatitis in young children. Pediatr Emerg Care, 2006, 22(4): 268-269.
10.	刘绍能. 锡类散的临床应用概况. 实用中医内科杂志, 1992, 6(2): 17-19.
11.	More J, Benazet F, Fioramonti J, et al. Effects of treatment with smectite on gastric and intestinal glycoproteins in the rat: A histochemical study. Histochem J, 1987, 19(12): 665-670.
12.	Szajewska H, Dziechciarz P, Mrukowicz J. Meta-analysis: Smectite in the treatment of acute infectious diarrhoea in children. Aliment Pharmacol Ther, 2006, 23(2): 217-227.
13.	Yen ZS, Lai MS. Best evidence topic report. Smectite for acute diarrhoea in children. Emerg Med J, 2006, 23(1): 65-66.
14.	Higgins JPT, Green S, editors. Assessing risk of bias in included studies: Cochrane Handbook for Systematic Reviews of Interventions 5.0.1 [updated September 2008], The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
15.	韩霞, 刘翠梅. 思密达治疗儿童口腔溃疡62例临床报告. 临床儿科杂志, 1995, 13(3): 212-213.
16.	胡小琴. 思密达治疗小儿口腔溃疡50例报告. 临床儿科杂志, 1995, 13(6): 421.
17.	吴琴琴. 思密达与锡类散治疗小儿疱疹性齿龈口炎的临床比较. 浙江实用医学, 1997, 2(5): 1007-3299.
18.	咸云平, 章岚岚. 思密达治疗婴幼儿口腔溃疡30例疗效观察. 浙江中西医结合杂志, 1997, 7(4): 1005-4561.
19.	陈沛文, 陈霖. 思密达治疗手足口病口腔溃疡32例疗效观察. 中国皮肤性病学杂志, 1999, 13(6): 1001-7089.
20.	王保兴, 陈丽平. 思密达加蜂蜜治疗小儿口腔溃疡46例. 中国社区医师, 19991): 20.
21.	董美玲. 思密达治疗小儿口腔溃疡疗效观察. 中国实用儿科杂志, 2000, 15(1): 18.
22.	李晓莺, 徐春. 思密达治疗小儿疱疹性口炎临床分析(附38例报告). 儿科药学杂志, 2001, 7(4): 34.
23.	盛瑛. 思密达在小儿口腔溃疡中的应用. 护理学杂志, 2001, 16(6): 372.
24.	程敏芳. 思密达治疗溃疡性口腔炎30例疗效观察. 福建医药杂志, 2001, 23(2): 72-73.
25.	王泉华, 陈铭. 思密达治疗儿童口腔溃疡的疗效观察. 辽宁药物与临床, 2002, 5(S1): 25-26.
26.	徐峰, 余文华. 思密达与维生素E治疗小儿口腔溃疡. 医药导报, 2002, 21(3): 167.
27.	洪秀萍, 常守枝. 思密达治疗手足口病口腔溃疡24例观察. 中国航天医药杂志, 2002, 4(3): 39.
28.	黎军. 思密达治疗小儿口疮的疗效观察及护理. 南京军医学院学报, 2003, 25(4): 355-356.
29.	梁香莲, 王巧燕. 思密达治疗小儿口腔溃疡疗效观察. 基层医学论坛, 2003, 7(5): 427.
30.	蒋玉平, 卢乃香. 思密达治疗小儿口腔溃疡40例疗效观察. 中原医刊, 2004, 31(4): 39.
31.	霍文凤. 思密达治疗小儿口腔溃疡疗效观察. 锦州医学院学报, 2004, 25(1): 16.
32.	范世慧. 思密达治疗小儿手足口病口腔溃疡疗效观察. 实用全科医学, 2005, 3(5): 418.
33.	王娅荣. 思密达治疗小儿口腔溃疡66例疗效观察. 实用医学杂志, 2006, 22(21): 2547.
34.	李仲明, 叶柱均. 思密达治疗小儿口腔溃疡的疗效观察. 中国医药导报, 2009, 6(19): 1673-7210.
35.	曹彦. 思密达治疗小儿口腔溃疡33例疗效观察. 吉林医学, 2010, 31(27): 1004-0412.
36.	张玉新. 思密达散治疗小儿手足口病口腔溃疡32例疗效分析. 中国社区医师(医学专业), 2011, 13(03): 56.
37.	Bian Z, Liu B, Moher D, et al. Consolidated standards of reporting trials (consort) for traditional chinese medicine: Current situation and future development. Front Med, 2011, 5(2): 171-177.
38.	曾宪涛, 冷卫东, 李胜, 等. 如何正确理解及使用GRADE系统. 中国循证医学杂志, 2011, 11(9): 985-990.

