Correlation of the Adiponectin Gene +45 in Exon 2 Polymorphisms and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LI Li ¹ , LIU Zhonghua ² , YU Fangxue ¹ , YAO Ke ¹ , FENG Hong ¹ , LI Hong ¹ ,  ZHU Cairong ¹

1. Statistics Teaching Section, West China Public Health School, Sichuan University, Chengdu 610041, China;2. Geriatrics Department, West China Fourth University Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

ZHU Cairong, Email: cairong.zhu@hotmail.com

Keywords：

Type 2 diabetes; Adiponectin gene; Polymorphism; Chinese population; Meta-analysis

DOI：

10.7507/1672-2531.20120192

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To evaluate the relationship between the single nucleotide polymorphisms (SNPs) of the adiponectin gene +45 in exon 2 and type 2 diabetes mellitus (T2DM) in Chinese population via meta-analysis.
Methods 　Databases including PubMed, Ovid, CBM, VIP, CNKI, and WanFang Data were searched from inception to June 2012, and the references of articles were also retrieved to collect case-control studies about the correlation of SNPs of the adiponectin gene +45 in exon 2 and T2DM in Chinese population. According to the self-designed inclusion and exclusion criteria, two reviewers screened articles, extracted data, and assessed the quality of the included studies independently. Then meta-analysis was performed STATA 11.0, with stability evaluated by both stratified analysis and sensitivity analysis. Moreover, Begg’s funnel plot and Egger’s method were used to assess the published bias of articles.
Results 　21 articles involving 22 studies were included (3272 T2DM cases and 2597 controls). There were significant differences between the two groups in dominant, recessive and addictive genetic models, and the pooled ORs (95% CI) were 1.36 (1.04, 1.78), 2.07 (1.55, 2.75), and 2.44 (1.59, 3.75), respectively.
Conclusion 　The genetic single nucleotide polymorphisms of the adiponectin +45 in exon 2 is associated with type 2 diabetes in Chinese population. G allele of APM1 is a risk factor for type 2 diabetes, no matter in dominant, recessive or addictive genetic models.

Citation： LI Li,LIU Zhonghua,YU Fangxue,YAO Ke,FENG Hong,LI Hong,ZHU Cairong. Correlation of the Adiponectin Gene +45 in Exon 2 Polymorphisms and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2012, 12(10): 1235-1240. doi: 10.7507/1672-2531.20120192 Copy

