Diagnostic Value of Bronchial Provocation Test for Chronic Cough_Chinese Journal of Evidence-Based Medicine

Authors：

 LIGuang-qing ,  WUZhao-ping , LIXiao-bo , XUDeng-cheng , QIZhan-zhong , LIANGYing-jun , XUYan , LIShao-hong , TANGWen-yan

Department of Respiratory Medicine, The 452^nd Military Hospital, Chengdu 610041, China;

Corresponding author：

WUZhao-ping, Email: wuzhaokjyy@163.com

Keywords：

Chronic cough; Bronchial provocation test; Cough variant asthma

DOI：

10.7507/1672-2531.20140028

Video：

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Objective To investigate the diagnostic value of bronchial provocation test in patients with chronic cough. Methods A total of 550 chronic cough patients were selected in the 452nd Military Hospital from March 2011 to February 2012. These patients all underwent the basic lung function test and the bronchial provocation test (BPT) to acetylcholine so as to assess the bronchial hyper-reactivity by inhaling methacholine. The diagnostic value of BPT was then evaluated. Results All included patients had normal lung function. There were 267 patients (48.5%) who showed positive results in BPT, of whom, 236 BPT-positive patients were finally diagnosed as cough variant asthma. After regular treatment, the cough symptoms were well controlled. Conclusion Cough variant asthma is one of the main causes of chronic cough. The BPT is an important method of aiding the diagnosis of cough variant asthma which helps early diagnosis of it.

Citation： LIGuang-qing, WUZhao-ping, LIXiao-bo, XUDeng-cheng, QIZhan-zhong, LIANGYing-jun, XUYan, LIShao-hong, TANGWen-yan. Diagnostic Value of Bronchial Provocation Test for Chronic Cough. Chinese Journal of Evidence-Based Medicine, 2014, 14(2): 162-164. doi: 10.7507/1672-2531.20140028 Copy

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1. Pavord ID, Chung KF. Management of chronic cough. Lancet, 2008, 371(9621):1375-1384.
2. Abouzgheib W, Pratter MR, Bartter T. Cough and asthma. Curr Opin Pulm Med, 2007, 13(1):44-48.
3. Chung KF. Chronic cough:future directions in chronic cough:mechanisms and antitussives. Chron Respir Dis, 2007, 4(3):159-165.
4. Barber CM, Fishwick D. Chronic cough-occupational considerations. Chron Respir Dis, 2008, 5(4):211-221.
5. Chung KF. Currently available cough suppressants for chronic cough. Lung, 2008, 186(Suppl 1):S82-87.
6. Tokayer AZ. Gastroesophageal reflux disease and chronic cough. Lung, 2008, 186(Suppl 1):S29-34.
7. Goldsobel AB, Kelkar PS. The adult with chronic cough. J Allergy Clin Immunol, 2012, 130(3):825.
8. Natt RS, Earis JE, Swift AC. Chronic cough:a multidisciplinary approach. J Laryngol Otol, 2012, 126(5):441-444.
9. Birring SS. Controversies in the evaluation and management of chronic cough. Am J Respir Crit Care Med, 2011, 183(6):708-715.
10. Chummun D, Lu H, Qiu Z. Empiric treatment of chronic cough in adults. Allergy Asthma Proc, 2011, 32(3):193-197.
11. Teoh L, Hurwitz M, Acworth JP, et al. Treatment of obstructive sleep apnoea for chronic cough in children. Cochrane Database Syst Rev, 2011, (4):CD008182.
12. McGarvey L. The management of cough:a clinical year in review. Lung, 2010, 188(Suppl 1):S3-8.
13. Wee B. Chronic cough. Curr Opin Support Palliat Care, 2008, 2(2):105-109.
14. Birring SS. New concepts in the management of chronic cough. Pulm Pharmacol Ther, 2011, 24(3):334-338.
15. Braman SS. Chronic cough due to acute bronchitis:ACCP evidencebased clinical practice guidelines. Chest, 2006, 129(Suppl 1):S95-103.
16. Simpson CB, Amin MR. Chronic cough:state-of-the-art review. Otolaryngol Head Neck Surg, 2006, 134(4):693-700.

Chinese Journal of Evidence-Based Medicine

Diagnostic Value of Bronchial Provocation Test for Chronic Cough

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