Short-Term Effect of Hyperbaric Oxygen Combined with Edaravone and Ozagrel Sodium in Treating Progressive Cerebral Infarction_Chinese Journal of Evidence-Based Medicine

Authors：

 CHEN Fuping , YU Xingxu

Department of Neurology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, China;

Corresponding author：

CHEN Fuping , Email: cfpyx2008@yahoo.cn

Keywords：

Progressive cerebral infarction; Hyperbaric oxygen; Edaravone; Ozagrel sodium; Randomized controlled trial

DOI：

10.7507/1672-2531.20130070

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To observe the short-term effect and safety of hyperbaric oxygen combined with edaravone and ozagrel sodium in treating progressive cerebral infarction.
Methods 　A total of 65 in-patients with acute progressive cerebral infarction were randomly divided into two groups: 33 in-patients in the trial group were treated by hyperbaric oxygen combined with edaravone and ozagrel sodium, while the other 32 in-patients in the control group were treated by edaravone and ozagrel sodium. The course of treatment was 14 days. The following indications were assessed before and after the treatment respectively: the national institutes of health stroke scale (NIHSS), activities of daily living (ADL), and clinical effects.
Results 　This study showed that the scores of both ADL and NIHSS in the trial group were higher than those in the control group, with significant differences (P lt;0.05). The clinical effective rate of the trial group was 90.91% which was obviously higher than the control group with a significant difference (P=0.028). There were no obvious adverse reactions in both groups.
Conclusion 　Hyperbaric oxygen combined with both edaravone and ozagrel sodium is notable in short-term effect and safe, thus it is worth being popularized in clinical treatment.

Citation： CHEN Fuping ,YU Xingxu. Short-Term Effect of Hyperbaric Oxygen Combined with Edaravone and Ozagrel Sodium in Treating Progressive Cerebral Infarction. Chinese Journal of Evidence-Based Medicine, 2013, 13(4): 413-416. doi: 10.7507/1672-2531.20130070 Copy

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2.	Jensen JK, Hallen J, Lund T, et al. Troponin I degradation in serum of patients with acute ischemic stroke. Scand J Clin Lab Invest, 2011, 71(1): 74-80.
3.	Sung SF, Ong CT, Wu CS, et al. Increased use of thrombolytic therapy and shorte ning of in-hospital delays following acute ischemic stroke: experience on the establishment of a primary stroke center at a comunity hospital. Acta Neurol Taiwan, 2010, 19(4): 24-252.
4.	朱晓莺, 邱有波, 杨拯. 奥扎格雷钠联合依达拉奉治疗脑梗死的系统评价. 中国循证医学杂志, 2011, 11(8): 932-939.
5.	李绍发, 梁柯. 依达拉奉联合早期高压氧疗对急性缺血性卒中的疗效观察. 中国实用神经疾病杂志, 2010, 13(22): 77-78.
6.	中华神经科学会. 各类脑血管疾病诊断要点. 中华神经科杂志, 1996, 29(9): 379-38.
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8.	MeCann SK, Dusting GJ, Roulston CL. Early increase of Nox4 NADPH ox idase and super ox ide generation following endothelin-1-induced stroke in conscious rats. J Neurosci Res, 2008, 86(11): 2524-2534．.
9.	Terao Y, Ohta H, Oda A, et al. Macrophage inflammatory protein-3 alpha plays a key role in the inflammatory cascade in rat focal cerebral ischemia. Neurosci Res, 2009, 64(1): 75-82.
10.	Dai HB, Fu QL, Shen Y, et al. The histamine H3 receptor antagonist clobenprop it enhances GABA release to protect against NMDA-induced excitotoxieity through the cAMP/protein kinase A pathway in cultured cortical neurons. Eur J Pharmacol, 2007, 563(3): 117-123.
11.	Rafferty M, Walters MR, Dawson J. Anti-Platelet therapy and aspirin resistance clinically and chemically relevant?. Curr Med Chem, 2010, 17(36): 4578-4586.
12.	Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract, 2009, 63(10): 1509-1515.
13.	Ansara AJ, Nisly SA, Arif SA, et al. Aspirin dosing for the prevention and treatment of isehemic stroke:an indication-specific review of the literature. Ann Pharma-cother, 2010, 44(5): 851-862.
14.	Nishi H, Watanabe T, Sakurai H, et al. Effect of MCI-186 on brain edema in rats. Stroke, 2001, 20: 1236-1240.
15.	Edaravone Acute Infaretion Study Group. Effect of a novel free radical scanenger edaravone (MCI-186). On acute brain irrfaretion, Randomized Iacebo-controlled, study at multicenters. Cerebrovase Dis, 2003, 15(3): 222-229.
16.	蒋明勇, 何举名, 王汉蛟. 依达拉奉联合醒脑静治疗成人急性脑梗死疗效的系统评价. 中国循证医学杂志, 2012, 12(11): 1339-1346.
17.	Zhu HP, Liu YZ, Liu L. Correlation of high—sensitivity C-reactive protein and carotid plaque in patients with acute cerebral infarction. Journal of Clinical Neurology, 2007, 20(4): 298.
18.	Tanahashi N. Antithrombotic therapy in cerebral infaction. Rinsho Shinkei- gaku, 2000, 40(12): 1251-1253.
19.	罗文芳, 易振佳, 李密, 等. 高压氧对颅脑损伤患者血液流变学的影响. 现代生物医学进展, 2008, 8(5): 892-894.
20.	Veltkamp R, Wamer DS, Domoki F, et al. Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats. Brain Res, 2003, 853(1): 68-73.
21.	Tighe SQ, Nelson RA. Hyperbaric oxygen therapy. Br J Anaesth, 2000, 85(4): 656-657.

