Analysis on Therapeutic Effects and Influencing Factors of Focused Ultrasound in 7027 Patients with Cervicitis Related Diseases_Chinese Journal of Evidence-Based Medicine

Authors：

LI Chengzhi ^1# , XIONG Xi ^1# , LI Youping ² , PENG Bin ³ , CAI Yujia ² , DU Liang ² , LI Jing ² , WANG Li ² , PAN Zhongli ¹ , CHEN Jinyun ¹ , XIAO Xiao ¹ ,  CHEN Wenzhi ^1,4 , WANG Zhibiao ¹

1. Department of Biomedical Engineering, Chongqing Medical University, Chongqing 400016,China;2. Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China;3. Department of Health Statistics, School of Public Health, Chongqing Medical University, Chongqing 400016, China;4. National Engineering Research Center of Ultrasound Medicine, Chongqing 401121, China;

Corresponding author：

CHEN Wenzhi, Email: chenwz@haifu.com.cn

Keywords：

Cervicitis related disease; Focused ultrasound; CZF single treatment; Efficacy evaluation

DOI：

10.7507/1672-2531.20120066

Video：

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Objective 　To explore the effectiveness, safety and applicability of focused ultrasound (FU) in rural patients with cervicitis-related diseases.
Methods 　Patients with cervicitis-related diseases (n=8 352) from 80 township health centers of 9 counties in Chongqing were enrolled in this multicenter clinical study, and they were treated with CZF Model of FU for one time and then were visited in the following 3 months. According to the category 4 scoring method and the curative index, the effectiveness, safety and applicability in 7027 cases (1 156 mild cases, 5 312 moderate cases, 559 severe cases) with complete records were analyzed. The influencing factors were also analyzed with logistic regression analysis.
Results 　A total of 6 413 cases (91.26%) were treated within 5 minutes. After 3-month follow-up, the total effective rate was 99.59%, and 5 012 cases (71.32%) were cured. Just little or medium amount of vaginal bleeding occurred in 656 cases (9.34%) after treatment, while only 12 cases (0.17%) had bleeding in the similar amount tomenstruation, which were relieved by hemostasis and anti-inflammatory treatment.
Conclusion 　As a promising new therapy, focused ultrasound therapy for treating cervicitis-related diseases is safe and effective, with little postoperative bleeding and short-term of vaginal effusion, so it is suitable to be popularized in rural areas.

Citation： LI Chengzhi,XIONG Xi,LI Youping,PENG Bin,CAI Yujia,DU Liang,LI Jing,WANG Li,PAN Zhongli,CHEN Jinyun,XIAO Xiao,CHEN Wenzhi,WANG Zhibiao. Analysis on Therapeutic Effects and Influencing Factors of Focused Ultrasound in 7027 Patients with Cervicitis Related Diseases. Chinese Journal of Evidence-Based Medicine, 2012, 12(4): 406-412. doi: 10.7507/1672-2531.20120066 Copy

