What drug dosage range is appropriate for treatment? What drug dosage range can maximally reduce the incidence of adverse drug reaction (ADR)? The gold zone method as a new method of evidence-based medical research was proposed to study those two blind areas of drug dosage in this article. Studying the dose-effect relationship, taking gold zone as the middle range and dividing empirical range into 3 sections were the key to study design. The evidence-based survey with extremely large sample showed a U-shaped rule existing between the antibiotics’ dosage and the incidence of ADR; and the dosage in gold zone appeared at the bottom of U-shaped curve. The gold zone method for determining dosage is a special breakthrough currently for solving those two blind areas of drug dosage
Citation： LIU Jianping. Controlling Drug Dosage Based on Gold Zone Method to Reduce Adverse Drug Reaction. Chinese Journal of Evidence-Based Medicine, 2012, 12(12): 1522-1525. doi: 10.7507/1672-2531.20120234 Copy