1. Israeli-korn SD, Schwammenthal Y, Yonash-Kimchi T, et al. Ischemic stroke duc to acute basilar artery occlusion: proportion and outcomes. Isr Med Assoc J, 2010, 12(11): 671-675.
2. Jensen JK, Hallen J, Lund T, et al. Troponin I degradation in serum of patients with acute ischemic stroke. Scand J Clin Lab Invest, 2011, 71(1): 74-80.
3. Sung SF, Ong CT, Wu CS, et al. Increased use of thrombolytic therapy and shorte ning of in-hospital delays following acute ischemic stroke: experience on the establishment of a primary stroke center at a comunity hospital. Acta Neurol Taiwan, 2010, 19(4): 24-252.
4. 朱晓莺, 邱有波, 杨拯. 奥扎格雷钠联合依达拉奉治疗脑梗死的系统评价. 中国循证医学杂志, 2011, 11(8): 932-939.
5. 李绍发, 梁柯. 依达拉奉联合早期高压氧疗对急性缺血性卒中的疗效观察. 中国实用神经疾病杂志, 2010, 13(22): 77-78.
6. 中华神经科学会. 各类脑血管疾病诊断要点. 中华神经科杂志, 1996, 29(9): 379-38.
7. 陈清棠. 脑卒中患者临床神经功能缺损程度评分标准及临床疗效评定标准. 中华神经科杂志, 1996, 29(9): 381-383.
8. MeCann SK, Dusting GJ, Roulston CL. Early increase of Nox4 NADPH ox idase and super ox ide generation following endothelin-1-induced stroke in conscious rats. J Neurosci Res, 2008, 86(11): 2524-2534．.
9. Terao Y, Ohta H, Oda A, et al. Macrophage inflammatory protein-3 alpha plays a key role in the inflammatory cascade in rat focal cerebral ischemia. Neurosci Res, 2009, 64(1): 75-82.
10. Dai HB, Fu QL, Shen Y, et al. The histamine H3 receptor antagonist clobenprop it enhances GABA release to protect against NMDA-induced excitotoxieity through the cAMP/protein kinase A pathway in cultured cortical neurons. Eur J Pharmacol, 2007, 563(3): 117-123.
11. Rafferty M, Walters MR, Dawson J. Anti-Platelet therapy and aspirin resistance clinically and chemically relevant?. Curr Med Chem, 2010, 17(36): 4578-4586.
12. Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract, 2009, 63(10): 1509-1515.
13. Ansara AJ, Nisly SA, Arif SA, et al. Aspirin dosing for the prevention and treatment of isehemic stroke:an indication-specific review of the literature. Ann Pharma-cother, 2010, 44(5): 851-862.
14. Nishi H, Watanabe T, Sakurai H, et al. Effect of MCI-186 on brain edema in rats. Stroke, 2001, 20: 1236-1240.
15. Edaravone Acute Infaretion Study Group. Effect of a novel free radical scanenger edaravone (MCI-186). On acute brain irrfaretion, Randomized Iacebo-controlled, study at multicenters. Cerebrovase Dis, 2003, 15(3): 222-229.
16. 蒋明勇, 何举名, 王汉蛟. 依达拉奉联合醒脑静治疗成人急性脑梗死疗效的系统评价. 中国循证医学杂志, 2012, 12(11): 1339-1346.
17. Zhu HP, Liu YZ, Liu L. Correlation of high—sensitivity C-reactive protein and carotid plaque in patients with acute cerebral infarction. Journal of Clinical Neurology, 2007, 20(4): 298.
18. Tanahashi N. Antithrombotic therapy in cerebral infaction. Rinsho Shinkei- gaku, 2000, 40(12): 1251-1253.
19. 罗文芳, 易振佳, 李密, 等. 高压氧对颅脑损伤患者血液流变学的影响. 现代生物医学进展, 2008, 8(5): 892-894.
20. Veltkamp R, Wamer DS, Domoki F, et al. Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats. Brain Res, 2003, 853(1): 68-73.
21. Tighe SQ, Nelson RA. Hyperbaric oxygen therapy. Br J Anaesth, 2000, 85(4): 656-657.

Chinese Journal of Evidence-Based Medicine

Short-Term Effect of Hyperbaric Oxygen Combined with Edaravone and Ozagrel Sodium in Treating Progressive Cerebral Infarction

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