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2.	Chen P. Cervicitis. Available at: http://www.nlm.nih.gov/medlineplus/ency/article/001495.htm. Accessed November 29, 2004.
3.	Gerrmain A, Holmes KK, Piot P. Reproductive Tract Infection. New York and London: Plenum Publishing Corporation, 1992: 1-55.
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5.	张开宁, 李晓梅, 时黎. 服务质量对农村妇女生殖道感染症状持续求医行为的影响. 中国初级卫生保健, 2001, 15(2): 44.
6.	汤莉. 农村妇女生殖健康现状调查. 现代医院, 2009, 9(12): 153-155.
7.	张红杰, 陈占良, 刘梅云. 山区育龄妇女慢性宫颈炎流行病学调查. 现代预防医学, 2006, 3(10): 1833-1837.
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9.	黄玉芝. 慢性宫颈炎相关因素流行病学调查. 中国临床医药研究杂志, 2008, (200): 63-64.
10.	郭秋灵. 农村育龄妇女慢性宫颈炎流行病学分析. 医药论坛杂志, 2007, 28(16): 33.
11.	沈琼. 安徽省淮北地区农村已婚育龄妇女生殖道感染现状及相关因素研究. 安徽: 安徽医科大学, 2010.
12.	H. Dalgic · N.K. Kuscu. Laser therapy in chronic cervicitis. Arch Gynecol Obstet, 2001, 265(15): 64-66.
13.	卞度宏正确认识和处理慢性宫颈炎. 中华妇产科杂志, 2007, 42(1): 4-5.
14.	孟海霞, 苏日娜, 其木格. 慢性宫颈炎的治疗研究进展. 中华妇幼临床医学杂志, 2007, 3(2): 115-117.
15.	金寒莹, 陶春霞, 付蓉芳. 聚焦超声用于治疗慢性宫颈炎2646例的临床疗效分析. 江西医学院学报, 2006, 46(3): 88-94.
16.	Chen J, Zhou D, Liu Y, et al. A comparison between ultrasound therapy and laser therapy for symptomatic cervical ectopy. Ultrasound Med Biol, 2008, 34(11): 1770-1774.
17.	任玉香, 吴凤英, 陈维, 等. 聚焦超声治疗宫颈病变3090例效果观察.第三军医大学学报, 2009, 13(14)：1408-1409.
18.	王莉, 高霑, 李幼平, 等. 聚焦超声单次治疗51962例慢性宫颈炎的安全性与有效性系统评价证据现状.
19.	熊希, 李幼平, 李成志. 重庆9区县97093名妇女慢性宫颈炎患病现况调查及影响因素分析. 待发表.
20.	狄文, 戴岚. 慢性宫颈炎最新诊治策略. 中国实用妇科与产科杂志, 2008, 24(1): 6-8.
21.	刘玉娟, 吴艺佳, 袁小莉, 等. 聚焦超声治疗慢性宫颈炎的临床研究. 中国妇幼健康研究, 2006, 17(1): 17-19.
22.	王智彪, 李发琪, 冯若, 等主编. 治疗超声原理与应用. 南京: 南京大学出版社, 2008: 272-277.
23.	Hensyl WR, editor. Stedman’s medical dictionary. 25th edition. Baltimore (MD): William & Wilkins; 1990.
24.	Robert EB, Beth YK. Disorders of the Uterine Cervix. In: James RS, Philip JD, Charles BH. Danforth’s Obstetrics＆Gynecology. 8th edition. Lippincott Williams＆ Wilkins, 1999.
25.	Byard RW, Mikhael NZ, Orlando G, et al. Prefontaine MThe clinicopathological significance of cytomegalovirus inclusions demonstrated by endocervical biopsy, 1991, 23(4): 318-321.
26.	魏丽慧. 宫颈病变诊治的策略与规范. 2011年中国医师协会妇产科医师大会主题讲座. 2011.
27.	梁伟国. 慢性宫颈炎物理治疗后创面出血的处理. 广东医学, 2002, 23(4): 932.
28.	史则峡, 冯余宽, 吴丽春, 等. 雌三醇栓促进宫颈糜烂物理疗法后创面修复的多中心临床试验研究. 实用妇产科杂志, 2002, 18(11): 241-242.
29.	丁惠芬, 胡敏. KS-5A治疗仪联合妇良片治疗重度宫颈糜烂疗效观察. 江西中医学院学报, 2004, 16(15): 38.