1. Gherunpong S, Tsakos G, Sheiham A. The prevalence and severity of oral impacts on daily performances in thai primary school children. Health Qual Life Outcomes, 2004, 2: 57.
2. Sepulveda E, Brethauer U, Rojas J, et al. Oral ulcers in children under chemotherapy: Clinical characteristics and their relation with herpes simplex virus type 1 and candida albicans. Med Oral Patol Oral Cir Bucal, 2005, 10 Suppl 1: E1-8.
3. Shulman JD, Beach MM, Rivera-Hidalgo F. The prevalence of oral mucosal lesions in u.S. Adults: Data from the third national health and nutrition examination survey, 1988-1994. J Am Dent Assoc, 2004, 135(9): 1279-1286.
4. Messadi DV, Younai F. Aphthous ulcers. Dermatol Ther, 2010, 23(3): 281-290.
5. Farah CS, Lynch N, McCullough MJ. Oral fungal infections: An update for the general practitioner. Aust Dent J, 2010, 55 Suppl 1(48-54.
6. Buczynski AK, Castro GF, Leao AT, et al. Impact of oral health on the quality of life of 3-6-years old hiv-infected children. Quality of life in hiv+ children. Eur J Paediatr Dent, 2011, 12(2): 81-86.
7. Krisdapong S, Sheiham A, Tsakos G. Impacts of recurrent aphthous stomatitis on quality of life of 12- and 15-year-old thai children. Qual Life Res, 2011.
8. Riordain RN, Meaney S, McCreary C. Impact of chronic oral mucosal disease on daily life: Preliminary observations from a qualitative study. Oral Dis, 2011, 17(3): 265-269.
9. Faden H. Management of primary herpetic gingivostomatitis in young children. Pediatr Emerg Care, 2006, 22(4): 268-269.
10. 刘绍能. 锡类散的临床应用概况. 实用中医内科杂志, 1992, 6(2): 17-19.
11. More J, Benazet F, Fioramonti J, et al. Effects of treatment with smectite on gastric and intestinal glycoproteins in the rat: A histochemical study. Histochem J, 1987, 19(12): 665-670.
12. Szajewska H, Dziechciarz P, Mrukowicz J. Meta-analysis: Smectite in the treatment of acute infectious diarrhoea in children. Aliment Pharmacol Ther, 2006, 23(2): 217-227.
13. Yen ZS, Lai MS. Best evidence topic report. Smectite for acute diarrhoea in children. Emerg Med J, 2006, 23(1): 65-66.
14. Higgins JPT, Green S, editors. Assessing risk of bias in included studies: Cochrane Handbook for Systematic Reviews of Interventions 5.0.1 [updated September 2008], The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
15. 韩霞, 刘翠梅. 思密达治疗儿童口腔溃疡62例临床报告. 临床儿科杂志, 1995, 13(3): 212-213.
16. 胡小琴. 思密达治疗小儿口腔溃疡50例报告. 临床儿科杂志, 1995, 13(6): 421.
17. 吴琴琴. 思密达与锡类散治疗小儿疱疹性齿龈口炎的临床比较. 浙江实用医学, 1997, 2(5): 1007-3299.
18. 咸云平, 章岚岚. 思密达治疗婴幼儿口腔溃疡30例疗效观察. 浙江中西医结合杂志, 1997, 7(4): 1005-4561.
19. 陈沛文, 陈霖. 思密达治疗手足口病口腔溃疡32例疗效观察. 中国皮肤性病学杂志, 1999, 13(6): 1001-7089.
20. 王保兴, 陈丽平. 思密达加蜂蜜治疗小儿口腔溃疡46例. 中国社区医师, 19991): 20.
21. 董美玲. 思密达治疗小儿口腔溃疡疗效观察. 中国实用儿科杂志, 2000, 15(1): 18.
22. 李晓莺, 徐春. 思密达治疗小儿疱疹性口炎临床分析(附38例报告). 儿科药学杂志, 2001, 7(4): 34.
23. 盛瑛. 思密达在小儿口腔溃疡中的应用. 护理学杂志, 2001, 16(6): 372.
24. 程敏芳. 思密达治疗溃疡性口腔炎30例疗效观察. 福建医药杂志, 2001, 23(2): 72-73.
25. 王泉华, 陈铭. 思密达治疗儿童口腔溃疡的疗效观察. 辽宁药物与临床, 2002, 5(S1): 25-26.
26. 徐峰, 余文华. 思密达与维生素E治疗小儿口腔溃疡. 医药导报, 2002, 21(3): 167.
27. 洪秀萍, 常守枝. 思密达治疗手足口病口腔溃疡24例观察. 中国航天医药杂志, 2002, 4(3): 39.
28. 黎军. 思密达治疗小儿口疮的疗效观察及护理. 南京军医学院学报, 2003, 25(4): 355-356.
29. 梁香莲, 王巧燕. 思密达治疗小儿口腔溃疡疗效观察. 基层医学论坛, 2003, 7(5): 427.
30. 蒋玉平, 卢乃香. 思密达治疗小儿口腔溃疡40例疗效观察. 中原医刊, 2004, 31(4): 39.
31. 霍文凤. 思密达治疗小儿口腔溃疡疗效观察. 锦州医学院学报, 2004, 25(1): 16.
32. 范世慧. 思密达治疗小儿手足口病口腔溃疡疗效观察. 实用全科医学, 2005, 3(5): 418.
33. 王娅荣. 思密达治疗小儿口腔溃疡66例疗效观察. 实用医学杂志, 2006, 22(21): 2547.
34. 李仲明, 叶柱均. 思密达治疗小儿口腔溃疡的疗效观察. 中国医药导报, 2009, 6(19): 1673-7210.
35. 曹彦. 思密达治疗小儿口腔溃疡33例疗效观察. 吉林医学, 2010, 31(27): 1004-0412.
36. 张玉新. 思密达散治疗小儿手足口病口腔溃疡32例疗效分析. 中国社区医师(医学专业), 2011, 13(03): 56.
37. Bian Z, Liu B, Moher D, et al. Consolidated standards of reporting trials (consort) for traditional chinese medicine: Current situation and future development. Front Med, 2011, 5(2): 171-177.
38. 曾宪涛, 冷卫东, 李胜, 等. 如何正确理解及使用GRADE系统. 中国循证医学杂志, 2011, 11(9): 985-990.

Chinese Journal of Evidence-Based Medicine

Smecta versus Xilei Powder for Oral Ulcer in Children: A Meta-Analysis

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