Objective 　To evaluate the clinical effectiveness of Periocline (2% minocycline hydrochloride ointment) versus Yakang (metronidazole stilus) for treating chronic periodontitis in adults by means of meta-analysis.
Methods 　The following electronic databases as PubMed, The Cochrane Library, EMbase, CNKI, CBM and WanFang Data were searched on computer from inception to July, 2012, and the references of all selected studies were also retrieved to collect the relevant randomized controlled trials (RCTs) on periocline vs. Yakang for chronic periodontitis. According to the inclusion and exclusion criteria, two reviewers independently screened studies, extracted data, and evaluated the methodological quality of the included RCTs. Then meta-analysis was performed using RevMan 5.0 software.
Results 　A total of 7 RCTs involving 737 patients were included. The results of meta-analysis showed that there were no significant differences in probing depth (MD=0.26, 95%CI −0.35 to 0.87, P=0.40), clinical attachment level (MD=−0.10, 95%CI −0.75 to 0.54, P=0.75), sulcus bleeding index (MD=0.12, 95%CI −0.30 to 0.53, P=0.59), and plaque index (MD=0.07, 95%CI −0.09 to 0.22, P=0.41) between the Periocline group and the Yakang group.
Conclusion 　The current evidence shows that based on periodental non-surgical treatment, Periocline is similar to Yakang in improving the symptoms of chronic periodontitis in adults. However, given the low methodological quality and the limited sample size of most included studies, this conclusion still needs to be further proved by conducting more strictly-designed, high-quality and large-scale RCTs. The long-term effectiveness of those 2 treatment modalities also needs to be observed in a longer follow-up duration.

Citation： LI Simin,GUO Liangwei,DING Ling. Periocline versus Yakang for Chronic Periodontitis in Adults: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2013, 13(2): 224-230. doi: 10.7507/1672-2531.20130038 Copy