1. 丰有吉, 沈铿, 主编. 妇产科学. 第2版（供8年制及7年制临床医学等专业用）. 北京: 人民卫生出版社. 2010年.
2. Chen P. Cervicitis. Available at: http://www.nlm.nih.gov/medlineplus/ency/article/001495.htm. Accessed November 29, 2004.
3. Gerrmain A, Holmes KK, Piot P. Reproductive Tract Infection. New York and London: Plenum Publishing Corporation, 1992: 1-55.
4. Sweet RL, Gibbs RS. Infectious diseases of the female genital tract (third edition). Baltimore: Willians & Wilkins, 1995.
5. 张开宁, 李晓梅, 时黎. 服务质量对农村妇女生殖道感染症状持续求医行为的影响. 中国初级卫生保健, 2001, 15(2): 44.
6. 汤莉. 农村妇女生殖健康现状调查. 现代医院, 2009, 9(12): 153-155.
7. 张红杰, 陈占良, 刘梅云. 山区育龄妇女慢性宫颈炎流行病学调查. 现代预防医学, 2006, 3(10): 1833-1837.
8. 张秀军. 安徽省农村已婚育龄妇女生殖道感染现状及相关因素研究. 安徽: 安徽医科大学, 2009.
9. 黄玉芝. 慢性宫颈炎相关因素流行病学调查. 中国临床医药研究杂志, 2008, (200): 63-64.
10. 郭秋灵. 农村育龄妇女慢性宫颈炎流行病学分析. 医药论坛杂志, 2007, 28(16): 33.
11. 沈琼. 安徽省淮北地区农村已婚育龄妇女生殖道感染现状及相关因素研究. 安徽: 安徽医科大学, 2010.
12. H. Dalgic · N.K. Kuscu. Laser therapy in chronic cervicitis. Arch Gynecol Obstet, 2001, 265(15): 64-66.
13. 卞度宏正确认识和处理慢性宫颈炎. 中华妇产科杂志, 2007, 42(1): 4-5.
14. 孟海霞, 苏日娜, 其木格. 慢性宫颈炎的治疗研究进展. 中华妇幼临床医学杂志, 2007, 3(2): 115-117.
15. 金寒莹, 陶春霞, 付蓉芳. 聚焦超声用于治疗慢性宫颈炎2646例的临床疗效分析. 江西医学院学报, 2006, 46(3): 88-94.
16. Chen J, Zhou D, Liu Y, et al. A comparison between ultrasound therapy and laser therapy for symptomatic cervical ectopy. Ultrasound Med Biol, 2008, 34(11): 1770-1774.
17. 任玉香, 吴凤英, 陈维, 等. 聚焦超声治疗宫颈病变3090例效果观察.第三军医大学学报, 2009, 13(14)：1408-1409.
18. 王莉, 高霑, 李幼平, 等. 聚焦超声单次治疗51962例慢性宫颈炎的安全性与有效性系统评价证据现状.
19. 熊希, 李幼平, 李成志. 重庆9区县97093名妇女慢性宫颈炎患病现况调查及影响因素分析. 待发表.
20. 狄文, 戴岚. 慢性宫颈炎最新诊治策略. 中国实用妇科与产科杂志, 2008, 24(1): 6-8.
21. 刘玉娟, 吴艺佳, 袁小莉, 等. 聚焦超声治疗慢性宫颈炎的临床研究. 中国妇幼健康研究, 2006, 17(1): 17-19.
22. 王智彪, 李发琪, 冯若, 等主编. 治疗超声原理与应用. 南京: 南京大学出版社, 2008: 272-277.
23. Hensyl WR, editor. Stedman’s medical dictionary. 25th edition. Baltimore (MD): William & Wilkins; 1990.
24. Robert EB, Beth YK. Disorders of the Uterine Cervix. In: James RS, Philip JD, Charles BH. Danforth’s Obstetrics＆Gynecology. 8th edition. Lippincott Williams＆ Wilkins, 1999.
25. Byard RW, Mikhael NZ, Orlando G, et al. Prefontaine MThe clinicopathological significance of cytomegalovirus inclusions demonstrated by endocervical biopsy, 1991, 23(4): 318-321.
26. 魏丽慧. 宫颈病变诊治的策略与规范. 2011年中国医师协会妇产科医师大会主题讲座. 2011.
27. 梁伟国. 慢性宫颈炎物理治疗后创面出血的处理. 广东医学, 2002, 23(4): 932.
28. 史则峡, 冯余宽, 吴丽春, 等. 雌三醇栓促进宫颈糜烂物理疗法后创面修复的多中心临床试验研究. 实用妇产科杂志, 2002, 18(11): 241-242.
29. 丁惠芬, 胡敏. KS-5A治疗仪联合妇良片治疗重度宫颈糜烂疗效观察. 江西中医学院学报, 2004, 16(15): 38.

Chinese Journal of Evidence-Based Medicine

Analysis on Therapeutic Effects and Influencing Factors of Focused Ultrasound in 7027 Patients with Cervicitis Related Diseases

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