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1. King H, Aubert RE, Herman WH, et al. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care, 1998, 21(9): 1414-1431.
2. Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Disbetes Care, 2004, 27(10): 2569.
3. 王润娇. 2型糖尿病的危险因素研究进展. 中国现代医生, 2010, 48(4): 37-39.
4. 董艳, 李果, 骆天红, 等. 脂联素基因多态性与2型糖尿病的关系. 上海第二医科大学学报, 2004, 24(12): 1001-1003.
5. Takahashi M, Arita Y, Yamagata K, et al. Genomic structure and mutations in adipose-specific gene, adiponectin. Int J Obes, 2000, 24(7): 861-868.
6. Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty acid oxidation by activating AMP actirated protein kinase. Nature Medicine, 2002, 8(11): 1288-1295.
7. Kondo H, Shimomura I, Matsukawa Y, et al. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes, 2002, 51(7): 2325-2328.
8. Mori Y, Otabe S, Dina C, et al. Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p. Diabetes, 2002, 4(51): 1247-1255.
9. Menzaghi C, Ercolino T, Paola RD, et al. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes, 2002, 51(7): 2306-2312.
10. Lindsay RS, Funahashi T, Hansonn RL, et al. Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet, 2002, 360(9326): 57-58.
11. Hara K, Boutin P, Mori Y, et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes, 2002, 51(2): 536-540.
12. Zacharova J, Chiasson JL, Laakso M. The common polymorphisms (single nucleotide polymorphism [SNP]+45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Diabetes, 2005, 54(3): 893-899.
13. Gonzalez-Sanchez JL, Zabena CA, Martinez-Larrad MT, et al. An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance. Obesity, 2005, 13(5): 807-812.
14. Fumeron F, Aubert R, Siddiq A, et al. Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period. Diabetes, 2004, 53(4): 1150-1157.
15. Hu FB, Doria A, Li T, et al. Genetic variation at the adiponectin locus and risk of type 2 diabetes in woman. Diabetes, 2004, 53(1): 209-213.
16. Vasseur F, Helbecque N, Dina C, et al. Single nucleotide polmorphism haplotypes in the beoth proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet, 2002, 11(21): 2607-2614.
17. Filippi E, Seutinelli F, Trischitta V, et al. Assosiation of the human adiponectin gene and insulin resistance. European Journal of Human Genetics, 2004, 12(3): 199-205.
18. Gu HF, Abulaiti A, Ostenson CG, et al. Single nueleotide polymorphisms in the proximal promoter region of the adiponectin(APM1) gene are associatod with type 2 diabetes in swedish caucasians. Diabetes, 2004, 53(1): 31-35.
19. Vozarova de Courten B, Hanson RL, Funabashi T, et al. Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in pima indians. Diabetes, 2005, 54(1): 284-289．.
20. Lee YY, Lee NS, Cho YM, et al. Genetic association study of adiponectin polymorphisms with risk of type 2 diabetes mellitus in Korean population. Diabet Med, 2005, 22(5): 569-575.
21. Stumvoll M, Tscbritter O, Fritsche A, et al. Association of the T-G polymorphism in adiponectin(exon 2) with obesity and insulin sensitivity:interaction with family history of type 2 diabetes. Diabetes, 2002, 51(1): 37-41.
22. 王艳, 王涛, 钟洪涛. 脂联素基因SNP45 T/G多态性与2型糖尿病相关性研究. 现代生物医学进展, 2008, 8(1): 84-86.
23. 康庄, 孙朝昆, 赵惠珠, 等. 大理白族、汉族2型糖尿病与脂联素基因多态性的相关性研究. 中国糖尿病杂志, 2008, 16(12): 718-720.
24. 周强, 杨静, 罗淼珊, 等. 脂联素单核苷酸多态性+45位点的表达在2型糖尿病中的研究. 国际检验医学杂志, 2009, 30(2): 105-107.
25. 王淑芳, 赵家军, 姜强, 等. 脂联素基因多态性与2型糖尿病相关性研究. 中华内分泌代谢杂志, 2007, 23(1): 51-52.
26. 叶红, 庄捷. 脂联素基因T45G多态性与中国汉族人2型糖尿病的相关性研究. 药学服务与研究, 2009, 9(2): 158-160.
27. 郝家明, 刁志宏, 刘锦星. 海南地区汉族人脂联素基因单核苷酸多态性与2型糖尿病的相关性研究. 海南医学, 2009, 20(7): 1-3.
28. 王迎雪, 赵磊, 于苏国, 等. 脂联素基因多态性与2型糖尿病的相关性研究. 山东医药, 2010, 50(37): 1-2.
29. 吴文君, 卜瑞芳, 刘国萍, 等. 2型糖尿病合并高甘油三酯血症患者血清脂联素水平与脂联素基因多态性分析. 中国糖尿病杂志, 2008, 16(7): 402-404.
30. 张君. 脂联素基因（+45，276位点）多态性与维吾尔族2糖尿病相关性研究. 新疆: 石河子大学, 2007.
31. 王燕, 何凌, 黄春苓. 广东汉族人群脂联素基因多态性与2 型糖尿病相关性研究. 热带医学杂志, 2007, 7(7): 651-653.
32. 陈青云, 苏庆建, 覃伟武, 等. 广西地区壮族2型糖尿病患者脂联素基因多态性研究. 广西医科大学学报, 2008, 25(6): 821-824.
33. 程伟, 易慧智, 麻献微. 豫南地区2 型糖尿病患者脂联素基因45位点多态性分布. 郑州大学学报(医学版). 2007, 42(6): 1145-1147.
34. 魏颖丽, 霍正浩, 赵巍. 我国西部人群脂联素基因+45位点多态性与肥胖、胰岛素抵抗及2型糖尿病的相关性. 中国糖尿病杂志, 2007, 15(10): 583-585.
35. 史晓红, 金锋, 孙亮, 等. 脂联素基因SNP+45(T/G)单核苷酸多态性与2型糖尿病的关系. 中国组织工程研究与临床康复, 2007, 11(25): 4941-4944.
36. 夏晖, 莫永珍, 卞茸文, 等. 中国人脂联素基因单核苷酸多态性与2 型糖尿病的相关性. 中华内分泌代谢杂志, 2004, 20(3): 236-237.
37. 孙红. 脂联素基因多态性在中国2 型糖尿病患者中的分布及其对罗格列酮疗效的影响. 长沙: 中南大学, 2007.
38. 王振贤. 脂联素基因多态性及其血清水平与不同糖耐量人群的相关性研究. 石家庄: 河北医科大学, 2003.
39. 翟冰, 叶玲, 刘建伟, 等. 北京社区人群脂联素和过氧化物酶增殖物活化受体γ2基因多态性及其交互作用与2型糖尿病的关系. 中国临床康复, 2006, 10 (4): 28-31.
40. 苏庆建. 脂联素基因外显子2多态性与糖尿病及相关危险因素的关联性研究. 南宁: 广西医科大学, 2005.
41. 何慧婧, 卫大英, 王淳秀, 等. 四川凉山汉族2型糖尿病与脂联素基因多态性. 中国公共卫生, 2012, 28(3): 302-304.
42. 平智广, 刘莉. 脂联素基因T45G与2型糖尿病关系的Meta分析. 现代预防医学, 2009, 36(15): 2812-2816.
43. 汝颖. 脂联素基因编码区变异与2型糖尿病的关联研究. 合肥: 安徽医科大学, 2005.
44. 康小龙. 脂联素基因多态性与新疆维吾尔、哈萨克、汉族2型糖尿病的相关性研究. 乌鲁木齐: 新疆医科大学, 2006.
45. 初明峰, 郭立新, 潘琦, 等. 脂联素基因多态性与2型糖尿病及颈动脉内膜中层厚度有关. 中华内分泌代谢杂志, 2006, 22(1): 24-26.
46. 王大鹏, 王长义, 赵晓雯, 等. 脂联素基因T45G多态性与2型糖尿病关系的Meta分析. 中国糖尿病杂志, 2010, 18(5): 338-341.
47. Devlin B, Roeder K. Genomic control for association studies. Biometrics, 1999, 55(4): 997-1004.
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Chinese Journal of Evidence-Based Medicine

Correlation of the Adiponectin Gene +45 in Exon 2 Polymorphisms and Type 2 Diabetes Mellitus in Chinese Population: A Meta-Analysis

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