Clinical Effectiveness and Safety of Carvedilol for Arrhythmia in Patients with Hypertension Complicated with Diabetes Mellitus: A Randomized Controlled Trial_Chinese Journal of Evidence-Based Medicine

Authors：

 LIJing ¹ , ZHUBao-yue ¹ , LIYing ² , ZHANGJian-jun ¹ , WANGWei-zhan ¹

1. Emergency Intensive Care Unit, Harrison International Peace Hospital Affiliated to Hebei Medical University, Hengshui 053000, China;
2. Hengshui Second Hospital, Hengshui 053000, China;

Corresponding author：

Keywords：

Carvedilol; Hypertension; Diabetes Mellitus; Arrhythmia; Randomized controlled trial

DOI：

10.7507/1672-2531.20140026

Video：

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Objective To investigate the clinical efficacy and safety of carvedilol in the treatment of arrhythmia in patients with hypertension complicated with diabetes mellitus. Methods We selected the patients with hypertension complicated with diabetes mellitus who were hospitalized in the Harrison International Peace Hospital Affiliated to Hebei Medical University for treatment from Oct. 2011 to Oct. 2013. The cases were divided into a trial group and a control group. The control group was given routine treatment (eg., hypoglycaemic drugs, angiotensin converting enzyme inhibitors). On the basis of the same treatment of the control group, the trial group was given carvedilol. The efficacy and adverse reaction were observed, recorded and then analyzed between the two groups. Results A total of 140 patients were included (70 cases in each group). With the loss of 10 cases in the control group, the data of 70 cases in the trial group and 60 cases in the control group were finally analyzed. The results showed that the trial group was superior to the control group in the total effectiveness (χ²=8.320, P=0.004) and the dynamic ECG improvement of premature ventricular contraction (χ²=5.333, P=0.014) with significant differences. Both groups were significantly improved in blood pressure and heart beats compared with the situation before treatment (Both P < 0.05), and the trial group was better than the control group with a significant difference. During the treatment, three cases in the trial group had mild gastrointestinal symptoms which spontaneously disappeared later. Conclusion The clinical effectiveness of carvedilol for arrhythmia in patients with hypertension complicated with diabetes mellitus is significant. It is safe and effective which is recommended in clinical application.

Citation： LIJing, ZHUBao-yue, LIYing, ZHANGJian-jun, WANGWei-zhan. Clinical Effectiveness and Safety of Carvedilol for Arrhythmia in Patients with Hypertension Complicated with Diabetes Mellitus: A Randomized Controlled Trial. Chinese Journal of Evidence-Based Medicine, 2014, 14(2): 152-155. doi: 10.7507/1672-2531.20140026 Copy

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12.	丁军, 慈书平. 258例老年糖尿病与心律失常关系的临床观察.实用老年医学, 2010, 10(24):424-425.
13.	张中亚, 於席芳, 刘鲜梅, 等.糖尿病家兔的心室电重构与心律失常的关系.临床心血管病杂志, 2013, 29(6):475-478.
14.	田芳, 毕会民, 朱骏科, 等. 2型糖尿病患者心律失常及相关因素分析.临床心血管病杂志, 2010, 10(26):726-729.
15.	刘青青, 陈瑶, 肖雨婷.卡维地洛和美托洛尔治疗高血压的疗效及其糖脂代谢影响的对比分析.中国老年学杂志, 2013, 3(16):1035-1037.
16.	胡小亮, 路方红, 刘振东, 等.降压降脂联合治疗对老年高血压患者动脉僵硬度的影响.中国循证医学杂志, 2011, 11(9):1008-1011.
17.	袁华兵, 齐晓勇, 等.卡维地洛对急性心肌梗死家兔室性心律失常的影响.中国老年学杂志, 2011, 4(31):1172-1174.
18.	任古松, 张春霞.卡维地洛治疗老年慢性充血性心衰合并快速型心律失常60例疗效观察.山东医药, 2013, 25(53):103-104.
19.	高昕.卡维地洛与比索洛尔治疗慢性心力衰竭患者的疗效及安全性对比分析.陕西医学杂志, 2013, 8(42):1061-1063.

1. 王龙, 张钲, 彭瑜.原发性高血压合并2型糖尿病患者的心律失常.中华高血压杂志, 2008, 3(16):220-224.
2. Greenberg JD, Tiwari A, Raian M, et al. Determinants of sustained uncontrolled blood pressure in a national cohort of persons with diabetes. Am J Hypertens, 2006, 19(2):161-169.
3. 楼建英. 2型糖尿病合并高血压诊断治疗新视野.实用老年医学, 2013, 4(27):272-276.
4. 任古松, 张春霞.卡维地洛治疗老年慢性充血性心衰合并快速型心律失常60例疗效观察.山东医药, 2013, 25(53):103-104.
5. 中国高血压防治指南修订委员会.中国高血压防治指南2010.中华高血压杂志, 2011, 8(19):701-743.
6. 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010年版).中国糖尿病杂志, 2012, 1(20):1-37.
7. 于赛华, 于金华.参松养心胶囊联合美托洛尔治疗女性更年期室性早搏的临床研究.中西医结合心脑血管病杂志, 2013, 11(2):163-164.
8. 刘国仗, 吴宁, 胡大一, 等.心血管药物治疗临床试验评价方法的建议.中华心血管病杂志, 1998, 26(1):405-413.
9. 贾淑杰, 周芸, 杨红霞, 等.高血压合并冠心病患者的冠脉病变特点.中国循证医学杂志, 2011, 11(6):640-643.
10. Varugbese GI, Tahrani AA, Scarpello JH. The putative link between glycemic control and cardiac arrhythmias. Arch Intern Med, 2007, 167(13):1433-1434.
11. 彭朝胜, 曹悦鞍, 张文洛, 等.老年2型糖尿病患者血糖波动与室性心律失常的关系.中国老年学杂志, 2011, 4(31):1423-1424.
12. 丁军, 慈书平. 258例老年糖尿病与心律失常关系的临床观察.实用老年医学, 2010, 10(24):424-425.
13. 张中亚, 於席芳, 刘鲜梅, 等.糖尿病家兔的心室电重构与心律失常的关系.临床心血管病杂志, 2013, 29(6):475-478.
14. 田芳, 毕会民, 朱骏科, 等. 2型糖尿病患者心律失常及相关因素分析.临床心血管病杂志, 2010, 10(26):726-729.
15. 刘青青, 陈瑶, 肖雨婷.卡维地洛和美托洛尔治疗高血压的疗效及其糖脂代谢影响的对比分析.中国老年学杂志, 2013, 3(16):1035-1037.
16. 胡小亮, 路方红, 刘振东, 等.降压降脂联合治疗对老年高血压患者动脉僵硬度的影响.中国循证医学杂志, 2011, 11(9):1008-1011.
17. 袁华兵, 齐晓勇, 等.卡维地洛对急性心肌梗死家兔室性心律失常的影响.中国老年学杂志, 2011, 4(31):1172-1174.
18. 任古松, 张春霞.卡维地洛治疗老年慢性充血性心衰合并快速型心律失常60例疗效观察.山东医药, 2013, 25(53):103-104.
19. 高昕.卡维地洛与比索洛尔治疗慢性心力衰竭患者的疗效及安全性对比分析.陕西医学杂志, 2013, 8(42):1061-1063.

Chinese Journal of Evidence-Based Medicine

Clinical Effectiveness and Safety of Carvedilol for Arrhythmia in Patients with Hypertension Complicated with Diabetes Mellitus: A Randomized Controlled Trial

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